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Ionospheric oblique backscatter sounding is an effective means of monitoring the ionosphere which can be used as a frequency selection system to serve HF communication and ensure its quality and stability. But how to obtain effective information from the oblique backscatter ionogram is still a hot issue. Due to this situation, a frequency selecting method for HF communication based on ionospheric oblique backscatter sounding is proposed in this study. After obtaining the ionograms, pattern recognition is used to separate the vertical echoes and the oblique backscatter echoes. Next, the leading edge of the oblique backscatter echoes are extracted, and then a two-dimensional electron density profile can be reconstructed. Then, with the help of ray tracing, the usable frequency range can be estimated. Finally, according to the signal-to-noise ratio reflected by the ionograms, several optimal communication frequencies can be selected. In order to verify this method, oblique ionograms are obtained through oblique sounding experiments to evaluate its accuracy. The result indicates that the usable frequency range and the selected frequencies are in accordance with the echo of the oblique ionogram, so the practicability and accuracy of the method are validated. Eventually, the maximum usable frequencies (MUFs) obtained from oblique backscatter sounding are compared with the MUFs from the oblique sounding ionogram; its Mean Absolute Percentage Error (MAPE) is 7.8% and its root mean squared error (RMSE) is 1.34 MHz.

The skin undertakes a safeguard against external dangers, sensations, and symbols of beauty and health, and different cosmetics provide targeted solutions to various skin problems. However, synthetic pigment and chemical components in cosmetics can harm sensitive skin, resulting in further damage to the skin. Anthocyanins are natural pigments that possess vivid colors, excellent bioactivity, and the absence of toxicity. Therefore, anthocyanins have garnered considerable interest owing to their potential applications in cosmetics for dermatological conditions and aesthetic purposes. This review aims to comprehensively summarize studies and advancements in the use of anthocyanins in cosmetics and their potential future directions. These findings confirmed the bioactivity of anthocyanins against photodamage and melanogenesis and revealed the underlying mechanism. Additionally, anthocyanins were found to have great potential as one colorant, but their use is limited by their low lipophilicity and susceptibility to high temperature and variations in pH. Future research should prioritize anthocyanin stabilization, pyranoanthocyanin use, and investigation of the effects of anthocyanins on the gut-skin axis. This review advances our understanding of the application of anthocyanins as functional pigments in cosmetics and provides a scientific basis for the potential use of anthocyanins to improve skin function.

Introduction Dent disease type I is a rare X-linked recessive renal tubular disease resulting from pathogenic variants in the CLCN5 gene. Due to the rarity of Dent disease type I and the diversity of its phenotypes, its clinical diagnosis is complex and poses a challenge to clinicians. Methods A foetus and a child from a 36-year-old pregnant woman with a birth history of abnormal children were enrolled in this study. Pregnant women undergo amniocentesis for prenatal diagnosis at the gestational age of 12 + 3 weeks. Chromosomal microarray (CMA) analysis and whole-exome sequencing (WES) were employed to investigate the chromosomal copy number and single gene variants. Literature retrieval and data analysis were performed for genotype and phenotype collection analysis. Results No chromosomal abnormalities or CNVs were detected in the entire family through karyotype and familial CMA analyses. WES identified a nonsense pathogenic variant in CLCN5 of the X chromosome, c.1942 C > T (exon 11, NM_000084), which was inherited from his mother, who exhibited regular clinical features. Conclusion This study suggests that children with low-molecular-weight proteinuria and hypercalciuria should undergo prompt genetic testing to exclude Dent disease.

IL-13 is a proinflammatory cytokine associated with multiple pathological conditions and the promotion of metastasis in lung cancer. Previous studies have demonstrated that IL-13 and YY1 are associated with PI3K/AKT signaling. In addition, miR-29a has been found to play a critical role in cell invasion in lung cancer. However, the molecular mechanism of miR-29a underlying its involvement in IL-13-induced lung cancer cell invasion remains largely unknown. In the present study, we aimed to investigate the role of miR-29a in cell invasion mediated by IL-13 in lung cancer. By using MTT and wound-scratch assays, we assessed cell proliferation and migration induced by IL-13, and identified activation of the PI3K/AKT/YY1 pathway. Inhibition of PI3K/AKT by LY294002 downregulated IL-13-induced YY1 expression. Furthermore, we found that miR-29a directly targets YY1 and suppressed its expression in lung cancer. By using MTT, flow cytometry and Transwell assays, overexpression of miR-29a restricted both YY1 and N-cadherin expression, and inhibited IL-13-induced invasion of lung cancer A549 cells. Taken together, these findings demonstrate that PI3K/AKT/YY1 is involved in the regulation of lung cancer cell behavior induced by IL-13, and miR-29a represents a promising therapeutic target.

Difficulty in resolving spatially overlapping barcodes is a major bottleneck for imaging-based spatial genomics methods. Here, we present an approach for untangling overlapping barcodes by using strong encoding and global optimization to reduce spurious solutions resulting from recombinations of barcodes. We demonstrate experimentally that cellular regions with average local densities of 127 barcodes per can be decoded with an estimated FDR of less than , enabling a new type of super-resolution microscopy by coding.