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Genetic and non-genetic clonal diversity in cancer evolution
The observation and analysis of intra-tumour heterogeneity (ITH), particularly in genomic studies, has advanced our understanding of the evolutionary forces that shape cancer growth and development. However, only a subset of the variation observed in a single tumour will have an impact on cancer evolution, highlighting the need to distinguish between functional and non-functional ITH. Emerging studies highlight a role for the cancer epigenome, transcriptome and immune microenvironment in functional ITH. Here, we consider the importance of both genetic and non-genetic ITH and their role in tumour evolution, and present the rationale for a broad research focus beyond the cancer genome. Systems-biology analytical approaches will be necessary to outline the scale and importance of functional ITH. By allowing a deeper understanding of tumour evolution this will, in time, encourage development of novel therapies and improve outcomes for patients.This Review discusses the role of functional (impacting tumour phenotype) and non-functional intra-tumour heterogeneity (ITH) in cancer evolution, highlighting the importance of considering genetic and non-genetic factors and their impact on patient outcomes.
Journal Article
Alternative investments : CAIA level I
\"The official CAIA Level 1 curriculum book, updated and expanded to reflect the March 2016 exam CAIA Level I is the curriculum book for the Chartered Alternative Investment Analyst (CAIA) Level 1 professional examination. Covering the fundamentals of the alternative investment space, this book helps you build a foundation in alternative investment markets. You'll look closely at the different types of hedge fund strategies and the range of statistics used to define investment performance as you gain a deep familiarity with alternative investment terms and develop the computational ability to solve investment problems. From strategy characteristics to portfolio management strategies, this book contains the core material you will need to succeed on the CAIA Level I exam. This updated third edition tracks to the latest version of the exam, and is accompanied by the following ancillaries: a workbook, study guide, learning objectives, and an ethics handbook. Most investment analyst education programs focus primarily on the traditional asset classes, pushing alternative investments to the sidelines. The CAIA designation was developed in response to the tremendous growth of alternative investing, and is the industry's premier educational standard. This book is your official study companion, bringing you fully up to speed on everything you need to know (with the exception of the ethics material covered in a separate handbook). Understand the complexities of each alternative asset class Learn the quantitative techniques professionals use every day Dig into the unique aspects of alternative investments Master the core material covered by the CAIA Level I exam More than 300 financial institutions and hedge funds have committed key executives to the CAIA exam, and this rapidly growing trend speaks to the designation's rising status as a must-have credential for anyone in the alternative investment sphere. Increase your chances of success by getting your information straight from the source in CAIA Level I\"-- Provided by publisher.
Book
Black enough : stories of being young & black in America
A collection of short stories explore what it is like to be young and black, centering on the experiences of black teenagers and emphasizing that one person's experiences, reality, and personal identity are different than someone else.
Book
Supporting the creative industries through the AI turn: A comparative analysis of Scottish policy and the needs of Scotland’s creative practitioners
In the creative industries (one of the largest UK sectors, which operates at the juncture of business, technology and the arts) creative practitioners are not only consumers of Artificial Intelligence (AI), but also its developers, originators and innovators. This has material consequences for how creative work is performed, valued and understood, as well as global consequences for business structures, the environment, equality and power discrepancies. We take Scotland as a case study for how governmental policy addresses the challenges of AI for the creative industries by comparing Scotland’s Artificial Intelligence Strategy with data gathered from grass roots creative industries practitioners in Scotland through workshops and a survey. We identify differences between the priorities of Scotland’s Artificial Intelligence Strategy and the creative industries, as well as a lack of advice specific to the needs of the creative industries, and offer recommendations on how to put creatives at the heart of AI developments.
Journal Article
Clinical implications of heterogeneity in PD-L1 immunohistochemical detection in hepatocellular carcinoma: the Blueprint-HCC study
Programmed cell death ligand-1 immunohistochemical detection (PD-L1 IHC) is a putative predictor of response to PD-1/PD-L1-targeted checkpoint inhibitors. However, there is no gold standard assay in hepatocellular carcinoma (HCC). We evaluated 5 PD-L1 IHC assay platforms (E1LN3, 28-8, 22c3, SP263 and SP142) in 100 HCCs reporting PD-L1 expression in malignant (M) and tumour-infiltrating immune cells (TICs) and non-tumorous cirrhotic tissues (NTICs). We found substantial inter-assay heterogeneity in detecting PD-L1 expression in M (
R
2
= 0.080–0.921), TICs (Cohen’s
κ
= 0.175–0.396) and NTICs (
κ
= 0.004–0.505). Such diversity may impact on the reliability and reproducibility of PD-L1 IHC assays as a predictor of response to immune checkpoint inhibitors.
Journal Article
Contemporary plays by African American women : ten complete works
African American women have increasingly begun to see their plays performed from regional stages to Broadway. Yet many of these artists still struggle to gain attention. In this volume, Sandra Adell draws from the vital wellspring of works created by African American women in the twenty-first century to present ten plays by both prominent and up-and-coming writers. Taken together, the selections portray how these women engage with history as they delve into--and shake up--issues of gender and class to craft compelling stories of African American life. Gliding from gritty urbanism to rural landscapes, these works expand boundaries and boldly disrupt modes of theatrical representation.
Book
Cancer gene identification from RNA variant allelic frequencies using RVdriver
Existing approaches to identifying cancer genes rely overwhelmingly on DNA sequencing data. Here, we introduce
RVdriver
, a computational tool that leverages paired bulk genomic and transcriptomic data to classify RNA variant allele frequencies (VAFs) of non-synonymous mutations relative to a synonymous mutation background. We analyze 7882 paired exomes and transcriptomes from 31 cancer types and identify novel, as well as known, cancer genes, complementing other DNA-based approaches. Furthermore, RNA VAFs of individual mutations are able to distinguish “driver” from “passenger” mutations within established cancer genes. This approach highlights the value of multi-omic approaches for cancer gene discovery.
Journal Article