Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
383
result(s) for
"Butler, Jessica"
Sort by:
Eastern Europe
Lonely Planet's Eastern Europe is your passport to the most relevant, up-to-date advice on what to see and skip, and what hidden discoveries await you. Hop from thermal baths to coffee houses to 'ruin bars' in Budapest, glide from island to island in Croatia and meander through 14th-century alleyways in Prague - all with your trusted travel companion. Get to the heart of Eastern Europe and begin your journey now!
Book
Vector-borne disease surveillance and control resource needs in Colorado public health organizations
Since 2002, Colorado has experienced a high vector-borne disease (VBD) burden from diseases like West Nile fever, plague, and tularemia. Recent evidence underscores a lack of vector-borne surveillance and control program capacity across public health organizations, prompting our evaluation of funding and resource needs for such programs in Colorado. We assessed the needs, organizational capacity, and mitigation strategies of Colorado public health organizations’ VBD programs using a convergent mixed methods study design. Between January and May 2024, we surveyed and interviewed key public health organizations leaders. Findings were determined through mixed methods integration of survey data, thematic analysis on interviews, and content analysis on financial and policy documents. Overall, 28 public health practitioners (35% response rate) at 24 Colorado public health organizations (63% urban, 25% rural, 13% frontier counties) were surveyed and 18 were interviewed. We found only 37.5% of Colorado’s public health organizations conducted vector surveillance for any vector species. Smaller rural and frontier communities (<100K people) were particularly vulnerable to inadequate VBD organizational capacity and resource availability, and public health organizations in areas with populations < 10K or between 51-100K did not conduct vector surveillance. Interviewees perceived their VBD surveillance and program capacity as inadequate and reported significant limitations in their ability to carry out vector control activities. Moreover, they reported that competing priorities for emerging diseases resulted in reactionary rather than proactive responses to VBDs, highlighting the lack of sustainable funding for vector programs. As VBDs continue to increase in Colorado, outbreaks of diseases like West Nile fever or plague will likely go undetected without improved surveillance. The findings from our study have implications for where surveillance and control are lacking and highlight opportunities to continue improving and supporting surveillance and controls programs for VBDs.
Journal Article
Playing for keeps
\"A burnt-out soccer star tries to win back his family but gets distracted by his wandering eye in this romantic comedy starring Gerard Butler. His bank account drained and his libido fatigued, professional soccer player George (Butler) hangs up his cleats and heads back to Virginia. Determined to do right in the eyes of his ex-wife (Jessica Biel) and their lonely son (Noah Lomax), George takes a job coaching a local soccer team and begins working to form the young players into true athletes. But with every cougar in town eyeing him from the sidelines, George finds that staying focused on the job and keeping his prurient impulses in check are easier said than done\"--Allmovie.com, viewed September 6, 2018.
DVD
Evolution of electron transfer out of the cell: comparative genomics of six Geobacter genomes
Background
Geobacter
species grow by transferring electrons out of the cell - either to Fe(III)-oxides or to man-made substances like energy-harvesting electrodes. Study of
Geobacter sulfurreducens
has shown that TCA cycle enzymes, inner-membrane respiratory enzymes, and periplasmic and outer-membrane cytochromes are required. Here we present comparative analysis of six
Geobacter
genomes, including species from the clade that predominates in the subsurface. Conservation of proteins across the genomes was determined to better understand the evolution of
Geobacter
species and to create a metabolic model applicable to subsurface environments.
Results
The results showed that enzymes for acetate transport and oxidation, and for proton transport across the inner membrane were well conserved. An NADH dehydrogenase, the ATP synthase, and several TCA cycle enzymes were among the best conserved in the genomes. However, most of the cytochromes required for Fe(III)-reduction were not, including many of the outer-membrane cytochromes. While conservation of cytochromes was poor, an abundance and diversity of cytochromes were found in every genome, with duplications apparent in several species.
Conclusions
These results indicate there is a common pathway for acetate oxidation and energy generation across the family and in the last common ancestor. They also suggest that while cytochromes are important for extracellular electron transport, the path of electrons across the periplasm and outer membrane is variable. This combination of abundant cytochromes with weak sequence conservation suggests they may not be specific terminal reductases, but rather may be important in their heme-bearing capacity, as sinks for electrons between the inner-membrane electron transport chain and the extracellular acceptor.
