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"Butler, James"
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3D Traction Forces in Cancer Cell Invasion
Cell invasion through a dense three-dimensional (3D) matrix is believed to depend on the ability of cells to generate traction forces. To quantify the role of cell tractions during invasion in 3D, we present a technique to measure the elastic strain energy stored in the matrix due to traction-induced deformations. The matrix deformations around a cell were measured by tracking the 3D positions of fluorescent beads tightly embedded in the matrix. The bead positions served as nodes for a finite element tessellation. From the strain in each element and the known matrix elasticity, we computed the local strain energy in the matrix surrounding the cell. We applied the technique to measure the strain energy of highly invasive MDA-MB-231 breast carcinoma and A-125 lung carcinoma cells in collagen gels. The results were compared to the strain energy generated by non-invasive MCF-7 breast and A-549 lung carcinoma cells. In all cases, cells locally contracted the matrix. Invasive breast and lung carcinoma cells showed a significantly higher contractility compared to non-invasive cells. Higher contractility, however, was not universally associated with higher invasiveness. For instance, non-invasive A-431 vulva carcinoma cells were the most contractile cells among all cell lines tested. As a universal feature, however, we found that invasive cells assumed an elongated spindle-like morphology as opposed to a more spherical shape of non-invasive cells. Accordingly, the distribution of strain energy density around invasive cells followed patterns of increased complexity and anisotropy. These results suggest that not so much the magnitude of traction generation but their directionality is important for cancer cell invasion.
Journal Article
Atlas of Mexico
\"This atlas, a part of a larger project devoted to developing a database of population of Mexico, will enhance understanding of Mexico, broaden US perspectives on Mexico, and interest others in using the data and maps in the information system.\" -- Provided by publisher
Book
Monolayer Stress Microscopy: Limitations, Artifacts, and Accuracy of Recovered Intercellular Stresses
In wound healing, tissue growth, and certain cancers, the epithelial or the endothelial monolayer sheet expands. Within the expanding monolayer sheet, migration of the individual cell is strongly guided by physical forces imposed by adjacent cells. This process is called plithotaxis and was discovered using Monolayer Stress Microscopy (MSM). MSM rests upon certain simplifying assumptions, however, concerning boundary conditions, cell material properties and system dimensionality. To assess the validity of these assumptions and to quantify associated errors, here we report new analytical, numerical, and experimental investigations. For several commonly used experimental monolayer systems, the simplifying assumptions used previously lead to errors that are shown to be quite small. Out-of-plane components of displacement and traction fields can be safely neglected, and characteristic features of intercellular stresses that underlie plithotaxis remain largely unaffected. Taken together, these findings validate Monolayer Stress Microscopy within broad but well-defined limits of applicability.
Journal Article
The real Metaphysical Club : the philosophers, their debates, and selected writings from 1870 to 1885
\"The Metaphysical Club, a gathering of intellectuals in the 1870s associated with Harvard, is widely recognized as the crucible where pragmatism, America's distinctively original philosophy, was refined and proclaimed. Louis Menand's bestseller about the group was a dramatic publishing success. However, only three actual members - Oliver Wendell Holmes Jr., Charles S. Peirce, and William James - appear in this book, alongside other thinkers such as John Dewey who were never in the Club. The Real Metaphysical Club tells the full story of how this influential group shifted the course of philosophy in America. In addition to pioneering pragmatism, the group explored radical empiricism and idealism, and formulated personalism and process philosophy, equally important developments. This volume contains thirty-seven important writings dating from 1870 to 1885 by the real members of the Metaphysical Club. The first section centers on pragmatism and science; the second part collects writings of the lawyers; and the third part covers idealist and personalist philosophers. Many of these writings have never been reprinted before, and nothing like this impressive collection has ever been attempted. A general introduction provides a narrative history, and the editors' three introductions to the volume's sections vividly bring to life the intense meetings, sustained debates, and pioneering thought from the Metaphysical Club\"-- Provided by publisher.
