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Spent sulfite liquor (SSL) from softwood processing is rich in hemicellulose (acetyl galactoglucomannan, AcGGM), lignin, and lignin-derived compounds. We investigated the effect of sequential AcGGM purification on the enzymatic bioconversion of AcGGM. SSL was processed through three consecutive purification steps (membrane filtration, precipitation, and adsorption) to obtain AcGGM with increasing purity. Significant reduction (~99%) in lignin content and modest loss (~18%) of polysaccharides was observed during purification from the least pure preparation (UFR), obtained by membrane filtration, compared to the purest preparation (AD), obtained by adsorption. AcGGM (~14.5 kDa) was the major polysaccharide in the preparations; its enzymatic hydrolysis was assessed by reducing sugar and high-performance anion-exchange chromatography analysis. The hydrolysis of the UFR preparation with Viscozyme L or Trichoderma reesei β-mannanase TrMan5A (1 mg/mL) resulted in less than ~50% bioconversion of AcGGM. The AcGGM in the AD preparation was hydrolyzed to a higher degree (~67% with TrMan5A and 80% with Viscozyme L) and showed the highest conversion rate. This indicates that SSL contains enzyme-inhibitory compounds (e.g., lignin and lignin-derived compounds such as lignosulfonates) which were successfully removed.

Wavefront shaping can refocus light after it reflects from an optically rough surface. One proposed use case of this effect is in indirect imaging; if any rough surface could be turned into an illumination source, objects out of the direct line of sight could be illuminated. In this paper, we demonstrate the superior performance of a genetic algorithm compared to other iterative feedback-based wavefront shaping algorithms in achieving reflective inverse diffusion for a focal plane system. Next, the ability to control the pointing direction of the refocused beam with high precision over a narrow angular range is demonstrated, though the challenge of increasing the overall scanning range of the refocused beam remains. The method of beam steering demonstrated in this paper could act as a vernier adjustment to a coarse adjustment offered by another method.

Determining the shapes of a rotating liquid droplet bound by surface tension is an archetypal problem in the study of the equilibrium shapes of a spinning and charged droplet, a problem that unites models of the stability of the atomic nucleus with the shapes of astronomical-scale, gravitationally-bound masses. The shapes of highly deformed droplets and their stability must be calculated numerically. Although the accuracy of such models has increased with the use of progressively more sophisticated computational techniques and increases in computing power, direct experimental verification is still lacking. Here we present an experimental technique for making wax models of these shapes using diamagnetic levitation. The wax models resemble splash-form tektites, glassy stones formed from molten rock ejected from asteroid impacts. Many tektites have elongated or ‘dumb-bell’ shapes due to their rotation mid-flight before solidification, just as we observe here. Measurements of the dimensions of our wax ‘artificial tektites’ show good agreement with equilibrium shapes calculated by our numerical model and with previous models. These wax models provide the first direct experimental validation for numerical models of the equilibrium shapes of spinning droplets, of importance to fundamental physics and also to studies of tektite formation.

Considerable evidence suggests that breast cancer therapeutic resistance and relapse can be driven by polyploid giant cancer cells (PGCCs). The number of PGCCs increases with the stages of disease and therapeutic stress. Given the importance of PGCCs, it remains challenging to eradicate them. To discover effective anti-PGCC compounds, there is an unmet need to rapidly distinguish compounds that kill non-PGCCs, PGCCs, or both. Here, we establish a single-cell morphological analysis pipeline with a high throughput and great precision to characterize dynamics of individual cells. In this manner, we screen a library to identify promising compounds that inhibit all cancer cells or only PGCCs ( e.g ., regulators of HDAC, proteasome, and ferroptosis). Additionally, we perform scRNA-Seq to reveal altered cell cycle, metabolism, and ferroptosis sensitivity in breast PGCCs. The combination of single-cell morphological and molecular investigation reveals promising anti-PGCC strategies for breast cancer treatment and other malignancies. Breast cancer resistance and relapse may stem from polyploid giant cancer cells (PGCCs), and eradicating them poses a challenge. A precise, high-throughput single-cell analysis can identify compounds that target non-PGCCs, PGCCs, or both cell types.

Analyses of care work typically speak of three necessary roles of care: the care worker, the care recipient, and an economic provider who makes care materially possible. This model provides no place for addressing the difficult political questions care poses for liberal representative democracy. I propose to fill this space with a new caring role to connect the care unit to the political sphere, as the economic provider connects the care unit to the economic sphere. I call this role that of the \"care claimant.\" The labor of claiming care consists in the development, expression, and advancement of the interests of the care unit. The argument for employing this fourth care role begins by comparing Nel Noddings's phenomenological care unit to Sara Ruddick's family-based analysis. It then moves to discuss the way Eva Kittay emphasizes the dependency of the charge and its political ramifications to illustrate the need for a care claimant. After distinguishing the care claimant from the other roles of care, I examine the power relationships in the care unit and the position of the care claimant in the public sphere.

Splash-form tektites are found with a wide range of sizes and in an intriguing array of shapes ranging from spheres to flat discs to dumbbells. Despite the considerable interest that exists in tektites, there has been relatively little effort to develop rational shape descriptors and to understand the origin of their shapes based on basic physics. Tektites represent a natural laboratory experiment that can be analyzed to better understand the physics of rotating fluid drops. In this paper, we propose a classification scheme based on the axial ratios of ellipsoids, and we analyze the frequency of tektite shapes using a database of over 1,000 measured tektites. We show that the shape distribution for tektites from Thailand and Vietnam are very similar and that the most common tektites are moderately deformed discs but there exist also a significant number of moderately deformed dumbbells, and we argue that this distribution comes about because fluid drops first deform as oblate forms and then undergo a non-axisymmetric instability to become prolate. We also find that the largest tektites are most likely to be weakly deformed oblate objects while the most strongly deformed and most highly prolate forms are considerably smaller. A numerical model for the evolution of an axisymmetric fluid drop, such as a tektite in its molten early stage, is presented which demonstrates that drops that deform relatively slowly over a longer period of time are likely to develop central thinning while those that deform more rapidly are more likely to retain the shape of an ellipsoid. For the numerical parameters used the characteristic time scale for deformation was less than 1 s.

HarperCollins is proud to present its incredible range of best-loved, essential classics.When Paris falls in love with legendary beauty Helen of Troy, the devastating effects of their affair on their families and fellow citizens are unimaginable. Battle lines are drawn, alliances are forged, and as the Greeks and Trojans march into battle, the resilience and humanity of all will be tested.In his epic story of divine ego, human frailty, and the ravages of war, Homer created an unforgettable cast of characters, whose moral dilemmas and heroic deeds will stay with readers long past the final pages of this book. Samuel Butler's famous prose translation of Homer's original brings the epic to an entirely new generation of readers.

HarperCollins is proud to present its incredible range of best-loved, essential classics. When Paris falls in love with legendary beauty Helen of Troy, the devastating effects of their affair on their families and fellow citizens are unimaginable. Battle lines are drawn, alliances are forged, and as the Greeks and Trojans march into battle, the resilience and humanity of all will be tested. In his epic story of divine ego, human frailty, and the ravages of war, Homer created an unforgettable cast of characters, whose moral dilemmas and heroic deeds will stay with readers long past the final pages of this book. Samuel Butler's famous prose translation of Homer's original brings the epic to an entirely new generation of readers.