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وثائق مكافحة كوفيد-19
بين يدي القارئ كتاب يجمع بين دفتيه الترجمة العربية لوثائق مكافحة كوفيد 19- التي أصدرتها لجنة الصحة الوطنية الصينية، ومـن بـين هذه الوثائق النسخ الست مـن آليات الوقاية مـن الالتهاب الرئوي الناجم عـن فيروس كـورونا المستجد ومكافحته، والنسخة التجريبية السابعة لآليات تـشخيص الالتـِهاب الـرئوي الناجِم عـن فـيروس كـورونا المستجد وعلاجه وغـيرها مـن الـمرفقات. وعـمل على ترجمة النـسخة الـعربية لوثائق مكافحة كـوفيد 19- الصينية فريـق ترجمة به أكـثر من عشريـن أستاذا وطالبا مـن قسم اللغة العربية بكلية اللغات الأجنبية بجامعة بكين بـالتعاون مع كلية الآداب في جامعة القاهرة والمعهد العالي للغات بتونس في جامعة قرطاج، في الفترة مـن مارس وحتى مايو 2020، قام خلالها فـريق الترجمة بترجمة قرابة 100 ألـف رمز صيني.
BOOK
Real-Time and Long-Term Monitoring of Coastal Water Turbidity Using an Ocean Buoy Equipped with an ADCP
In this study, an acoustic Doppler current profiler (ADCP) operating at 600 kHz was installed on an ocean data buoy in the Qigu waters, Taiwan, to gather real-time sound echo intensity data. These data were then correlated with turbidity measurements obtained by a turbidimeter mounted on the buoy’s mooring line at a water depth of 13 m. The data buoy operated from 6 June to 16 August 2017. During this period, turbidity measurements were recorded from 6 to 21 June 2017. This study established a calibration between the sound echo intensity measured by the ADCP and the turbidity measured using the turbidimeter; a strong linear correlation was discovered between these two variables. This correlation enabled the conversion of echo intensity data into a continuous time series of turbidity measurements, facilitating real-time and long-term monitoring of coastal water turbidity through the deployment of a buoy equipped with an ADCP. The relationships between turbidity and environmental factors such as rainfall, tides, current speeds, and wave activity over an extended period were then investigated. The results revealed that stronger tides and currents in the Qigu waters often lead to higher turbidity, suggesting that these two factors are the primary driving forces for sediment transport in the Qigu waters. Additionally, sampling of water in the Qigu area revealed sediment particles of size ranging from 2 to 120 μm.
Journal Article
Exploring expectations of Chinese patients for total knee arthroplasty: once the medicine is taken, the symptoms vanish
Background
Preoperative expectations of total knee arthroplasty (TKA) outcomes are important determinants of patient satisfaction. However, expectations of patients in different countries are affected by cultural background. The general goal of this study was to describe Chinese TKA patients’ expectations.
Methods
Patients scheduled for TKA were recruited in a quantitative study(
n
= 198). The Hospital for Special Surgery Total Knee Replacement Expectations Survey Questionnaire was used for survey TKA patients’ expectations. Descriptive phenomenological design was used for the qualitative research. Semi-structured interviews were conducted with 15 TKA patients. Colaizzi’s method was used for interview data analysis.
Results
The mean expectation score of Chinese TKA patients was 89.17 points. The 4 highest score items were walk short distance, remove the need for walker, relieve pain and make knee or leg straight. The 2 lowest score items were employed for monetary reimbursement and sexual activity. Five main themes and 12 sub-themes emerged from the interview data, including multiple factors raised expectations, expectations of physical comfort, expect various activities back to normal, hope for a long joint lifespan, and expect a better mood.
Conclusions
Chinese TKA patients reported a relatively high level of expectations, and differences across cultures result in different expectation points than other national populations, requiring adjustment of items when using assessment tools across cultures. Strategies for expectation management should be further developed.
Level of evidence
Level IV.
Journal Article
Atomically engineering activation sites onto metallic 1T-MoS2 catalysts for enhanced electrochemical hydrogen evolution
Engineering catalytic sites at the atomic level provides an opportunity to understand the catalyst’s active sites, which is vital to the development of improved catalysts. Here we show a reliable and tunable polyoxometalate template-based synthetic strategy to atomically engineer metal doping sites onto metallic 1T-MoS
2
, using Anderson-type polyoxometalates as precursors. Benefiting from engineering nickel and oxygen atoms, the optimized electrocatalyst shows great enhancement in the hydrogen evolution reaction with a positive onset potential of ~ 0 V and a low overpotential of −46 mV in alkaline electrolyte, comparable to platinum-based catalysts. First-principles calculations reveal co-doping nickel and oxygen into 1T-MoS
2
assists the process of water dissociation and hydrogen generation from their intermediate states. This research will expand on the ability to improve the activities of various catalysts by precisely engineering atomic activation sites to achieve significant electronic modulations and improve atomic utilization efficiencies.
