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Nitrogen (N) dominates Earth's atmosphere (78% N2) but occurs in trace abundances in silicate minerals, making it a sensitive tracer of recycled surface materials into the mantle. The mechanisms controlling N transfer between terrestrial reservoirs remain uncertain because low N abundances in mineral‐hosted fluid inclusions (FIs) are difficult to measure. Using new techniques, we analyzed N and He isotope compositions and abundances in olivine‐ and pyroxene‐hosted FIs from arc volcanoes in Southern Chile, Cascadia, Central America, and the Southern Marianas. These measurements enable an estimate of the global flux of N outgassing from arcs (4.0 × 1010 mol/yr). This suggests that Earth is currently in a state of net N ingassing, with roughly half of subducted N returned to the mantle. Additionally, the N outgassing flux of individual arcs correlates with the thickness of subducting pelagic sediment, suggesting that N cycling in the modern solid Earth is largely controlled by sediment subduction. Plain Language Summary Nitrogen (N) largely behaves like an inert gas, and so it is substantially more concentrated at Earth's surface than in Earth's deep interior. Over geologic time, N can be transported between the solid Earth and the surface, and its concentration can change in both of these settings. Volcanic gases transport N from the interior to the surface, while some surface N returns into the solid Earth via plate subduction. Here, we present measurements of N and helium (He) gas trapped within crystals in volcanic rocks to determine how much N is transported to the surface through volcanism associated with plate subduction. We find that the amount of N returning to the surface through volcanism is less than estimates of how much N is transported into the solid Earth, suggesting that, overall, N is being returned to the planet's deep interior. Additionally, we observe that the amount of oceanic sediment that is subducted correlates with the amount of N that comes out of volcanoes, making it the primary carrier of N into the solid Earth. Key Points Arc lavas yield fluxes of 4.0 × 1010 mol N/yr, similar to estimates from volcanic arc gases, likely resulting in net mantle ingassing of N Nitrogen isotopes and N‐He mixing models highlight that small contributions of sediment dominate volcanic arc N budgets Subducted sediment thickness correlates with N2/3He ratios, and likely controls arc N fluxes rather than slab parameters or thermal state

The Miocene Columbia River Basalt Group (CRBG) of the Pacific Northwest of the United States is the world’s youngest and smallest large igneous province. Its earliest formations are the Imnaha, Steens, and now the Picture Gorge Basalt (PGB), and they were sourced from three different dike swarms exposed from SE Washington to Nevada to northcentral Oregon. PGB is often viewed to be distinct from the other formations, as its magmas are sourced from a shallow, relatively depleted, and later subduction-induced metasomatized mantle, along with its young stratigraphic position. It has long been known that the lowermost American Bar flows (AB1&2) of the Imnaha Basalt are chemically similar to those of the PGB, yet the Imnaha Basalt is generally thought to carry the strongest plume source component. These opposing aspects motivated us to revisit the compositional relationships between AB1&2 and PGB. Our findings suggest that tapping a shallow, variably depleted, and metasomatized mantle reservoir to produce earliest CRBG lavas occurred across the province, now pinpointed to ~17 Ma. Moreover, compositional provinciality exists indicating regional differences in degree of depletion and subduction overprint that is preserved by regionally distributed lavas, which in turn implies relatively local lava emplacement at this stage.

The Columbia River Basalt Group (CRBG) is the youngest continental flood basalt province, proposed to be sourced from the deep-seated plume that currently resides underneath Yellowstone National Park. If so, the earliest erupted basalts from this province, such as those in the Picture Gorge Basalt (PGB), aid in understanding and modeling plume impingement and the subsequent evolution of basaltic volcanism. Using geochemical and isotopic data, this study explores potential mantle sources and magma evolution of the PGB. Long known geochemical signatures of the PGB include overall large ion lithophile element (LILE) enrichment and relative depletion of high field strength elements (HFSE) typical of other CRBG main-phase units. Basaltic samples of the PGB have 87Sr/86Sr ratios on the low end of the range displayed by other CRBG lavas and mantle-like δ18O values. The relatively strong enrichment of LILE and depletion of HFSE coupled with depleted isotopic signatures suggest a metasomatized upper mantle as the most likely magmatic source for the PGB. Previous geochemical modeling of the PGB utilized the composition of two high-MgO primitive dikes exposed in the northern portion of the Monument Dike swarm as parental melt. However, fractionation of these dike compositions cannot generate the compositional variability illustrated by basaltic lavas and dikes of the PGB. This study identifies a second potential parental PGB composition best represented by basaltic flows in the extended spatial distribution of the PGB. This composition also better reflects the lowest stratigraphic flows identified in the previously mapped extent of the PGB. Age data reveal that PGB lavas erupted first and throughout eruptions of main-phase CRBG units (Steens, Imnaha, Grande Ronde Basalt). Combining geochemical signals with these age data indicates cyclical patterns in the amounts of contributing mantle components. Eruption of PGB material occurred in two pulses, demonstrated by a ~0.4 Ma temporal gap in reported ages, 16.62 to 16.23 Ma. Coupling ages with observed geochemical signals, including relative elemental abundances of LILE, indicates increased influence of a more primitive, potentially plume-like source with time.

