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This in vitro study evaluated the flexural strength, fluoride release, water sorption, and solubility of a high-viscosity hybrid glass ionomer cement (HVGIC, Equia Forte HT, GC Europe) over 28 days following six surface treatments: Equia Forte Coat (light-cured, 20s), bonding agent (Clearfil SE Universal Bond, 20s), light-curing alone as thermal treatment (20s or 60s), petroleum jelly, and untreated control. Specimens were stored in artificial saliva at 37 °C. Flexural strength (three-point bend test, ISO 4049:2019) and fluoride release were assessed at 24, 48, 96 h and 28 days. Sorption and solubility were measured at 28 days. Statistical analysis included bivariate tests, Kaplan-Meier survival curves, Tukey’s post-hoc, and Weibull regression. Proprietary coat and bonding agent reached the minimum required strength (MRS = 80 MPa) fastest (< 2 days), followed by petroleum jelly (2.5 days), 60s light curing (3 days), 20s (4 days), and control (5.5 days). Control showed the highest fluoride release initially, while at 28 days, 60s light-curing released the most fluoride. Proprietary coat and bonding agent showed minimal release. No significant differences in water sorption or solubility were found. These findings suggest that specific coatings or prolonged light curing can improve HVGIC performance and longevity of restorations.

This paper provides new evidence on the impact of electronic trading on brokerage commissions by investigating a sample period that covers the period of transition from floor to electronic trading on the Sydney Futures Exchange. After controlling for liquidity, volatility and broker identity, the introduction of electronic trading remains to be associated with lower brokerage commissions relative to floor markets. The study also provides new evidence on brokerage commissions in futures markets finding that commission fees charged on futures trades average 0.002% of transaction value. This is up to 120 times smaller than the magnitude of brokerage fees charged in stock markets, and considerably lower than the magnitude of brokerage fees assumed for futures markets in previous research. Consistent with existing studies based on stock markets, commissions charged per contract decrease with order size reflecting economies of scale in the provision of brokerage services in futures markets. Commission rates are positively related to bid-ask spreads and price volatility, which proxy for the probability of execution error costs and execution difficulty, respectively. Finally, the identity of the broker is found to be a significant determinant of commissions reflecting different pricing schedules across brokers.

High hepatocyte proliferation has been recently proposed as a risk factor for the development of hepatocellular carcinoma (HCC). The aim of this study was to assess whether hepatocyte proliferation is an independent risk factor for HCC when considered together with clinical and demographic characteristics. We retrospectively evaluated 97 consecutive patients with a histological diagnosis of cirrhosis and preserved liver function, enrolled in a surveillance program for early diagnosis of HCC. Hepatocyte proliferation was evaluated by flow-cytometric analysis in liver samples collected at the time of histological diagnosis of cirrhosis. All patients were followed with abdominal US and serum α-fetoprotein (AFP) assays every 6 months. During a mean follow-up of 53 months (range, 12–120 months), 12 patients developed HCC, giving an annual incidence of 2.8%. The mean S-phase fraction was 2.5%± 1.6 in patients who developed HCC and 0.9%± 0.6 in those who did not (p < 0.0001). By univariate analysis, S-phase fraction 1.8% or higher and AFP higher than 20 ng/ml were the only two variables significantly correlated with the development of HCC (p < 0.0001, p < 0.0001). Multivariate analysis found that both variables were independently associated with HCC development (p < 0.003 and p < 0.005, respectively), with hazard ratios of 8.0 and 7.3 (confidence intervals, 2.1–31.2 and 1.8–29.2). Among patients with high AFP and/or high S-phase fraction, 11 (39%) developed HCC, compared with only one (1%) with a low S-phase fraction and normal AFP, corresponding to HCC yearly incidences of 9.5% and 0.3% (p < 0.00009). Patients with high S-phase fraction and/or above-normal serum AFP are at higher risk of developing HCC and should be offered a close surveillance program.