Journal Article
Legibility Zones: An Empirically-Informed Framework for Considering Unbelonging and Exclusion in Contemporary English Academia
This article introduces a new, empirically-derived conceptual framework for considering exclusion in English higher education (HE): legibility zones. Drawing on interviews with academic employees in England, it suggests that participants orientate themselves to a powerful imaginary termed the hegemonic academic. Failing to align with this ideal can engender a sense of dislocation conceptualised as unbelonging. The mechanisms through which hegemonic academic identity is constituted and unbelonging is experienced are mapped onto three domains: the institutional, the ideological, and the embodied. The framework reveals the mutable and intersecting nature of these zones, highlighting the complex dynamics of unbelonging and the attendant challenge presented to inclusion projects when many apparatuses of exclusion are perceived as fundamental to what HE is for, what an academic is, and how academia functions.
Journal Article
Identifying multimorbidity clusters in an unselected population of hospitalised patients
Multimorbidity (multiple coexisting chronic health conditions) is common and increasing worldwide, and makes care challenging for both patients and healthcare systems. To ensure care is patient-centred rather than specialty-centred, it is important to know which conditions commonly occur together and identify the corresponding patient profile. To date, no studies have described multimorbidity clusters within an unselected hospital population. Our aim was to identify and characterise multimorbidity clusters, in a large, unselected hospitalised patient population. Linked inpatient hospital episode data were used to identify adults admitted to hospital in Grampian, Scotland in 2014 who had ≥ 2 of 30 chronic conditions diagnosed in the 5 years prior. Cluster analysis (Gower distance and Partitioning around Medoids) was used to identify groups of patients with similar conditions. Clusters of conditions were defined based on clinical review and assessment of prevalence within patient groups and labelled according to the most prevalent condition. Patient profiles for each group were described by age, sex, admission type, deprivation and urban–rural area of residence. 11,389 of 41,545 hospitalised patients (27%) had ≥ 2 conditions. Ten clusters of conditions were identified: hypertension; asthma; alcohol misuse; chronic kidney disease and diabetes; chronic kidney disease; chronic pain; cancer; chronic heart failure; diabetes; hypothyroidism. Age ranged from 51 (alcohol misuse) to 79 (chronic heart failure). Women were a higher proportion in the chronic pain and hypothyroidism clusters. The proportion of patients from the most deprived quintile of the population ranged from 6% (hypertension) to 14% (alcohol misuse). Identifying clusters of conditions in hospital patients is a first step towards identifying opportunities to target patient-centred care towards people with unmet needs, leading to improved outcomes and increased efficiency. Here we have demonstrated the face validity of cluster analysis as an exploratory method for identifying clusters of conditions in hospitalised patients with multimorbidity.
Journal Article
Inequalities in children’s mental health care: analysis of routinely collected data on prescribing and referrals to secondary care
Background
One in eight children in the United Kingdom are estimated to have a mental health condition, and many do not receive support or treatment. The COVID-19 pandemic has negatively impacted mental health and disrupted the delivery of care. Prevalence of poor mental health is not evenly distributed across age groups, by sex or socioeconomic groups. Equity in access to mental health care is a policy priority but detailed socio-demographic trends are relatively under-researched.
Methods
We analysed records for all mental health prescriptions and referrals to specialist mental health outpatient care between the years of 2015 and 2021 for children aged 2 to 17 years in a single NHS Scotland health board region. We analysed trends in prescribing, referrals, and acceptance to out-patient treatment over time, and measured differences in treatment and service use rates by age, sex, and area deprivation.
Results
We identified 18,732 children with 178,657 mental health prescriptions and 21,874 referrals to specialist outpatient care. Prescriptions increased by 59% over the study period. Boys received double the prescriptions of girls and the rate of prescribing in the most deprived areas was double that in the least deprived. Mean age at first mental health prescription was almost 1 year younger in the most deprived areas than in the least. Referrals increased 9% overall. Initially, boys and girls both had an annual referral rate of 2.7 per 1000, but this fell 6% for boys and rose 25% for girls. Referral rate for the youngest decreased 67% but increased 21% for the oldest. The proportion of rejected referrals increased steeply since 2020 from 17 to 30%. The proportion of accepted referrals that were for girls rose to 62% and the mean age increased 1.5 years.
Conclusions
The large increase in mental health prescribing and changes in referrals to specialist outpatient care aligns with emerging evidence of increasing poor mental health, particularly since the start of the COVID-19 pandemic. The static size of the population accepted for specialist treatment amid greater demand, and the changing demographics of those accepted, indicate clinical prioritisation and unmet need. Persistent inequities in mental health prescribing and referrals require urgent action.
Journal Article
Impulse Control Disorders in Dopamine Agonist-Treated Hyperprolactinemia: Prevalence and Risk Factors
Abstract
Context
There are growing reports of dopamine agonist (DA)-induced impulse control disorders (ICDs) in hyperprolactinemic patients. However, the magnitude of this risk and predictive factors remain uncertain.
Objective
To determine ICD prevalence and risk factors in DA-treated hyperprolactinemic patients compared to community controls.
