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Abstract Pet rabbits have increased their popularity in a lot of countries. However, most of the laboratory profiles in rabbit medicine come from the observations made in rabbit as biomodels or meat production. So that further researches are necessary to obtain reference values for hematology and biochemical profiles in pet rabbits and the different breeds, especially, in relation to acid-base balance. The aim of this report was to offer the mean values of the main parameters connected with acid-base profile in Netherland Dwarf breed. Thirty-five healthy rabbits (15 males and 20 females) were studied. Venous blood sample from lateral saphenous vein was analyzed to measure: haematocrit, haemoglobin, blood urea nitrogen, glucose, blood pH, partial pressure of CO2 (pCO2), total CO2, ions bicarbonate, chloride, sodium, potassium, base excess and anion Gap. Results showed a shorter range that those reported by different researchers. Moreover, differences between genders were showed in pCO2, its values were higher in males. It may be associated with a greater cellular metabolism. Values obtained in this research should be taken into account by veterinary clinicians for this breed in their clinical assessments. Besides, these values provide new results in parameters with few reference values. Resumo A popularidade de coelhos como animais de estimação aumentou em muitos países. No entanto, a maioria dos perfis de laboratório em medicina de coelhos advém das observações de biomodelos animais ou da produção de carne. Assim, são necessárias pesquisas adicionais para obter valores de referência para hematologia e perfis bioquímicos em coelhos de estimação, e das diferentes raças, especialmente, em relação ao equilíbrio ácido-base. O objetivo deste relatório foi oferecer os valores médios dos principais parâmetros ligados ao perfil ácido-base na raça Anã Holandês. Trinta e cinco coelhos saudáveis (15 machos e 20 fêmeas) foram estudados. A amostra de sangue venoso da veia safena lateral foi analisada para mensuração: hematócrito, hemoglobina, nitrogênio ureico sanguíneo, glicose, pH sanguíneo, pressão parcial de CO2 (pCO2), CO2 total, íons bicarbonato, cloreto, sódio, potássio, excesso de base e ânion Gap. Os resultados apresentaram um intervalo menor do que aqueles relatados por diferentes pesquisadores. Além disso, as diferenças entre os gêneros foram mostradas na pCO2, seus valores foram maiores no sexo masculino. Pode estar associado a um maior metabolismo celular. Os valores obtidos nesta pesquisa devem ser levados em consideração pelos clínicos veterinários para esta raça em suas avaliações clínicas. Além disso, esses valores fornecem novos resultados em parâmetros com poucos valores de referencia.

Pet rabbits have increased their popularity in a lot of countries. However, most of the laboratory profiles in rabbit medicine come from the observations made in rabbit as biomodels or meat production. So that further researches are necessary to obtain reference values for hematology and biochemical profiles in pet rabbits and the different breeds, especially, in relation to acid-base balance. The aim of this report was to offer the mean values of the main parameters connected with acid-base profile in Netherland Dwarf breed. Thirty-five healthy rabbits (15 males and 20 females) were studied. Venous blood sample from lateral saphenous vein was analyzed to measure: haematocrit, haemoglobin, blood urea nitrogen, glucose, blood pH, partial pressure of C[O.sub.2] (pC[O.sub.2]), total C[O.sub.2], ions bicarbonate, chloride, sodium, potassium, base excess and anion Gap. Results showed a shorter range that those reported by different researchers. Moreover, differences between genders were showed in pC[O.sub.2], its values were higher in males. It may be associated with a greater cellular metabolism. Values obtained in this research should be taken into account by veterinary clinicians for this breed in their clinical assessments. Besides, these values provide new results in parameters with few reference values.