Food is often considered to be a precipitating factor of irritable bowel syndrome (IBS) symptoms. In recent years, there has been a growing interest in FODMAPs (Fermentable Oligo-, Di-, Mono-saccharides, And Polyols), which can be found in many common foods. A low FODMAP diet (LFD) is increasingly suggested for IBS treatment. However, long-term, large, randomized controlled studies are still lacking, and certainties and doubts regarding LFDs have grown, often in a disorderly and confused manner. Some potential LFD limitations and concerns have been raised, including nutritional adequacy, cost, and difficulty in teaching the diet and maintaining it. Most of these limitations can be solved with the involvement of a skilled nutritionist, who can clearly explain the different phases of the LFD and ensure nutritional adequacy and compliance. Further studies should focus on new methods of teaching and learning the LFD and on predictors of response. Moreover, particular interest should be focused on the possible use of LFD in gastrointestinal diseases other than functional disorders and, possibly, also in non-gastrointestinal diseases. The aim of the present review was to clarify the effective and appropriate indications and limitations of an LFD and to discuss its possible future uses.

The atmospheric boundary layer (ABL) represents the lowermost part of the atmosphere directly in contact with the Earth's surface. The estimation of its depth is of crucial importance in meteorology and for anthropogenic pollution studies. ABL height (ABLH) measurements are usually far from being adequate, both spatially and temporally. Thus, different remote sensing sources can be of great help in growing both the spatial and temporal ABLH measurement capabilities. To this aim, aerosol backscatter profiles are widely used as a proxy to retrieve the ABLH. Hence, the scientific community is making remarkable efforts in developing automatic ABLH retrieval algorithms applied to lidar observations. In this paper, we propose a ABLH estimation algorithm based on image processing techniques applied to the composite image of the total attenuated backscatter coefficient. A pre-processing step is applied to the composite total backscatter image based on morphological filters to properly set-up and adjust the image to detect edges. As final step, the detected edges are post-processed through both mathematical morphology and an object-based analysis. The performance of the proposed approach is assessed on real data acquired by two different lidar systems, deployed in Potenza (Italy) and Évora (Portugal), belonging to the European Aerosol Research Lidar Network (EARLINET). The proposed approach has shown higher performance than the benchmark consisting of some state-of-the-art ABLH estimation methods.

Although the parasitoid Cotesia flavipes (Cameron) has proven effective in controlling sugarcane borer Diatraea saccharalis (Fabricius) for many years, concern has arisen over the quality of individuals produced at large scales. The parasitoid has been reared in laboratories in Brazil for more than 40 years, with no new introductions of new populations during that period. Since the quality of the parasitoids was not verified at the time of the species' introduction in Brazil, we do not know if there has been any reduction in quality so far. However, it is possible to determine whether the parasitoid could reduce in quality in future generations. Thus, the objective of this research was to assess the quality of these insects over 10 generations and look for evidence of any loss in quality. We used two populations: one from a biofactory that has been maintained in the laboratory for over 40 years, and an inbred laboratory population. Both were bred, and compared for 10 generations. We wanted to determine what happened to the quality of the parasitoid after 10 generations in an extreme inbreeding situation. To assure inbreeding, newly emerged females were forced to mate with a sibling. Individual females were then allowed to parasitize larvae of D. saccharalis. We performed evaluations for each generation until the tenth generation, and recorded the sex ratio, percentage emergence, number of offspring/females, and longevity of both males and females. Results of the measurements of biological characteristics demonstrated random significant differences between populations; best results were obtained intermittently for both the biofactory population and the inbred population. No significant differences across generations for the same population were observed. Thus, rearing of a C. flavipes population subjected to inbreeding for 10 generations was not sufficient to reveal any deleterious effects of inbreeding.

