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COSINUS is a dark matter (DM) direct search experiment that uses sodium iodide (NaI) crystals as cryogenic calorimeters. Thanks to the low nuclear recoil energy threshold and event-by-event discrimination capability, COSINUS will address the long-standing DM claim made by the DAMA/LIBRA collaboration. The experiment is currently under construction at the Laboratori Nazionali del Gran Sasso, Italy, and employs a large cylindrical water tank as a passive shield to meet the required background rate. However, muon-induced neutrons can mimic a DM signal therefore requiring an active veto system, which is achieved by instrumenting the water tank with an array of photomultiplier tubes (PMTs). This study optimizes the number, arrangement, and trigger conditions of the PMTs as well as the size of an optically invisible region. The objective was to maximize the muon veto efficiency while minimizing the accidental trigger rate due to the ambient and instrumental background. The final configuration predicts a veto efficiency of 99.63 ± 0.16% and 44.4 ± 5.6% in the tagging of muon events and showers of secondary particles, respectively. The active veto will reduce the cosmogenic neutron background rate to 0.11 ± 0.02 cts · kg - 1 · year - 1 , corresponding to less than one background event in the region of interest for the whole COSINUS-1 π exposure of 1000 kg · days.

COSINUS is a new cryogenic observatory for rare event searches located in the Laboratori Nazionali del Gran Sasso in Italy. COSINUS’s first goal is to clarify whether the signal detected by the DAMA/LIBRA experiment originates from dark matter particle interactions or has a different nature. To this aim, sodium iodide (NaI) cryogenic scintillating calorimeters read out by transition edge sensors (TESs) are developed. To preserve the NaI crystal from the TES fabrication process, COSINUS implemented a novel design, the remoTES, where the TES is deposited on a separate wafer and coupled to the absorber through a Au-bonding wire and a Au-phonon collector. This design has reached baseline resolutions below 100 eV for Si, 200 eV for TeO 2 and 400 eV for NaI absorbers. These results show that the remoTES not only brings COSINUS close to its performance goal of 1 keV energy threshold, but also offers the possibility to employ delicate crystals previously excluded for cryogenic applications as absorbers and to avoid the exposure of the absorbers to the TES fabrication process. It therefore extends the choice of target materials of the rare event searches using TES. In this work, we will provide a detailed description of the remoTES design and present the results of the latest prototypes.

In the last years, the COSINUS (Cryogenic Observatory for SIgnals seen in Next generation Underground Searches) experiment has made significant progress both in the construction of its facility and in pursuing its physics goals: At Laboratori Nazionali del Gran Sasso (LNGS) in Italy, an underground facility was constructed, which will house experimental detectors for dark matter direct detection in a dry dilution cryostat. Construction of the main structures at the COSINUS site is finished, including the control building, the cryostat access level, and the water tank which will serve as a Cherenkov muon veto around the cryostat. With a nuclear recoil threshold of 4 keV, the latest COSINUS detector prototype approaches the design goal of 1 keV, and particle discrimination on event-by-event basis has been demonstrated. This contribution gives a brief overview on the status of COSINUS.

COSINUS is a dark matter (DM) direct search experiment that uses sodium iodide (NaI) crystals as cryogenic calorimeters. Thanks to the low nuclear recoil energy threshold and event-by-event discrimination capability, COSINUS will address the long-standing DM claim made by the DAMA/LIBRA collaboration. The experiment is currently under construction at the Laboratori Nazionali del Gran Sasso, Italy, and employs a large cylindrical water tank as a passive shield to meet the required background rate. However, muon-induced neutrons can mimic a DM signal therefore requiring an active veto system, which is achieved by instrumenting the water tank with an array of photomultiplier tubes (PMTs). This study optimizes the number, arrangement, and trigger conditions of the PMTs as well as the size of an optically invisible region. The objective was to maximize the muon veto efficiency while minimizing the accidental trigger rate due to the ambient and instrumental background. The final configuration predicts a veto efficiency of 99.63 \\(\\pm\\) 0.16 \\(\\%\\) and 44.4 \\(\\pm\\) \\(5.6\\%\\) in the tagging of muon events and showers of secondary particles, respectively. The active veto will reduce the cosmogenic neutron background rate to 0.11 \\(\\pm\\) 0.02 cts\\(\\cdot\\)kg$^{-1}$$\\cdot\\(year\\)^{-1}\\(, corresponding to less than one background event in the region of interest for the whole COSINUS-1\\)\\pi\\( exposure of 1000 kg\\)\\cdot$days.