Information gleaned from the medical records included breed, sex, age, body condition score (BCS, 1 to 5), complaints/clinical signs, cell blood count, serum biochemistry profile, feline immunodeficiency virus/feline leukemia virus (FIV/FeLV) status (SNAP® FIV, FeLV Combo, IDEXX), serum folate and cobalamin concentrations, abdominal ultrasound changes [(increased GI wall thickness, loss of GI layering, lymphadenomegaly) according to a modified scoring system (Ripolles et al. 2013)], type of GI biopsy (endoscopic vs full-thickness), GI cytological/histopathological findings, clonality of GI lymphoid infiltrates, treatment, response to treatment (persistence, complete or partial remission of clinical signs), definitive diagnosis (FRE, IBD, AL) and follow-up (alive vs. date and cause of death). Previous studies have variously documented the prevalence of hypocobalaminemia in cats with GI disease (Simpson et al. 2001, Ibarrola et al. 2005, Reed et al. 2007, Barron et al. 2009). [...]failure to recognize and correct hypocobalaminemia can delay clinical recovery, even when specific therapy for IBD is instituted (Ruaux et al. 2005). [...]the diagnostic procedures were not strictly standardized and not all cats underwent endoscopy/laparotomy and clonality testing. [...]adult and elderly cats with muscle wasting, increased values of BUN and serum folate and reduced values of cobalamin at presentation may suffer from AL.

Pituitary-dependent hypercortisolism (PDH) is one of the most frequent endocrinopathies in dogs, but prognostic factors are largely unknown. The aim of this retrospective case series study was to determine the prognostic value of different clinical and clinicopathological variables evaluated in dogs newly diagnosed with PDH that were subsequently treated with trilostane. Medical records from one referral centre were evaluated. Eighty-five dogs with PDH were included. The median survival time was 852 days (range 2–3210 days); 60/85 (70 per cent) and 25/85 (29 per cent) dogs survived more than one and three years, respectively. In multivariable model analysis the length of survival of older dogs (HR 1.24, 95% CI 1.09 to 1.40) and dogs with higher serum phosphate concentrations (HR 1.35, 95% CI 1.01 to 1.81) was shorter. Serum phosphate concentrations were above the reference range in 37/85 (44 per cent) of animals. Clinical signs, liver enzymes, serum cortisol concentrations of the endocrine tests, proteinuria, systolic hypertension, the presence of concomitant disorders, and the frequency of trilostane administration were not associated with survival time. Hyperphosphataemia is a common finding in dogs with newly diagnosed PDH and represents a negative prognostic factor.

Background Measurement of hair cortisol is a noninvasive technique used for several purposes in humans and in animals. Objectives To measure hair cortisol concentrations (HCC) in dogs with spontaneous hypercortisolism (HC) and determine whether it can represent a useful diagnostic test for this syndrome. Animals Twenty‐two dogs with spontaneous HC before treatment, 28 sick control dogs (SCD), and 40 healthy dogs. Methods In this prospective, observational clinical study, the HCC was measured by an RIA assay after extraction in HC dogs, in dogs with other chronic diseases, and in healthy dogs. The diagnostic accuracy of HCC was evaluated by subjecting data from dogs with HC and dogs with other chronic diseases to receiver operating characteristic (ROC) curve analysis. Results Median (range) cortisol concentration in dogs with HC was 4.53 pg/mg (0.32–74.62 pg/mg) and was significantly higher than in SCD (1.49 pg/mg, 0.13–14.19 pg/mg) and healthy dogs (1.28 pg/mg, 0.34–5.38 pg/mg). Within the 3 groups, there was a large overlap of HCC. The area under the ROC curve was 0.80 (95% CI: 0.67–0.92). A cut‐off value of HCC of 1.93 pg/mg revealed 91% sensitivity and 61% specificity to diagnose HC. Conclusions and Clinical Importance Hair cortisol concentrations are higher in dogs with HC compared to SCD and healthy dogs. It is a noninvasive technique that should be further investigated as a possible diagnostic procedure for the diagnosis of HC in dogs.

Galaxy-galaxy strong lensing in galaxy clusters is a unique tool for studying the subhalo mass distribution, as well as for testing predictions from cosmological simulations. We describe a novel method that simulates realistic lensed features embedded inside the complexity of observed data by exploiting high-precision cluster lens models. Such methodology is used to build a large dataset with which Convolutional Neural Networks have been trained to identify strong lensing events in galaxy clusters. In particular, we inject lensed sources around cluster members using the images acquired by the Hubble Space Telescope. The resulting simulated mock data preserve the complexity of observation by taking into account all the physical components that could affect the morphology and the luminosity of the lensing events. The trained networks achieve a purity-completeness level of ∼ 91% in detecting such events. The methodology presented can be extended to other data-intensive surveys carried out with the next-generation facilities.