The aim of this study was to clinically evaluate the guided bone regeneration (GBR) potential of allograft, xenograft, and alloplastic materials in combination with resorbable membranes in extraction sockets. The qualitative and quantitative assessments of this prospective study were accomplished through histologic and histomorphometric analysis. Three experimental groups and 1 control group for comparison (n = 8) received either an allograft (human cancellous bone, freeze dried, Deutsches Institut für Zell und Gewebeersatz, Berlin, Germany), xenograft (BioOss, Geistlich Pharma AG, Wolhusen, Switzerland), or alloplast (biphasic calcium sulphate, Bondbone, MIS Implants Technologies Ltd., Charlotte, NC). The negative control group received no regenerative material. Tissue samples were then qualitatively and quantitatively evaluated as a function of percentage of new vital bone, graft particles content, soft tissue, and bone marrow over time. All 3 study groups presented bone volume suitable for the successful placement of a dental implant. The xenograft group yielded significantly less amount of vital bone compared with the allograft and alloplast groups. When comparing the percentage of residual graft particles, there was significantly greater amounts associated with the xenograft group in contrast to the allograft and alloplast groups. Similarly, a significantly increased amount of soft tissue percentage was observed within the xenograft group relative to all other groups. No significant differences were observed in the percentage of residual graft particles between the allograft and alloplast groups. There were also no significant differences detected in vital bone percentage between the allograft, alloplast, and control groups. When evaluating the bone marrow percentage, the only significant difference detected was between the xenograft and alloplast materials. Overall, no complications (ie, fever, malaise, purulence or fistula) were observed during the entirety of clinical trial among all patients. The greatest GBR potential was associated with the allograft material because of the greater degree of vital bone and the lowest percentage of residual graft particles. All studied bone substitute materials resulted in bone apposition for efficient use in alveolar ridge preservation procedures.

Gastro-esophageal reflux disease (GERD) is a highly prevalent, chronic disorder, whose knowledge remains limited and the management of these patients changes continuously. This review provides a summary of the most recent advancements in the pathogenesis of this disease and the new drugs introduced into the market to overcome some of the unmet needs of traditional therapies. Nowadays, the most fruitful diagnostic examinations are 24-hour impedance-pH monitoring, which allows us to separate true NERD from esophageal functional disorders and high-resolution manometry, which helps to exclude the existence of motility disorders sharing the same symptoms of GERD. Proton pump inhibitors (PPIs) remain the first-choice therapy in the treatment of GERD, but a consistent proportion of these patients continue to experience symptoms despite their intake. These cases pertain mainly to the subpopulation with non-erosive reflux disease (NERD) and represent very challenging clinical situations, because it is mandatory to understand the reasons for PPI failure. The management of these difficult patients requires necessarily to test them and avoid the use of empiric treatments that are often unsuccessful, costly and potentially dangerous. Recently, several new drugs have been used to increase the defensive properties of this mucosa with promising results in randomized clinical trials.

The CALIPSO Level 3 (CL3) product is the most recent data set produced by the observations of the Cloud–Aerosol Lidar with Orthogonal Polarization (CALIOP) instrument onboard the Cloud–Aerosol Lidar and Pathfinder Satellite Observations (CALIPSO) space platform. The European Aerosol Research Lidar Network (EARLINET), based mainly on multi-wavelength Raman lidar systems, is the most appropriate ground-based reference for CALIPSO calibration/validation studies on a continental scale. In this work, CALIPSO data are compared against EARLINET monthly averaged profiles obtained by measurements performed during CALIPSO overpasses. In order to mitigate uncertainties due to spatial and temporal differences, we reproduce a modified version of CL3 data starting from CALIPSO Level 2 (CL2) data. The spatial resolution is finer and nearly 2°  ×  2° (latitude  ×  longitude) and only simultaneous measurements are used for ease of comparison. The CALIPSO monthly mean profiles following this approach are called CALIPSO Level 3*, CL3*. We find good agreement on the aerosol extinction coefficient, yet in most of the cases a small CALIPSO underestimation is observed with an average bias of 0.02 km−1 up to 4 km and 0.003 km−1 higher above. In contrast to CL3 standard product, the CL3* data set offers the possibility to assess the CALIPSO performance also in terms of the particle backscatter coefficient keeping the same quality assurance criteria applied to extinction profiles. The mean relative difference in the comparison improved from 25 % for extinction to 18 % for backscatter, showing better performances of CALIPSO backscatter retrievals. Additionally, the aerosol typing comparison yielded a robust identification of dust and polluted dust. Moreover, the CALIPSO aerosol-type-dependent lidar ratio selection is assessed by means of EARLINET observations, so as to investigate the performance of the extinction retrievals. The aerosol types of dust, polluted dust, and clean continental showed noticeable discrepancy. Finally, the potential improvements of the lidar ratio assignment have been examined by adjusting it according to EARLINET-derived values.