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This paper introduces the development of a self-propelled hard hose traveler to accelerate the transition of the traditional JP50-180 hard hose traveler toward becoming an irrigation robot and enhancing its applicability in farmland. The uniformity model of linear motion water distribution is established by utilizing the total frequency of application during the sprinkler motion and the radial application depth once during the fixed sprinkler rotation. The average application depth deviation between the tested and calculated values is 7.4%. The effect of combined irrigation with sprinkler motion is superior to that of motion irrigation with a single sprinkler. The average application depth decreases as the motion speed increases while the water distribution uniformity (CU value) remains constant. The average application depth decreases as the path spacing increases. In contrast, the CU value first increases and then decreases. The highest CU value is approximately 94%, with the optimal path spacing being 1.5R and the optimal combinations of sprinkler rotation angles α, β, and γ being 0°, 90°, and 90°, or 90°, 90°, and, 0°, or 0°, 180°, and 0°, respectively depending on the case. The above indicators are significant for planning the irrigation application of a self-propelled hard hose traveler.

This paper investigates research on the dynamic mechanical and energy consumption models during the polyethylene tube retrieval for a self-propelled hard hose traveler. Moreover, the drive parameter design methodology of a traveler is refined to address the irrigation challenges faced by existing sprinklers in sloping fields and fragmented farmland. First, the sprinkler’s electric-drive carrier parameters are designed based on established mechanical theory models of the polyethylene tube deployment. The carrier employs two planetary reduction gearboxes with a transmission ratio of 40 and six batteries with a voltage of 12 V and a capacity of 200 A h. Secondly, the dynamic changes in tensile force and energy consumption are studied by establishing mechanical and energy consumption models for retrieving polyethylene tubes. Then, the drive parameters for the reel truck are designed. The tensile force required for its rotation increases because the polyethylene tube winds longer onto the reel. Moreover, the tensile force and total energy consumption required for retrieving the polyethylene tube decrease. The force required for reel no-load rotation is 49.98 N. When the friction coefficient between the polyethylene tube and soil is 1.0, the tensile force and energy consumption required for sliding are maximized, to 2356.70 N and 52.06 × 10−3 kW h, respectively. The reel truck selects a reduction gearbox with a transmission ratio of 25 and an efficiency of 85%, along with a three-phase asynchronous motor with a power of 750 W, a speed of 1400 r min−1, and a voltage of 220 V. This research will enable in-depth analysis of mechanical and energy consumption characteristics across different operational stages of the polyethylene tube, facilitate structural optimization, and provide technical support for irrigation in sloped and fragmented farmlands.

In order to evaluate the influence of preform preparation processes on thermal cycle stability of glass-to-metal seals, this work embraced two different methods to produce the preform for seals. For the conventional powder metallurgy (PM) method, the molten glass was quenched to form frits, then the frits were ball milled to prepare glass powders. These glass powders were pressed into green bodies and heated to prepare preforms. While for the casting-machining (CM) method, the molten glass was cast into a graphite mold and annealed before accurate machining to preforms. In contrast to the PM method, the CM method provided an ultralow-porosity preform structure and a low porosity glass seal region. Field emission scanning electron microscope (FE-SEM) was conducted to investigate the bubbles and cracks in glass region. Furthermore, thermal cycling tests confirmed that these two tremendously different glass regions strongly affected the thermal cycle stability of the seals. To support the understanding of cracking in seals, the damage features of the samples were observed by FE-SEM and the extended finite element method (XFEM) was used to simulate the crack initiation and propagation. The experimental results demonstrated that cracking in the seals made from CM preforms occurred in the glass region near the sealing interface. However, cracks initiated from the bubbles in the seals made from PM preforms, which was verified by the XFEM simulation results. In addition, the CM seals demonstrated little degradation of the leakage rate until 105 thermal cycles, while cracking was found in the PM seals after 70 thermal cycles, indicating a decreased thermal cycle stability and resulting in hermetic failure.

