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"CHARLES, JESSICA"
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Spy Guy : the not-so-secret agent
Spy Guy's determined to become a good, sneaky spy, but he can't do it without the help of his father, the Chief.
Book
12th GCC Closed Forum: critical reagents; oligonucleotides; CoA; method transfer; HRMS; flow cytometry; regulatory findings; stability and immunogenicity
The 12th GCC Closed Forum was held in Philadelphia, PA, USA, on 9 April 2018. Representatives from international bioanalytical Contract Research Organizations were in attendance in order to discuss scientific and regulatory issues specific to bioanalysis. The issues discussed at the meeting included: critical reagents; oligonucleotides; certificates of analysis; method transfer; high resolution mass spectrometry; flow cytometry; recent regulatory findings and case studies involving stability and nonclinical immunogenicity. Conclusions and consensus from discussions of these topics are included in this article.
Journal Article
Game play therapy : therapeutic use of games with children and adolescents
\"The purpose of this comprehensive, \"state-of-the art\" guidebook is to provide mental health practitioners with essential information about the field of Game Play Therapy, including its theoretical foundations, and practical applications to children and adolescents. It will describe both classic games that have stood the test of time as well as the latest innovations and advances in game play approaches, such as Electronic Games and Disorder-Specific Games. Not withstanding the wide spread and growing practice of Game Play Therapy across the globe, most child and adolescent practitioners have received little or no formal training about why and how to use this intervention most effectively. Thus, the chapter contributors in the volume will provide expert advice on how to select the most useful therapy games (over 700 that are now available), the \"nuts-and-bolts\" of administering and using these game effectively, case illustrations of the process of game therapy, and empirical evidence of its effectiveness. The contributors will all be credentialed play therapists with extensive experience practicing Game Play Therapy\"-- Provided by publisher.
Book
Revisiting the Visiting Teacher
Drawing on primary documents, we examine the visiting teacher movement (VTM; ca. 1906–40), focusing on three questions: (1) What lessons from the VTM challenge the social and political aims of education in our historical moment? (2) What are lessons for redefining school social work practice today? and (3) What lessons can today’s school social workers use to organize for more expansive views of their practice? We argue the VTM challenged educational bureaucracy by creating blended roles across professions and bridging boundaries between home and school. Although visiting teachers’ work stood in contrast to the factory model of schooling, they had the ear of high-ranking educators across the country. Their vision for the work that was needed, well-organized channels of communication, and networks of support positioned them as a counterweight to contemporaneous views. Their example is a model for reimagining social work, the school space, and the state apparatus
In the city of which I am a representative, many of the visiting teachers are on either the paid or volunteer staff of the settlement adjacent to the school where they work. The teacher knows her neighborhood and is chosen for that knowledge. She knows not only the traditions of her children but their national traditions and family advantages. This knowledge she brings to the teacher. . . . So often the making of Americans in our public schools means crushing out what they bring to us in order to make them into a supposed American model. This kind of “education” would be blotted out if every elementary school teacher had an intelligent knowledge of the national history of her children. (Jane McCoady [1916], head worker, Ellis Memorial and Eldredge House, “The Visiting Teacher and the Settlement”)
Journal Article
The sleeping beauty
\"A retelling of the classic ballet story brought to life by music! Set to the sound of Tchaikovsky's original music, this favorite ballet story features a a musical note to press on each spread. Join the King and Queen as they throw a party for their new baby, Princess Aurora. But when a terrible guest arrives and places a curse on princess, the kingdom must find the one special person who can defeat it\"--Provided by publisher.
BOOK
Multiple factors interact to produce responses resembling spectrum of human disease in Campylobacter jejuni infected C57BL/6 IL-10-/- mice
Background
Campylobacter jejuni
infection produces a spectrum of clinical presentations in humans – including asymptomatic carriage, watery diarrhea, and bloody diarrhea – and has been epidemiologically associated with subsequent autoimmune neuropathies. This microorganism is genetically variable and possesses genetic mechanisms that may contribute to variability in nature. However, relationships between genetic variation in the pathogen and variation in disease manifestation in the host are not understood. We took a comparative experimental approach to explore differences among different
C. jejuni
strains and studied the effect of diet on disease manifestation in an interleukin-10 deficient mouse model.
