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The search for flavor oscillations in the neutral Bs - B meson system constitutes a flagship analysis of the Tevatron proton-anti-proton collider physics program and an important probe for effects due to new physics beyond the Standard Model of particles and interactions. In particular, the precise measurement of a process such as Boscillations sets a strong constraint on the parameters of quark-flavor mixing in the Standard Model.This dissertation reports the analysis which, for the first time, observed B- Bs oscillations, using data collected with the CDF detector. The sub-percent precision of the measurement is also noteworthy. The data sample used for this analysis includes fully and partially reconstructed Bdecays: ...The focus of this thesis is the algorithm of same-side-kaon tagging which provides _-0 a large fraction of the flavor-tagging power available to this analysis of B- B8 oscillations. Flavor tagging consists in assessing whether a B, meson is creates as a B_--0 or a B, state, and constitutes an important ingredient in the analysis presented in this document. The algorithm which is here described combines particle identification information and kinematic characteristics of the Bevent in an artificial neural network to provide improved tagging power E'2 of about 4.0 - 4.8%, depending on the data sample to which the algorithm is applied.The search for B1 oscillations is performed using an amplitude method based on a frequency scanning procedure. Applying a neural network-based combination of lepton, kaon and jet charge opposite-side tagging algorithms, with a total tagging power of ED2 = 1.8%, and the same-side-kaon tagging algorithm to a data sample of 1 fb-1, a signal of B- B_ oscillations with a significance greater than 5 standard deviations is found ...

Results on the effects of ionizing radiation on the signal produced by plastic scintillating rods manufactured by Eljen Technology company are presented for various matrix materials, dopant concentrations, fluors (EJ-200 and EJ-260), anti-oxidant concentrations, scintillator thickness, doses, and dose rates. The light output before and after irradiation is measured using an alpha source and a photomultiplier tube, and the light transmission by a spectrophotometer. Assuming an exponential decrease in the light output with dose, the change in light output is quantified using the exponential dose constant \\(D\\). The \\(D\\) values are similar for primary and secondary doping concentrations of 1 and 2 times, and for antioxidant concentrations of 0, 1, and 2 times, the default manufacturer's concentration. The \\(D\\) value depends approximately linearly on the logarithm of the dose rate for dose rates between 2.2 Gy/hr and 70 Gy/hr for all materials. For EJ-200 polyvinyltoluene-based (PVT) scintillator, the dose constant is approximately linear in the logarithm of the dose rate up to 3400 Gy/hr, while for polystyrene-based (PS) scintillator or for both materials with EJ-260 fluors, it remains constant or decreases (depending on doping concentration) above about 100 Gy/hr. The results from rods of varying thickness and from the different fluors suggest damage to the initial light output is a larger effect than color center formation for scintillator thickness \\(1\\) cm. For the blue scintillator (EJ-200), the transmission measurements indicate damage to the fluors. We also find that while PVT is more resistant to radiation damage than PS at dose rates higher than about 100 Gy/hr for EJ-200 fluors, they show similar damage at lower dose rates and for EJ-260 fluors.

Future lepton colliders such as the FCC-ee, CEPC, ILC, or a muon collider will collect large data samples that allow precision physics studies with unprecedented accuracy, especially when the data is collected by innovative state-of-the-art detectors. An electromagnetic calorimeter based on scintillating crystals, designed to separately record Cherenkov and scintillation light, can achieve precision measurements of electrons and photons without sacrificing jet energy resolution, given adequate light collection efficiency and separation. This paper presents initial measurements from a program aimed at developing such a calorimeter system for future colliders. We focus on using PbF2 crystals to enhance the understanding of Cherenkov light collection, marking the first step in this endeavor.

This report, as part of the 2021 Snowmass Process, summarizes the current status of collider physics at the Energy Frontier, the broad and exciting future prospects identified for the Energy Frontier, the challenges and needs of future experiments, and indicates high priority research areas.

The precise measurement of physics observables and the test of their consistency within the standard model (SM) are an invaluable approach, complemented by direct searches for new particles, to determine the existence of physics beyond the standard model (BSM). Studies of massive electroweak gauge bosons (W and Z bosons) are a promising target for indirect BSM searches, since the interactions of photons and gluons are strongly constrained by the unbroken gauge symmetries. They can be divided into two categories: (a) Fermion scattering processes mediated by s- or t-channel W/Z bosons, also known as electroweak precision measurements; and (b) multi-boson processes, which include production of two or more vector bosons in fermion-antifermion annihilation, as well as vector boson scattering (VBS) processes. The latter categories can test modifications of gauge-boson self-interactions, and the sensitivity is typically improved with increased collision energy. This report evaluates the achievable precision of a range of future experiments, which depend on the statistics of the collected data sample, the experimental and theoretical systematic uncertainties, and their correlations. In addition it presents a combined interpretation of these results, together with similar studies in the Higgs and top sector, in the Standard Model effective field theory (SMEFT) framework. This framework provides a model-independent prescription to put generic constraints on new physics and to study and combine large sets of experimental observables, assuming that the new physics scales are significantly higher than the EW scale.

