Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
4
result(s) for
"Brabham, Peter"
Sort by:
Basic geological mapping / Richard J. Lisle, Peter J. Brabham, and John W. Barnes
\"Basic Geological Mapping, 5th Edition is an essential basic guide to field techniques in mapping geology\"-- Provided by publisher.
Book
The glacial origins of relict ‘pingos’, Wales, UK
Ramparted depressions (doughnut-shaped debris-cored ridges with peat- and/or sediment-filled central basins) are commonly perceived to represent the relict collapsed forms of permafrost ground-ice mounds (i.e. pingos or lithalsas). In Wales, UK, ramparted depressions of Late Pleistocene age have been widely attributed to permafrost-related processes. However, a variety of alternative glacial origins for these enigmatic landforms are also consistent with the available geological and geomorphological evidence, although previous studies have barely considered such alternative processes of formation. From detailed geophysical, sedimentological and remote-sensing studies at two field sites, we demonstrate that: (i) the wastage of stagnating glacier ice is a viable alternative explanation for the formation of ramparted depressions in Wales; (ii) the glacial geomorphology and geology of these landforms is analogous to supraglacial and subglacial landforms from the last Laurentide and Fennoscandian ice sheets; (iii) these landforms have significant potential for characterising the nature of deglaciation around the margins of the Irish Sea during the last glacial cycle, and may record evidence for the overextension and stagnation of the south-eastern margin of the Irish Sea Ice Stream; and (iv) investigations of ramparted depressions within formerly glaciated terrains must consider both glacial and periglacial mechanisms of formation.
Journal Article
Safety of Continuous Anticoagulation With Dabigatran During Implantation of Cardiac Rhythm Devices
The perioperative bleeding risk associated with therapeutic anticoagulation at cardiac implantable electronic device implantation has previously been demonstrated to vary by the specific anticoagulant used. Although uninterrupted anticoagulation with warfarin appears to be safe, heparin products have been shown to increase the risk of perioperative bleeding. However, the risk associated with cardiac implantable electronic device implantation with anticoagulation using dabigatran, a novel oral direct thrombin inhibitor, is not known. We performed a prospective observational study of patients receiving dabigatran for anticoagulation who underwent cardiac implantable electronic device implantation from June 2011 through May 2012. The study end points included thromboembolic and bleeding complications within 30 days of surgery. Major bleeding complications were defined as bleeding requiring surgical intervention, prolongation of hospitalization, and discontinuation of the anticoagulant or transfusion of blood products within 30 days of surgery. Minor bleeding complications included the development of a hematoma not requiring additional intervention. The thrombotic end points included stroke, transient ischemic attack, myocardial infarction, pulmonary embolism, and deep vein thrombosis. A total of 25 patients were identified for inclusion. During the index hospitalization, no thromboembolic or bleeding complications developed. No major bleeding complications occurred within 30 days of surgery. One minor bleeding event (4%) occurred within 30 days of surgery in 1 patient who was also receiving dual antiplatelet therapy. In conclusion, although no thromboembolic or major bleeding events were observed, additional studies are required to define the optimal antithrombotic management in the perioperative period.
Journal Article
Discovery of functional NLRs using expression level, high-throughput transformation, and large-scale phenotyping
Protecting crops from pests and diseases is vital for the sustainable agricultural systems needed for food security. Introducing functional resistance genes to enhance the plant immune system is an effective method of disease control, but identifying new immune receptors is time-consuming and resource intensive. We observed that functional immune receptors of the NLR class show a signature of high expression in uninfected plants across both monocot and dicot species. Here we show that this signature, combined with high throughput crop transformation, can be used to rapidly identify candidate NLRs from diverse plant species and validate pathogen resistance directly in crop plants. As a proof of concept, we generated a wheat transgenic library carrying 995 NLRs from 18 grass species. Screening the collection with the stem rust pathogen Puccinia graminis, which is a major threat to wheat production, we confirm 19 new resistance genes. This pipeline facilitates resistance gene discovery, unlocking a large gene pool of diverse and non-domesticated plant species and providing in-planta gene validation of disease resistance directly in crops.
Paper