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Background Carpal tunnel syndrome (CTS) is the most common entrapment symptom in the peripheral nerves. High-frequency ultrasound (HFUS) is widely used in the diagnosis of CTS. Virtual Touch Tissue Imaging and Quantification (VTIQ), which provides more information about the hardness of organization, is used to diagnose CTS. However, the data of diagnostic value of them in various degrees of CTS are limited. Whether the combination of HFUS and VTIQ can improve the diagnostic efficiency also remains unknown. The study aimed to explore the diagnostic value of HFUS and VTIQ in various degrees of CTS and whether combination of HFUS and VTIQ could improve the diagnostic efficiency of CTS. Methods A collection and analysis of 133 CTS patients and 35 volunteers from January 2016 to January 2019 were performed. We compared the clinical characteristics, cross-sectional area (CSA) value and shear wave velocity SWV mean value of CTS group with volunteer group. Results The CSA value and SWV mean value of CTS cohort were significantly higher than volunteer group (10.79 ± 2.88 vs. 8.06 ± 1.39, p  < 0.001, 4.36 ± 0.95 vs. 3.38 ± 1.09, p <  0.001, respectively). The area under the curve (AUC) of receiver operating characteristic (ROC) curve of CSA value and SWV mean value were 0.794 and 0.757, respectively. Hierarchical analysis of CSA value and SWV mean value showed that the AUC in the moderate and severe CTS group were higher than in mild CTS group. Furthermore, the CSA value combined with SWV mean value used to diagnose mild CTS was 0.758, which was higher than that of single CSA value or single SWV mean value. Conclusions Both HFUS and VTIQ technology were feasible to evaluate CTS. HFUS was suitable for use in diagnosis of moderate and severe CTS. For mild CTS, combination of HFUS and VTIQ was relevant to improve the diagnostic efficiency of CTS.

Soil structure plays an important role in understanding soil attributes as well as hydrological processes. Effective method to obtain high quality soil map is therefore important for both soil science research and soil work ability improvement. However,traditional method such as digging soil pits is destructive and time-consuming. In this study, the structure of headwater hillslopes from Hemuqiao catchment（Taihu Basin, China） have been analyzed both by indirect（ground penetrating radar, GPR） and direct（excavation or soil auger） methods. Four transects at different locations of hillslopes in the catchment were selected for GPR survey. Three of them（#1, #2, and #3） were excavated to obtain fullscale soil information for interpreting radar images.We found that the most distinct boundary that can be detected by GPR is the boundary between soil and underlain bedrock. In some cases（e.g., 8-17 m in transect #2）, in which the in situ soil was scarcely affected by colluvial process, different soil layers can be identified. This identification process utilized the sensitive of GPR to capture abrupt changes of soil characteristics in layer boundaries, e.g., surface organic layer（layer #1） and bamboo roots layer（layer#2, contain stone fragments）, illuvial deposits layer（layer #3） and regolith layer（layer #4）. However, in areas where stone fragments were irregularly distributed in the soil profile（highly affected bycolluvial and/or fluvial process）, it was possible to distinguish which part contains more stone fragments in soil profile on the basis of reflection density（transect #3）. Transect #4（unexcavated） was used to justify the GPR method for soil survey based on experiences from former transects. After that, O horizon thickness was compared by a hand auger.This work has demonstrated that GPR images can be of a potential data source for hydrological predictions.

Sexually transmitted infections (STIs) are associated with vaginal dysbiosis, and co-infections are common but understudied. In this study, 6217 reproductive-age women are recruited from 38 study centres across China at baseline and 2738 participants are followed up at 6 months. We profile the vaginal microbiota by 16S rRNA gene sequencing in conjunction with measurement of nine common STIs. The primary outcome of this study is STI status, and secondary outcome is the risk of cervical lesions. Mycoplasmas hominis (MH) far exceeds other STIs in the association with vaginal microbiota, whereases previously reported associations between Human papillomavirus (HPV) and vaginal dysbiosis might be confounded by the co-infected MH in this study. Both MH infection and increased bacterial diversity are independently associated with increased risk of cervical lesion in HPV-negative women (Shannon, OR (odds ratio) = 1.71, 95% CI (confidence interval) = 1.23-2.36; MH, OR = 2.42 95% CI = 1.36-4.30). These associations are also identified in longitudinal analyses (Shannon, HR (hazard ratio) = 1.72, 95% CI = 1.04-2.86; MH, HR = 2.37, 95% CI = 0.98-5.72). Our findings highlight the importance of considering MH status when studying vaginal microbiota in cervical lesions, and suggest the need for further investigation of microbiota-associated mechanisms in HPV-negative cervical lesions. (ClinicalTrials.gov. NCT04694495). Here, in a study of over 6,000 women across China, the authors show that Mycoplasma hominis infection strongly influences vaginal microbiota and is linked to higher risk of cervical lesions, highlighting its importance in women’s reproductive health.

