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Fixed income analysis
In this text, readers will be introduced to a variety of important fixed income analysis issues, including the general principles of credit analysis, term structure and volatility of interest rates, and valuing bonds with embedded options.
Shannon Pratt's the lawyer's business valuation handbook: understanding financial statements, appraisal reports, and expert testimony
by
Roger J. Grabowski, FASA
,
Pratt, Shannon
,
Alina V. Niculita, ASA, ARM-BV, CFA, MBA
in
Appraisers
,
Corporations
,
Deskbook
2025,2024
Highly technical and often difficult to understand, business valuations are a critical subject for lawyers in many areas, such as divorce, bankruptcy, corporate and tax law, and estate and financial planning. The authors of this book, who have over 40 years of combined experience in transactional matters and litigation, present and discuss key concepts in valuation. At the same time, they explain how to dig beneath the surface of expert opinions and show how to find the most pertinent facts, interpret the data, and evaluate the quality and comprehensiveness of evidence. This easy-to-use manual covers all aspects of determining the value of a business, including definitions of value; personal versus enterprise goodwill, valuing professional practices and small businesses, cross-examination, commonly used terminology and bodies of evidence, professional credentials and standards; and recognized and accepted valuation methods. Adding to the books usefulness are Questions to Ask for most sections, extensive case citations throughout to courts positions on many issues, and appendices that include a glossary, bibliography of business valuation databases, and other useful tools.
Investments
2011
A comprehensive guide to investment analysis and portfolio management by an expert team from the CFA Institute In a world of specialization, no other profession likely requires such broad, yet in-depth knowledge than that of financial analyst. Financial analysts must not only possess a broad understanding of the financial markets-including structure, organization, efficiency, portfolio management, risk and return, and planning and construction-but they must also have a strong sense of how to evaluate industries and companies prior to engaging in an analysis of a specific stock. Investments: Principles of Portfolio and Equity Analysis provides the broad-based knowledge professionals and students of the markets need to manage money and maximize return. The book Details market structure and functions, market anomalies, secondary market basics, and regulation Describes investment assets and asset classes, types of positions and orders, as well as forecasting methodologies Discusses return and risk characteristics, portfolio diversification and management, the basics of both technical analysis and major technical indicators, and much more A companion Workbook, which includes learning outcomes, summary overviews, and problems and solutions sections is available and sold separately Investments provides readers unparalleled access to the best in professional quality information on investment analysis and portfolio management.
Change Is a Good Thing
by
Finke, Michael S.
,
Blanchett, CFA, David M.
,
Licato, James A.
in
Defined contribution plans
,
Mutual funds
,
Portfolio management
2020
Do DC plan sponsors add value by monitoring and refreshing the menu of investments offered to participants? The authors find evidence that they do, particularly by successfully removing underperforming funds.
Empirical research offers little evidence that monitoring defined-contribution menus adds value, despite the time, effort, and resources spent by plan sponsors on such activities. Using a unique longitudinal dataset of plan menus from January 2010 to November 2018 that included 4,215 fund replacements, we found that the replacement fund outperformed the replaced fund over future one-year and three-year periods. The outperformance remained even after we controlled for various fund characteristics and risk factors. It can be attributed primarily to the subsequent underperformance of replaced funds and to the lower expense ratios of the replacements.
Disclaimer: Two of the authors' companies offer menu services for defined-contribution plans.
Editor's note
Submitted 12 June 2019
Accepted 17 September 2019 by Stephen J. Brown
Journal Article
Financial Econometric Basics
2014
An accessible guide to the growing field of financial econometrics As finance and financial products have become more complex, financial econometrics has emerged as a fast-growing field and necessary foundation for anyone involved in quantitative finance. The techniques of financial econometrics facilitate the development and management of new financial instruments by providing models for pricing and risk assessment. In short, financial econometrics is an indispensable component to modern finance. The Basics of Financial Econometrics covers the commonly used techniques in the field without using unnecessary mathematical/statistical analysis. It focuses on foundational ideas and how they are applied. Topics covered include: regression models, factor analysis, volatility estimations, and time series techniques. In addition, an associated website contains a number of real-world case studies related to important issues in this area. Covers the basics of financial econometrics-an important topic in quantitative finance Contains several chapters on topics typically not covered even in basic books on econometrics such as model selection, model risk, and mitigating model risk A companion website includes mini-cases that explain important topics in portfolio management, credit risk modeling, option pricing, and risk management Geared towards both practitioners and finance students who need to understand this dynamic discipline, but may not have advanced mathematical training, this book is a valuable resource on a topic of growing importance.
Metformin versus insulin in glycemic control in pregnancy (MevIP): a randomized clinical trial protocol
by
Pereira, Belmiro G.
,
Amaral-Moreira, Carolina Freitas Alves
,
Rehder, Patricia Moretti
in
Biomedicine
,
Blood Glucose - drug effects
,
Blood Glucose - metabolism
2025
Background
Gestational diabetes is one of the most prevalent diseases in pregnancy, with an incidence of 5 to 18% in Brazil, and is associated with high morbidity rates. The first-line treatment is insulin, although some recent studies have indicated that metformin might also be effective. Metformin is safe in pregnancy and appears to produce better results than insulin, including reduced gestational weight gain (GWG) and smaller gestational-age newborns. Few studies have been conducted on this topic in low- and middle-income countries.