We present high-precision strong lensing models for the galaxy clusters MACS J0416.1–0403 at z=0.396 and Abell 2744 at z=0.307. The models are constrained by two of the largest data-sets of secure multiple images ever used in lensing. These are identified from the photometric images observed by the Hubble space telescope and JWST in combination with spectroscopic data obtained by the Multi-Unit Spectroscopic Explorer at the Very Large Telescope. The same spectro-photometric data are used to create pure and complete samples of cluster member galaxies. Our models allow an extremely precise estimation of the cluster total mass distribution and produce accurate magnification maps that are fundamental to study the physical properties (mass, size, luminosity, etc.) of the lensed high-redshift galaxies.

Lubricant oils are largely responsible for environmental contamination and surfactants can hopefully improve the bioremediation process in soils contaminated with this kind of waste. However, to date only a few studies have elucidated how different surfactants affect the bioremediation process in oil-contaminated soils using the bioaugmentation technique. Thus, this study aimed to compare the effects of surfactants on the bioremediation process of waste lubricant oil in soil in association or not with bioaugmentation. Three biostimulating agents were tested: a chemical detergent, a synthetic surfactant, and a biosurfactant (rhamnolipid). The bioaugmentation process with Pseudomonas aeruginosa showed a faster biodegradation activity with total biodegradation on 181 day after application. The biosurfactant increased the number of microbial and fungal colonies leading to high biodegradation levels and a quicker treatment with or without the bioaugmentation. Bioaugmentation associated with biosurfactant reached 30.43 mg of CO 2 of production on 181 day (90% of total biodegradation of waste lubricant oil) and reduced soil toxicity to 30%. Therefore, results showed that the association of biosurfactant and bioaugmentation with P. aeruginosa represents an ecologically viable strategy for bioremediation of soils contaminated with waste lubricant oil.

Food-responsive enteropathy (FRE), idiopathic inflammatory bowel disease (IBD), and alimentary tract lymphoma (AL) are often the remaining differentials for cats presenting with chronic gastrointestinal (GI) signs. Differential diagnosis is further complicated by overlapping clinicopathological features and histopathological changes, however. In this study we describe the clinical presentation of cats with chronic GI signs secondary to FRE, IBD, and AL, and evaluate possible associations between clinical, clinicopathological, ultrasonographic findings and diagnosis. The medical records of client-owned cats with chronic GI signs secondary to FRE, IBD, and AL were reviewed. Univariate and multivariate logistic regression models and receiver-operating characteristic curve (ROC) analysis were used for testing the data. Of the 56 cats included in the study, 22 were diagnosed with FRE (mean age, 70 months ± 49), 17 with IBD (mean age, 101 months ± 40), and 17 with AL (mean age, 122 months ± 45). Cats with FRE were younger and presented more often with diarrhea and less frequently with muscle wasting than cats with IBD or AL. In cats with AL, serum cobalamin levels were lower than in those with FRE or IBD (239 ± 190 ng/L vs. 762 ± 408 ng/L and 625 ± 443 ng/L, respectively) and folate levels were higher than in cats with IBD (18.2 ± 4.2 μg/L vs. 9.1 ± 4.7 μg/L, respectively). Multivariate/ROC curve analysis showed increased values of BUN (sensitivity 100, specificity 29.4, criterion >37 mg/dl) and serum folate (sensitivity 80, specificity 100, criterion >15.6 μg/L) and reduced values of cobalamin (sensitivity 100, specificity 62.5, criterion ≤540 ng/L), which suggested a diagnosis of AL versus IBD. Some clinicopathological features evaluated at diagnosis might suggest AL; however, because differentiating AL from IBD is often difficult, definitive diagnosis should be based on invasive diagnostic workup.

Issue Title: LXI ANNUAL MEETING of the ITALIAN SOCIETY for VETERINARY SCIENCES (SISVET) Salsomaggiore Terme (Parma) 2007