Background： Prolongation of the Tpeak-Tend （TpTe） interval as a measurement of transmural dispersion of repolarization （TDR） is an independent risk factor for chronic heart failure mortality, However, the cardiac resynchronization therapy＇s （CRT） effect on TDR is controversial. Therefore, this study aimed to evaluate CRTs acute and chronic effects on repolarization dispersion. Furthermore, we aimed to investigate the relationship between TpTe changes and ventricular arrbythmia. Methods： The study group consisted of 101 patients treated with CRT-defibrillator （CRT-D）. According to whether TpTe was shortened, patients were grouped at immediate and l-year follow-up after CRT, respectively. The echocardiogram index and ventricular arrhythmia were observed and compared in these subgroups. Results： For all patients, TpTe slightly increased immediately after CRT-D implantation, and then decreased at the l -year follow-up （from 107 ± 23 to 110 ± 21 rns within 24 h, to 94 ± 24 ms at 1-year follow-up, F 19.366, P 〈 0.001）. No significant difference in the left ventricular reverse remodeling and ventricular tachycardia/ventricular fibrillation （VT/VF） episodes between the TpTe immediately shortened and TpTe immediately nonshortened groups. However, patients in the TpTe at l-year shorten had a higher rate of the lelt ventricular （LV） reverse remodeling （65% vs. 44%, Z2 = 4.495, P - 0.038） and less VT/VF episodes （log-rank test, X2 - 10.207, P = 0.001 ） compared with TpTe I-year nonshortened group. TpTe immediately alter CRT-D independently predicted VT/VF episodes at l-year follow-up （hazard ratio [HR], 1.030; P = 0.001 ）. Conclusions： Patients with TpTe shortened at l -year after CRT had a higher rate of LV reverse remodeling and less VT/VF episodes. The acute changes of TpTe after CRT have minimal value on mechanical reverse remodeling and ventricular arrhythmia.

Strain has been shown to modulate the electronic structure of noble metal nanomaterials and alter their catalytic performances. Since strain is spatially dependent, it is challenging to expose the active strained interfaces by structural engineering with atomic precision. Herein, we report a facile method to manipulate the planar strain in ultrathin noble metal nanosheets by constructing amorphous–crystalline phase boundaries that can expose the active strained interfaces. Geometric-phase analysis and electron diffraction profile demonstrate the in-plane amorphous–crystalline boundaries can induce about 4% surface tensile strain in the nanosheets. The strained Ir nanosheets display substantially enhanced intrinsic activity toward the hydrogen evolution reaction electrocatalysis with a turnover frequency value 4.5-fold higher than the benchmark Pt/C catalyst. Density functional theory calculations verify that the tensile strain optimizes the d -band states and hydrogen adsorption properties of the strained Ir nanosheets to improve catalysis. Furthermore, the in-plane strain engineering method is demonstrated to be a general approach to boost the hydrogen evolution performance of Ru and Rh nanosheets. While inducing strain to noble metal nanomaterials can modulate catalytic activities, the strain is often spatially dependent. Here, authors manipulate the planar strain in noble metal nanosheets for hydrogen evolution electrocatalysis by constructing amorphous–crystalline phase boundaries.

The alternating electromagnetic（EM） field is one of the most sensitive physical fields related to earthquakes. There have been a number of publications reporting EM anomalies associated with earthquakes. With increasing applications and research of artificial-source extremely low frequency EM and satellite EM technologies in earthquake studies, the amount of observed data from the alternating EM method increases rapidly and exponentially, so it is imperative to develop suitable and effective methods for processing and analyzing the influx of big data. This paper presents research on the self-adaptive filter and wavelet techniques and their applications to analyzing EM data obtained from ground measurements and satellite observations, respectively. Analysis results show that the self-adaptive filter method can identify both natural- and artificial-source EM signals, and enhance the ratio between signal and noise of EM field spectra, apparent resistivity, and others. The wavelet analysis is capable of detecting possible correlation between EM anomalies and seismic events. These techniques are effective in processing and analyzing massive data obtained from EM observations.

