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Background Mayaro virus ( Togaviridae ) is an endemic arbovirus of the Americas with epidemiological similarities with the agents of other more prominent diseases such as dengue ( Flaviviridae ), Zika ( Flaviviridae ), and chikungunya ( Togaviridae ). It is naturally transmitted in a sylvatic/rural cycle by Haemagogus spp., but, potentially, it could be incorporated and transmitted in an urban cycle by Aedes aegypti , a vector widely disseminated in the Americas. Methods The Mayaro arbovirus dynamics was simulated mathematically in the colombian population in the eight biogeographical provinces, bearing in mind the vector’s population movement between provinces through passive transport via truck cargo. The parameters involved in the virus epidemiological dynamics, as well as the vital rates of Ae. aegypti in each of the biogeographical provinces were obtained from the literature. These data were included in a meta-population model in differential equations, represented by a model structured by age for the dynamic population of Ae. aegypti combined with an epidemiological SEI/SEIR-type model. In addition, the model was incorporated with a term of migration to represent the connectivity between the biogeographical provinces. Results The vital rates and the development cycle of Ae. aegypti varied between provinces, having greater biological potential between 23 °C and 28 °C in provinces of Imerí, biogeographical Chocó, and Magdalena, with respect to the North-Andean Moorland (9.33–21.38 °C). Magdalena and Maracaibo had the highest flow of land cargo. The results of the simulations indicate that Magdalena, Imerí, and biogeographical Chocó would be the most affected regarding the number of cases of people infected by Mayaro virus over time. Conclusions The temperature in each of the provinces influences the local population dynamics of Ae. aegypti and passive migration via transport of land cargo plays an important role on how the Mayaro virus would be disseminated in the human population. Once this arbovirus begins an urban cycle, the most-affected departments would be Antioquia, Santander, Norte de Santander, Cesar (Provinces of Magdalena), and Valle del Cauca, and Chocó (biogeographical province of Chocó), which is why vector control programmes must aim their efforts at these departments and include some type of vector control to the transport of land cargo to avoid a future Mayaro epidemic.

Within the medical community there is persistent debate as to whether the information available through social media is trustworthy and valid, and whether physicians are ready to adopt these technologies and ultimately embrace them as a format for professional development and lifelong learning. To identify how physicians are using social media to share and exchange medical information with other physicians, and to identify the factors that influence physicians' use of social media as a component of their lifelong learning and continuing professional development. We developed a survey instrument based on the Technology Acceptance Model, hypothesizing that technology usage is best predicted by a physician's attitudes toward the technology, perceptions about the technology's usefulness and ease of use, and individual factors such as personal innovativeness. The survey was distributed via email to a random sample of 1695 practicing oncologists and primary care physicians in the United States in March 2011. Responses from 485 physicians were analyzed (response rate 28.61%). Overall, 117 of 485 (24.1%) of respondents used social media daily or many times daily to scan or explore medical information, whereas 69 of 485 (14.2%) contributed new information via social media on a daily basis. On a weekly basis or more, 296 of 485 (61.0%) scanned and 223 of 485 (46.0%) contributed. In terms of attitudes toward the use of social media, 279 of 485 respondents (57.5%) perceived social media to be beneficial, engaging, and a good way to get current, high-quality information. In terms of usefulness, 281 of 485 (57.9%) of respondents stated that social media enabled them to care for patients more effectively, and 291 of 485 (60.0%) stated it improved the quality of patient care they delivered. The main factors influencing a physician's usage of social media to share medical knowledge with other physicians were perceived ease of use and usefulness. Respondents who had positive attitudes toward the use of social media were more likely to use social media and to share medical information with other physicians through social media. Neither age nor gender had a significant impact on adoption or usage of social media. Based on the results of this study, the use of social media applications may be seen as an efficient and effective method for physicians to keep up-to-date and to share newly acquired medical knowledge with other physicians within the medical community and to improve the quality of patient care. Future studies are needed to examine the impact of the meaningful use of social media on physicians' knowledge, attitudes, skills, and behaviors in practice.

Commercial premixes provide trace minerals (TM) such as zinc (Zn), manganese (Mn), and copper (Cu) in excess of the requirements to maximize broiler performance. High inclusion levels of TM in broiler feed and their low absorption in the gastrointestinal tract leads to increased levels of TM in the excreta, resulting in the contamination of the environment. A 35-day broiler trial was conducted with 2880 one-day-old Cobb broiler males to test the effect of the supplementation of different sources of TM on growth performance, while evaluating levels in the excreta. Inorganic (ITM), organic (OTM), and hydroxy (HTM) sources of TM were tested against a positive control of current recommended levels of ITM. At 35 d, birds fed HTM were 55 g (p < 0.05) heavier than those fed ITM at the same inclusion level. In contrast, birds fed the control, OTM, and HTM showed no significant difference in body weight. Providing broilers with HTM significantly (p < 0.05) reduced Zn and Cu excretion at 35 d of when compared to those who were fed diets containing ITM or PC. Supplementing different sources of TM to broiler diets at levels below the recommendations showed no negative effect on broiler performance. The use of HTM significantly reduced TM excretion in broilers. The use of HTM in broiler diets can maintain broiler performance and reduce the negative impact on the environment.

