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Coming into fashion : a century of photography at Condâe Nast
This title, featuring the work of 85 great fashion photographers past and present, drawn from the Condâe Nast archives in New York, Paris and Milan, illustrates the early work of such celebrated practitioners as Cecil Beaton, Irving Penn and David Bailey that have appeared in the pages of the company's magazines.
Book
Functional Implications of Ubiquitous Semicircular Canal Non-Orthogonality in Mammals
The 'canonical model' of semicircular canal orientation in mammals assumes that 1) the three ipsilateral canals of an inner ear exist in orthogonal planes (i.e., orthogonality), 2) corresponding left and right canal pairs have equivalent angles (i.e., angle symmetry), and 3) contralateral synergistic canals occupy parallel planes (i.e., coplanarity). However, descriptions of vestibular anatomy that quantify semicircular canal orientation in single species often diverge substantially from this model. Data for primates further suggest that semicircular canal orthogonality varies predictably with the angular head velocities encountered in locomotion. These observations raise the possibility that orthogonality, symmetry, and coplanarity are misleading descriptors of semicircular canal orientation in mammals, and that deviations from these norms could have significant functional consequences. Here we critically assess the canonical model of semicircular canal orientation using high-resolution X-ray computed tomography scans of 39 mammal species. We find that substantial deviations from orthogonality, angle symmetry, and coplanarity are the rule for the mammals in our comparative sample. Furthermore, the degree to which the semicircular canals of a given species deviate from orthogonality is negatively correlated with estimated vestibular sensitivity. We conclude that the available comparative morphometric data do not support the canonical model and that its overemphasis as a heuristic generalization obscures a large amount of functionally relevant variation in semicircular canal orientation between species.
Journal Article
Mapping the HLA ligandome landscape of acute myeloid leukemia: a targeted approach toward peptide-based immunotherapy
Identification of physiologically relevant peptide vaccine targets calls for the direct analysis of the entirety of naturally presented human leukocyte antigen (HLA) ligands, termed the HLA ligandome. In this study, we implemented this direct approach using immunoprecipitation and mass spectrometry to define acute myeloid leukemia (AML)-associated peptide vaccine targets. Mapping the HLA class I ligandomes of 15 AML patients and 35 healthy controls, more than 25 000 different naturally presented HLA ligands were identified. Target prioritization based on AML exclusivity and high presentation frequency in the AML cohort identified a panel of 132 LiTAAs (ligandome-derived tumor-associated antigens), and 341 corresponding HLA ligands (LiTAPs (ligandome-derived tumor-associated peptides)) represented subset independently in >20% of AML patients. Functional characterization of LiTAPs by interferon-γ ELISPOT (Enzyme-Linked ImmunoSpot) and intracellular cytokine staining confirmed AML-specific CD8
+
T-cell recognition. Of note, our platform identified HLA ligands representing several established AML-associated antigens (e.g. NPM1, MAGED1, PRTN3, MPO, WT1), but found 80% of them to be also represented in healthy control samples. Mapping of HLA class II ligandomes provided additional CD4
+
T-cell epitopes and potentially synergistic embedded HLA ligands, allowing for complementation of a multipeptide vaccine for the immunotherapy of AML.
Journal Article
No photos on the dance floor! : Berlin 1989-today
It's 1989. The Berlin Wall has fallen and the city's youth are tasting a new found freedom. Throughout Europe, electronic dance music is powering nightclubs and fueling day-long raves, which makes Berlin-a city hit by economic hardship and with acres of empty warehouses and factories-the perfect incubator for an underground music scene. This book brings that scene, which has continued for nearly three decades, to life. Taking its name from a strict ban on cameras in the city's nightclubs, this book documents Berlin's club culture.
Book
Posterior instrumented correction and fusion of Scheuermann´s results in physiological reconstruction of sagittal alignment and excellent overall clinical outcome- clinical trail of 73 patients
Purpose
The aim was to assess the clinical outcomes after posterior spinal fusion (PSF) in patients with Scheuermann’s disease (SD).