The incidence of hepatocellular carcinoma is rising worldwide. It is predicted that nearly half of the early-stage hepatocellular carcinoma (E-HCC) patients will develop recurrence. Dysregulated pH, a hallmark of E-HCC, is correlated with poor prognosis. The acidic microenvironment has been shown to promote the release of exosomes, the membrane vesicles recognized as intercellular communicators associated with tumor progression, recurrence, and metastasis. We, therefore, aimed to identify exosomes induced by acidic microenvironment that may regulate E-HCC progression and to explore their mechanisms and clinical significance in E-HCCs. miRNA microarray analysis and LASSO logistic statistic model were used to identify the main functional exosomal miRNAs. Invasion and scratch assays were performed to examine the migration and invasion of HCC cells. Immunoblotting and immunofluorescence were employed to detect the epithelial-to-mesenchymal transition (EMT) in HCC cells. Chromatin immunoprecipitation (ChIP) was used to analyze the binding of HIF-1α and HIF-2α to promoter regions of miR-21 and miR-10b. The acidic microenvironment in HCC was correlated with poor prognosis of patients. Exosomes from HCC cells cultured in the acidic medium could promote cell proliferation, migration, and invasion of recipient HCC cells. We identified miR-21 and miR-10b as the most important functional miRNAs in acidic HCC-derived exosomes. Also, the acidic microenvironment triggered the activation of HIF-1α and HIF-2α and stimulated exosomal miR-21 and miR-10b expression substantially promoting HCC cell proliferation, migration, and invasion both and . In E-HCC patients, serum exosomal miR-21 and miR-10b levels were associated with advanced tumor stage and HIF-1α and HIF-2α expression and were independent prognostic factors for disease-free survival of E-HCC patients. Most importantly, we developed a nano-drug to target exosomal miR-21 and/or miR-10b and examined its therapeutic effects against HCC . Our findings suggested that the exosomal miR-21 and miR-10b induced by acidic microenvironment in HCC promote cancer cell proliferation and metastasis and may serve as prognostic molecular markers and therapeutic targets for HCC.

The adenomatous polyposis coli (APC) gene plays a pivotal role in the pathogenesis of colorectal carcinoma (CRC) but remains a challenge for drug development. Long noncoding RNAs (lncRNAs) are invaluable in identifying cancer pathologies and providing therapeutic options for patients with cancer. Here, we identified a lncRNA (lncRNA-APC1) activated by APC through lncRNA microarray screening and examined its expression in a large cohort of CRC tissues. A decrease in lncRNA-APC1 expression was positively associated with lymph node and/or distant metastasis, a more advanced clinical stage, as well as a poor prognosis for patients with CRC. Additionally, APC could enhance lncRNA-APC1 expression by suppressing the enrichment of PPARα on the lncRNA-APC1 promoter. Furthermore, enforced lncRNA-APC1 expression was sufficient to inhibit CRC cell growth, metastasis, and tumor angiogenesis by suppressing exosome production through the direct binding of Rab5b mRNA and a reduction of its stability. Importantly, exosomes derived from lncRNA-APC1-silenced CRC cells promoted angiogenesis by activating the MAPK pathway in endothelial cells, and, moreover, exosomal Wnt1 largely enhanced CRC cell proliferation and migration through noncanonicial Wnt signaling. Collectively, lncRNA-APC1 is a critical lncRNA regulated by APC in the pathogenesis of CRC. Our findings suggest that an APC-regulated lncRNA-APC1 program is an exploitable therapeutic approach for the treatment of patients with CRC.

The ideal elastic limit is the upper bound to the stress and elastic strain a material can withstand. This intrinsic property has been widely studied for crystalline metals, both theoretically and experimentally. For metallic glasses, however, the ideal elastic limit remains poorly characterized and understood. Here we show that the elastic strain limit and the corresponding strength of submicron-sized metallic glass specimens are about twice as high as the already impressive elastic limit observed in bulk metallic glass samples, in line with model predictions of the ideal elastic limit of metallic glasses. We achieve this by employing an in situ transmission electron microscope tensile deformation technique. Furthermore, we propose an alternative mechanism for the apparent 'work hardening' behaviour observed in the tensile stress–strain curves. The elastic limit represents the maximum stress and strain a material can withstand and is well characterized in many crystalline solids, yet remains elusive for metallic glasses. Here, this limit is investigated in submicron metallic glass structures and is found to be twice as high as that of bulk samples.

Time-Sensitive Networking (TSN) and edge computing are promising networking technologies for the future of the Industrial Internet. TSN provides a reliable and deterministic low-latency communication service for edge computing. The Frame Replication and Elimination for Reliability (FRER) mechanism is important for improving the network reliability of TSN. It achieves high reliability by transmitting identical frames in parallel on two disjoint paths, while eliminating duplicated frames at the destination node. However, there are two problems with the FRER mechanism. One problem is that it does not consider the path reliability, and the other one is that it is difficult to find two completely disjoint path pairs in some cases. To solve the above problems, this paper proposes a method to find edge-disjoint path pairs considering path reliability for FRER in TSN. The method includes two parts: one is building a reliability model for paths, and the other one is computing a working path and a redundant path with the Edge-Disjoint Path Pairs Selection (EDPPS) algorithm. Theoretical and simulation results show that the proposed method effectively improves path reliability while reducing the delay jitter of frames. Compared with the traditional FRER mechanism, the proposed method reduces delay jitter by 15.6% when the network load is 0.9.