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In this paper, we discuss an approach for relaxing a failing query in the context of flexible (or fuzzy) querying. The approach relies on the notion of a parameterized proximity relation which is defined in a relative way. We show how such a proximity relation allows for transforming a gradual predicate into an enlarged one. The resulting predicate is semantically close to the original one and it is obtained by a simple fuzzy arithmetic operation. Such a transformation provides the basis for a flexible query relaxation which can be controlled in a non-empirical rigorous way without requiring any additional information from the user. We also show how the search for a non-failing relaxed query over the lattice of relaxed queries can be improved by exploiting the notion of Minimal Failing Sub-queries derived from the failing query.

In this paper, we are interested in taking preferences into account for a family of queries inspired by the relational division. A division query aims at retrieving the elements associated with a specified set of values and usually the results remain not discriminated. So, we suggest the introduction of preferences inside such queries with the following specificities: (i) the user gives his/her preferences in an ordinal way and (ii) the preferences apply to the divisor which is defined as a hierarchy of sets. Different uses of the hierarchy are investigated, which leads to queries conveying different semantics and the property of the result in terms of a quotient is studied. Special attention is paid to the implementation of such extended division queries using a regular database management system along which some experiments to support the feasibility of the approach. Moreover, the issue of empty or overabundant answers is dealt with.

Issue Title: Special Issue on Flexible Queries in Information Systems; Guest Editors: Patrick Bosc, Allel Hadjali, Gabriella Pasi

In the context of regular relational databases, functional dependencies have received a lot of attention, since they capture some semantics about the data related to redundancy. Functional dependencies lead to an appropriate design of a database in terms of a set of relations and can make the checking process of integrity constraints significantly easier. For about 10 years, several proposals to deal with ill‐known information in database management systems have been made, and extensions of the relational data model have been proposed accordingly. In this context, the idea of fuzzy functional dependency has emerged to extend the classical functional dependency, and several definitions have been proposed. In this article, an overview of these different proposals is provided, and the connection between fuzzy functional dependencies and database design is discussed. In addition, some semantics and use of fuzzy functional dependencies are suggested. © 1998 John Wiley & Sons, Inc.

Colorectal cancer (CRC) is a major cause of cancer-related death of worldwide with high incidence and mortality rate, accessible to a screening program in France, first with guaiac-based fecal occult blood test (g-FOBT) then with fecal immunochemical tests (FIT), since 2015, because of better accuracy. The aim of our study was to compare the characteristics of screen-detected lesions in two successive CRC screening campaigns, using two different tests (Hemoccult II® and OC Sensor®) in the department of Maine-et-Loire, and to precise the performance of these tests [participation rate, detection rates (DR), positive predictive value (PPV)]. Participants, invited by CAP SANTE 49, with polyps or cancer at the colonoscopy after a positive screening test between 01/01/2013 and 31/12/2016 were included. A guaiac-based fecal occult blood test (g-FOBT) was used from January 2013 to December 2014 and a FIT was used from June 2015 to December 2016). 2575 participants, 642 in g-FOBT group and 1933 in FIT group had lesions. Participation rate was not different between tests (p = 0.104), whereas DR and PPV were statistically higher in FIT for all lesions (2.61, 95% CI [2.50–2.70] vs 0.93, 95% CI [0.90–1.00], p < 0.0001 and 64.84, 95% CI [63.10–66.60], 50.00, 95% CI [47.30–52.70], p < 0.0001 respectively). FIT detects more precancerous lesions (adenomas, p < 0.001, and advanced adenomas, p < 0.001) than g-FOBT but g-FOBT detects more serrated polyps (p = 0.025). AAs were more in right colon in FIT than g-FOBT (p = 0.035). No different participation rate was detected between FIT and g-FOBT but DR and PPV of all lesions was higher with FIT.

Numerical modeling was used to provide a new estimate of the amount of 137Cs released directly into the ocean from the Fukushima Daiichi nuclear power plant (NPP) after the accident in March 2011 and to gain insights into the physical processes that led to its dispersion in the marine environment during the months following the accident. An inverse method was used to determine the time‐dependent137Cs input responsible for the concentrations observed at the NPP's two liquid discharge outlets. The method was then validated through comparisons of the simulated concentrations with concentrations measured in seawater at different points in the neighborhood of the plant. An underestimation was noticed for stations located 30 km offshore. The resulting bias in the release inventory was estimated. Finally, the maximum 137Cs activity released directly to the ocean was estimated to lie between 5.1 and 5.5 PBq (Peta Becquerel = 1015 Bq) but uncertainties remain on the amount of radionuclides released during the first few days after the accident. This estimate was compared to previous ones and differences were analyzed further. The temporal and spatial variations of the 137Cs concentration present in the coastal waters were shown to be strongly related to the wind intensity and direction. During the first month after the accident, winds blowing toward the south confined the radionuclides directly released into the ocean to a narrow coastal band. Afterwards, frequent northward wind events increased the dispersion over the whole continental shelf, leading to strongly reduced concentrations. Key Points Assessment of cesium‐137 released from Fukushima power plant Dispersion of radionuclides induced by winds

