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Purpose This paper aims to identify, analyse and organise the literature about blockchains in supply chain management (SCM) context (blockchain–SCM integration) and proposes an agenda for future research. This study aims to shed light on what the main current blockchain applications in SCM are, what the main disruptions and challenges are in SCM because of blockchain adoption and what the future of blockchains holds in SCM. Design/methodology/approach This study followed the systematic review approach to analyse and synthesise the extant literature on blockchain–SCM integration. The review analysed 27 papers between 2008 and 2018 in peer-reviewed journals. Findings Blockchain–SCM integration is still in its infancy. Scholars and practitioners are not fully aware of the potential of blockchain technology to disrupt traditional business models. However, the electric power industry seems to have a relatively mature understanding of blockchain–SCM integration, demonstrated by the use of smart contracts. Additionally, the disintermediation provided by blockchain applications has the potential to disrupt traditional industries (e.g. health care, transportation and retail). Research limitations/implications The limitations of this study are represented mainly by the scarcity of studies on blockchain–SCM integration in leading journals and databases. Practical implications This study highlights examples of blockchain–SCM integration, emphasising the need to rethink business models to incorporate blockchain technology. Originality/value This study is the first attempt to synthesise existing publications about the blockchain–SCM integration, shedding light on the disruption caused by, and the necessity of, the SCM reconfigurations.

The new evolution of the production and industrial process called Industry 4.0, and its related technologies such as the Internet of Things, big data analytics, and cyber–physical systems, among others, still have an unknown potential impact on sustainability and the environment. In this paper, we conduct a literature-based analysis to discuss the sustainability impact and challenges of Industry 4.0 from four different scenarios: deployment, operation and technologies, integration and compliance with the sustainable development goals, and long-run scenarios. From these scenarios, our analysis resulted in positive or negative impacts related to the basic production inputs and outputs flows: raw material, energy and information consumption and product and waste disposal. As the main results, we identified both positive and negative expected impacts, with some predominance of positives that can be considered positive secondary effects derived from Industry 4.0 activities. However, only through integrating Industry 4.0 with the sustainable development goals in an eco-innovation platform, can it really ensure environmental performance. It is expected that this work can contribute to helping stakeholders, practitioners and governments to advance solutions to deal with the outcomes emerging through the massive adoption of those technologies, as well as supporting the expected positive impacts through policies and financial initiatives.

The great urban population growth generates several changes in life style, land use, energy demand and consequent environmental pressure. In this way, studies related to environmental sustainability of urban systems and the availability of natural resources are of major importance. EMergy is considered to be a powerful tool to environmental accounting and measures both natural and human resources to generate products and services. The evaluation through eMergy synthesis of cities, states, nations and its base resources provides large scale perspective to evaluation of environmental areas and can help selection of policies for public benefit. This preliminary study applies the eMergy synthesis to evaluate the sustainability of the cities that compose the ABC Paulista, accounting the local free renewable and the purchased resources that give support to the cities. [PUBLICATION ABSTRACT]

This study evaluates two Brazilian water treatment plants for public supply, located at São Paulo, from a biophysical perspective, using emergy accounting. The emergy methodology enables all type of resources to be measured in a common basis. It also as considers not only direct and indirect resources but also the environmental work that sustains human inputs. Local development and road construction led to industrial growth and unplanned settlement with the consequent water reservatory degradation. In this way, the \"Baixo Cotia\" plant treats water from a reservoir located within the over occupied region whereas the \"Alto Cotia\" plant is located in a preserved area. This legally preserved area contains one of the typical Brazilian biomes, \"Mata Atlântica\". The environmental and financial costs associated to lack of preservation and proper public policies are evidenced by means of the applied methodology. Results derived from the most polluted water reservoir showed low global treatment efficiency and an unsustainable behavior. On the other hand, the plant located at the preserved area showed a sustainable behavior over a short run. Results were compared to literature data from a treatment plant located in USA. Also the necessity of public policies and environmental education programs is briefly discussed. [PUBLICATION ABSTRACT]

Tissue regeneration declines with ageing but little is known about whether this arises from changes in stem-cell heterogeneity. Here, in homeostatic skeletal muscle, we identify two quiescent stem-cell states distinguished by relative CD34 expression: CD34High, with stemness properties (genuine state), and CD34Low, committed to myogenic differentiation (primed state). The genuine-quiescent state is unexpectedly preserved into later life, succumbing only in extreme old age due to the acquisition of primed-state traits. Niche-derived IGF1-dependent Akt activation debilitates the genuine stem-cell state by imposing primed-state features via FoxO inhibition. Interventions to neutralize Akt and promote FoxO activity drive a primed-to-genuine state conversion, whereas FoxO inactivation deteriorates the genuine state at a young age, causing regenerative failure of muscle, as occurs in geriatric mice. These findings reveal transcriptional determinants of stem-cell heterogeneity that resist ageing more than previously anticipated and are only lost in extreme old age, with implications for the repair of geriatric muscle.García-Prat, Perdiguero, Alonso-Martín et al. show that skeletal muscle contains a subpopulation of quiescent stem cells, maintained by FoxO signalling, that is preserved into late life but declines in advanced geriatric age.

