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Red glove
When federal agents learn that seventeen-year-old Cassel Sharpe, a powerful transformation worker, may be of use to them, they offer him a deal to join them rather than the mobsters for whom his brothers work.
Book
Genetic and non-genetic clonal diversity in cancer evolution
The observation and analysis of intra-tumour heterogeneity (ITH), particularly in genomic studies, has advanced our understanding of the evolutionary forces that shape cancer growth and development. However, only a subset of the variation observed in a single tumour will have an impact on cancer evolution, highlighting the need to distinguish between functional and non-functional ITH. Emerging studies highlight a role for the cancer epigenome, transcriptome and immune microenvironment in functional ITH. Here, we consider the importance of both genetic and non-genetic ITH and their role in tumour evolution, and present the rationale for a broad research focus beyond the cancer genome. Systems-biology analytical approaches will be necessary to outline the scale and importance of functional ITH. By allowing a deeper understanding of tumour evolution this will, in time, encourage development of novel therapies and improve outcomes for patients.This Review discusses the role of functional (impacting tumour phenotype) and non-functional intra-tumour heterogeneity (ITH) in cancer evolution, highlighting the importance of considering genetic and non-genetic factors and their impact on patient outcomes.
Journal Article
When a heart turns rock solid : the lives of three Puerto Rican brothers on and off the streets
Employing a sociological storytelling method, Black, associate professor of sociology at the University of Hartford, recounts the lives of three Puerto Rican brothers living in poor, gang-dominated Springfield, Mass., whom he befriended and followed for 18 years. The book is not so much about the brothers--Julio, Fausto and Sammy--and their friends as it is about the cultural and social forces and the economic and political policies that in the latter decades of the 20th century determined the boys' fates and the fates of thousands of others. Flawed bilingual education programs doomed them to virtual illiteracy, while harsh drug laws warehoused them in a rapidly expanding prison system. While the author provided concrete forms of assistance--especially for the two younger brothers, who battled addiction--the pull of the street as well as the inadequacy of their education led to failed or marginally productive lives, even for the motivated eldest son, Julio.
Book
Knowledge for Justice
Knowledge for Justice is a joint publication of UCLA's
four ethnic studies research centers: American Indian Studies,
Asian American Studies, Chicana/o Studies, and African American
Studies. The book addresses the intersectional intellectual,
social, and political struggles that confront the groups
represented in the anthology. The selections articulate the
specificity of each racial ethnic group's struggle while
simultaneously interrogating the ways in which such labels or
categories are inadequate.
eBook
The effects of armed conflict on the health of women and children
Women and children bear substantial morbidity and mortality as a result of armed conflicts. This Series paper focuses on the direct (due to violence) and indirect health effects of armed conflict on women and children (including adolescents) worldwide. We estimate that nearly 36 million children and 16 million women were displaced in 2017, on the basis of international databases of refugees and internally displaced populations. From geospatial analyses we estimate that the number of non-displaced women and children living dangerously close to armed conflict (within 50 km) increased from 185 million women and 250 million children in 2000, to 265 million women and 368 million children in 2017. Women's and children's mortality risk from non-violent causes increases substantially in response to nearby conflict, with more intense and more chronic conflicts leading to greater mortality increases. More than 10 million deaths in children younger than 5 years can be attributed to conflict between 1995 and 2015 globally. Women of reproductive ages living near high intensity conflicts have three times higher mortality than do women in peaceful settings. Current research provides fragmentary evidence about how armed conflict indirectly affects the survival chances of women and children through malnutrition, physical injuries, infectious diseases, poor mental health, and poor sexual and reproductive health, but major systematic evidence is sparse, hampering the design and implementation of essential interventions for mitigating the harms of armed conflicts.
Journal Article
Prevalence of Multiple Chronic Conditions Among US Adults, 2018
This analysis provides prevalence estimates of diagnosed single and multiple (≥2) chronic conditions among the noninstitutionalized, civilian US adult population. Data from the 2018 National Health Interview Survey (NHIS) were used to estimate percentages for US adults by selected demographic characteristics. More than half (51.8%) of adults had at least 1 of 10 selected diagnosed chronic conditions (arthritis, cancer, chronic obstructive pulmonary disease, coronary heart disease, current asthma, diabetes, hepatitis, hypertension, stroke, and weak or failing kidneys), and 27.2% of US adults had multiple chronic conditions.
Journal Article
