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"CHOI, YOUNG"
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Pillar of books
\"This debut collection in English from Korean poet Moon Bo Young insists that you, as a reader, put down your expectations of what should be important or serious. While these poems are about god, death, love, and literature, they are also just as much about a hat with a herd of cows on it, science experiments on monkeys' attention, the eating of cherry tomatoes, weeping carrots, and pimple popping. The surrealism and humor in these poems allow them to travel so far in the span of a stanza. Reading this book is like going on a picnic with your weirdest best friend and asking them what-if questions until the sun goes down--there's room for everything, from dark anecdotes to funny quips and surprising vulnerability. This book is like that: there's room for everything. Skillfully rendered by award-winning translator Hedgie Choi, this is a book that will change the way you think about what a poem can accomplish.\"--Amazon.com
Zebrafish as an animal model for biomedical research
Zebrafish have several advantages compared to other vertebrate models used in modeling human diseases, particularly for large-scale genetic mutant and therapeutic compound screenings, and other biomedical research applications. With the impactful developments of CRISPR and next-generation sequencing technology, disease modeling in zebrafish is accelerating the understanding of the molecular mechanisms of human genetic diseases. These efforts are fundamental for the future of precision medicine because they provide new diagnostic and therapeutic solutions. This review focuses on zebrafish disease models for biomedical research, mainly in developmental disorders, mental disorders, and metabolic diseases.
Animal models: Zebrafish help unlock clues to human disease
With their see-through bodies, low maintenance costs and genetic similarity to humans, zebrafish provide a powerful animal model for studying mental disorders and metabolic diseases in the laboratory. Tae-Young Choi from Wonkwang University, Iksan, South Korea, and coworkers review the many physiological advantages and logistical benefits of rearing these small tropical fish for biomedical research. These include the ease of tissue imaging, the large number of offspring in each generation and the increasing number of genetic techniques available. The researchers highlight the various ways in which zebrafish have contributed to scientists’ understanding of mental disorders and the communication pathways between brain and other organs in the body. They also discuss the potential of zebrafish for tracking metabolism and how it can go awry in various disease settings.
Journal Article
العملة المعجزة
يعد هذا الكتاب العملة المعجزة وهي قصة مخصصة للأطفال تستهدف الطفولة المبكرة وتعمل على استثمار الطفل في بناء المهارات المختلفة المرتبطة بالخيال والابتكار وقوة الشخصية والبحث عن حلول إبداعية ويستمد الطفل من خلالها الكثير من العلم والمعرفة والمعلومات ويعد من المنهج السلوكي التربوي رائع يعلم الطفل كيف يستخلص من مشكلاته.
BOOK
Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
Brain organoids derived from human pluripotent stem cells provide a highly valuable in vitro model to recapitulate human brain development and neurological diseases. However, the current systems for brain organoid culture require further improvement for the reliable production of high-quality organoids. Here, we demonstrate two engineering elements to improve human brain organoid culture, (1) a human brain extracellular matrix to provide brain-specific cues and (2) a microfluidic device with periodic flow to improve the survival and reduce the variability of organoids. A three-dimensional culture modified with brain extracellular matrix significantly enhanced neurogenesis in developing brain organoids from human induced pluripotent stem cells. Cortical layer development, volumetric augmentation, and electrophysiological function of human brain organoids were further improved in a reproducible manner by dynamic culture in microfluidic chamber devices. Our engineering concept of reconstituting brain-mimetic microenvironments facilitates the development of a reliable culture platform for brain organoids, enabling effective modeling and drug development for human brain diseases.
Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids. Here the authors combine human brain extracellular matrix and culture in a microfluidic device to promote structural and functional maturation of human brain organoids.
Journal Article
CRISPR-Knockout of CSE Gene Improves Saccharification Efficiency by Reducing Lignin Content in Hybrid Poplar
Caffeoyl shikimate esterase (CSE) has been shown to play an important role in lignin biosynthesis in plants and is, therefore, a promising target for generating improved lignocellulosic biomass crops for sustainable biofuel production. Populus spp. has two CSE genes (CSE1 and CSE2) and, thus, the hybrid poplar (Populus alba × P. glandulosa) investigated in this study has four CSE genes. Here, we present transgenic hybrid poplars with knockouts of each CSE gene achieved by CRISPR/Cas9. To knockout the CSE genes of the hybrid poplar, we designed three single guide RNAs (sg1–sg3), and produced three different transgenic poplars with either CSE1 (CSE1-sg2), CSE2 (CSE2-sg3), or both genes (CSE1/2-sg1) mutated. CSE1-sg2 and CSE2-sg3 poplars showed up to 29.1% reduction in lignin deposition with irregularly shaped xylem vessels. However, CSE1-sg2 and CSE2-sg3 poplars were morphologically indistinguishable from WT and showed no significant differences in growth in a long-term living modified organism (LMO) field-test covering four seasons. Gene expression analysis revealed that many lignin biosynthetic genes were downregulated in CSE1-sg2 and CSE2-sg3 poplars. Indeed, the CSE1-sg2 and CSE2-sg3 poplars had up to 25% higher saccharification efficiency than the WT control. Our results demonstrate that precise editing of CSE by CRISPR/Cas9 technology can improve lignocellulosic biomass without a growth penalty.
