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Quantum phase transitions (QPTs) are usually associated with many-body systems in the thermodynamic limit when their ground states show abrupt changes at zero temperature with variation of a parameter in the Hamiltonian. Recently it has been realized that a QPT can also occur in a system composed of only a two-level atom and a single-mode bosonic field, described by the quantum Rabi model (QRM). Here we report an experimental demonstration of a QPT in the QRM using a 171 Yb + ion in a Paul trap. We measure the spin-up state population and the average phonon number of the ion as two order parameters and observe clear evidence of the phase transition via adiabatic tuning of the coupling between the ion and its spatial motion. An experimental probe of the phase transition in a fundamental quantum optics model without imposing the thermodynamic limit opens up a window for controlled study of QPTs and quantum critical phenomena. Quantum phase transition occurs in many-body systems with abrupt changes in the ground state around zero temperature. Here the authors report signatures of quantum phase transition in single trapped ion that can be described using quantum Rabi model.

The epithelial-mesenchymal transition (EMT) is crucial to cancer progression and metastasis. Although multiple cellular miRNAs have been identified to regulate the EMT and metastasis in cancers, the role of viral miRNAs in cancer progression remains largely unknown. Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated malignancy typically characterized by its early metastasis. In the present study, we have discovered the involvement of a viral miRNA, EBV-miR-BART7-3p, in the EMT and metastasis of NPC cells. Initially, we observed that EBV-miR-BART7-3p was highly expressed in NPC and positively correlated with lymph node metastasis and clinical stage of NPC. Subsequently, we demonstrated that EBV-miR-BART7-3p enhanced cell migration/invasion in vitro , cancer metastasis in vivo , and particularly the EMT characterized by loss of epithelial markers and gain of mesenchymal features in NPC cells. Furthermore, mechanistic studies disclosed that EBV-miR-BART7-3p targeted a major human tumor suppressor PTEN, modulating PI3K/Akt/GSK-3β signaling and eventually leading to the high expression and nuclear accumulation of Snail and β-catenin, which favor EMT. Knockdown of PTEN could phenocopy the effect of EBV-miR-BART7-3p, whereas re-expression of PTEN resulted in a phenotypic reversion. Moreover, these findings were supported by an observation of an EBV-positive cell model in which silencing of endogenous EBV-miR-BART7-3p partially attenuated cell migration/invasion and altered EMT protein expression pattern via reverting PI3K/Akt, Snail and β-catenin expression. Thus, this study suggests a novel mechanism by which EBV-miR-BART7-3p modulates the EMT and metastasis of NPC cells, and a clinical implication of EBV-miR-BART7-3p as a potential biomarker or therapeutic target.

Supersymmetry (SUSY) helps solve the hierarchy problem in high-energy physics and provides a natural groundwork for unifying gravity with other fundamental interactions. While being one of the most promising frameworks for theories beyond the Standard Model, its direct experimental evidence in nature still remains to be discovered. Here we report experimental realization of a supersymmetric quantum mechanics (SUSY QM) model, a reduction of the SUSY quantum field theory for studying its fundamental properties, using a trapped ion quantum simulator. We demonstrate the energy degeneracy caused by SUSY in this model and the spontaneous SUSY breaking. By a partial quantum state tomography of the spin-phonon coupled system, we explicitly measure the supercharge of the degenerate ground states, which are superpositions of the bosonic and the fermionic states. Our work demonstrates the trapped-ion quantum simulator as an economic yet powerful platform to study versatile physics in a single well-controlled system. Quantum simulators should be able to give insight on exotic physics models such as supersymmetric extensions of Standard Model. Here, the authors demonstrate a first step in this direction, realising a prototypical SUSY model (and spontaneous SUSY breaking within it) using a trapped ion quantum simulator.

A new framework for adopting inertial sensors in a clinical test was proposed and tested in this study. A self-assembled-and-coded, inertial sensor-based wearable system was validated by comparing it with a commercialized optical tracking apparatus. Twenty-five post-stroke patients were enrolled in a clinical walk test while wearing this validated system to simultaneously assess the affected lower extremities’ functional walk competency through extracted kinematic parameters. Their average walking speeds were correlated with various gait parameters, such as the ranges of motion of the individual joints along the sagittal plane and the low back motion. The validation results proved this developed system is precise and accurate. The average walking speeds showed a modest correlation with the range of motion of the hip (r = 0.33) and a moderate and negative correlation with the motion along the coronal plane of the low back (r = -0.55). Thus, this framework supports a new method to adopt wearable devices for clinical application. It also broadens the application of the clinical walk test as an integral assessment tool for assessing functional walking competency and gait parameters, which is feasible for rehabilitation canters to monitor post-stroke patients.