Methods
We designed an open randomized controlled trial comparing two treatments for pregnant women with type II diabetes mellitus (DM) and gestational diabetes (DMG): the metformin group (intervention) and the insulin group (as a routine service). The primary outcome is glycemic control. The secondary outcomes are GWG, the occurrence of hypertensive syndromes, macrosomia, and neonatal hypoglycemia. The sample will comprise 92 pregnant women, 46 per group. The inclusion criteria will be GDM or type II DM requiring medication for glycemic control, singleton pregnancy, and gestational age under 34 weeks. The exclusion criteria will be current treatment with any medication for glycemic control, type I DM, and intolerance to the study medications (metformin or insulin). Women will be routinely followed during antenatal care, childbirth, and the postpartum period. Statistical analyses will include the intention-to-treat approach and a comparison between the two groups.
Discussion
Considering the Brazilian socioeconomic reality and the safety of metformin demonstrated in previous trials, we expect that the MevIP study will demonstrate that metformin is an adequate and appropriate medication for GDM treatment in the Brazilian population, representing an alternative to insulin for GDM.
Trial registration
This protocol has been registered prospectively in ReBEC under the ID RBR-3j3cktx in August 11, 2023.
Journal Article
Encorafenib, Binimetinib and Cetuximab Combined Therapy for Patients with BRAFV600E Mutant Metastatic Colorectal Cancer
by
Bernards, Rene
,
van Geel, Robin MJM
,
Beijnen, Jos H
in
Biomarkers
,
Cancer therapies
,
Chemotherapy
2020
Approximately 10-15% of colorectal cancers (CRCs) harbor an activating
mutation, leading to tumor growth promotion by activation of the mitogen-activated protein kinases pathway.
mutations are prognostic for treatment failure after first-line systemic therapy in the metastatic setting. In contrast to the efficacy of combined BRAF and MEK inhibition in melanoma,
mutant CRC is intrinsically unresponsive due to upregulation of HER/EGFR. However, combining the EGFR inhibitor cetuximab, the BRAF inhibitor encorafenib and the MEK inhibitor binimetinib improves overall survival. This review discusses the current treatment field for patients with
mutant metastatic CRC and summarizes the pharmacology, efficacy and safety of the novel doublet and triplet therapies consisting of encorafenib and cetuximab with or without binimetinib.
Journal Article
Financial models with Lévy processes and volatility clustering
by
Rachev, Svetlozar T
,
Kim, Young Shin
,
Bianchi, Michele L
in
BUSINESS & ECONOMICS
,
Capital assets pricing model
,
Finance
2011
An in-depth guide to understanding probability distributions and financial modeling for the purposes of investment management In Financial Models with Lévy Processes and Volatility Clustering, the expert author team provides a framework to model the behavior of stock returns in both a univariate and a multivariate setting, providing you with practical applications to option pricing and portfolio management. They also explain the reasons for working with non-normal distribution in financial modeling and the best methodologies for employing it. The book's framework includes the basics of probability distributions and explains the alpha-stable distribution and the tempered stable distribution. The authors also explore discrete time option pricing models, beginning with the classical normal model with volatility clustering to more recent models that consider both volatility clustering and heavy tails. Reviews the basics of probability distributions Analyzes a continuous time option pricing model (the so-called exponential Lévy model) Defines a discrete time model with volatility clustering and how to price options using Monte Carlo methods Studies two multivariate settings that are suitable to explain joint extreme events Financial Models with Lévy Processes and Volatility Clustering is a thorough guide to classical probability distribution methods and brand new methodologies for financial modeling.
A single-ion trap with minimized ion–environment interactions
2016
We present a new single-ion endcap trap for high-precision spectroscopy that has been designed to minimize ion–environment interactions. We describe the design in detail and then characterize the working trap using a single trapped
171
Yb
+
ion. Excess micromotion has been eliminated to the resolution of the detection method, and the trap exhibits an anomalous phonon heating rate of
d
⟨
n
⟩
/
d
t
=
24
-
24
+
30
s
-
1
. The thermal properties of the trap structure have also been measured with an effective temperature rise at the ion’s position of
Δ
T
(
ion
)
=
0.14
±
0.14
K
. The small perturbations to the ion caused by this trap make it suitable to be used for an optical frequency standard with fractional uncertainties below the
10
-
18
level.
Journal Article
Music Therapy Enhances Episodic Memory in Alzheimer’s and Mixed Dementia: A Double-Blind Randomized Controlled Trial
by
Gomes, Carlos Falcão de Azevedo
,
Moreira, Shirlene Vianna
,
Justi, Francis Ricardo dos Reis
in
Adults
,
Alzheimer's disease
,
Brain research
2023
Objective: This study aimed to assess whether a music therapy (MT) intervention could improve memory decline in older adults with and without cognitive impairment. A dual-retrieval model of episodic memory was employed to estimate memory processes. Methods: Forty-three older adults with a mean age of 76.49 years (n = 25 with Alzheimer’s disease (AD) and mixed dementia, and n = 18 healthy older adults) were randomly selected for the experimental and control groups. The study design was a double-blind randomized controlled clinical trial and a certified music therapist delivered the MT. The primary outcomes were measures of working memory, episodic memory, and autobiographical memory. Results: In the primary outcome measures, MT effects were restricted to episodic memory measures like the Figure Memory Test of the BCSB and the Speech and Sing Memory Test. In both tests, the experimental group improved from pre-test to post-test in delayed recall, but in the Speech and Sing Memory Test, the improvement was restricted to the AD and mixed dementia group. MT had no effects on the secondary outcome measures. Conclusions: These findings suggest that a structured MT intervention can be promising for rehabilitating episodic memory in older adults with dementia.
Journal Article