While heterogeneous catalysts can act as tangible, efficient materials for energy conversion, understanding the active catalytic sites is challenging. Here, authors engineer specific catalytic sites into molybdenum sulfide to improve and elucidate hydrogen evolution electrocatalysis.
Journal Article
Indicators and medical tests to identify lower limb swelling causes after total knee arthroplasty: a Delphi study with multidisciplinary experts
Background
Lower limb swelling after total knee arthroplasty (TKA) hinders surgical effectiveness. The poor results of studies on swelling interventions are due to the lack of a classification of swelling causes through appropriate medical tests. A gold standard is missing. This study aimed to clarify the causes of TKA postoperative swelling and how to identify them through indicators and medical tests by consulting a wide range of experts from multiple disciplines.
Method
The Delphi method was used. A first draft of the index was prepared based on a systematic search of the literature. A total of 11 experts from several disciplines were invited to evaluate the rationality of the indicators and suggest modifications. After two rounds of consultation, the experts reached a consensus, and the consultation was stopped.
Results
The response rate of the 11 experts was 100%, and the authoritative Cr was 0.896. Kendall's W values for opinion coordination of the two rounds of consultation were 0.262 and 0.226, respectively (P < 0.001). Among the final indicators, there were 4 primary indicators for swelling cause classification (inflammatory response, poor venous return, joint hematoma, muscle damage, and healing), 19 secondary and 19 tertiary indicators.
Conclusion
The indications obtained by systematic literature review and multidisciplinary expert consultation are reliable and scientific. Multiple causes of lower extremity swelling after TKA were identified. Blood test indicators can reflect an inflammatory response, suggest poor venous return, and reflect muscle damage and healing progress. Ultrasound scans are needed to identify underlying thrombotic or valvular problems, joint hematomas, and muscle damage. These tests help clinicians and researchers determine the cause of swelling after TKA and take appropriate management.
Journal Article
Synthesis of magnetically recyclable Fe3O4@polydopamine–Pt composites and their application in hydrogenation reactions
Pt dendrimer-like nanoparticles were in situ deposited on the magnetic Fe₃O₄@polydopamine core–shell composites due to the metal-binding ability and weak reducibility of polydopamine. Such core–shell–satellite catalyst structure endowed the Fe₃O₄@polydopamine–Pt catalyst with excellent magnetical recyclability, aqueous dispersity, and high catalytic performance for the catalytic reduction of 4-nitrophenol and its derivatives, and methylene blue. This catalyst could be reused for 12 cycles without losing its catalytic activity, indicating the high stability.
Journal Article
‘Motivating Implicit Chinese to Express Themselves Is the Biggest Barrier’: A Qualitative Study of Chinese Researchers' Perceptions of Barriers and Facilitators to Patient Engagement in Research
Background Patient Engagement in Research (PER) has demonstrated benefits for patients, researchers and research outcomes. However, China lacks substantial experience in implementing PER. The implementation of PER in China faces unique challenges due to social‐cultural differences. This study explores the perspectives of Chinese researchers to identify barriers and facilitators, aiming to guide future PER initiatives and enhance the role of patients in research. Method Purposive sampling was employed to recruit clinical researchers with diverse healthcare backgrounds in China. Semi‐structured interviews, conducted by a qualified researcher, followed interview guidelines derived from a literature review and pilot study modifications. Thematic analysis was applied using QSR Nvivo 8.0. Results A total of 13 participants were included. Five main themes were identified from interview: (1) selection of patients for research engagement, (2) strategies to alleviate the patient burden in implementing PER, (3) strategies to encourage patients for active expression, (4) benefits to attract patient engagement and (5) researcher's preparation. Conclusion The cultural trait of ‘reservedness’ in Chinese culture hinders active expression by patients in the research engagement process. Researchers tend to recruit patients with specific characteristics and emphasize the importance of aligning benefits with patient values to motivate engagement. Addressing patient burden is crucial, and researchers should be well‐prepared before PER. These findings underscore the necessity of adopting culturally adapted strategies in PER to effectively address specific challenges. Patient or Public Contribution The public participated in the interpretation of the interview results, enriching our understanding of the results.
