Explore the vast range of titles available.

Hidradenitis suppurativa (HS) is a chronic inflammatory disorder characterized by painful nodules, sinus tracts, and scars occurring predominantly in intertriginous regions. The prevalence of HS is currently 0.053–4%, with a predominance in African-American women and has been linked to low socioeconomic status. The majority of the reported literature is  retrospective, population based, epidemiologic studies. In this regard, there is a need to establish a repository of biospecimens, which represent appropriate gender and racial demographics amongst HS patients. These efforts will diminish knowledge gaps in understanding the disease pathophysiology. Hence, we sought to outline a step-by-step protocol detailing how we established our HS biobank to facilitate the formation of other HS tissue banks. Equipping researchers with carefully detailed processes for collection of HS specimens would accelerate the accumulation of well-organized human biological material. Over time, the scientific community will have access to a broad range of HS tissue biospecimens, ultimately leading to more rigorous basic and translational research. Moreover, an improved understanding of the pathophysiology is necessary for the discovery of novel therapies for this debilitating disease. We aim to provide high impact translational research methodology for cutaneous biology research and foster multidisciplinary collaboration and advancement of our understanding of cutaneous diseases.

The full data set of the NEMO-3 experiment has been used to measure the half-life of the two-neutrino double beta decay of \\[^{100}\\]Mo to the ground state of \\[^{100}\\]Ru, \\[T_{1/2} = \\left[ 6.81 \\pm 0.01\\,\\left( \\text{ stat }\\right) ^{+0.38}_{-0.40}\\,\\left( \\text{ syst }\\right) \\right] \\times 10^{18}\\] year. The two-electron energy sum, single electron energy spectra and distribution of the angle between the electrons are presented with an unprecedented statistics of \\[5\\times 10^5\\] events and a signal-to-background ratio of \\[\\sim \\] 80. Clear evidence for the Single State Dominance model is found for this nuclear transition. Limits on Majoron emitting neutrinoless double beta decay modes with spectral indices of \\[\\mathrm{n}=2,3,7\\], as well as constraints on Lorentz invariance violation and on the bosonic neutrino contribution to the two-neutrino double beta decay mode are obtained.

The NEMO-3 results for the double-$\\beta $ decay of $^{150}$Nd to the 0$^+_1$ and 2$^+_1$ excited states of $^{150}$Sm are reported. The data recorded during 5.25 year with 36.6 g of the isotope $^{150}$Nd are used in the analysis. The signal of the $2\\nu \\beta \\beta $ transition to the 0$^+_1$ excited state is detected with a statistical significance exceeding 5$\\sigma $. The half-life is measured to be $T_{1/2}^{2\\nu \\beta \\beta }(0^+_1) = \\left[ 1.11 ^{+0.19}_{-0.14} \\,\\left( \\hbox {stat}\\right) ^{+0.17}_{-0.15}\\,\\left( \\hbox {syst}\\right) \\right] \\times 10^{20}$ year, which is the most precise value that has been measured to date. 90% confidence-level limits are set for the other decay modes. For the $2\\nu \\beta \\beta $ decay to the 2$^+_1$ level the limit is $T^{2\\nu \\beta \\beta }_{1/2}(2^+_1) > 2.42 \\times 10^{20}~\\hbox {year}$. The limits on the $0\\nu \\beta \\beta $ decay to the 0$^+_1$ and 2$^+_1$ levels of $^{150}$Sm are significantly improved to $T_{1/2}^{0\\nu \\beta \\beta }(0^+_1) > 1.36 \\times 10^{22}~\\hbox {year}$ and $T_{1/2}^{0\\nu \\beta \\beta }(2^+_1) > 1.26 \\times 10^{22}~\\hbox {year}$.

The possibility to probe new physics scenarios of light Majorana neutrino exchange and right-handed currents at the planned next generation neutrinoless double β decay experiment SuperNEMO is discussed. Its ability to study different isotopes and track the outgoing electrons provides the means to discriminate different underlying mechanisms for the neutrinoless double β decay by measuring the decay half-life and the electron angular and energy distributions.