The COSINUS direct dark matter experiment situated at Laboratori Nazionali del Gran Sasso in Italy is set to investigate the nature of the annually modulating signal detected by the DAMA/LIBRA experiment. COSINUS has already demonstrated that sodium iodide crystals can be operated at mK temperature as cryogenic scintillating calorimeters using transition edge sensors, despite the complication of handling a hygroscopic and low melting point material. With results from a new COSINUS prototype, we show that particle discrimination on an event-by-event basis in NaI is feasible using the dual-channel readout of both phonons and scintillation light. The detector was mounted in the novel remoTES design and operated in an above-ground facility for 9.06 g\\(\\cdot\\)d of exposure. With a 3.7 g NaI crystal, e\\(^-\\)/\\(\\gamma\\) events could be clearly distinguished from nuclear recoils down to the nuclear recoil energy threshold of 15 keV.

Scant literature exists evaluating utilization patterns for direct oral anticoagulants (DOACs). The primary objective was to assess DOAC prescribing in patients with venous thromboembolism (VTE) and nonvalvular atrial fibrillation (NVAF) in outpatient clinics. Secondary objectives were to compare utilization between family medicine (FM) and internal medicine (IM) clinics, characterize potentially inappropriate use, and identify factors associated with adverse events (AEs). This was a retrospective cohort study of adults with NVAF or VTE who received a DOAC at FM or IM clinics between 10/19/2010 and 10/23/2014. Descriptive statistics were utilized for the primary aim. Fisher's exact test was used to evaluate differences in prescribing using an adapted medication appropriateness index. Logistic regression evaluated factors associated with inappropriate use and AEs. One-hundred twenty patients were evaluated. At least 1 inappropriate criterion was met in 72 patients (60.0%). The most frequent inappropriate criteria were dosage (33.0%), duration of therapy (18.4%), and correct administration (18.0%). Apixaban was dosed inappropriately most frequently. There was no difference in dosing appropriateness between FM and IM clinics. The odds of inappropriate choice were lower with apixaban compared to other DOACs (odds ratio [OR]=0.088; 95% confidence interval [CI] 0.008-0.964; =0.047). Twenty-seven patients (22.5%) experienced an AE while on a DOAC, and the odds of bleeding doubled with each inappropriate criterion met (OR=1.949; 95% CI 1.190-3.190; =0.008). Potentially inappropriate prescribing of DOACs is frequent with the most common errors being dosing, administration, and duration of therapy. These results underscore the importance of prescriber education regarding the appropriate use and management of DOACs.

Low-temperature calorimeters based on a readout via Transition Edge Sensors (TESs) and operated below \\(100\\) mK are well suited for rare event searches with outstanding resolution and low thresholds. We present first experimental results from two detector prototypes using a novel design of the thermometer coupling denoted remoTES, which further extends the applicability of the TES technology by including a wider class of potential absorber materials. In particular, this design facilitates the use of materials whose physical and chemical properties, as e.g. hygroscopicity, low hardness and low melting point, prevent the direct fabrication of the TES onto their surface. This is especially relevant in the context of the COSINUS experiment (Cryogenic Observatory for SIgnals seen in Next-Generation Underground Searches), where sodium iodide (NaI) is used as absorber material. With two remoTES prototype detectors operated in an above-ground R&D facility, we achieve energy resolutions of \\(\\sigma=87.8\\) eV for a \\(2.33\\) g silicon absorber and \\(\\sigma = 193.5\\) eV for a \\(2.27\\) g \\(\\alpha\\)-TeO\\(_{2}\\) absorber, respectively. RemoTES calorimeters offer - besides the wider choice of absorber materials - a simpler production process combined with a higher reproducibility for large detector arrays and an enhanced radiopurity standard.