As widely used pesticides, organophosphate, pyrethroid, and neonicotinoid insecticides have different modes of action. In the present study, we evaluated individual and joint acute toxicities of two organophosphates, two pyrethroids, and two neonicotinoids against the second-instar silkworm by feeding silkworm with the insecticide-treated mulberry leaves. The 96-h lethal concentration 50 (LC50) values of chlorpyrifos, acephate, imidacloprid, thiamethoxam, cypermethrin, and deltamethrin against silkworm were 3.45 (2.95–4.31), 44.45 (39.34–48.56), 1.27 (1.19–1.35), 2.38 (2.19–2.54), 0.36 (0.30–0.43), and 0.037 (0.033–0.041) mg/liter, respectively. Moreover, the 96-h LC50 values of 50:50 binary mixtures of insecticides against silkworm ranged from 0.048 (0.043–0.054) to 3.52 (2.09–4.51) mg/liter. In addition, the combination coefficient (Q) values of all tested mixtures ranged from 0.36 to 3.37. According to the obtained Q values, the binary mixture of deltamethrin–chlorpyrifos showed antagonistic effects at 96-h interval, while the other binary mixtures had additive effects. Taken together, our results provided valuable guidelines in assessing the ecological risk of these insecticide mixtures against silkworm.

Respiratory dysfunction caused by high spinal cord injury is fatal damage. Three treatment methods commonly used in the clinic, diaphragm pacing, mechanical ventilation, and respiratory muscle training, were chosen to explain the respiratory function reconstruction of spinal cord injury. The characteristics, research status, advantages, and disadvantages of these three treatment methods are reviewed. Diaphragm pacing technology has attracted much attention due to its price-friendly, efficient, and closer to physiological respiration. Therefore, the emphasis is on describing the characteristics of the stimulation waveform of diaphragm pacing and the mathematical correspondence between stimulation parameters (pulse interval, inspiratory time, etc.) and tidal volume. Meanwhile, it also briefly introduces that for patients with SCI with poor diaphragm pacing, intercostal muscle pacing can be used as the second option to restore respiratory function. Also, the development of electronic technology has promoted the emergence of closed-loop diaphragm pacing technology. Finally, we propose that the method of respiratory function reconstruction after spinal cord injury should pay more attention to physiology and the safety of surgery.

Jaynes-Cummings-Hubbard (JCH) model is a fundamental many-body model for light-matter interaction. As a leading platform for quantum simulation, the trapped ion system has realized the JCH model for two to three ions. Here we report the quantum simulation of the JCH model using up to 32 ions. We verify the simulation results even for large ion numbers by engineering low excitations and thus low effective dimensions; then we extend to 32 excitations for an effective dimension of \\(2^{77}\\), which is difficult for classical computers. By regarding the phonon modes as baths, we explore Markovian or non-Markovian spin dynamics in different parameter regimes of the JCH model, similar to quantum emitters in a structured photonic environment. We further examine the dependence of the non-Markovian dynamics on the effective Hilbert space dimension. Our work demonstrates the trapped ion system as a powerful quantum simulator for many-body physics and open quantum systems.

Supersymmetry (SUSY) helps solve the hierarchy problem in high-energy physics and provides a natural groundwork for unifying gravity with other fundamental interactions. While being one of the most promising frameworks for theories beyond the Standard Model, its direct experimental evidence in nature still remains to be discovered. Here we report experimental realization of a supersymmetric quantum mechanics (SUSY QM) model, a reduction of the SUSY quantum field theory for studying its fundamental properties, using a trapped ion quantum simulator. We demonstrate the energy degeneracy caused by SUSY in this model and the spontaneous SUSY breaking. By a partial quantum state tomography of the spin-phonon coupled system, we explicitly measure the supercharge of the degenerate ground states, which are superpositions of the bosonic and the fermionic states. Our work demonstrates the trapped-ion quantum simulator as an economic yet powerful platform to study versatile physics in a single well-controlled system.

Quantum simulation of 1D relativistic quantum mechanics has been achieved in well-controlled systems like trapped ions, but properties like spin dynamics and response to external magnetic fields that appear only in higher dimensions remain unexplored. Here we simulate the dynamics of a 2D Weyl particle. We show the linear dispersion relation of the free particle and the discrete Landau levels in a magnetic field, and we explicitly measure the spatial and spin dynamics from which the conservation of helicity and properties of antiparticles can be verified. Our work extends the application of an ion trap quantum simulator in particle physics with the additional spatial and spin degrees of freedom.

Dissipation is often considered as a detrimental effect in quantum systems for unitary quantum operations. However, it has been shown that suitable dissipation can be useful resources both in quantum information and quantum simulation. Here, we propose and experimentally simulate a dissipative phase transition (DPT) model using a single trapped ion with an engineered reservoir. We show that the ion's spatial oscillation mode reaches a steady state after the alternating application of unitary evolution under a quantum Rabi model Hamiltonian and sideband cooling of the oscillator. The average phonon number of the oscillation mode is used as the order parameter to provide evidence for the DPT. Our work highlights the suitability of trapped ions for simulating open quantum systems and shall facilitate further investigations of DPT with various dissipation terms.