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Isolation of microparticles and biological cells from mixtures and suspensions is a central problem in a variety of biomedical applications. This problem, for instance, is of an immense importance for microfluidic devices manipulating with whole blood samples. It is instructive to know how the mobility and dynamics of rigid microparticles is altered by the presence of micrometer-size roughness on walls. The presented theoretical study addresses this issue via computer simulations. The approach is based on a combination of the Lattice Boltzmann method for calculating hydrodynamics and the Lagrangian Particle dynamics method to describe the dynamics of cell membranes. The effect of the roughness on the mobility of spheroidal microparticles in a shear fluid flow was quantified. We conclude that mechanical and hydrodynamic interactions lift the particles from the surface and change their mobility. The effect is sensitive to the shape of particles.

National energy efficiency is a key driver for the sustainable development of society. However, the conditions for increasing energy efficiency vary widely around the world and depend on numerous controllable and uncontrollable factors. Existing indicators for assessing energy efficiency typically focus on individual factors, neglecting the complex interplay of socioeconomic, environmental, technological, and other factors that influence energy efficiency. This limitation hampers the quality of assessments. The goal of this study is to develop and apply a comprehensive methodological approach for assessing the influence of key factors on energy efficiency across different countries. The approach utilizes factor analysis methods to identify correlations between indicators and energy-efficiency factors. The study’s findings offer a model for assessing energy efficiency that enables a more profound and comprehensive analysis of the multifactorial impact experienced by national economies in various energy-efficiency domains and areas.

Consideration is given to the modernization of a pulse method of nondestructive control of the diffusion coefficient with the aim of improving the accuracy of its use to investigate massive products from porous materials. The method makes it unnecessary to precalibrate the used diffusant-concentration meter and ensures a rise in the accuracy of determining the sought diffusion coefficient due to the possibility to select measured parameters involved in a calculation expression on portions of the static characteristic of the sensor with high sensitivity and antijamming capability. Technical implementation of the method with a data-measuring system is considered.

The treatment of tuberculosis is still a challenging process due to the widespread of pathogen strains resistant to antibacterial drugs, as well as the undesirable effects of anti-tuberculosis therapy. Hence, the development of safe and effective new anti-antitubercular agents, in addition to suitable nanocarrier systems, has become of utmost importance and necessity. Our research aims to develop liposomal vesicles that contain newly synthesized compounds with antimycobacterial action. The compound being studied is a derivative of imidazo-tetrazine named 3-(3,5-dimethylpyrazole-1-yl)-6-(isopropylthio) imidazo [1,2-b] [1,2,4,5] tetrazine compound. Several factors that affect liposomal characteristics were studied. The maximum encapsulation efficiency was 53.62 ± 0.09. The selected liposomal formulation T8* possessed a mean particle size of about 205.3 ± 3.94 nm with PDI 0.282, and zeta potential was + 36.37 ± 0.49 mv. The results of the in vitro release study indicated that the solubility of compound I was increased by its incorporation in liposomes. The free compound and liposomal preparation showed antimycobacterial activity against Mycobacterium tuberculosis H 37 R v (ATCC 27294) at MIC value 0.94–1.88 μg/ml. We predict that the liposomes may be a good candidate for delivering new antitubercular drugs.

A brief description of scientific program and papers of International Conference \"Physics of Dispersed Media for Electronics and IT devices\" is presented. It is an annual conference of Moscow Region State University (MRSU).

It is common knowledge that using different oxygen contents in the working gas during sputtering deposition results in fabrication of indium zinc oxide (IZO) films with a wide range of optoelectronic properties. It is also important that high deposition temperature is not required to achieve excellent transparent electrode quality in the IZO films. Modulation of the oxygen content in the working gas during RF sputtering of IZO ceramic targets was used to deposit IZO-based multilayers in which the ultrathin IZO unit layers with high electron mobility (μ-IZO) alternate with ones characterized by high concentration of free electrons (n-IZO). As a result of optimizing the thicknesses of each type of unit layer, low-temperature 400 nm thick IZO multilayers with excellent transparent electrode quality, indicated by the low sheet resistance (R ≤ 8 Ω/sq.) with high transmittance in the visible range (T¯ > 83%) and a very flat multilayer surface, were obtained.

The work is devoted to the study of a MEMS resonator dynamics under the action of phase-locked and automatic gain control loops. Particular attention is directed to the study of the nonlinearity factor of the resonator elastic restoring force. It was found that the determination of control system parameters based on the stability analysis of the operating resonant mode, in the general case, does not provide the required phase adjustment and stabilization of the oscillation amplitude. Stable multifrequency modes of oscillations are found, and an analytical study of the mechanisms of their appearance and evolution is carried out under variation of the key parameters of the system. The real regions of the control system stable operation are determined (which do not coincide, as was found, with the regions of stability of the operating resonant mode, due to the presence of hidden attractors in the phase space of the system). A methodology has been developed for identifying such areas of stable operation. A significant complication of the structure of possible motions in the system with an increase in the Q-factor of the resonator is revealed.

ABSTRACTNew h-, p-, and hp-versions of the least-squares collocation method (LSCM) are proposed and implemented for solving the Dirichlet problem for a Poisson equation. Examples are considered of solving problems with singularities such as large gradients, fast growing rate of solution derivatives with increasing order of differentiation, discontinuities of second-order derivatives at angular points of the domain boundary, and solution oscillations with various frequencies for an infinite discontinuity point for derivatives of any order. The new versions of the method are based on a special selection of collocation points in the roots of Chebyshev polynomials of the first kind. The basis functions are defined as products of Chebyshev polynomials. The behavior of numerical solutions on a sequence of grids with an increasing degree of the approximating polynomial is analyzed by using exact analytical solutions. Formulas for the extension operation of transition from a coarse grid to a finer one on a multi-grid complex in the Fedorenko method are obtained.

The conditions of soliton formation in a liquid crystal layer for generation of a pair of photons in an entangled quantum state (biphotons) during quantum calculations are considered. The geometrical dimensions of the soliton generated by a pulse of optical radiation, its dynamics and stability are estimated by using the knowledge of the liquid crystal physical parameters as well as its non-linear optical properties. The possibility of overlapping of optical solitons neighboring in space or time (or regions inside the liquid crystal layer, in which the deformation induced by the light wave field from successive light pulses occurs) is considered. In nematic liquid crystals (LCs), it is possible to obtain single solitons with spatial size of several tens of micrometers and less, the formation time from fractions of a millisecond to tens of milliseconds, and the existence time from fractions of the millisecond to hundreds of milliseconds. On this basis, it is possible to “encode” entangled states with a high level of signal distinction and to carry out quantum calculations.