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Background and purposeAlthough systolic blood pressure variation (ΔSBP) has been regarded as a predictor of poor outcome after endovascular therapy (EVT), its effect at the different time intervals on the prognosis of acute anterior large vessel occlusion remains unclear. The study aims to assess the impact of ΔSBP at different time intervals on futile recanalisation (FRT) of acute anterior circulation large-vessel occlusion stroke after EVT.MethodsA total of 554 consecutive patients who achieved successful recanalisation after EVT were enrolled from the Effect of Endovascular Treatment Alone versus Intravenous Alteplase Plus Endovascular Treatment on Functional Independence in Patients with Acute Ischemic Stroke (DEVT) and Effect of Intravenous Tirofiban versus Placebo Before Endovascular Thrombectomy on Functional Outcomes in Large Vessel Occlusion Stroke (RESCUE BT) trials. ΔSBP was defined as SBP max minus SBP min at different time intervals, including 0–6 hours, 6–12 hours and 12–24 hours after EVT. The primary outcome was FRT at 90 days, defined as a modified Rankin Scale score of 3 to 6. The secondary outcome was symptomatic intracranial haemorrhage within 48 hours.ResultsAmong these patients, 278 patients underwent FRT and 276 achieved useful recanalisation at 90 days. ΔSBP 0–6 hours was found to be positively associated with an increased likelihood of FRT (adjusted OR (aOR) per 5 mm Hg SBP change, 1.014, 95% CI 1.002 to 1.026). Large variation of SBP (ΔSBP >40 mm Hg) in the first 6 hours had a higher probability of FRT (aOR, 1.817, 95% CI 1.059 to 3.117) compared with a ΔSBP of 0–20 mmHg.ConclusionSBP variation within the first 6 hours after EVT was associated with FRT. Large fluctuations (ΔSBP >40 mm Hg) of SBP in 0–6 hours following EVT were found to increase the probability of FRT.

Ischemic stroke, an intractable neurovascular disease with high lethality, disability and recurrence rates, poses a serious challenge to human health. The only effective treatment for acute stroke is reperfusion therapy. However, the inflammatory response caused by reperfusion therapy often aggravates secondary brain tissue damage, which greatly affects the treatment effect. Currently, therapeutic options for reperfusion injury remain unsatisfactory, and neuroprotective options are lacking. The inhibition of microglia polarization and promotion of neovascular maturation are essential for reestablishing the integrity of the BBB. Specifically, McM/RNPs effectively inhibited the secretion of pro-inflammatory factors such as tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) and promoted the release of anti-inflammatory and neuroprotective factors such as interleukin-10 (IL-10), vascular endothelial growth factor-A (VEGF-A), and brain-derived neurotrophic factor (BDNF). This effect not only alleviated the inflammatory response but also promoted the expression of endothelial tight junction proteins (such as ZO-1 and Claudin 5), thereby enhancing the integrity of the BBB. Furthermore, McM/RNPs exerted multiple effects, such as promoting neuronal survival, regulating pericyte function, and accelerating the maturation of the neovasculature, which are essential for repairing the damaged BBB. Through the multi-functional effects of anti-inflammation, anti-apoptosis and pericyte regulation, the McM/RNPs nanosystem successfully maintained the stability of the intracerebral environment, providing novel ideas and strategies for the clinical treatment of reperfusion injury in ischemic stroke. Graphical Abstract

In patients with stroke and patent large and medium-sized cerebral vessels, the glycoprotein IIb/IIIa receptor inhibitor tirofiban resulted in a greater likelihood of an excellent outcome than low-dose aspirin.

Developing a precise and reproducible bandgap tuning method that enables tailored design of materials is of crucial importance for optoelectronic devices. Towards this end, we report a sphere diameter engineering (SDE) technique to manipulate the bandgap of two-dimensional (2D) materials. A one-to-one correspondence with an ideal linear working curve is established between the bandgap of MoS 2 and the sphere diameter in a continuous range as large as 360 meV. Fully uniform bandgap tuning of all the as-grown MoS 2 crystals is realized due to the isotropic characteristic of the sphere. More intriguingly, both a decrease and an increase of the bandgap can be achieved by constructing a positive or negative curvature. By fusing individual spheres in the melted state, post-synthesis bandgap adjustment of the supported 2D materials can be realized. This SDE technique, showing good precision, uniformity and reproducibility with high efficiency, may further accelerate the potential applications of 2D materials. The bandgap of 2D molybdenum disulfide can be tuned uniformly, reproducibly and precisely over a large range by using a glass sphere support and changing the diameter of the spheres.

