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"Betts, Matt"
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Sciencia : mathematics, physics, chemistry, biology, and astronomy for all
\"From the structure of the cosmos to that of the human body, the discoveries of science over the past few hundred years have been remarkable. Sciencia spans the realms of mathematics, physics, chemistry, biology, and astronomy, offering an invaluable introduction to each. Curious about quarks, quasars, and the fantastic universe around you? Ever wanted to explore a mathematical proof? Need an introduction to biochemistry? Beautifully illustrated with engravings, woodcuts, and original drawings and diagrams, Sciencia will inspire inquisitive readers of all ages to appreciate the interconnected knowledge of the modern sciences\"--Page 4 of cover.
Book
White blood cell estimates correlate to measures of population and individual health in an endangered population of Marbled Murrelets (Brachyramphus marmoratus)
Estimated white blood cell (WBC) counts are a valuable tool for assessing individual and population health in wildlife and domestic animals due to their role in the response to environmental stressors and disease. These measures are infrequently used in the study of wild seabird species, despite their utility when used alongside other common health assays - such as infectious disease testing, body condition, and population monitoring efforts. The Marbled Murrelet (
) is a seabird of conservation concern that is federally listed as threatened by the states of Oregon, Washington, and California, thus necessitating the evaluation of its physiological health.
We evaluated the utility of estimated WBC counts as measures of health, asking whether counts changed by measures of individual health (i.e., sex,
hemoparasite burden, body condition index, and nesting propensity) and population health (i.e., changes in counts by year). We used blood smears collected from over 350 murrelets captured along the Oregon Coast between April and June of 2017-2019 and 2021-2022 to estimate total WBC and differential counts.
Estimated WBC counts were found to appear lower in years with more favorable ocean conditions, when nesting propensity was relatively high. Male murrelets, individuals less likely to nest, and individuals with greater
burden had significantly lower estimated WBC counts, whereas individuals with a lower body condition index had elevated estimated WBC counts.
These results demonstrate the utility of estimated WBC counts to further assess health at the individual and population levels in the study of species of heightened conservation concern and should be considered as an addition to research plans.
Journal Article
Predicting Business Success
Going beyond the usual slicing and dicing of HR data, this book shows HR professionals how to definitively connect the dots between people data and business outcomes with a straightforward approach for scaling analytics to all leaders and all levels. --
eBook
Therapeutic potential of targeting group iii metabotropic glutamate receptors as a disease modifying strategy in the treatment of parkinson's disease
Parkinson’s disease (PD) is characterised by a progressive loss of dopaminergic neurones from the SNpc, leading to numerous downstream changes in the basal ganglia circuitry. Overactivity of the glutamatergic subthalamonigral pathway may underlie this continual degeneration of the nigrostriatal system. With this in mind, this thesis examined whether selective activation of group III metabotropic glutamate receptor subtypes may offer a novel strategy to halt persistent degeneration in PD. Initial distribution studies revealed mGlu4 and 7 group III mGlu receptor subtypes, demonstrated particularly intense immunoreactivity in the SNpc, suggesting these receptors may be ideally positioned to provide neuroprotective effects. Therefore, the first objective was to confirm this neuroprotective possibility using a broad spectrum agonist, L-AP4. Sub-chronic supranigral L-AP4 treatment mediated functional neuroprotection against a unilateral 6-OHDA lesion of the SN, confirmed by behavioural assessment and post-mortem analyses. Secondly, the pharmacological identity of the group III mGlu receptor mediating this protective effect was examined. To investigate mGlu4 receptors, the novel mGlu4 selective PAM VU0155041, was also shown to provide functional neuroprotection in the 6-OHDA rat model to an almost comparable level reached with L-AP4. Whilst these neuroprotective effects are likely mediated by an inhibition of glutamate to protect from glutamate-mediated excitotoxicity, VU015504 also led to a significant reduction in levels of GFAP and IBA-1 suggesting an additional anti-inflammatory action. Further studies revealed little evidence for co-localisation of mGlu4 receptors with GFAP in the SN suggesting this anti-inflammatory component likely reflects an indirect effect via stimulation of neuronal mGlu4 receptors. Finally, to investigate mGlu7 receptors, the selective allosteric agonist AMN082, was also shown to protect the nigrostriatal tract and demonstrate a degree of preservation of motor function. In contrast, mGlu8 receptor activation using the selective agonist DCPG, failed to protect the nigrostriatal tract or preserve motor behaviour. Collectively, these findings demonstrate that, of the group III mGlu receptors investigated, mGlu4 offers the most potential as a promising target for establishing disease modification in PD.
Dissertation
Predicting Business Success: 6 Stops on the Business Partner Road Map
[...]having influential company leaders and decision-makers participate in this process is crucial. Several characteristics of each outcome that is measured must be assessed, including the following: * The frequency of the measurement (e.g., monthly, quarterly, annually). * The level at which the key metrics are measured (e.g., by line of business, by work unit, at the store level, at the organization level). * The key organizational owner(s) of each of the outcome measures (e.g., the department or leader of the particular measurement). [...]the analyses may indicate that improving employee attitudes about career-development opportunities leads to increased employee productivity, customer satisfaction, and decreased impact and could be candidates for cost cutting.
Trade Publication Article