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Systematic genetic studies of a handful of diverse organisms over the past 50 years have transformed our understanding of biology. However, many aspects of primate biology, behavior, and disease are absent or poorly modeled in any of the current genetic model organisms including mice. We surveyed the animal kingdom to find other animals with advantages similar to mice that might better exemplify primate biology, and identified mouse lemurs (Microcebus spp.) as the outstanding candidate. Mouse lemurs are prosimian primates, roughly half the genetic distance between mice and humans. They are the smallest, fastest developing, and among the most prolific and abundant primates in the world, distributed throughout the island of Madagascar, many in separate breeding populations due to habitat destruction. Their physiology, behavior, and phylogeny have been studied for decades in laboratory colonies in Europe and in field studies in Malagasy rainforests, and a high quality reference genome sequence has recently been completed. To initiate a classical genetic approach, we developed a deep phenotyping protocol and have screened hundreds of laboratory and wild mouse lemurs for interesting phenotypes and begun mapping the underlying mutations, in collaboration with leading mouse lemur biologists. We also seek to establish a mouse lemur gene “knockout” library by sequencing the genomes of thousands of mouse lemurs to identify null alleles in most genes from the large pool of natural genetic variants. As part of this effort, we have begun a citizen science project in which students across Madagascar explore the remarkable biology around their schools, including longitudinal studies of the local mouse lemurs. We hope this work spawns a new model organism and cultivates a deep genetic understanding of primate biology and health. We also hope it establishes a new and ethical method of genetics that bridges biological, behavioral, medical, and conservation disciplines, while providing an example of how hands-on science education can help transform developing countries.

BackgroundMultiple factors contribute to symptom generation and treatment response in proton-pump inhibitor non-responders (PPI-NRs). We aimed to test whether PPI-NRs with normal acid exposure have a higher degree of esophageal hypersensitivity and hypervigilance and can be identified using functional lumen imaging probe (FLIP) topography at the time of endoscopy.MethodsData from PPI-NRs whom underwent endoscopy, FLIP and wireless 96-h pH-metry were retrospectively analyzed. Patients were grouped according to acid exposure time (AET) as (a) 0 days abnormal (AET > 6%), (b) 1–2 days abnormal, or (c) 3–4 days abnormal. The esophageal hypervigilance and anxiety scale (EHAS) score and other symptom scores were compared between groups. The discriminatory ability of the esophagogastric junction (EGJ) distensibility index (DI) and max EGJ diameter in identifying patients with 0 days abnormal AET was tested via receiver-operating-characteristic (ROC) curve analysis.ResultsEHAS score was 38.6 in the 0 days abnormal AET group, 30.4 in the 1–2 days abnormal AET group (p = 0.073 when compared to 0 days abnormal) and 28.2 in the 3–4 days abnormal AET group (p = 0.031 when compared to 0 days abnormal). Area-under-the-curve (AUC) for the DI in association with 0 days AET > 6% was 0.629. A DI of < 2.8 mm2/mmHg had a sensitivity of 83.3%, and negative predictive value of 88% in classifying patients with 0 days abnormal acid exposure (p = 0.004).ConclusionsFLIP complements prolonged wireless pH-metry in distinguishing the subset of PPI-NRs with completely normal acid exposure and a higher burden of esophageal hypervigilance. Proper identification of patients along the functional heartburn spectrum can improve overall surgical outcomes.

This article argues that groundwater—accounting for 98% of all fresh water on earth—is central to human development. Drawing upon studies at the regional and sub-regional level, this review article explores synergies and trade-offs between groundwater development and human development. On one hand, groundwater exploitation may enhance human development. Groundwater’s “untapped potential” related to various aspects of human development involves (a) water supply for irrigation and domestic purposes; (b) climate change adaptation and hydrological resilience; (c) hydrogeological storage of CO 2 ; and (d) access to (renewable) energy. On the other hand, human development may come at the expense of quality deterioration or depletion of groundwater. The review concludes that achieving a sound understanding of local groundwater characteristics and human impact on groundwater resources across scales is paramount to implementing the sustainable development goals in an integrated manner.

In 2015, the United Nations agreed on 17 Sustainable Development Goals (SDGs) as an “integrated and indivisible” set of policy objectives with the aim, among others, to unite the diverse and vast system of international organizations under one shared normative agenda. And yet, have these SDGs really become such an integrative force in global governance? Our conclusion here is negative, and our research suggests that the SDGs have not lived up to these high expectations. We find instead that the 17 global goals have not been taken up by a substantial group of international organizations, and some organizations rather cherry-pick those goals that best fit their own agenda and interests. To overcome these challenges and to fulfill the promise of integrated global sustainability governance enshrined in the SDGs, we propose three urgent actions: first, to further push the use of the SDGs across all international organizations, in particular regional organizations outside the United Nations system; second, to facilitate better collaboration across policy domains; and third, to focus attention on those SDGs that are so far “left behind.”

We conduct a systematic search for transients in 3 yr of data (2017–2019) from the Atacama Cosmology Telescope (ACT). ACT covers 40% of the sky at three bands spanning from 77–277 GHz. Analysis of 3 day mean-subtracted sky maps, which were match filtered for point sources, yielded 29 transient detections. Eight of these transients are due to known asteroids, and three others were previously published. Four of these events occur in areas with poor noise models and thus we cannot be confident they are real transients. We are left with 14 new transient events occurring at 11 unique locations. All of these events are associated with either rotationally variable stars or cool stars. Ten events have flat or falling spectra indicating radiation from synchrotron emission. One event has a rising spectrum indicating a different engine for the flare.

We conduct a systematic search for transients in three years of data (2017-2019) from the Atacama Cosmology Telescope (ACT). ACT covers 40 percent of the sky at three bands spanning from 77 GHz to 277 GHz. Analysis of 3-day mean-subtracted sky maps, which were match-filtered for point sources, yielded 29 transients detections. Eight of these transients are due to known asteroids, and three others were previously published. Four of these events occur in areas of with poor noise models and thus we cannot be confident they are real transients. We are left with 14 new transient events occurring at 11 unique locations. All of these events are associated with either rotationally variable stars or cool stars. Ten events have flat or falling spectra indicating radiation from synchrotron emission. One event has a rising spectrum indicating a different engine for the flare.