The developing advances of microresonator-based Kerr cavity solitons have enabled versatile applications ranging from communication, signal processing to high-precision measurements. Resonator dispersion is the key factor determining the Kerr comb dynamics. Near the zero group-velocity-dispersion (GVD) regime, low-noise and broadband microcomb sources are achievable, which is crucial to the application of the Kerr soliton. When the GVD is almost vanished, higher-order dispersion can significantly affect the Kerr comb dynamics. Although many studies have investigated the Kerr comb dynamics near the zero-dispersion regime in microresonator or fiber ring system, limited by dispersion profiles and dispersion perturbations, the near-zero-dispersion soliton structure pumped in the anomalous dispersion side is still elusive so far. Here, we theoretically and experimentally investigate the microcomb dynamics in fiber-based Fabry-Perot microresonator with ultra-small anomalous GVD. We obtain 2/3-octave-spaning microcombs with ~10 GHz spacing, >84 THz span, and >8400 comb lines in the modulational instability (MI) state, without any external nonlinear spectral broadening. Such widely-spanned MI combs are also able to enter the soliton state. Moreover, we report the first observation of anomalous-dispersion based near-zero-dispersion solitons, which exhibits a local repetition rate up to 8.6 THz, an individual pulse duration <100 fs, a span >32 THz and >3200 comb lines. These two distinct comb states have their own advantages. The broadband MI combs possess high conversion efficiency and wide existing range, while the near-zero-dispersion soliton exhibits relatively low phase noise and ultra-high local repetition rate. This work complements the dynamics of Kerr cavity soliton near the zero-dispersion regime, and may stimulate cross-disciplinary inspirations ranging from dispersion-controlled microresonators to broadband coherent comb devices.

Security systems are essential for maintaining public safety and protecting critical assets, yet most existing evaluation approaches remain static, capture only partial interactions among assets, security systems, and offenders, and lack qualitative analyses of long-term stability. To address these limitations, this study introduces an integrated Petri net–ordinary differential equation framework that combines the discrete-event modeling strength of Petri nets with the continuous-time analysis capability of ordinary differential equations, thereby capturing the dynamic interplay among assets, security systems, and offenders and enabling equilibrium and stability analysis. Numerical simulations are conducted under different parameter settings to validate both the stability of the framework and the role of the security effectiveness parameter. The results demonstrate that enhancing this parameter improves protection capability, suppresses offender activity, reduces asset losses and promotes long-term system stability. By capturing interdependent dynamics within a unified model, the proposed approach advances beyond traditional methods and provides both a theoretical foundation and practical guidance for optimizing resource allocation and designing protection strategies.

Electronic phase separation in complex oxides is the inhomogeneous spatial distribution of electronic phases, involving length scales much larger than those of structural defects or nonuniform distribution of chemical dopants. While experimental efforts focused on phase separation and established its correlation with nonlinear responses under external stimuli, it remains controversial whether phase separation requires quenched disorder for its realization. Early theory predicted that if perfectly “clean” samples could be grown, both phase separation and nonlinearities would be replaced by a bicritical-like phase diagram. Here, using a layer-by-layer superlattice growth technique we fabricate a fully chemically ordered “tricolor” manganite superlattice, and compare its properties with those of isovalent alloyed manganite films. Remarkably, the fully ordered manganite does not exhibit phase separation, while its presence is pronounced in the alloy. This suggests that chemical-dopinginduced disorder is crucial to stabilize the potentially useful nonlinear responses of manganites, as theory predicted.