Results
In the comparative study, C57BL/6 interleukin-10
-/-
mice were infected with seven genetically distinct
C. jejuni
strains. Four strains colonized the mice and caused disease; one colonized with no disease; two did not colonize. A DNA:DNA microarray comparison of the strain that colonized mice without disease to
C. jejuni
11168 that caused disease revealed that putative virulence determinants, including loci encoding surface structures known to be involved in
C. jejuni
pathogenesis, differed from or were absent in the strain that did not cause disease. In the experimental study, the five colonizing strains were passaged four times in mice. For three strains, serial passage produced increased incidence and degree of pathology and decreased time to develop pathology; disease shifted from watery to bloody diarrhea. Mice kept on an ~6% fat diet or switched from an ~12% fat diet to an ~6% fat diet just before infection with a non-adapted strain also exhibited increased incidence and severity of disease and decreased time to develop disease, although the effects of diet were only statistically significant in one experiment.
Conclusion
C. jejuni
strain genetic background and adaptation of the strain to the host by serial passage contribute to differences in disease manifestations of
C. jejuni
infection in C57BL/6 IL-10
-/-
mice; differences in environmental factors such as diet may also affect disease manifestation. These results in mice reflect the spectrum of clinical presentations of
C. jejuni
gastroenteritis in humans and contribute to usefulness of the model in studying human disease.
Journal Article
The tall man : fear takes a new shape
When her child goes missing, a mother (Jessica Biel) looks to unravel the legend of the Tall Man, an entity who allegedly abducts children.
DVD
Recommendations for classification of commercial LBA kits for biomarkers in drug development from the GCC for bioanalysis
Over the last decade, the use of biomarker data has become integral to drug development. Biomarkers are not only utilized for internal decision-making by sponsors; they are increasingly utilized to make critical decisions for drug safety and efficacy. As the regulatory agencies are routinely making decisions based on biomarker data, there has been significant scrutiny on the validation of biomarker methods. Contract research organizations regularly use commercially available immunoassay kits to validate biomarker methods. However, adaptation of such kits in a regulated environment presents significant challenges and was one of the key topics discussed during the 12th Global Contract Research Organization Council for Bioanalysis (GCC) meeting. This White Paper reports the GCC members’ opinion on the challenges facing the industry and the GCC recommendations on the classification of commercial kits that can be a win-win for commercial kit vendors and end users.
Journal Article
The formation of teacher work teams under adverse conditions: Towards a more realistic scenario for schools in distress
Group formation studies are rare in the literature on teacher professional learning communities (PLCs). But they are needed to render realistic scenarios and design interventions for practitioners who work in schools where teachers encounter distress and social adversity. Under these conditions, we may need approaches to PLC development that are not adequately captured with conventional models. Drawing from the literature on teacher collaboration, effective work teams, group development and identity, problem solving, conflict and collective resilience, the article traces the development of a grade level team in a distressed urban middle school that was charged to make the learning environment for students safer, more orderly, and more caring. When teachers face the social adversity that students bring to them from their life experiences, the problems faced by teachers are often not “friendly” problems. Rather these problems cause suffering: being challenged in one’s basic competencies as a teacher or one’s personal integrity. Oftentimes, they require collective action while they at the same time increase individual distress, fear of being seen as weak, and isolation. Work team development under these circumstances needs to capitalize on the desire to connect that may be imbued in collective suffering. Against norms of privacy, non-interference, and conflict avoidance, ideological rifts, and interfering interpersonal dynamics work team members need to look for the seeds of the desire to connect in the midst of this suffering.
Journal Article