The CSC (cryogenic scintillating calorimeter) technology devoted to rare event searches is reaching the sensitivity level required for the hunt of dark matter-electron scatterings. Dark matter-electron interactions in scintillating targets are expected to stimulate the emission of single photons, each of energy equal to the target electronic band gap. The electronic band gap in scintillators like NaI/GaAs is of O(eV). The search for this signal can be done by an array of cryogenic light detectors with eV/sub-eV energy resolution. In this work, we describe the detection principle, the detector response and the envisioned detector design to search for dark matter interacting with electrons via the measurement of the scintillation light at millikelvin. First sensitivity projections are provided, which show the potential of this research.

While neutrinos are often treated as a background for many dark matter experiments, these particles offer a new avenue for physics: the detection of core-collapse supernovae. Supernovae are extremely energetic, violent and complex events that mark the death of massive stars. During their collapse stars emit a large number of neutrinos in a short burst. These neutrinos carry 99\\% of the emitted energy which makes their detection fundamental in understanding supernovae. This paper illustrates how COSINUS (Cryogenic Observatory for SIgnatures seen in Next-generation Underground Searches), a sodium iodide (NaI) based dark matter search, will be sensitive to the next galactic core-collapse supernova. The experiment is composed of two separate detectors which will be sensitive to far and nearby supernovae. The inner core of the experiment will consist of NaI crystals operating as scintillating calorimeters, mainly sensitive to the Coherent Elastic Scattering of Neutrinos (CE\\(\\nu\\)NS) against the Na and I nuclei. The low mass of the cryogenic detectors gives the experiment a sensitivity to close supernovae below 1kpc without pileup. They will see up to hundreds of CE\\(\\nu\\)NS events from a supernova happening at 200pc. The crystals reside at the center of a cylindrical 230T water tank, instrumented with 30 photomultipliers. This tank acts as a passive and active shield able to detect the Cherenkov radiation induced by impinging charged particles from ambient and cosmogenic radioactivity. A supernova near the Milky Way Center (10kpc) will be easily detected inducing \\(\\sim\\)60 measurable events, and the water tank will have a 3\\(\\sigma\\) sensitivity to supernovae up to 22kpc, seeing \\(\\sim\\)10 events. This paper shows how, even without dedicated optimization, modern dark matter experiments will also play their part in the multi-messenger effort to detect the next galactic core-collapse supernova.

Sodium iodide (NaI) based cryogenic scintillating calorimeters using quantum sensors for signal read out have shown promising first results towards a model-independent test of the annually modulating signal detected by the DAMA/LIBRA dark matter experiment. The COSINUS collaboration has previously reported on the first above-ground measurements using a dual channel readout of phonons and light based on transition edge sensors (TESs) that allows for particle discrimination on an event-by-event basis. In this letter, we outline the first underground measurement of a NaI cryogenic calorimeter read out via the novel remoTES scheme. A 3.67 g NaI absorber with an improved silicon light detector design was operated at the Laboratori Nazionali del Gran Sasso, Italy. A significant improvement in the discrimination power of \\(e^-\\)/\\(\\gamma\\)-events to nuclear recoils was observed with a five-fold improvement in the nuclear recoil baseline resolution, achieving \\(\\sigma\\) = 441 eV. Furthermore, we present a limit on the spin-independent dark-matter nucleon elastic scattering cross-section achieving a sensitivity of \\(\\mathcal{O}\\)(pb) with an exposure of only 11.6 g d.