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Ultimate Marvel
This definitive in-world guide to the Marvel Comics Universe features, in chronological order, every significant Marvel Comic character, location, vehicle, and weapon in the company's illustrious history. Go on a fact- and fun-filled journey via the first major Marvel heroes, villains, cowboy stars, and comic characters of the 1940s and 1950s to the iconic, timeless Super Heroes and Super Villains of the Marvel Age of the 1960s and beyond, such as Thor, Hulk, Spider-Man, Black Widow, Doctor Strange, Iron Man, the Avengers, Storm, Loki, and Green Goblin. Further sections feature key vehicles and technology, magical artifacts, planets, countries, and places, plus a glimpse behind the scenes into Marvel Comics' creative processes and techniques. Cover artwork is by esteemed comic book artist Adi Granov. Including authoritative text by Marvel Comics experts and spectacular artwork from the original comic books.
Book
Efficient assembly of nanopore reads via highly accurate and intact error correction
Long nanopore reads are advantageous in de novo genome assembly. However, nanopore reads usually have broad error distribution and high-error-rate subsequences. Existing error correction tools cannot correct nanopore reads efficiently and effectively. Most methods trim high-error-rate subsequences during error correction, which reduces both the length of the reads and contiguity of the final assembly. Here, we develop an error correction, and de novo assembly tool designed to overcome complex errors in nanopore reads. We propose an adaptive read selection and two-step progressive method to quickly correct nanopore reads to high accuracy. We introduce a two-stage assembler to utilize the full length of nanopore reads. Our tool achieves superior performance in both error correction and de novo assembling nanopore reads. It requires only 8122 hours to assemble a 35X coverage human genome and achieves a 2.47-fold improvement in NG50. Furthermore, our assembly of the human WERI cell line shows an NG50 of 22 Mbp. The high-quality assembly of nanopore reads can significantly reduce false positives in structure variation detection.
Nanopore reads have been advantageous for de novo genome assembly; however these reads have high error rates. Here, the authors develop an error correction and de novo assembly tool, NECAT, which produces efficient, high quality assemblies of nanopore reads.
Journal Article
Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome
There are many transmembrane receptor-like proteins whose ligands have not been identified. A strategy for finding ligands when little is known about their tissue source is to screen each extracellular protein individually expressed in an array format by using a sensitive functional readout. Taking this approach, we have screened a large collection (3,191 proteins) of extracellular proteins for their ability to activate signaling of an orphan receptor, leukocyte tyrosine kinase (LTK). Only two related secreted factors, FAM150A and FAM150B (family with sequence similarity 150 member A and member B), stimulated LTK phosphorylation. FAM150A binds LTK extracellular domain with high affinity ( K D = 28 pM). FAM150A stimulates LTK phosphorylation in a ligand-dependent manner. This strategy provides an efficient approach for identifying functional ligands for other orphan receptors.
Significance Secreted factors and their cell-surface receptors play important roles in the communication between cells in normal and pathological conditions. There are many transmembrane receptor-like proteins whose ligands have not been identified (also known as orphan receptors). Knowledge of the ligand should help in understanding the biological role of the receptor. We used a strategy of screening the extracellular proteome, one protein at a time, to identify ligands for such receptors. We discovered the ligands for the orphan receptor leukocyte tyrosine kinase. To our knowledge, this is the first case in which secreted factor ligands were identified for an orphan receptor with this technique. This approach is especially valuable when little is known about the ligand.
Journal Article
Military Information Technology Certification Training Addressing Implementation Procedures Against Cyber-Attacks: An Exploratory Case Study
The leadership within the military must have a good understanding of how to defend multiple computer networks against cyber threats by developing strategies that lessen cyber-threats and vulnerabilities on the government information system networks. The Department of Defense plays a considerable role in this process by pursuing training and certification programs from the civilian sector. The intent of the programs is to safeguard the critical infrastructure against cyber-attacks. The purpose of this qualitative exploratory case study was to gain a better understanding of the Army lower level leaders and junior enlisted perspectives of integrating training from the civilian certification sector and how the new certification process will align with the current DoD policy 8570. The exploratory case study research method consisted of military-related experiences from the Southeastern United States Forts to provide a diverse and large variety of level leaders and junior enlisted soldiers. The research question \"What obstacles prevent the implementation of certification training program information in the field?\" shaped the case study in creating a shared understanding related to the training programs aligning with DoD policy 8570. The data collection focused on information from 20 military personnel through audio-recorded interviews. The information was then triangulated using in-depth interviews, archival data process, andreflexive journal.
Dissertation
In the gaps and on the margins: social work in england, 1940-1970
This thesis examines the role of social work within post-war England, particularly its place within the welfare state and wider society. The thesis focuses on social work’s ambiguous position ‘in the gaps’ and ‘on the margins’, where it operated between a variety of spheres, including other professions in the medical and social services, policy-makers, individual clients and communities, and social researchers. Within this position, social workers were commonly tasked with mediating between these different groups, and helping to interpret the various languages and expectations present in post-war English welfare and society. This meant that social workers aimed to make the provision and consumption of welfare more effective, both through working closely with individuals, families, and communities, and through promoting efficient coordination and cooperation between the welfare services. The thesis discusses the problems which this approach sought to address, and the issues which resulted. The study of social workers offers an insight into the negotiations and compromises implicit in post-war society, and also allows us to consider how issues of social change and the problems which emerged or persisted in post-war England were navigated. The thesis also considers the relationship of social work with the psychological and social sciences, and seeks to reconsider how concepts from those disciplines were utilised within welfare practice. This includes an emphasis on pragmatic practice, on the discretion of the individual worker, and on the attempts of social workers to generate knowledge about the field of their work and the efficacy of their intervention. Overall, the thesis shows how closer attention to social work can illuminate some of the tensions which arose in the post-war provision of medical and social services, in the everyday practice of welfare, and as a result of social, cultural, and demographic change.
Dissertation
Fast and accurate assembly of Nanopore reads via progressive error correction and adaptive read selection
Although long Nanopore reads are advantageous in de novo genome assembly, applying Nanopore reads in genomic studies is still hindered by their complex errors. Here, we developed NECAT, an error correction and de novo assembly tool designed to overcome complex errors in Nanopore reads. We proposed an adaptive read selection and two-step progressive method to quickly correct Nanopore reads to high accuracy. We introduced a two-stage assembler to utilize the full length of Nanopore reads. NECAT achieves superior performance in both error correction and de novo assembly of Nanopore reads. NECAT requires only 7,225 CPU hours to assemble a 35X coverage human genome and achieves a 2.28-fold improvement in NG50. Furthermore, our assembly of the human WERI cell line showed an NG50 of 29 Mbp. The high-quality assembly of Nanopore reads can significantly reduce false positives in structure variation detection.
Paper
We can do bettah
The Clinton Administration has pronounced the economy to be on the path to sustainable growth, and the president is claiming credit for the good news. Pres Clinton's growth claims are examined.
Magazine Article