The NEMO-3 results for the double- β decay of 150 Nd to the 0 1 + and 2 1 + excited states of 150 Sm are reported. The data recorded during 5.25 year with 36.6 g of the isotope 150 Nd are used in the analysis. The signal of the 2 ν β β transition to the 0 1 + excited state is detected with a statistical significance exceeding 5 σ . The half-life is measured to be T 1 / 2 2 ν β β ( 0 1 + ) = 1 . 11 - 0.14 + 0.19 stat - 0.15 + 0.17 syst × 10 20  year, which is the most precise value that has been measured to date. 90% confidence-level limits are set for the other decay modes. For the 2 ν β β decay to the 2 1 + level the limit is T 1 / 2 2 ν β β ( 2 1 + ) > 2.42 × 10 20 year . The limits on the 0 ν β β decay to the 0 1 + and 2 1 + levels of 150 Sm are significantly improved to T 1 / 2 0 ν β β ( 0 1 + ) > 1.36 × 10 22 year and T 1 / 2 0 ν β β ( 2 1 + ) > 1.26 × 10 22 year .

The NEMO-3 results for the double-$$\\beta $$β decay of$$^{150}$$150 Nd to the 0$$^+_1$$1 + and 2$$^+_1$$1 + excited states of$$^{150}$$150 Sm are reported. The data recorded during 5.25 year with 36.6 g of the isotope$$^{150}$$150 Nd are used in the analysis. The signal of the$$2\\nu \\beta \\beta $$2 ν β β transition to the 0$$^+_1$$1 + excited state is detected with a statistical significance exceeding 5$$\\sigma $$σ . The half-life is measured to be$$T_{1/2}^{2\\nu \\beta \\beta }(0^+_1) = \\left[ 1.11 ^{+0.19}_{-0.14} \\,\\left( \\hbox {stat}\\right) ^{+0.17}_{-0.15}\\,\\left( \\hbox {syst}\\right) \\right] \\times 10^{20}$$T 1 / 2 2 ν β β ( 0 1 + ) = 1 . 11 - 0.14 + 0.19 stat - 0.15 + 0.17 syst × 10 20  year, which is the most precise value that has been measured to date. 90% confidence-level limits are set for the other decay modes. For the$$2\\nu \\beta \\beta $$2 ν β β decay to the 2$$^+_1$$1 + level the limit is$$T^{2\\nu \\beta \\beta }_{1/2}(2^+_1) > 2.42 \\times 10^{20}~\\hbox {year}$$T 1 / 2 2 ν β β ( 2 1 + ) > 2.42 × 10 20 year . The limits on the$$0\\nu \\beta \\beta $$0 ν β β decay to the 0$$^+_1$$1 + and 2$$^+_1$$1 + levels of$$^{150}$$150 Sm are significantly improved to$$T_{1/2}^{0\\nu \\beta \\beta }(0^+_1) > 1.36 \\times 10^{22}~\\hbox {year}$$T 1 / 2 0 ν β β ( 0 1 + ) > 1.36 × 10 22 year and$$T_{1/2}^{0\\nu \\beta \\beta }(2^+_1) > 1.26 \\times 10^{22}~\\hbox {year}$$T 1 / 2 0 ν β β ( 2 1 + ) > 1.26 × 10 22 year .

Abstract The NEMO-3 results for the double- $$\\beta $$ β decay of $$^{150}$$ 150 Nd to the 0 $$^+_1$$ 1 + and 2 $$^+_1$$ 1 + excited states of $$^{150}$$ 150 Sm are reported. The data recorded during 5.25 year with 36.6 g of the isotope $$^{150}$$ 150 Nd are used in the analysis. The signal of the $$2\\nu \\beta \\beta $$ 2 ν β β transition to the 0 $$^+_1$$ 1 + excited state is detected with a statistical significance exceeding 5 $$\\sigma $$ σ . The half-life is measured to be $$T_{1/2}^{2\\nu \\beta \\beta }(0^+_1) = \\left[ 1.11 ^{+0.19}_{-0.14} \\,\\left( \\hbox {stat}\\right) ^{+0.17}_{-0.15}\\,\\left( \\hbox {syst}\\right) \\right] \\times 10^{20}$$ T 1 / 2 2 ν β β ( 0 1 + ) = 1 . 11 - 0.14 + 0.19 stat - 0.15 + 0.17 syst × 10 20  year, which is the most precise value that has been measured to date. 90% confidence-level limits are set for the other decay modes. For the $$2\\nu \\beta \\beta $$ 2 ν β β decay to the 2 $$^+_1$$ 1 + level the limit is $$T^{2\\nu \\beta \\beta }_{1/2}(2^+_1) > 2.42 \\times 10^{20}~\\hbox {year}$$ T 1 / 2 2 ν β β ( 2 1 + ) > 2.42 × 10 20 year . The limits on the $$0\\nu \\beta \\beta $$ 0 ν β β decay to the 0 $$^+_1$$ 1 + and 2 $$^+_1$$ 1 + levels of $$^{150}$$ 150 Sm are significantly improved to $$T_{1/2}^{0\\nu \\beta \\beta }(0^+_1) > 1.36 \\times 10^{22}~\\hbox {year}$$ T 1 / 2 0 ν β β ( 0 1 + ) > 1.36 × 10 22 year and $$T_{1/2}^{0\\nu \\beta \\beta }(2^+_1) > 1.26 \\times 10^{22}~\\hbox {year}$$ T 1 / 2 0 ν β β ( 2 1 + ) > 1.26 × 10 22 year .

