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Community-based natural resource management (CBNRM) seeks to align the interests of local communities and conservation institutions. A significant challenge to this realignment is that CBNRM is often implemented in locations with colonial histories of oppression, persecution, and dispossession that have left legacies of inequity and marginalization. Social networks are one method for discerning how marginalized CBNRM actors can negotiate entitlements and agency. Through the lens of social networks, marginalization can be viewed as insufficient connectivity between the center and the periphery of the network. One possible remedy to this dysfunction are boundary actors, which are thought to be vital to connecting parts of social networks that would otherwise be poorly connected. Using social network analysis to visualize interactions between the Topnaar community and CBNRM institutional actors in Namibia’s Namib-Naukluft and Dorob National Parks, we find a number of individuals well-positioned to serve as boundary actors. Although our results suggest these individuals can be effective in sharing and translating key knowledge, supporting transfers of benefits, and enabling or negotiating entitlements, we also found that social, political, institutional, and geographic constraints limited their effectiveness. In particular, the Topnaar Traditional Authority, adopted a “neo-traditional,” top-down, gatekeeper role, while their community wanted them to be more responsive and engaged in directly addressing the communities’ problems. In general, the boundary actors were the focus of much discontent and conflict, in large part because of unclear pathways of accountability. We recommend the co-creation of boundary objects that specify responsibilities and thus reduce conflict and support effective boundary actors.

Ephemeral rivers in arid regions act as linear oases, where corridors of vegetation supported by accessible groundwater and intermittent surface flows provide biological refugia in water-limited landscapes. The ecological and hydrological dynamics of these systems are poorly understood compared to perennial systems and subject to wide variation over space and time. This study used imagery obtained from an unmanned aerial vehicle (UAV) to enhance satellite data, which were then used to quantify change in woody vegetation cover along the ephemeral Kuiseb River in the Namib Desert over a 35-year period. Ultra-high resolution UAV imagery collected in 2016 was used to derive a model of fractional vegetation cover from five spectral vegetation indices, calculated from a contemporaneous Landsat 8 Operational Land Imager (OLI) image. The Normalized Difference Vegetation Index (NDVI) provided the linear best-fit relationship for calculating fractional cover; the model derived from the two 2016 datasets was subsequently applied to 24 intercalibrated Landsat images to calculate fractional vegetation cover for the Kuiseb extending back to 1984. Overall vegetation cover increased by 33% between 1984 and 2019, with the most highly vegetated reach of the river exhibiting the greatest positive change. This reach corresponds with the terminal alluvial zone, where most flood deposition occurs. The spatial and temporal trends discovered highlight the need for long-term monitoring of ephemeral ecosystems and demonstrate the efficacy of a multi-sensor approach to time series analysis using a UAV platform.

Surprisingly little is known about the spatial dimensions of most tropical ungulate migrations, including that of wildebeest Connochaetes taurinus, a species famous for long-distance movements. Using non-invasive photographic identification of 834 adult wildebeest from 8,530 images collected over 4 years we characterize patterns of migratory connectivity throughout the northern Tarangire–Manyara Ecosystem, Tanzania. We document movements between Tarangire and Lake Manyara National Parks and northwards to the shore of Lake Natron, a straight-line distance of > 130 km. Fifty-six percent of observed movements occur outside the ecosystem's three main protected areas. We supplement photographic data with fine-scale movement data from two individuals with global positioning system collars, and identify three narrow bottlenecks, each vulnerable to human development. We discuss the possible consequences for the wildebeest population if these bottlenecks become impeded. Persistence of this migration alongside a growing human population and proposed road improvement will require additional measures to ensure that pathways remain open to wildlife movement and protected from illegal hunting.