The ATLAS experiment at the Large Hadron Collider (LHC) at CERN is currently waiting to record the first collision data in spring 2009. Its muon spectrometer is designed to achieve a momentum resolution of 10% pT(mu) = 1 TeV/c. The spectrometer consists of a system of three superconducting air-core toroid magnets and is instrumented with three layers of Monitored Drift Tube chambers (Cathode Strip Chambers in the extreme forward region) as precision detectors. Resistive Plate Chambers in the barrel and Thin Gap Chambers in the endcap regions provide a fast trigger system. The spectrometer passed important milestones in the last year. The most notable milestone was the installation of the inner layer of endcap muon chambers, which constituted the last big piece of the ATLAS detector to be lowered in the ATLAS cavern. In addition, during the last two years most of the muon detectors were commissioned with cosmic rays while being assembled in the underground experimental cavern. We will report on our experience with the precision and trigger chambers, the optical spectrometer alignment system, the level-1 trigger, and the ATLAS data acquisition system. Results of the global performance of the muon system from data with magnetic field will also be presented.

This study aimed to analyze Optical Coherence Tomography (OCT) parameters and Macular Pigment Optical Density (MPOD) changes in patients affected by Retinitis pigmentosa (RP). Eighteen eyes of 18 patients suffering from early-stage RP were enrolled in our observational study. 18 eyes of 18 patients age and gender matched were enrolled as controls. Patients were analyzed at baseline by undergoing complete baseline ophthalmologic examination, Spectral-domain Optical Coherence Tomography (OCT), Electroretinogram (ERG) and Heterochromatic Flicker Photometry (HFP). Main outcome measures were Macular Pigment Optical Density (MPOD), Central macular thickness (CMT), Central Choroidal Thickness (CCT) and Choroidal Vascularity Index (CVI). Lower CCT ( p  = 0.006), CVI ( p  < 0.001) and MPOD levels ( p  = 0.038) were found in affected patients, whereas higher CMT was detected in cases compared to healthy controls. Correlation analysis revealed the presence of a negative correlation between BCVA and Age and CMT and BCVA and a positive correlation between CCT and MPOD and CVI and CCT. Retinal and choroidal variations occur in patients affected by early-stage RP regarding functional and anatomical changes.

This article provides comprehensive recommendations for the systemic treatment of severe pediatric psoriasis based on evidence obtained from a systematic review of the literature and the consensus opinion of expert dermatologists and pediatricians. For each systemic treatment, the grade of recommendation (A, B, C) based on the treatment’s approval by the European Medicines Agency for childhood psoriasis and the experts’ opinions is discussed. The grade of recommendation for narrow-band-ultraviolet B phototherapy, cyclosporine, and retinoids is C, while that for methotrexate is C/B. The use of adalimumab, etanercept, and ustekinumab has a grade A recommendation. No conventional systemic treatments are approved for pediatric psoriasis. Adalimumab is approved by the European Medicines Agency as a first-line treatment for severe chronic plaque psoriasis in children (≥ 4 years old) and adolescents. Etanercept and ustekinumab are approved as second-line therapy in children ≥ 6 and ≥ 12 years, respectively. Conclusion : A treatment algorithm as well as practical tools (i.e., tabular summaries of differential diagnoses, treatment mechanism of actions, dosing regimens, control parameters) are provided to assist in therapeutic reasoning and decision-making for individual patients. These treatment recommendations are endorsed by major Italian Pediatric and Dermatology Societies. What is Known: • Guidelines for the treatment of severe pediatric psoriasis are lacking and most traditional systemic treatments are not approved for use in young patients. Although there has been decades of experience with some of the traditional agents such as phototherapy, acitretin, and cyclosporine in children, there are no RCTs on their pediatric use while RCTs investigating new biologic agents have been performed. What is New: • In this manuscript, an Italian multidisciplinary team of experts focused on treatment recommendations for severe forms of psoriasis in children based on an up-to-date review of the literature and experts’ opinions.

Currently, there are a few detailed guidelines on the overall management of children and adolescents with moderate-severe atopic dermatitis. AD ​​is a complex disease presenting with different clinical phenotypes, which require an individualized and multidisciplinary approach. Therefore, appropriate interaction between primary care pediatricians, pediatric allergists, and pediatric dermatologists is crucial to finding the best management strategy. In this manuscript, members of the Italian Society of Pediatric Allergology and Immunology (SIAIP), the Italian Society of Pediatric Dermatology (SIDerP), and the Italian Society of Pediatrics (SIP) with expertise in the management of moderate-severe atopic dermatitis have reviewed the latest scientific evidence in the field. This narrative review aims to define a pathway to appropriately managing children and adolescents with moderate-severe atopic dermatitis.