Book
MODIS and VIIRS Calibration History and Future Outlook
The MODIS is a key instrument for NASA’s EOS program, currently operated onboard the Terra and Aqua spacecraft launched in 1999 and 2002, respectively. The VIIRS is a MODIS follow-on instrument for the JPSS program. Adding to the ones operated onboard the S-NPP and NOAA-20 satellites launched in 2011 and 2017, respectively, three nearly identical VIIRS instruments will also be launched. This will enable the data records from MODIS and VIIRS to be extended beyond 2040. In addition to various applications and scientific studies of the Earth’s system, long-term data records from MODIS and VIIRS observations will greatly benefit the space-based climate observing system. This is attributed to the high-quality measurements and extensive calibration efforts, from pre-launch to post-launch. This paper provides an overview of MODIS and VIIRS calibration history and approaches applied to establish and maintain sensor calibration traceability and accuracy. It illustrates calibration and performance issues through different phases of the mission using examples derived from ground testing equipment, on-board calibrators, and other calibration targets. Moreover, discussed in this paper are outstanding challenges and future efforts to maintain and improve sensor calibration stability and long-term data quality, and to better support the space-based climate observing system.
Journal Article
The Rough Guide to Myanmar (Burma)
The Rough Guide to Myanmar (Burma) is the ultimate travel guide to this exciting, largely undiscovered country with clear maps and detailed coverage of all the best Burmese attractions. Discover Myanmar's highlights with stunning photography and information on everything from exploring the iconic temples of Bagan, boating across beautiful Inle Lake or trekking through remote Shan highland villages. Find detailed practical advice on what to see and do in Myanmar, relying on up-to-date descriptions of the best hotels, bars, shops and restaurants for all budgets. Explore every corner of this exciting country with easy-to-use maps to help make sure you don't miss the unmissable.
Book
Identification of optimal binders for torrefied biomass pellets
The pretreatment of biomass through torrefaction is an effective means of improving the fuel quality of woody biomass and its suitability for use in existing facilities burning thermal coal. Densification of torrefied biomass produces a fuel of similar energy density, moisture content, and fixed carbon content to low-grade coals. Additionally, if the torrefaction conditions are optimized, the produced torrefied pellet will be resistant to weathering and biological degradation, allowing for outdoor storage and transport in a manner similar to coal. In untreated biomass, lignin is the primary binding agent for biomass pellets and is activated by the heat and pressures of the pellet extrusion process. The thermal degradation of lignin during torrefaction reduces its binding ability, resulting in pellets of low durability not suitable for transportation. The use of a binding agent can increase the durability of torrefied pellets/briquettes through a number of different binding mechanisms depending on the binder used. This study gives a review of granular binding mechanisms, as they apply to torrefied biomass and assesses a variety of organic and inorganic binding agents, ranking them on their applicability to torrefied pellets based on a number of criteria, including durability, hydrophobicity, and cost. The best binders were found to be solid lignin by-product derived from pulp and paper processing, biomass tar derived from biomass pyrolysis, tall oil pitch, and lime.
Journal Article
Fairy tales of Ireland
A collection of Irish fairy tales, with a concentration on the fairies themselves, including \"The Stolen Child,\" \"The Witches' Excursion,\" and \"The Horned Women.\"
Book
Mechanical waves during tissue expansion
The processes by which an organism develops its shape and heals wounds involve expansion of a monolayer sheet of cells. The mechanism underpinning this epithelial expansion remains obscure, despite the fact that its failure is known to contribute to several diseases, including carcinomas, which account for about 90% of all human cancers. Here, using the micropatterned epithelial monolayer as a model system, we report the discovery of a mechanical wave that propagates slowly to span the monolayer, traverses intercellular junctions in a cooperative manner and builds up differentials of mechanical stress. Essential features of this wave generation and propagation are captured by a minimal model based on sequential fronts of cytoskeletal reinforcement and fluidization. These findings establish a mechanism of long-range cell guidance, symmetry breaking and pattern formation during monolayer expansion.
Tissue growth and regrowth rely on the collective migration of sheets of cells. Gradients in tension established through intercellular forces guide this migration, but the mechanism driving the gradients has remained unclear. Innovative experiments now reveal their origin—in a mechanical wave set up by sequential cell reinforcement and fluidization.
Journal Article