Journal Article
Mental health status and quality of life in elderly patients with coronary heart disease
Coronary heart disease (CHD) is the leading cause of morbidity and mortality among elderly individuals. Patients with CHD are at high risk for mental health disorders, and psychological issues may affect the quality of life (QoL) of these patients. Nevertheless, there is little evidence regarding the psychological issues and QoL of patients with CHD among the elderly population. This study aimed to investigate the relationship between comorbidities and mental status as well as QoL among elderly patients with CHD.
Overall, 216 patients were included in this cross-sectional, observational, single-center study. The demographics and clinical manifestations of the patients were collected from electronic medical records. All patients were interviewed using the Chinese version of Symptom Checklist 90 (SCL-90) to assess the mental health status and the World Health Organization Quality of Life-BREF questionnaire (WHOQOL-BREF) to assess the QoL.
In total, 96 men and 120 women, with a mean age of 71.69 ± 8.30 years, were included. When controlling for the patients' sex, marital status and stroke, multiple stepwise linear regression analyses suggested that for CHD patients, comorbid type 2 diabetes mellitus had the significant influence on average positive factors (Coef., 5.809; 95% CI [2.467-9.152]
= 0.001); when controlling for the patients' sex, marital status and type 2 diabetes mellitus, multiple stepwise linear regression analyses suggested that for CHD patients, comorbid stroke had the significant influence on average positive factors (Coef., 8.680; 95% CI [4.826-12.534];
< 0.001); when controlling for the patients' sex, marital status, type 2 diabetes mellitus and stroke, multiple stepwise linear regression analyses suggested that for CHD patients, comorbid primary hypertension had the significant influence on phobic anxiety (Coef., 0.178; 95% CI [0.010-0.347];
= 0.038).
For elderly CHD patients, comorbid type 2 diabetes mellitus and stroke were at risk for psychological problems and lower QoL. Our findings may guide patients and clinicians to make better decisions and achieve better outcomes.
Journal Article
Quercetin promotes bone marrow mesenchymal stem cell proliferation and osteogenic differentiation through the H19/miR-625-5p axis to activate the Wnt/β-catenin pathway
Background
Quercetin and H19 can promote osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). However, whether quercetin regulates H19 expression to promote osteogenic differentiation of BMSCs is unclear.
Methods
BMSC proliferation, matrix mineralization, and alkaline phosphatase (ALP) activity were assessed using the Cell Counting Kit-8, ALP assay kit, and alizarin red staining kit, respectively. Expression of H19, miR-625-5p, BMP-2, osteocalcin, and RUNX2 were measured by qRT-PCR; β-catenin protein level was measured by western blotting.
Results
Quercetin promoted BMSC proliferation, enhanced ALP activity, and upregulated the expression of BMP-2, osteocalcin, and RUNX2 mRNAs, suggesting that it promoted osteogenic differentiation of BMSCs. Moreover, quercetin increased H19 expression, while the effect of quercetin on BMSCs was reversed by silencing H19 expression. Additionally, miR-625-5p, interacted with H19, was downregulated during quercetin-induced BMSC osteogenic differentiation, which negatively correlated with H19 expression. Silencing miR-625-5p expression promoted BMSC proliferation and osteogenic differentiation, whereas miR-625-5p overexpression weakened the effect of quercetin on BMSCs. Finally, quercetin treatment or downregulation of miR-625-5p expression increased β-catenin protein level in BMSCs. Upregulation or downregulation of miR-625-5p or H19 expression, respectively, inhibited β-catenin protein level in quercetin treated-BMSCs.
Conclusion
H19 promotes, while miR-625-5p inhibits BMSC osteogenic differentiation. Quercetin activates the Wnt/β-catenin pathway and promotes BMSC osteogenic differentiation via the H19/miR-625-5p axis.
Journal Article
Advanced biomaterials in pressure ulcer prevention and care: from basic research to clinical practice
Pressure ulcers are a common and serious medical condition. Conventional treatment methods often fall short in addressing the complexities of prevention and care. This paper provides a comprehensive review of recent advancements in advanced biomaterials for pressure ulcer management, emphasizing their potential to overcome these limitations. The study highlights the roles of biomaterials in enhancing wound healing, preventing infections, and accelerating recovery. Specific focus is placed on the innovation and application of multi-functional composite materials, intelligent systems, and personalized solutions. Future research should prioritize interdisciplinary collaboration to facilitate the clinical translation of these materials, providing more effective and tailored treatment approaches. These advancements aim to improve the quality of life and health outcomes for patients by offering more reliable, efficient, and patient-specific therapeutic options.
Journal Article