An increasingly common assessment of the Second Temple period posits a widespread belief, even among Jews living in Judea, that Israel remained in a state of ongoing exile long after the sixth-century return from exile following the decree of Cyrus. This essay evaluates that claim in relation to the reception of Jeremiah's prophecy that the exile would last for seventy years. The texts that reflect on the prophecy of seventy years do not adopt exegetical strategies that greatly extend the length of the exile, as if the return under Cyrus were not the “real return from exile.” This is true even in Daniel, where the literal fulfillment of Jeremiah's prophecy of a seventy-year exile and Daniel's penitent preparation for that fulfillment serve as a starting point and a model for reflecting on another hoped-for experience of God's mercy at the end of seventy weeks of years. Though the texts that refer to Jeremiah's prediction of a seventy-year exile do not handle the seventy years in a completely uniform way, the fulfillment of Jeremiah's prophecy is placed firmly in the past, reflecting the belief that the exile had ended. Not all the texts examined regard the period following the seventy-year exile as a time of unremitting punishment. Texts that do assess the period following the exile in negative terms do not view that period as an extension of exile. Rather, the literal fulfillment of Jeremiah's prophecy that the exile would come to an end inspires hope that the God who was faithful to keep his promise would also keep his promise of an ultimate restoration that would far outstrip the initial jubilee (Dan 9:25), “the brief moment of favor” (Ezra 9:8) that had brought the exile to an end.

By the end of the nineteenth century, the world was ready to adopt the gold standard out of concerns of national power, prestige, and anti-English competition. Yet although the gold standard allowed countries to enact a virtual single world currency, the years before World War I were not a time of unfettered liberal economics and one-world, one-market harmony. Outside of Europe, the gold standard became a tool for nationalists and protectionists primarily interested in growing domestic industry and imperial expansion. This overlooked trend, provocatively reassessed in Steven Bryan's well-documented history, contradicts our conception of the gold standard as a British-based system infused with English ideas, interests, and institutions. In countries like Japan and Argentina, where nationalist concerns focused on infant-industry protection and the growth of military power, the gold standard enabled the expansion of trade and the goals of the age: industry and empire. Bryan argues that these countries looked less to Britain and more to North America and the rest of Europe for ideological models. Not only does this history challenge our idealistic notions of the prewar period, but it also reorients our understanding of the history that followed. Policymakers of the 1920s latched onto the idea that global prosperity before World War I was the result of a system dominated by English liberalism. Their attempt to reproduce this triumph helped bring about the global downturn, the Great Depression, and the collapse of the interwar world.

Biological nanopore technology broadened the horizon for analysis on base-level sequences from single DNA molecules. Solid state nanopores have the capability to be much faster than biological nanopores but are currently much noisier. In this thesis, we use machine learning to distinguish between linear and circular DNA molecule data gathered via solid state nanopore experiments despite the noise present in some of the data. The three methods of analysis were k-means clustering on its own, principal component analysis in conjunction with k-means clustering, and a long short-term memory classification model. In addition, the long short-term memory model demonstrates its ability to learn from labeled samples and classifies previously unlabeled data. Despite achieving a wide range of accuracies across a variety of data sets, when all models are tested on the same data set, we obtain a better relative measure of their performance. K-means clustering performed with an accuracy of 58%, K-means clustering coupled with principal component analysis performed with an accuracy of 66%, and the long short-term memory model performed with an accuracy of 80%.

Jesus and Israel's Traditions of Judgement and Restoration examines the eschatology of Jesus by evaluating his appropriation of sacred traditions related to Israel's restoration. It addresses the way in which Jesus' future expectations impinged upon his understanding of key features of Jewish society. Scholars have long debated the degree to which Jesus' eschatology can be said to have been realized. This 2002 book considers Jesus' expectations regarding key constitutional features of the eschaton: the shape of the people of God, purity, Land and Temple. Bryan shows that Jesus' anticipation of coming national judgement led him to use Israel's sacred traditions in ways that differed significantly from their use by his contemporaries. This did not lead Jesus to the conviction that Israel's restoration had been delayed. Instead he employed Israel's traditions to support a different understanding of restoration and a belief that the time of restoration had arrived.