is a rare cricetid genus endemic to Europe, known from the Early Oligoceneto the Early Miocene. It is usually a very rare find, and even in the few localities where remains are found, those are scarce and fragmentary. Only a few Central European localities have yielded rich remains of the genus. Currently, two species are known from the Early Miocene: which is based on two teeth from the MN2 German locality of Haslach and only found in two other sites of similar age (Ulm-Uniklinik and La Chaux, from Germany and Switzerland respectively); and found in MN3 and MN4 localities across Europe, even though the scarce and fragmentary remains make some of these attributions dubious. For that reason, has become a catch-all species. However, Mokrá-Quarry represents one of the best documented findings of remains from MN4 localities of Europe. The assemblage from Mokrá-Quarry has been studied thoroughly, providing metrics and detailed descriptions of all teeth positions, as well as complete comparisons with other MN3 and MN4 localities bearing remains. In this work, new remains of have been identified as a new morphotype that clearly differs from by its unique m1 morphology but still shows some resemblance with Based on that, we here propose the hypothesis of an evolutionary lineage starting from , diverging from the lineage leading towards With this finding, there are at least two different taxa of known during the Early Miocene, prior to the genus extinction. This study arises the certainty that the evolution history of the genus is more complex than previously thought and that more studies are necessary to elucidate it, including a complete revision of the type material of and in the light of current knowledge of the genus, which will help to elucidate the attribution of the populations from Mokrá-Quarry. For the time being, the assemblage presented here is referred as aff.

Baseline cerebral microbleeds (CMBs) and APOE ε4 allele copy number are important risk factors for amyloid-related imaging abnormalities in patients with Alzheimer disease (AD) receiving therapies to lower amyloid-β plaque levels. To provide prevalence estimates of any, no more than 4, or fewer than 2 CMBs in association with amyloid status, APOE ε4 copy number, and age. This cross-sectional study used data included in the Amyloid Biomarker Study data pooling initiative (January 1, 2012, to the present [data collection is ongoing]). Data from 15 research and memory clinic studies were pooled and harmonized. Participants included individuals for whom data on age, cognitive status, amyloid status, and presence of CMBs were available. Data were analyzed from October 22, 2023, to April 26, 2024. The main outcomes were age, cognitive status, amyloid status and presence, location, and number of CMBs. Presence of amyloid pathology was determined based on 42 amino acid-long form of amyloid-β peptide (Aβ42) levels in cerebrospinal fluid or on amyloid-positron emission tomography. Presence and, in a subset, location (lobar vs deep) and number of CMBs were determined on magnetic resonance imaging (locally with visual rating). Among 4080 participants included in the analysis, the mean (SD) age was 66.5 (8.9) years, and 2241 (54.9%) were female. A total of 2973 participants had no cognitive impairment (cognitive unimpairment [CU]), and 1107 had mild cognitive impairment (MCI) or AD dementia (ADD). One thousand five hundred and thirteen participants (37.1%) had amyloid pathology, 1368 of 3599 (38.0%) with data available were APOE ε4 carriers, and 648 (15.9%) had CMBs. In the CU group, amyloid pathology and APOE ε4 copy number were not associated with presence of any, no more than 4, or fewer than 2 CMBs but were associated with increased odds of lobar CMBs (odds ratio [OR] for amyloid, 1.42 [95% CI, 1.20-1.69], P < .001; OR for 2 vs 0 alleles, 1.81 [95% CI, 1.19-2.74], P = .006; OR for 1 vs 0 alleles, 1.10 [95% CI, 0.83-1.46], P = .49; and OR for 2 vs 1 allele, 1.64 [95% CI, 0.90-2.97], P = .11; overall P = .02). In the MCI-ADD group, amyloid pathology was associated with presence of any CMBs (OR, 1.51 [95% CI, 1.17-1.96], P = .002), no more than 4 CMBs (OR, 1.44 [95% CI, 1.18-1.82], P = .002), and fewer than 2 CMBs (OR 1.34 [95% CI, 1.03-1.74], P = .03) but not lobar CMBs. APOE ε4 copy number was associated with presence of any (OR for 2 vs 0 alleles, 1.72 [95% CI, 0.88-3.35], P = .11; OR for 1 vs 0 alleles, 0.78 [95% CI, 0.59-1.04], P = .09; and OR for 2 vs 1 allele, 2.20 [95% CI, 1.32-3.67], P = .002; overall P < .001) and no more than 4 CMBs (OR for 2 vs 0 alleles, 1.31 [95% CI, 0.64-2.68], P = .45; OR for 1 vs 0 alleles, 0.75 [95% CI, 0.54-1.04], P = .08; and OR for 2 vs 1 allele, 1.76 [95% CI, 0.97-3.19], P = .06; overall P = .03) but not with fewer than 2 or lobar CMBs. Prevalence estimates of CMBs ranged from 6% at 50 years of age in a non-APOE ε4 allele carrier with no amyloid pathology and no cognitive impairment to 52% at 90 years of age in an APOE ε4 homozygote carrier with amyloid pathology and cognitive impairment. In this cross-sectional study of 4080 participants, prevalence estimates of CMBs were associated with amyloid status, APOE ε4 copy number, and age. CMB prevalence estimates may help inform safety evaluations for antiamyloid clinical trials.