IntroductionObstructive sleep apnoea (OSA) is a prevalent disease associated with cardiovascular events. Hypertension is one of the major intermediary mechanisms leading to long-term cardiovascular adverse events. Intermittent hypoxia and hypercapnia associated with nocturnal respiratory events stimulate chemoreflexes, resulting in sympathetic overactivity and blood pressure (BP) elevation. Continuous positive airway pressure (CPAP) is the primary treatment for OSA and induces a small but significant reduction in BP. The use of auto-adjusting positive airway pressure (APAP) has increased in the last years and studies showed different ranges of BP reduction when comparing both modalities. However, the pathophysiological mechanisms implicated are not fully elucidated. Variations in pressure through the night inherent to APAP may induce persistent respiratory efforts and sleep fragmentation that might impair sympathovagal balance during sleep and result in smaller decreases in BP. Therefore, this double-blind randomised controlled trial aims to compare muscle sympathetic nerve activity (MSNA) assessed by microneurography (reference method for measuring sympathetic activity) after 1 month of APAP versus fixed CPAP in treatment-naive OSA patients. This present manuscript describes the design of our study, no results are presented herein. and is registered under the below reference number.Methods and analysisAdult subjects with newly diagnosed OSA (Apnoea–Hypopnoea Index >20/hour) will be randomised for treatment with APAP or fixed CPAP. Measurements of sympathetic activity by MSNA, heart rate variability and catecholamines will be obtained at baseline and after 30 days. The primary composite outcome will be the change in sympathetic tone measured by MSNA in bursts/min and bursts/100 heartbeats. Sample size calculation was performed with bilateral assumption. We will use the Student’s t-test to compare changes in sympathetic tone between groups.Ethics and disseminationThe protocol was approved by The French Regional Ethics Committee. The study started in March 2018 with primary completion expected to March 2019. Dissemination plans of the results include presentations at conferences and publication in peer-reviewed journals.Trial registration number NCT03428516; Pre-results.

Fibrate derivatives and HMG-CoA reductase inhibitors modify homeostasis of cholesterol. The aim of this study was to assess in an unselected population whether these hypolipidemic drugs are risk factors for cholelithiasis or, conversely, are protective agents. Both sexes, all socioeconomic categories, pregnant women, and cholecystectomized subjects were included. Clinical data collection and gallbladder ultrasonography were both carried out in a double-blind fashion. Fibrate derivatives were predominantly fenofibrate, HMG-CoA reductase inhibitors were simvastatin and pravastatin. On univariate analysis, age (>50 years), sex, and use of fibrates were found to be significantly related to the presence of cholelithiasis. Age, sex, and fibrate treatment remained independently correlated with the presence of gallstones on multivariate analysis. With fibrates, the relative risk for lithiasis was 1.7 (P = 0.04). The HMG-CoA reductase inhibitors were not associated with a protective effect on univariate analysis. Of the lipid-lowering drugs, only fibrate derivatives were found to increase the risk of gallstone formation.

Aim: The objective of this study was to reveal the present population structure and infer the gene-flow history of the Indo-Pacific tropical eel Anguilla bicolor. Location: The Indo-Pacific region. Methods: The entire mitochondrial control region sequence and the genotypes at six microsatellite loci were analysed for 234 specimens collected from eight representative localities where two subspecies have been historically designated. In order to infer the population structure, genetic differentiation estimates, analysis of molecular variance and gene-tree reconstruction were performed. The history of migration events and population growth was assessed using neutrality tests based on allelic frequency spectrum, coalescent-based estimation of gene flow and Bayesian demographic analysis using control region sequences. Results: Population structure analysis showed genetic divergence between eels from the Indian and Pacific oceans (F ST = 0.0174-0.0251, P < 0.05 for microsatellites; Φ ST = 0.706, P < 0.001 for control region), while no significant variation was observed within each ocean. Two mitochondrial sublineages that do not coincide with geographical regions were found in the Indian Ocean clade of a gene tree. However, these two sublineages were not differentiated at the microsatellite markers. The estimation of mitochondrial gene-flow history suggested allopatric isolation between the Indian and Pacific oceans, and a possible secondary contact within the Indian Ocean after an initial population splitting. Bayesian demographic history reconstruction and neutrality tests indicated population growth in each ocean after the Indo-Pacific divergence. Main conclusions: Anguilla bicolor has diverged between the Indian and Pacific oceans, which is consistent with the classical subspecies designation, but is apparently genetically homogeneous in the Indian Ocean. The analysis of geneflow and demographic history indicated that the two mitochondrial sublineages observed in the Indian Ocean probably represent the haplotype groups of relict ancestral populations. A comparison with a sympatric congener suggested that absolute physical barriers to gene flow may not be necessary for population divergence in eels.