The distribution of non-ant arthropods was examined in 40 urban habitat fragments in coastal San Diego County, California, USA, to look for effects of fragmentation, proximity to developed edge, and the non-native Argentine ant (Linepithema humile). Arthropods were sampled with pitfall traps and by vacuum sampling from California buckwheat shrubs (Eriogonum fasciculatum). Individual arthropods were identified to order and Recognizable Taxonomic Unit (RTU), or morphospecies. At the fragment scale we looked for correlations in the point diversity and abundance of arthropods as a function of the age and area of the fragment being sampled. At the scale of the individual sample points we looked for correlations of abundance and diversity with variables that describe the species composition of the shrub vegetation and disturbance. As indicators of disturbance we used the cover of native woody and exotic non-woody vegetation, the distance to the nearest developed edge, and the abundance of Argentine ants. The following patterns were found: (1) In general, arthropods showed a fragmentation effect with point diversity and abundance positively correlated with fragment area and negatively correlated with fragment age. (2) The pitfall samples were dominated by three primarily non-native orders, Isopoda (pillbugs), Dermaptera (earwigs), and Blattaria (roaches). Over 35% of all pitfall-captured arthropods belonged to four species in these orders. Dermaptera and Blattaria increased in abundance in smaller and older fragments, respectively. Isopod abundance, in contrast, was unrelated to fragment attributes. None of these groups appeared to be associated with edges, but were distributed throughout the fragments. (3) Point diversity and abundance in ground-active spiders appears to be enhanced by fragmentation. (4) Total pitfall RTU richness and abundance, and abundance or richness in the Coleoptera (vacuum), Diptera, non-ant Hymenoptera, Hemiptera, Microcoryphia, and Acarina had significant partial negative correlations with Argentine ant abundance. The Diptera and Coleoptera had this negative partial relationship with the Argentine ants despite the fact that both they and the ants were positively associated with edges. (5) In general, diversity in most orders was higher in sampling locations dominated by coastal sage scrub habitat than in those with appreciable cover of chaparral shrub species. (6) There was a strong seasonal variation in abundance and diversity in most orders. Diversity and abundance were highest in spring, intermediate in winter, and lowest in the fall. (7) Although higher trophic levels are often considered to be more sensitive to fragmentation, two groups of arthropod predators, spiders and carabid beetles, increased in abundance in older fragments. Abundance of these predators was positively correlated with the abundance of Argentine ants and the non-native Isopods, Dermaptera, and Blattaria.

ObjectiveChildhood burns represent a burden on health services, yet the full extent of the problem is difficult to quantify. We estimated the annual UK incidence from primary care (PC), emergency attendances (EA), hospital admissions (HA) and deaths.MethodsThe population was children (0–15 years), across England, Wales, Scotland and Northern Ireland (NI), with medically attended burns 2013–2015. Routinely collected data sources included PC attendances from Clinical Practice Research Datalink 2013–2015), EAs from Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI, 2014) and National Health Services Wales Informatics Services, HAs from Hospital Episode Statistics, National Services Scotland and Social Services and Public Safety (2014), and mortality from the Office for National Statistics, National Records of Scotland and NI Statistics and Research Agency 2013–2015. The population denominators were based on Office for National Statistics mid-year population estimates.ResultsThe annual PC burns attendance was 16.1/10 000 persons at risk (95% CI 15.6 to 16.6); EAs were 35.1/10 000 persons at risk (95% CI 34.7 to 35.5) in England and 28.9 (95% CI 27.5 to 30.3) in Wales. HAs ranged from 6.0/10 000 person at risk (95% CI 5.9 to 6.2) in England to 3.1 in Wales and Scotland (95% CI 2.7 to 3.8 and 2.7 to 3.5, respectively) and 2.8 (95% CI 2.4 to 3.4) in NI. In England, Wales and Scotland, 75% of HAs were aged <5 years. Mortality was low with 0.1/1 000 000 persons at risk (95% CI 0.06 to 0.2).ConclusionsWith an estimated 19 574 PC attendances, 37 703 EAs (England and Wales only), 6639 HAs and 1–6 childhood deaths annually, there is an urgent need to improve UK childhood burns prevention.

Spatial variation in habitat quality and anthropogenic factors, as well as social structure, can lead to spatially structured populations of animals. Demographic approaches can be used to improve our understanding of the dynamics of spatially structured populations and help identify subpopulations critical for the long-term persistence of regional metapopulations. We provide a regional metapopulation analysis to inform conservation management for Masai giraffes ( Giraffa camelopardalis tippelskirchi ) in five subpopulations defined by land management designations. We used data from an individual-based mark–recapture study to estimate subpopulation sizes, subpopulation growth rates, and movement probabilities among subpopulations. We assessed the source–sink structure of the study population by calculating source–sink statistics, and we created a female-based matrix metapopulation model composed of all subpopulations to examine how variation in demographic components of survival, reproduction, and movement affected metapopulation growth rate. Movement data indicated no subpopulation was completely isolated, but movement probabilities varied among subpopulations. Source–sink statistics and net flow of individuals indicated three subpopulations were sources, while two subpopulations were sinks. We found areas with higher wildlife protection efforts and fewer anthropogenic impacts were sources, and less-protected areas were identified as sinks. Our results highlight the importance of identifying source–sink dynamics among subpopulations for effective conservation planning and emphasize how protected areas can play an important role in sustaining metapopulations.