The Columbia River Basalt Group (CRBG) is the youngest and volumetrically smallest continental flood basalt exposed across the Pacific Northwest, USA. Similar to other large igneous provinces, the majority of material erupted during the initial 1 million years of activity, these lavas are subdivided into four main-phase units. The Picture Gorge Basalt (PGB) is the only main-phase unit of the CRBG whose age is not precisely known and understanding of PGB petrogenesis is largely based on a limited number of samples when compared with other main-phase units. It is suggested that a time gap of over 0.5 myr existed between eruptions of Steens Basalt and PGB (Wolff et al., 2013), however my initial results suggest otherwise as I have identified PGB interstratified between Steens Basalt flows in added extent near the Malheur Gorge.Age constraint is critical to developing a petrologic and eruptive model that supports the geochemical data. Geochronological work via 40Ar-39Ar analysis constrains the timing of PGB eruptions and demonstrates that these lavas were the earliest and had the longest eruptive interval. Eruptions of PGB lavas span approximately 1.4 million years, potentially occurring as two discrete pulses. The first pulse occurred as the initial pulse of CRBG eruptive activity, and the second erupted contemporaneous with the Grande Ronde Basalt. This corroborates previous field observations of PGB and Grande Ronde Basalt lavas being interstratified, as the youngest PGB age ranges down to 15.76 ± 0.11 Ma. The spatial distribution of PGB lavas were thought to be relatively confined to the type locality of Picture Gorge in eastern Oregon. However newly identified basaltic lavas and dikes geochemically correlative to the PGB indicates this CRBG unit covers a larger areal extent than previously recognized. Combining stratigraphic correlation and geochemical similarities with 40Ar/39Ar geochronology, I am able to extrapolate the spatial extent of early and later PGB eruptions to newly correlated PGB lava flows and dikes. With the oldest age of 17.23 ± 0.04 Ma, the PGB erupted earlier and longer than other CRBG main-phase unit, and CRBG volcanism initiated over a broad region that includes Picture Gorge.Geochemical and isotopic signatures observed in the PGB suggest contributions from two primitive (Mg# >58) compositional groups. Based on MELTS modeling, these basaltic compositions produce two different evolutionary patterns. The geochemical diversity of the PGB however cannot be attributed exclusively to fractionation of either composition, and PGB magmas were likely modified by crustal contamination. The wide distribution of PGB volcanism was likely the result of PGB lavas traveling further than previously recognized, although local tapping of a similar mantle to produce PGB-like lavas is also plausibleThis research identifies three primary hypotheses, 1. Lava flows and dikes of the PGB were emplaced earlier than previously recognized and have a longer eruptive duration based on observed stratigraphic relationships, 2. Newly identified exposures of volcanic material geochemically correlated to PGB suggests this CRBG unit erupted across a wide spatial footprint of eastern Oregon, and therefore reflects a larger volume of this continental flood basalt, and 3. There is more than one significant contributing mantle component which yields PGB, and isotopic differences suggest that contributing components were not all depleted. The broader significance of this work expands the initial magmatic footprint for CRBG eruptions and highlights two temporal pulses of eruptive activity in PGB volcanism, also demonstrated by all CRBG ages. The revised distribution area of PGB increases the total eruptive volume of this continental flood basalt and when coupled with ages illustrates a clearer picture of spatial and temporal relationships to other main-phase CRBG units. Geochemical signatures in PGB lavas indicate at least two mantle components which reflect fluctuations in their contributions through time.