Journal Article
موزارت
لقد أظهر الموسيقي النمساوي موزارت موهبة عظيمة في الموسيقى منذ نعومة أظفاره وسافر حول أوروبا ليقدم أعماله الموسيقية، حين تقرأ قصة موزارت ستكون فكرة شاملة عن حياة هذا العبقري الموسيقي الذي ألف مسرحيات أوبرالية مذهلة وسيمفونيات رائعة في أحلك الظروف وتظهر لنا هذه القصة فكرة شاملة عن حياة العبقري الموسيقي موزارت، ألذ كما قلنا سلفا إنه صاحب موهبة عظيمة في الموسيقى منذ نعومة أظفاره وقد ألف موزارت مسرحيات أوبرالية مذهلة وسيمفونيات رائعة في أحلك الظروف.
Book
Molecular Mechanisms of Dermal Aging and Antiaging Approaches
The dermis is primarily composed of the extracellular matrix (ECM) and fibroblasts. During the aging process, the dermis undergoes significant changes. Collagen, which is a major component of ECM, becomes fragmented and coarsely distributed, and its total amount decreases. This is mainly due to increased activity of matrix metalloproteinases, and impaired transforming growth factor-β signaling induced by reactive oxygen species generated during aging. The reduction in the amount of collagen hinders the mechanical interaction between fibroblasts and the ECM, and consequently leads to the deterioration of fibroblast function and further decrease in the amount of dermal collagen. Other ECM components, including elastic fibers, glycosaminglycans (GAGs), and proteoglycans (PGs), also change during aging, ultimately leading to a reduction in the amount of functional components. Elastic fibers decrease in intrinsically aged skin, but accumulate abnormally in photoaged skin. The changes in the levels of GAGs and PGs are highly diverse, and previous studies have reported conflicting results. A reduction in the levels of functional dermal components results in the emergence of clinical aging features, such as wrinkles and reduced elasticity. Various antiaging approaches, including topicals, energy-based procedures, and dermal fillers, can restore the molecular features of dermal aging with clinical efficacy. This review summarizes the current understanding of skin aging at the molecular level, and associated treatments, to put some of the new antiaging technology that has emerged in this rapidly expanding field into molecular context.
Journal Article
Park Chan-kyong : Red Asia Complex
Park Chan-kyong is the second artist selected for the \"MMCA Artist Studies\" series. Since the late 1980s, Park has been a member of a community of critics writing art and organizing exhibitions through forums such as the Research Society for Art Criticism (misul bipyeong yeonguhoe), Forum A, BOL. Park took his first steps as an artist with the solo exhibition Black Box: The Memory of Cold War Images, held at the Kumho Museum in 1997, and has since continued to produce film and video works critically examining the Cold War, Korean modernity, and colonialism. Under the title Red Asia Complex, this book examines, from various perspectives, the nearly thirty-years trajectory of Park Chan-kyong's art and writing.--Gallery Website.
Premature ventricular contraction is associated with increased risk of atrial fibrillation: a nationwide population-based study
Premature ventricular contraction (PVC) and atrial fibrillation (AF) are common arrhythmias affecting 1–2% of the general population. During PVC, retrograde ventriculo-atrial activation can occur and act like an atrial ectopy. However, the clinical significance of this phenomenon is not fully understood. We aimed to elucidate whether the clinical diagnosis of PVC can increase the risk of new-onset AF. We performed a nationwide population-based analysis using the Korean National Health Insurance Service database. A total of 9,537,713 people without prior history of PVC and AF were identified. Among these people, 4135 developed PVC in 2009, and people with and without PVC were followed until 2018. People who had PVC showed an increased risk of new-onset AF as compared with people without PVC (hazard ratio [HR] = 2.705; 95% confidence interval [CI] = 2.428–3.013; p < 0.001). The risk of ischemic stroke was also significantly increased in people with PVC (HR 1.160; 95% CI 1.048–1.284; p = 0.0041). New-onset AF developed in 72 people (19.3%) among 374 people with PVC who had ischemic stroke during their follow-up. A significant interaction was observed between PVC and age with people < 65 years at greater risk of new-onset AF for having PVC. In this observational analysis, the risk of new-onset AF and ischemic stroke was increased in people with PVC. Additional evaluation to identify AF in people with PVC can be helpful.
Journal Article