Methods
SD undergoing PSF were retrospectively analyzed. Clinical outcome was determined using SRS-22- and Eq. 5D-questionaires preop and after 3, 12, 24 months after surgery. Whole spine x-rays were analyzed (preop, postop, after 6, 12, 24 months): sagittal and coronary Cobb angles, and pelvic parameters were evaluated; ideal lumbar lordosis (LL) was calculated using formula of le Huec (LL = 0.54*PI + 27.6). Surgical time, complications and blood loss were compared. Postop appearance of proximal (PJF) and distal junction failure (DJF) were calculated. Values were given as mean. Comparison with significance α = 0.05.
Results
73 patients were included. SRS-22 total score and EQ5D showed significant increase from preop to two-year FU (each
p
< 0.001). Preop Thoracic kyphosis (TK) was 75.1° with significant correction to 48.5° (
p
< 0.001). LL showed mean correction from 68.2° to 46.7° (
p
< 0.001). Difference between ideal and measured LL showed improvement from − 17.2° preop to -3.3° 6 month postop, good spontaneous correction of hyperlordosis. 63% had < 10° deviation from ideal LL 6 month postoperatively, whereas only 21.4% were in this range preoperatively. No significant changes for spinopelvic parameters during FU. Complications occurred in 13,7% of cases. A low revision rate for PJF (2,7%) was necessary. Subscore mental health showed a correlation to preop TK (
p
< 0.05).
Conclusion
Physiological reconstruction of sagittal alignment could be achieved in most cases (63%). Clinical FU results were convincing with significant improvement of patient’s satisfaction. Complication rate was moderate and risk of PJF after PSF low.
Journal Article
Watched! : surveillence, art and photography
How can art and visual theory contribute to the understanding of our current surveillance society? Watched! presents a selection of European artists who relate to current issues of discipline, control and security in our contemporary surveillance society. Surveillance is an expanding part of daily life. Since the start of the new millennium, we have seen major developments in security policies, data collection, software for private use, biometric science, social media, smartphones and technological innovations in other areas of ?smart surveillance?. Parallel to this change that has taken place in all parts of society, critical responses have increased across a wide range of disciplines, one of them being the arts. This publication offers a selection of artistic works and practices that addresses and reflects on issues of surveillance over the past fifteen years.
Book
OTOF mutations revealed by genetic analysis of hearing loss families including a potential temperature sensitive auditory neuropathy allele
Introduction: The majority of hearing loss in children can be accounted for by genetic causes. Non-syndromic hearing loss accounts for 80% of genetic hearing loss in children, with mutations in DFNB1/GJB2 being by far the most common cause. Among the second tier genetic causes of hearing loss in children are mutations in the DFNB9/OTOF gene. Methods: In total, 65 recessive non-syndromic hearing loss families were screened by genotyping for association with the DFNB9/OTOF gene. Families with genotypes consistent with linkage or uninformative for linkage to this gene region were further screened for mutations in the 48 known coding exons of otoferlin. Results: Eight OTOF pathological variants were discovered in six families. Of these, Q829X was found in two families. We also noted 23 other coding variant, believed to have no pathology. A previously published missense allele I515T was found in the heterozygous state in an individual who was observed to be temperature sensitive for the auditory neuropathy phenotype. Conclusions: Mutations in OTOF cause both profound hearing loss and a type of hearing loss where otoacoustic emissions are spared called auditory neuropathy.
Journal Article
Mutations in the Connexin 26 Gene (GJB2) among Ashkenazi Jews with Nonsyndromic Recessive Deafness
Congenital deafness occurs in approximately 1 in 1000 live births, and 50 percent of these cases are hereditary.
1
Nonsyndromic recessive deafness, defined as lack of hearing with no other associated clinical features, accounts for approximately 80 percent of cases of hereditary deafness.
1
The existence of at least 20 genes that, if mutated, result in nonsyndromic recessive deafness has been demonstrated through genetic-linkage studies, although most of these genes have not yet been identified.
2
Population studies suggest that many more are likely to exist.
1
,
3
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8
Recently, mutations in the
GJB2
gene were shown to be among the causes of the . . .
Journal Article