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Populations of several species of gregarine parasites within a single host species, the damselfly Ischnura verticalis, were examined over the course of 1 season at 4 geographic localities separated by a maximum distance of 9.7 km. Gregarines, having a life cycle with both exogenous and endogenous stages, are subject to a wide variety of selective pressures that may drive adaptation. Gregarine species showed some specificity for host life cycle stage, i.e., Steganorhynchus dunwoodyi and Hoplorhynchus acanthatholius were most prevalent in larval hosts while Steganorhynchus dunwoodyi, Actinocephalus carrilynnae, and Nubenocephalus nebraskensis were most prevalent in adult hosts. Species prevalence and abundance differed by geographic locality. Gregarine prevalence was significantly higher in adult female damselflies than in males at 2 localities; sex differences in prevalence were insignificant for larval damselflies at all 4 localities. In larval hosts, gregarine abundance was independent of age (size). The present study, therefore, shows that pond characteristics, host life cycle stage, and adult host sex are the main factors that influence the prevalence and abundance of gregarine populations.

Utah Lake, the largest freshwater lake in the third driest state, is a vital, yet underappreciated natural resource. In 2018, the Utah State Legislature passed the Utah Lake Restoration Act in an attempt to restore and enhance the lake's ecological and recreational value. Yet the new law has been met with strong public resistance because it leaves the lake vulnerable to exploitation and further ecological degradation, a concern made real by a proposed development plan that would build a city of islands on top of the lake. Community members cite specific concerns about threats to native species, disruption of water rights, and burdens on local taxpayers. But such a plan also presents potential legal issues as the scheme likely violates the public trust doctrine. A legal doctrine with historic roots, the public trust doctrine asserts that the public has a right to the beneficial use of lands underlying navigable waters. The state, as trustee, has an inalienable responsibility to preserve this public benefit. Utah's Constitution, statutes, and common law all support continued adherence to the public trust doctrine, suggesting that the state legislature has written an illegal law. Amending the Utah Lake Restoration Act to comply with the public trust doctrine, or repealing it altogether, will provide notice to would-be developers to construct their plans accordingly and safeguard against potential lawsuits against the state.

The MET receptor tyrosine kinase is mutated or amplified in ~6% of non-small cell lung cancer (NSCLC) and overexpressed in ~80% of all NSCLC cases. A theranostic agent that can both see and treat MET-altered NSCLC has never been described before in the literature. Here, we report a shark-derived single-domain variable new antigen receptor (VNAR) for MET with theranostic applications. Following the immunization of a juvenile nurse shark ( ) with the extracellular domain of human MET, we identified a VNAR clone that specifically engaged MET with high affinity. Engineering the lead VNAR into a bivalent human Fc, vMET1-Fc, yielded a construct that selectively targeted and was internalized by MET-positive cells without affecting cell viability or downstream MET signaling. When radiolabeled with the positron emitting isotope Zr-89, [ Zr]Zr-vMET1-Fc enabled longitudinal PET/CT imaging. High tumor uptake with low background was observed in MET-positive NSCLC xenografts administered [ Zr]Zr-vMET1-Fc. As a targeted beta-particle radiotherapy, [ Lu]Lu-vMET1-Fc resulted in marked tumor-growth delay and exhibited a favorable toxicity profile, collectively improving progression-free survival in NSCLC mouse models. Non-human primate PET/CT imaging studies with ([ Zr]Zr-vMET1-Fc in healthy rhesus macaques confirmed favorable biodistribution and dosimetry, predictable clearance, and minimal off-target uptake. Additional blood chemistry analysis found no significant immune response or cytotoxicity. Together, these findings establish vMET1-Fc as a theranostic agent for imaging and treating MET-altered NSCLC.

Ultracool T (Teff ≈ 500–1200 K) and Y dwarfs (Teff ⪅ 500 K) have historically been found only a few hundred parsecs from the Sun. The sensitivity and wavelength coverage of the NIRCam instrument on board the James Webb Space Telescope offer a unique method for finding low-temperature brown dwarfs in deep extragalactic datasets out to multiple kiloparsecs. Here we report on the selection of a sample of 41 brown dwarfs and brown dwarf candidates across the JWST Advanced Deep Extragalactic Survey in the GOODS-S and GOODS-N regions. We introduce a new open-source Bayesian tool, Near-Infrared Fitting for T and Y dwarfs (NIFTY), to derive effective temperatures, metallicities, and distances from JWST photometry. We find that 31 candidates have fits consistent with T dwarf temperatures out to 5–6 kpc, and 10 candidates have fits consistent with Y dwarf temperatures out to 1–2 kpc. The majority of the sources are best fit with subsolar metallicity models. We report proper motions for 10 brown dwarf candidates (three are newly presented), and calculate the number density of T and Y dwarfs as a function of temperature and distance above the Milky Way midplane. We further discuss how Y dwarfs can serve as contaminants in the search for ultra-high-redshift galaxies. Together, these results demonstrate the power of deep JWST extragalactic imaging to probe the coldest substellar populations far beyond the solar neighborhood, providing new constraints on the Milky Way’s structure and brown dwarf demographics.