The double-beta decay of 82Se to the 0+1 excited state of 82Kr has been studied with the NEMO-3 detector using 0.93 kg of enriched 82Se measured for 4.75 y, corresponding to an exposure of 4.42 kg y. A dedicated analysis to reconstruct the gamma-rays has been performed to search for events in the 2e2g channel. No evidence of a 2nbb decay to the 0+1 state has been observed and a limit of T2n 1/2(82Se; 0+gs -> 0+1) > 1.3 1021 y at 90% CL has been set. Concerning the 0nbb decay to the 0+1 state, a limit for this decay has been obtained with T0n 1/2(82Se; 0+g s -> 0+1) > 2.3 1022 y at 90% CL, independently from the 2nbb decay process. These results are obtained for the first time with a tracko-calo detector, reconstructing every particle in the final state.

SuperNEMO is a double-\\(\\beta\\) decay experiment, which will employ the successful tracker-calorimeter technique used in the recently completed NEMO-3 experiment. SuperNEMO will implement 100 kg of double-\\(\\beta\\) decay isotope, reaching a sensitivity to the neutrinoless double-\\(\\beta\\) decay (\\(0\\nu\\beta\\beta\\)) half-life of the order of \\(10^{26}\\) yr, corresponding to a Majorana neutrino mass of 50-100 meV. One of the main goals and challenges of the SuperNEMO detector development programme has been to reach a calorimeter energy resolution, \\(\\Delta\\)E/E, around 3%/\\(sqrt(E)\\)(MeV) \\(\\sigma\\), or 7%/\\(sqrt(E)\\)(MeV) FWHM (full width at half maximum), using a calorimeter composed of large volume plastic scintillator blocks coupled to photomultiplier tubes. We describe the R\\&D programme and the final design of the SuperNEMO calorimeter that has met this challenging goal.

The BiPo-3 detector, running in the Canfranc Underground Laboratory (Laboratorio Subterráneo de Canfranc, LSC, Spain) since 2013, is a low-radioactivity detector dedicated to measuring ultra low natural radionuclide contaminations of \\(^{208}\\)Tl (\\(^{232}\\)Th chain) and \\(^{214}\\)Bi (\\(^{238}\\)U chain) in thin materials. The total sensitive surface area of the detector is 3.6 m\\(^2\\). The detector has been developed to measure radiopurity of the selenium double \\(\\beta\\)-decay source foils of the SuperNEMO experiment. In this paper the design and performance of the detector, and results of the background measurements in \\(^{208}\\)Tl and \\(^{214}\\)Bi, are presented, and validation of the BiPo-3 measurement with a calibrated aluminium foil is discussed. Results of the \\(^{208}\\)Tl and \\(^{214}\\)Bi activity measurements of the first enriched \\(^{82}\\)Se foils of the double \\(\\beta\\)-decay SuperNEMO experiment are reported. The sensitivity of the BiPo-3 detector for the measurement of the SuperNEMO \\(^{82}\\)Se foils is \\(\\mathcal{A}\\)(\\(^{208}\\)Tl) \\(<2\\) \\(\\mu\\)Bq/kg (90\\% C.L.) and \\(\\mathcal{A}\\)(\\(^{214}\\)Bi) \\(<140\\) \\(\\mu\\)Bq/kg (90\\% C.L.) after 6 months of measurement.