Background Although the photosensitising effects of oestrogens may increase the impact of ultraviolet radiation (UVR) on melanoma risk, few prospective studies have comprehensively assessed the association between oestrogen-related factors and melanoma. Methods We examined the associations between reproductive factors, exogenous oestrogen use and first primary invasive melanoma among 167 503 non-Hispanic white, postmenopausal women in the NIH-AARP Diet and Health Study. Satellite-based ambient UVR estimates were linked to geocoded residential locations of participants at study baseline. Results Increased risk of melanoma was associated with early age at menarche (≤10 vs ≥15 years: HR = 1.25, 95% CI: 0.92, 1.71; P for trend = 0.04) and late age at menopause (≥50 vs <45 years: HR = 1.34, 95% CI: 1.13, 1.59; P for trend = 0.001). The relationship between ambient UVR and melanoma risk was highest among women with age at menarche ≤10 years (HR per UVR quartile increase = 1.29; 95% CI: 1.05, 1.58; P -interaction = 0.02). Melanoma risk was not associated with parity, age at first birth, use of oral contraceptives or use of menopausal hormone therapy. Conclusions Our findings suggest that increased melanoma risk is associated with early age at menarche and late age at menopause. Effect modification findings support the hypothesis that endogenous oestrogen exposure in childhood increases photocarcinogenicity. Future studies should include information on personal UVR exposure and sun sensitivity.

The synaptonemal complex (SC) is a conserved meiotic structure that regulates the repair of double-strand breaks (DSBs) into crossovers or gene conversions. The removal of any central-region SC component, such as the Drosophila melanogaster transverse filament protein C(3)G, causes a complete loss of SC structure and crossovers. To better understand the role of the SC in meiosis, we used CRISPR/Cas9 to construct 3 in-frame deletions within the predicted coiled-coil region of the C(3)G protein. Since these 3 deletion mutations disrupt SC maintenance at different times during pachytene and exhibit distinct defects in key meiotic processes, they allow us to define the stages of pachytene when the SC is necessary for homolog pairing and recombination during pachytene. Our studies demonstrate that the X chromosome and the autosomes display substantially different defects in pairing and recombination when SC structure is disrupted, suggesting that the X chromosome is potentially regulated differently from the autosomes.

Mitochondria regulate a myriad of cellular functions. Dysregulation of mitochondrial control within airway epithelial cells has been implicated in the pro-inflammatory response to allergens in asthma patients. Because of their multifaceted nature, mitochondrial structure must be tightly regulated through fission and fusion. Dynamin Related Protein 1 (DRP1) is a key driver of mitochondrial fission. During allergic asthma, airway epithelial mitochondria appear smaller and structurally altered. The role of DRP1-mediated mitochondrial fission, however, has not been fully elucidated in epithelial response to allergens. We used a Human Bronchial Epithelial Cell line (HBECs), primary Mouse Tracheal Epithelial Cells (MTECs), and conditional DRP1 ablation in lung epithelial cells to investigate the impact of mitochondrial fission on the pro-inflammatory response to house dust mite (HDM) in vitro and in vivo. Our data suggest that, following HDM challenge, mitochondrial fission is rapidly upregulated in airway epithelial cells and precedes production of pro-inflammatory cytokines and chemokines. Further, deletion of Drp1 in lung epithelial cells leads to decreased fission and enhanced pro-inflammatory signaling in response to HDM in vitro, as well as enhanced airway hyper-responsiveness (AHR), inflammation, differential mucin transcription, and epithelial cell death in vivo. Mitochondrial fission, therefore, regulates the lung epithelial pro-inflammatory response to HDM.

Background: There are few modifiable risk factors for Hodgkin lymphoma (HL), the most common cancer among young adults in Western populations. Some studies have found a reduced risk with exposure to ultraviolet radiation (UVR), but findings have been inconsistent and limited to HL as a group or the most common subtypes. Methods: We evaluated UVR and incidence of HL subtypes using data from 15 population-based cancer registries in the United States from 2001 to 2010 ( n =20 021). Ground-based ambient UVR estimates were linked to county of diagnosis. Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated for UVR quintiles using Poisson regression models adjusted for age, sex, race/ethnicity, diagnosis year, and registry. Results: Hodgkin lymphoma incidence was lower in the highest UVR quintile for nodular sclerosis (IRR=0.84, 95% CI=0.75–0.96, P -trend<0.01), mixed cellularity/lymphocyte-depleted (IRR=0.66, 95% CI=0.51–0.86, P -trend=0.11), lymphocyte-rich (IRR=0.71, 95% CI=0.57–0.88, P -trend<0.01), and nodular lymphocyte predominant HL (IRR=0.74, 95% CI=0.56–0.97, P -trend<0.01), but ‘not otherwise specified’ HL (IRR=1.19, 95% CI=0.96–1.47, P -trend=0.11). Conclusions: This is the largest study of UVR and HL subtypes covering a wide range of UVR levels; however, we lack information on personal UVR and other individual risk factors. These findings support an inverse association between UVR and HL.