Large area observations of extragalactic deep fields with the James Webb Space Telescope (JWST) have provided a wealth of candidate low-mass L- and T-class brown dwarfs. The existence of these sources, which are at derived distances of hundreds of parsecs to several kiloparsecs from the Sun, has strong implications for the low-mass end of the stellar initial mass function, and the link between stars and planets at low metallicities. In this letter, we present a JWST/NIRSpec PRISM spectrum of brown dwarf JADES-GS-BD-9, confirming its photometric selection from observations taken as part of the JWST Advanced Deep Extragalactic Survey (JADES) program. Fits to this spectrum indicate that the brown dwarf has an effective temperature of 800–900 K (T5–T6) at a distance of 1.8–2.3 kpc from the Sun, with evidence of the source being at low metallicity ([M/H] ≤ −0.5). Finally, because of the cadence of JADES NIRCam observations of this source, we additionally uncover a proper motion between the 2022 and 2023 centroids, and we measure a proper motion of 20 ± 4 mas yr−1 (a transverse velocity of 214 km s−1 at 2.25 kpc). At this predicted metallicity, distance, and transverse velocity, it is likely that this source belongs either to the edge of the Milky Way thick disk or the galactic halo. This spectral confirmation demonstrates the efficacy of photometric selection of these important sources across deep extragalactic JWST imaging.

While media multitasking is an emerging issue, little is known about the underlying motivations of this behavior. We ran a large-scale online study with 351 Facebook users to examine people who multitask when using social media, and why they multitask. We found that the motivation to use Facebook for social reasons significantly predicted increased media multitasking. Moreover, this connection was mediated by individual differences in sensation seeking. These findings contribute to understanding of multitasking behavior and its relationship with the use of social media. Implications and directions for future research are discussed.

Ultra-cool T- (T\\(_eff \\) 500 - 1200 K) and Y-dwarfs (T\\(_eff\\) \\( 500\\) K) have historically been found only a few hundred parsecs from the Sun. The sensitivity and wavelength coverage of the NIRCam instrument on board the James Webb Space Telescope offer a unique method for finding low-temperature brown dwarfs in deep extragalactic datasets out to multiple kiloparsecs. Here we report on the selection of a sample of 41 brown dwarf and brown dwarf candidates across the JWST Advanced Deep Extragalactic Survey (JADES) in the GOODS-S and GOODS-N regions. We introduce a new open-source Bayesian tool, the Near-Infrared Fitting for T and Y-dwarfs (NIFTY), to derive effective temperatures, metallicities, and distances from JWST photometry. We find that 31 candidates have fits consistent with T-dwarf temperatures out to 5 - 6 kpc, and 10 candidates have fits consistent with Y-dwarf temperatures out to 1 - 2 kpc. The majority of the sources are best fit with sub-solar metallicity models, consistent with them being subdwarfs in the Milky Way thick disk and halo. We report proper motions for nine brown dwarf candidates (three are newly presented), and calculate the number density of T- and Y-dwarfs as a function of temperature and distance above the Milky Way midplane. We further discuss how Y-dwarfs can serve as contaminants in the search for ultra-high-redshift galaxies. Together, these results demonstrate the power of deep JWST extragalactic imaging to probe the coldest substellar populations far beyond the solar neighborhood, providing new constraints on the Milky Way's structure and brown dwarf demographics.

Ultra-cool T- (T\\(_eff \\) 500 - 1200 K) and Y-dwarfs (T\\(_eff\\) \\( 500\\) K) have historically been found only a few hundred parsecs from the Sun. The sensitivity and wavelength coverage of the NIRCam instrument on board the James Webb Space Telescope offer a unique method for finding low-temperature brown dwarfs in deep extragalactic datasets out to multiple kiloparsecs. Here we report on the selection of a sample of 41 brown dwarf and brown dwarf candidates across the JWST Advanced Deep Extragalactic Survey (JADES) in the GOODS-S and GOODS-N regions. We introduce a new open-source Bayesian tool, the Near-Infrared Fitting for T and Y-dwarfs (NIFTY), to derive effective temperatures, metallicities, and distances from JWST photometry. We find that 31 candidates have fits consistent with T-dwarf temperatures out to 5 - 6 kpc, and 10 candidates have fits consistent with Y-dwarf temperatures out to 1 - 2 kpc. The majority of the sources are best fit with sub-solar metallicity models, consistent with them being subdwarfs in the Milky Way thick disk and halo. We report proper motions for nine brown dwarf candidates (three are newly presented), and calculate the number density of T- and Y-dwarfs as a function of temperature and distance above the Milky Way midplane. We further discuss how Y-dwarfs can serve as contaminants in the search for ultra-high-redshift galaxies. Together, these results demonstrate the power of deep JWST extragalactic imaging to probe the coldest substellar populations far beyond the solar neighborhood, providing new constraints on the Milky Way's structure and brown dwarf demographics.

Large area observations of extragalactic deep fields with the James Webb Space Telescope (JWST) have provided a wealth of candidate low-mass L- and T-class brown dwarfs. The existence of these sources, which are at derived distances of hundreds of parsecs to several kiloparsecs from the Sun, has strong implications for the low-mass end of the stellar initial mass function, and the link between stars and planets at low metallicities. In this letter, we present a JWST/NIRSpec PRISM spectrum of brown dwarf JADES-GS-BD-9, confirming its photometric selection from observations taken as part of the JWST Advanced Deep Extragalactic Survey (JADES) program. Fits to this spectrum indicate that the brown dwarf has an effective temperature of 800-900K (T5 - T6) at a distance of \\(1.8 - 2.3\\)kpc from the Sun, with evidence of the source being at low metallicity ([M/H] \\( -0.5\\)). Finally, because of the cadence of JADES NIRCam observations of this source, we additionally uncover a proper motion between the 2022 and 2023 centroids, and we measure a proper motion of \\(20 4\\) mas yr\\(^-1\\) (a transverse velocity of 214 km s\\(^-1\\) at 2.25 kpc). At this predicted metallicity, distance, and transverse velocity, it is likely that this source belongs either to the edge of the Milky Way thick disk or the galactic halo. This spectral confirmation demonstrates the efficacy of photometric selection of these important sources across deep extragalactic JWST imaging.