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Background Low-intensity treatments imply reduced therapist contact due to an emphasis on self-help and the use of technologies to deliver treatment. The role of the remoteness, the reduced therapist contact, and the interplay of these components has not been differentiated from a patients’ perspective so far. This study’s purpose is to capture patients’ experiences with telephone-based self-help cognitive behavioural therapy (tel-CBT). Methods A subsample of mildly to moderately depressed patients ( N = 13) who finished tel-CBT as part of a larger randomised controlled trial (RCT) in routine care were interviewed using a semi-structured questionnaire. Interviews were audiotaped, transcribed verbatim, and independently coded by two coders blind to treatment outcome. Using qualitative content analysis with deductive and inductive procedures, a two-level category system was established. Results The category system contains four category clusters regarding expectations, self-help related aspects, telephone-related aspects, and implications for patients’ treatment pathway, and subsumes a total of 15 categories. Self-help related aspects circulate around the interplay between written materials and professional input, trust and support in the therapeutic relationship and its relation to the initial personal contact, as well as CBT principles. Telephone-related aspects entail perceived advantages and disadvantages of the telephone on an organisational and content level as well as a discourse around distance and closeness in the interaction. Although patients raised doubts regarding the long-term effect of the intervention on symptomatology, patients expressed satisfaction with the treatment and reported an immediate as well as a longer lasting personal impact of the treatment. These results indicate user acceptance with tel-CBT. Conclusions This qualitative analysis captures patients’ experiences with tel-CBT and the perceived helpfulness of the diverse treatment components. This can facilitate refining aspects of low-intensity treatments and might improve dissemination. Trial registration ClinicalTrials.gov NCT02667366. Registered on 3 December 2015.

In the framework of the future High Luminosity upgrade of the Large Hadron Collider (HL-LHC) at CERN, most superconducting magnets in the Long Straight Sections will be replaced. Among them, the new D2 recombination dipole will be a He II conduction-cooled magnet with a larger aperture than the LHC dipoles. To provide the required cooling (up to 70 W) to the D2 and to comply with its cryostat integration constraints, a compact heat exchanger was designed by the CEA Département des Systèmes Basses Températures (DSBT) based on a CERN preliminary analysis and a CEA review of the possible cooling schemes. This heat exchanger provides the required heat transfer between the He II pressurized bath and the He II saturated bath to cool the D2 magnet in different operating conditions at 1.8 K and 2 K. The detailed design of the heat exchanger was defined and one prototype was manufactured by industry under the CEA supervision. The heat exchanger prototype is composed of roughly one hundred oxygen-free high purity copper tubes, electron beam welded to the stainless steel He II bath enclosure. The present paper describes the successful cryogenic performance tests of the prototype of the D2 heat exchanger measured in the CEA 400W@1.8K test facility in Grenoble.

After the successful completion of the cryogenic performance tests of the He II heat exchanger prototype for the D2 recombination dipole of the future HL-LHC project at CERN, specific measurements were performed to determine the operation safety margin in case of abnormal operating conditions. This is particularly relevant in case of the failure of liquid helium supply in the He II cold source. For nominal operation, the liquid level is regulated at a constant value and it is not necessary to know its value very accurately. However, in case of a partial drying of the heat exchanger due to discontinuation of the helium liquid supply, it is essential to monitor the absolute value of the liquid level to anticipate any cooling malfunction. This paper describes the procedure for an accurate in-situ He II level measurement as well as for the heat loss and mass flow rate estimates in a He II phase separator. The operation safety margins of the He II heat exchanger prototype for the D2 magnet are then analyzed for the different operating conditions considered during the HL-LHC runs in case of non-nominal liquid level in the He II cold source.

The measurement of missing transverse momentum in the ATLAS detector, described in this paper, makes use of the full event reconstruction and a calibration based on reconstructed physics objects. The performance of the missing transverse momentum reconstruction is evaluated using data collected in pp collisions at a centre-of-mass energy of 7 TeV in 2010. Minimum bias events and events with jets of hadrons are used from data samples corresponding to an integrated luminosity of about 0.3 [nb.sup.-1] and 600 [nb.sup.-1] respectively, together with events containing a Z boson decaying to two leptons (electrons or muons) or a W boson decaying to a lepton (electron or muon) and a neutrino, from a data sample corresponding to an integrated luminosity of about 36 [pb.sup.-1]. An estimate of the systematic uncertainty on the missing transverse momentum scale is presented.