Design, Setting and Participants
Multicenter cross-sectional analysis of 113 patients and 99 healthy controls.
Main Outcome Measures
Participants completed a neuropsychological questionnaire consisting of the Depression Anxiety Stress Scale (DASS21), Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease (QUIP-S), Hypersexual Behavior Inventory (HBI), Hypersexual Behavior Consequences Scale and Social Desirability Response Set Scale. Demographic and clinical data were collated to determine ICD risk factors. Patients testing positive for an ICD were offered a semistructured psychological interview.
Results
Patients were more likely than controls to test positive by QUIP-S for any ICD (61.1 vs 42.4%, P = .01), hypersexuality (22.1 vs 8.1%, P = .009), compulsive buying (15.9 vs 6.1%, P = .041) and punding (18.6 vs 6.1%, P = 0.012), and by HBI for hypersexuality (8.0 vs 0.0%, P = 0.004). Independent risk factors were male sex (odds ratio [OR] 13.85), eugonadism (OR 7.85), Hardy’s tumor score and psychiatric comorbidity (OR 6.86) for hypersexuality, and age (OR 0.95) for compulsive buying. DASS21 subset scores were higher in patients vs controls and in patients with vs without different ICDs. Only 19/51 (37.3%) interviewed patients were aware of the relationship between DAs and ICDs before the study.
Conclusions
DA therapy poses a high, previously underestimated risk of ICDs, especially in the form of hypersexuality in eugonadal men.
Journal Article
Genome Sequence of the Deltaproteobacterial Strain NaphS2 and Analysis of Differential Gene Expression during Anaerobic Growth on Naphthalene
Anaerobic polycyclic hydrocarbon (PAH) degradation coupled to sulfate reduction may be an important mechanism for in situ remediation of contaminated sediments. Steps involved in the anaerobic degradation of 2-methylnaphthalene have been described in the sulfate reducing strains NaphS3, NaphS6 and N47. Evidence from N47 suggests that naphthalene degradation involves 2-methylnaphthalene as an intermediate, whereas evidence in NaphS2, NaphS3 and NaphS6 suggests a mechanism for naphthalene degradation that does not involve 2-methylnaphthalene. To further characterize pathways involved in naphthalene degradation in NaphS2, the draft genome was sequenced, and gene and protein expression examined.
Draft genome sequencing, gene expression analysis, and proteomic analysis revealed that NaphS2 degrades naphthoyl-CoA in a manner analogous to benzoyl-CoA degradation. Genes including the previously characterized NmsA, thought to encode an enzyme necessary for 2-methylnaphthalene metabolism, were not upregulated during growth of NaphS2 on naphthalene, nor were the corresponding protein products. NaphS2 may possess a non-classical dearomatizing enzyme for benzoate degradation, similar to one previously characterized in Geobacter metallireducens. Identification of genes involved in toluene degradation in NaphS2 led us to determine that NaphS2 degrades toluene, a previously unreported capacity. The genome sequence also suggests that NaphS2 may degrade other monoaromatic compounds.
This study demonstrates that steps leading to the degradation of 2-naphthoyl-CoA are conserved between NaphS2 and N47, however while NaphS2 possesses the capacity to degrade 2-methylnaphthalene, naphthalene degradation likely does not proceed via 2-methylnaphthalene. Instead, carboxylation or another form of activation may serve as the first step in naphthalene degradation. Degradation of toluene and 2-methylnaphthalene, and the presence of at least one bss-like and bbs-like gene cluster in this organism, suggests that NaphS2 degrades both compounds via parallel mechanisms. Elucidation of the key genes necessary for anaerobic naphthalene degradation may provide the ability to track naphthalene degradation through in situ transcript monitoring.
Journal Article
Rare case of cystic anterior mediastinal tuberculosis in an immunocompetent patient
We report a case of a 28‐year‐old immunocompetent woman found to have a mediastinal lesion on chest x‐ray performed as part of a visa renewal process. Computed tomographic imaging revealed a cystic superior anterior mediastinal mass. Although initially asymptomatic, the woman subsequently developed progressive chest discomfort. She underwent surgical resection of the mass. Histological assessment demonstrated necrotizing granulomatous inflammation, while Gene Xpert™ testing was positive for Mycobacterium tuberculosis complex and she was subsequently commenced on anti‐tuberculous therapy. We report a rare case of a 28‐year‐old immunocompetent woman found to have a cystic superior anterior mediastinal mass. She underwent surgical resection of the mass and, based on histological appearances of necrotizing granulomatous inflammation and a Gene Xpert™ positive for Mycobacterium tuberculosis complex, she was subsequently commenced on anti‐tuberculous therapy.
Journal Article