Multi-drug-resistant Staphylococcus aureus infections necessitate novel antibiotic development. D-3263, a transient receptor potential melastatin member 8 (TRPM8) agonist, has potential antineoplastic properties. Here, we reported the antibacterial and antibiofilm activities of D-3263. Minimum inhibitory concentrations (MICs) against S. aureus , Enterococcus faecalis and E. faecium were ≤ 50 µM. D-3263 exhibited bactericidal effects against clinical methicillin-resistant S. aureus (MRSA) and E. faecalis strains at 4× MIC. Subinhibitory D-3263 concentrations effectively inhibited S. aureus and E. faecalis biofilms, with higher concentrations also clearing mature biofilms. Proteomic analysis revealed differential expression of 29 proteins under 1/2 × MIC D-3263, influencing amino acid biosynthesis and carbohydrate metabolism. Additionally, D-3263 enhanced membrane permeability of S. aureus and E. faecalis . Bacterial membrane phospholipids phosphatidylethanolamine (PE), phosphatidylglycerol (PG), and cardiolipin (CL) dose-dependently increased D-3263 MICs. Overall, our data suggested that D-3263 exhibited potent antibacterial and antibiofilm activities against S. aureus by targeting the cell membrane.

IntroductionAgents used in antitumour therapy have toxic effects on the cardiovascular system of breast cancer (BC) patients, increasing the risk of cardiovascular disease, which has become the most common non-cancer cause of death in BC patients. Exercise can effectively prevent or reduce the occurrence of cardiotoxicity, however, most BC patients have low levels of physical activity. The Health Action Process Approach (HAPA) model has been successfully applied to encourage patients to adhere to physical exercise. This study aims to explore the impact of exercise interventions based on the HAPA model on the monitoring indicators related to cardiotoxicity in BC patients during chemotherapy, aiming to prevent cardiotoxicity in BC patients and improve their physical activity level, exercise self-efficacy, exercise social support and exercise compliance.Methods and analysisIn a protocol for a quasi-randomised controlled trial involving a 4-month intervention, 62 patients with BC will be recruited from a tertiary care centre in China. Participants from the first oncology department will be assigned to the HAPA model-based exercise intervention group (n=31), while participants from the second oncology department will be assigned to the control group that will receive standard exercise guidance (n=31). The primary outcome will be the incidence of cardiotoxicity assessed by Electrocardiogram (ECG). The secondary outcomes will include physical activity level, exercise self-efficacy, exercise social support and exercise compliance, which will be evaluated by the short form of the International Physical Activity Questionnaire (IPAQ-SF), Self-Efficacy for Exercise Scale (SEE), Social Support Scale for Exercise (SSSE), and percentage of achieving the recommended total time of exercise per week. The chi-square test or Mann-Whitney U tests will be applied to compare the differences in ECG results and exercise compliance between the two groups. To evaluate the effect of exercise intervention on IPAQ-SF, SSE and SSSE, repeated measures ANOVA will be employed to examine the group-by-time interactions and main effects.Ethics and disseminationThis study has been approved by the Ethics Committee of the First Affiliated Hospital of Dalian Medical University (PJ-KS-KY-2024-267(X)). The results of this study will be published via peer-reviewed publications and presentations at conferences.Trail registration numberChiCTR2400090672.

IntroductionCancer-related fatigue (CRF) is one of the most common and debilitating side effects experienced by patients with breast cancer (BC) during postoperative chemotherapy. Family-involvement combined aerobic and resistance exercise has been introduced as a promising non-pharmacological intervention for CRF symptom relief and improving patients’ muscle strength, exercise completion, family intimacy and adaptability and quality of life. However, evidence for the practice of home participation in combined aerobic and resistance exercise for the management of CRF in patients with BC is lacking.Methods and analysisWe present a protocol for a quasi-randomised controlled trial involving an 8-week intervention. Seventy patients with BC will be recruited from a tertiary care centre in China. Participants from the first oncology department will be assigned to the family-involvement combined aerobic and resistance exercise group (n=28), while participants from the second oncology department will be assigned to the control group that will receive standard exercise guidance (n=28). The primary outcome will be the Piper Fatigue Scale-Revised (R-PFS) score. The secondary outcomes will include muscle strength, exercise completion, family intimacy and adaptability and quality of life, which will be evaluated by the stand-up and sit-down chair test, grip test, exercise completion rate, Family Adaptability and Cohesion Scale, Second Edition-Chinese Version (FACESⅡ-CV) and Functional Assessment of Cancer Therapy -Breast (FACT-B) scale. Analysis of covariance will be applied for comparisons between groups, and paired t-tests will be used for comparison of data before and after exercise within a group.Ethics and disseminationThis study has been approved by the Ethics Committee of the First Affiliated Hospital of Dalian Medical University (PJ-KS-KY-2021-288). The results of this study will be published via peer-reviewed publications and presentations at conferences.Trail registration numberChiCTR2200055793.