We present studies of W and Z bosons with associated high energy photons produced in pp collisions at sqrt(s)=7 TeV. The analysis uses 35 pb-1 of data collected by the ATLAS experiment in 2010. The event selection requires W and Z bosons decaying into high pT leptons (electrons or muons) and a photon with ET>15 GeV separated from the lepton(s) by a distance Delta_R(l,gamma)>0.7 in eta-phi space. A total of 95 (97) pp->e nu gamma + X (pp->mu nu gamma + X) and 25 (23) pp->e+ e- gamma + X (pp->mu+ mu- gamma + X) event candidates are selected. The kinematic distributions of the leptons and photons and the production cross sections are measured. The data are found to agree with Standard Model predictions that include next-to-leading-order O(alpha alpha_s) contributions.

Results are presented of searches for the production of supersymmetric particles decaying into final states with missing transverse momentum and exactly two isolated leptons in sqrt{s}=7 TeV proton-proton collisions at the Large Hadron Collider. Search strategies requiring lepton pairs with identical sign or opposite sign electric charges are described. In a data sample corresponding to an integrated luminosity of 35 pb-1 collected with the ATLAS detector, no significant excesses are observed. Based on specific benchmark models, limits are placed on the squark mass between 450 and 690 GeV for squarks approximately degenerate in mass with gluinos, depending on the supersymmetric mass hierarchy considered.

Abstract Lysobisphosphatidic acid (LBPA) is highly accumulated in specific domains of the late endosome and is involve in the biogenesis and function of this organelle. Little is known about the biosynthesis and metabolism of this lipid. We examined its FA composition and the incorporation of exogenous FA into LBPA in the human monocytic leukemia cell line THP‐1. The LBPA FA composition in THP‐1 cells exhibits an elevated amount of oleic acid (18∶1n−9) and enerichment of PUFA, especially DHA (22∶6n−3). DHA supplemented to the medium was efficiently incorporated into LBPA. In contrast, arachidonic acid (20∶4n−6) was hardly esterified to LBPA under the same experimental conditions. The turnover of DHA in LBPA was similar to that in other phospholipids. Specific incorporation of DHA into LBPA was also observed in baby hamster kidney fibroblasts, although LBPA in these cells contains very low endogenous levels of DHA in normal growth conditions. Our results, together with published observations, suggest that the specific incorporation of DHA into LBPA is a common phenomenon in mammalian cells. The physiological significance of DHA‐enriched LBPA is discussed.

An experimental study of the normalized three-jet rate of b quark events with respect to light quarks events (light=ℓ≡u,d,s) has been performed using the CAMBRIDGE and DURHAM jet algorithms. The data used were collected by the DELPHI experiment at LEP on the Z peak from 1994 to 2000. The results are found to agree with theoretical predictions treating mass corrections at next-to-leading order. Measurements of the b quark mass have also been performed for both the b pole mass: Mb and the b running mass: mb(MZ). Data are found to be better described when using the running mass. The measurement yields: \\(m_b(M_Z)=2.85\\pm0.18 (\\text{stat}) \\pm0.13 (\\text{exp}) \\pm0.19 (\\text{had}) \\pm0.12 (\\text{theo}) \\text{GeV}/c^2.\\)for the CAMBRIDGE algorithm.This result is the most precise measurement of the b mass derived from a high energy process. When compared to other b mass determinations by experiments at lower energy scales, this value agrees with the prediction of quantum chromodynamics for the energy evolution of the running mass. The mass measurement is equivalent to a test of the flavour independence of the strong coupling constant with an accuracy of 7 ‰.

Measurements are presented of R_b, the ratio of the b bbar cross-section to the q qbar cross-section in e+e- collisions, and the forward-backward asymmetry A^b_FB at twelve energy points in the range sqrt(s) = 130-207 GeV. These results are found to be consistent with the Standard Model expectations. The measurements are used to set limits on new physics scenarios involving contact interactions.