PurposeThis study was conducted to investigate the safety and tolerability of increasing doses of liposomal curcumin in patients with metastatic cancer. Investigations of anti-tumor activity and of the pharmacokinetics of curcumin were secondary objectives.MethodsIn this phase I, single-center, open-label study in patients with metastatic tumors, liposomal curcumin was administered as a weekly intravenous infusion for 8 weeks. Dose escalation was started at 100 mg/m2 over 8 h and the dose increased to 300 mg/m2 over 6 h.Results32 patients were treated. No dose-limiting toxicity was observed in 26 patients at doses between 100 and 300 mg/m2 over 8 h. Of six patients receiving 300 mg/m2 over 6 h, one patient developed hemolysis, and three other patients experienced hemoglobin decreases > 2 g/dL without signs of hemolysis. Pharmacokinetic analyses revealed stable curcumin plasma concentrations during infusion followed by rapid declines to undetectable levels after the infusion. Anti-tumor activity by RECIST V1.1 was not detected. Significant tumor marker responses and transient clinical benefit were observed in two patients.Conclusion300 mg/m2 liposomal curcumin over 6 h was the maximum tolerated dose in these heavily pretreated patients, and is the recommended starting dose for anti-cancer trials.

We investigated the response of Gyrinophilus porphyriticus (Plethodontidae), the spring salamander, to timber harvest in headwater streams in New Hampshire (U.S.A.). We conducted cover-controlled, whole-stream surveys for G. porphyriticus in 25 first-order streams in drainages encompassing a range of timber-harvest histories. Streams in two different landscape configurations were chosen, isolated, or paired, based on the presence or absence of a confluent first-order stream-a potential source of immigrants. We analyzed salamander abundance with respect to logging history, presence of the brook trout (Salvelinus fontinalis), salamander population connectivity, and other measures of physical habitat and aquatic conditions. In stepwise multiple-regression analysis, the best multivariate model of G. porphyriticus abundance included fish presence/absence; effect category, a combined function of years since harvest and substrate embeddedness by fine sediment; and landscape configuration. These three factors explained 74% of the variation in G. porphyriticus abundance. G. porphyriticus was less abundant in streams where fish were present, likely because of predation by S. fontinalis or asymmetric competition between these species. Abundance also declined with increasing substrate embeddedness and/or decreasing years since harvest, indicating an effect of fine sediment inputs and harvest history on this species. Finally, G. porphyriticus was less abundant in isolated streams than in paired streams. This result suggests that landscape-scale population connectivity may buffer this species from the negative effects of local (i.e., stream-scale) habitat perturbation. We hope this work will encourage others to develop multiscale models of land-use effects on stream biota and thereby ultimately increase the range and effectiveness of conservation strategies for these species.

Recently, climate change research has emphasized the potential increase in the frequency and severity of climatic extremes. We compared the reproductive effort and output among four species of passerine birds in coastal southern California, USA, a semi-arid region, during a normal precipitation year (2001) and the driest year in a 150-year climate record (2002). Both reproductive effort and output differed dramatically between years. Mean reproductive output among the four species was 2.37 fledglings/pair in 2001 and 88.4% of all pairs observed attempted at least one nest. The birds attempted a mean of 1.44 nests per pair and were successful in 47.7% of those attempts. In 2002, only 6.7% of the pairs even attempted a nest and only 1.8% were successful, for a total output of 0.07 fledglings per pair. The abundance of suitable arthropod prey items in the environment was also much lower in 2002, suggesting that low food availability was the proximal cause of the reproductive failure. The data for one of these species, the rufous-crowned sparrow (Aimophila ruficeps), were combined with reproductive and rainfall data from a previous 3-year study (1997-1999) in the same sites. The combined data sets suggest that the response of reproduction to rainfall variation is linear, and that the low end of the precipitation range brings the population near reproductive failure. Any change in climate that would increase the frequency of extreme dry conditions would likely endanger populations of these species.

From 1997 to 1999, we monitored the reproductive success of individual rufous-crowned sparrows (Aimophila ruficeps) in coastal sage scrub habitat of southern California, USA. Annual reproductive output of this ground-nesting species varied strongly with annual variation in rainfall, attributed to the El Niño-Southern Oscillation. Birds fledged 3.0 young per breeding pair in 1997, when rainfall was near the long-term mean, 5.1 offspring per pair in 1998, a wet El Niño year, and 0.8 fledglings per pair in 1999, a dry La Niña year. Variation in many components of reproductive output was consistent with the hypothesis that food availability was positively correlated with rainfall. However, the factor most responsible for the high reproductive output in 1998 was low early season nest predation which, combined with favorable nesting conditions, enabled more pairs to multiple-brood. Cool, rainy El Niño conditions may have altered the activity of snakes, the main predator of these nests, in the early season of 1998. Overall, more of the annual variation in fecundity was attributable to variation in within-season components of reproductive output (mean number of nests fledged per pair) than to within-nest components (mean brood size). Annual variation in rufous-crowned sparrow fecundity appears to be driven primarily by food resource-mediated processes in La Niña years and by predator-mediated processes in El Niño years.