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"Berger, Stefan"
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Constructing industrial pasts : heritage, historical culture and identity in regions undergoing structural economic transformation
\"Since the 1960s, nations across the \"developed world\" have been profoundly shaped by deindustrialization. In regions in which previously dominant industries faced crises or have disappeared altogether, industrial heritage offers a fascinating window into the phenomenon's cultural dimensions. As the contributions to this volume demonstrate, even as forms of industrial heritage provide anchors of identity for local populations, their meanings remain deeply contested, as both radical and conservative varieties of nostalgia intermingle with critical approaches and straightforward apologias for a past that was often full of pain, exploitation and struggle\"-- Provided by publisher.
Book
The role of L-type voltage-gated calcium channels Cav1.2 and Cav1.3 in normal and pathological brain function
The use of specific activators and inhibitors that penetrate the central nervous system has suggested an essential functional role of L-type calcium channels (LTCC) in several important physiological processes of the brain, including the modulation of the mesoaccumbal dopamine signalling pathway, synaptic transmission of auditory stimuli and synaptic plasticity of neutral and aversive learning and memory processes. However, the lack of selectivity of available pharmacological agents towards the most prominent LTCC isoforms in the brain, namely Ca
v
1.2 and Ca
v
1.3, has hampered the elucidation of the precise contribution made by each specific channel isoform within these specific physiological processes. Modern genetic approaches, both in rodents and in human, have recently enhanced our understanding of the selective functional roles of Ca
v
1.2 and Ca
v
1.3 channels. In rodents, the characterisation of global and conditional isoform-specific knockouts suggests a contribution of Ca
v
1.2 channels in spatial memory formation, whereas Ca
v
1.3 channels seem to be involved in the consolidation of fear memories and in neurodegenerative mechanisms associated with the development of Parkinson’s disease. With regard to the molecular mechanisms underlying drug addiction, Ca
v
1.3 channels are necessary for the development and Ca
v
1.2 channels for the expression of cocaine and amphetamine behavioural sensitisation. In humans, both the identification of naturally occurring LTCC variants (“channelopathies”) and unbiased genome-wide association studies have linked LTCCs to working memory performance in healthy individuals and schizophrenic patients. Individually,
CACNA1C
polymorphisms and
CACNA1D
variants have been linked to a variety of psychiatric diseases and to congenital deafness, respectively. However, the contribution of individual LTCCs and their polymorphisms to human brain function and diseases remains unclear, necessitating the use of isoform-specific pharmacological agents.
Journal Article
The transnational activist : transformations and comparisons from the Anglo-world since the nineteenth century
\"This book provides the first historical and comparative study of the 'transnational activist.' A range of important recent scholarship has considered the rise of global social movements, the presence of transnational networks, and the transfer or diffusion of political techniques. Much of this writing has registered the pivotal role of 'transnational' or 'global' activists. However, if the significance of the 'transnational activist' is now routinely acknowledged, then the history of this actor is still something of a mystery. Most commentators have associated the figure with contemporary history. Hence much of the debate around 'transnational activism' is ahistorical, and claims for novelty are not often based on developed historical comparison. As this volume argues, it is possible to identify the 'transnational activist' in earlier decades and even centuries. But when did this figure first appear? What are the historical conditions that nurtured its emergence? What are the principal moments in the development of the transnational activist? And do the transnational activists of the Internet age differ in number or nature from those of earlier years? These historical questions will be at the heart of this volume.\"--Page 4 of cover.
Book
Trainable embedding quantum physics informed neural networks for solving nonlinear PDEs
This paper proposes a novel approach for solving nonlinear partial differential equations (PDEs) with a quantum computer, the trainable embedding quantum physics informed neural network (TE-QPINN). We combine quantum machine learning (QML) with physics informed neural networks (PINNs) in a hybrid approach. By leveraging the advantages of classical and quantum computers, we can create algorithms that have a potential to be run on noisy intermediate-scale quantum devices (NISQ). We use feedforward neural networks (FNN) as problem-agnostic embedding functions, giving the used quantum circuit greater expressibility than previously introduced embedding. This expressibility allows us to solve a wide range of problems without using a problem specific ansatz. Additionally, we introduce a hybrid backpropagation algorithm that allows efficient updates of the used weights and biases in the FNN embedding functions. In this paper we showcase the capabilities of TE-QPINNs of a wide range of problems, including the two-dimensional Poisson, Burgers and Navier-Stokes equations. In direct comparison with classical PINNs, this approach showed an ability to achieve superior results while using the same number of parameters, highlighting their potential for more efficient optimization in high-dimensional parameter spaces, which could be transformative for future applications.
Journal Article
Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation. Long term, it is associated with acute rejection and chronic graft dysfunction due to interstitial fibrosis and tubular atrophy. Recently, more insight has been gained in the underlying molecular pathways and signalling cascades involved, which opens the door to new therapeutic opportunities aiming to reduce IRI and improve graft survival. This review systemically discusses the specific molecular pathways involved in the pathophysiology of IRI and highlights new therapeutic strategies targeting these pathways.
Journal Article
Writing history : theory & practice
'Writing History' is designed to provide the necessary material for general courses in historiography, identifying in turn the evolution of 'traditional' approaches, the challenge of the 'linguistic turn' and contemporary perspectives that inform our current understandings.
Book
Nationalism and the Economy
This book is the first attempt to bridge the current divide between studies addressing ‘economic nationalism’ as a deliberate ideology and movement of economic ‘nation-building’, and the literature concerned with more diffuse expressions of economic ‘nationness’ – from national economic symbols and memories, to the ‘banal’ world of product communicationThe editors seeks to highlight the importance of economic issues for the study of nations and nationalism, and its findings point to the need to give economic phenomena a more prominent place in the field of nationalism studies. The authors of the essays come from disciplines as diverse as economic and cultural history, political science, business studies, as well as sociology and anthropology. Their chapters address the nationalism-economy nexus in a variety of realms, including trade, foreign investment, and national control over resources, as well as consumption, migration, and welfare state policies. Some of the case studies have a historical focus on nation-building in the nineteenth and early twentieth centuries, while others are concerned with contemporary developments. Several contributions provide in-depth analyses of single cases while others employ a comparative method. The geographical focus of the contributions vary widely, although, on balance, the majority of our authors deal with European countries.
eBook
The Complement System in Dialysis: A Forgotten Story?
Significant advances have lead to a greater understanding of the role of the complement system within nephrology. The success of the first clinically approved complement inhibitor has created renewed appreciation of complement-targeting therapeutics. Several clinical trials are currently underway to evaluate the therapeutic potential of complement inhibition in renal diseases and kidney transplantation. Although, complement has been known to be activated during dialysis for over four decades, this area of research has been neglected in recent years. Despite significant progress in biocompatibility of hemodialysis (HD) membranes and peritoneal dialysis (PD) fluids, complement activation remains an undesired effect and relevant issue. Short-term effects of complement activation include promoting inflammation and coagulation. In addition, long-term complications of dialysis, such as infection, fibrosis and cardiovascular events, are linked to the complement system. These results suggest that interventions targeting the complement system in dialysis could improve biocompatibility, dialysis efficacy, and long-term outcome. Combined with the clinical availability to safely target complement in patients, the question is not if we should inhibit complement in dialysis, but when and how. The purpose of this review is to summarize previous findings and provide a comprehensive overview of the role of the complement system in both HD and PD.
Journal Article