TE lncRNAs are associated with m6A modification across tissues We first retrieved the TE lncRNAs from 38 normal tissues from LncSpA in 4 data resources (Fig. 1a), including Human Body Map (HBM2.0), Human Protein Atlas (HPA), the Genotype-Tissue Expression (GTEx), and the Function Annotation Of The Mammalian Genome (FANTOM) project. The extent to which variation in m6A modification of TE lncRNAs may be attributed to the expression of m6A regulators remains unknown. [...]we next sought to analyze the correlation between the expressions of m6A-modified TE lncRNAs and regulators. Table S4). [...]we identified 28 m6A-modified TE lncRNAs that had significantly higher expression in cancer patients than in healthy controls and 8 m6A-modified TE lncRNAs that had significantly lower expression (Fig. 2a and Additional file 5: Several studies have also shown that m6Am can regulate the expression of noncoding RNAs. [...]it would also be interesting to integrate such m6A and m6Am data to identify potential lncRNA biomarkers in cancer.

Although indispensable, significant uncertainty still exists in the underlying processes of the formation, dynamics, and emission of greenhouse gases (GHGs), the critical elements needed for the accurate estimation of greenhouse gas fluxes in inland lakes and reservoirs. Seasonal changes in water thermal stratification and turbulence strongly influence the concentration and emission of dissolved GHGs in water columns. Here, we studied the stratification and overturn processes of water column in the subtropical Lianhe Reservoir during different seasons and determined the dynamics of dissolved CO 2 , CH 4 , and N 2 O in the reservoir. Observation of temperature and analysis of chlorofluorocarbons (CFCs) clearly suggested that stratification of water column occurred in summer, but not in winter. The results showed that while dissolved oxygen (DO) was high in the top 5-m layer (the upper epilimnion layer), it dropped considerably especially below 10 m, resulting in an increase in concentration of CO 2 and CH 4 . The high concentrations of dissolved N 2 O and CH 4 were related to the decomposition of organic matter in the hypolimnion layer under anaerobic conditions after stratification. In winter overturn period, vertical circulants of water not only homogenized the concentration of DO in the water column, but also potentially moved CO 2 , CH 4 , and N 2 O from the bottom to the surface of the reservoir. The estimated GHG flux from the reservoir was − 7.13 mmol m −2 day −1 in summer and 2.14 mmol m −2 day −1 in winter. There was the potential that CO 2 fluxes from subtropical lakes and reservoirs are overestimated by traditional geochemical models.

The bonding strengths, microscopic characteristics and fracture properties of borosilicate glass-to-SA105 carbon steel seals were investigated, and two different glass-to-metal bonding mechanisms were compared. First, a mechanical interlocking mechanism was found via precipitates formed from chemical reactions at the interface of the seal bonded to unoxidized SA105 carbon steel. Second, a transitional layer mechanism was proven by the dissolution of metal oxides, which was on the surface of preoxidized SA105 carbon steel, into the glass. The bonding strength results showed that both mechanisms effectively contributed to the joining of dissimilar phases, but the effect of the latter mechanism was more prominent than that of the former mechanism. Various microstructures and chemical compositions of the surface oxide scales were obtained by applying different preoxidation conditions to SA105 carbon steel. Additionally, different sealing interfaces were reported through this process. The width of the interfacial transitional layer ranged from 0.5 μm to 1.5 μm, and the strength of the seal was closely related to this width. The sealing of SA105 carbon steel that was preoxidized at 800 °C for 30 min with a moderate width of the transitional layer had an optimal shear strength of 25.4 MPa. However, a wide transitional layer composed of the remaining oxide scales deteriorated the strength of the seal. In addition, fracture analysis of the seals after the shear test was conducted, and the intrinsic correlations between the macroscopic shear strength and microscopic bonding mechanism were established. The present work should provide a reference for the characterization of bonding strength in joining dissimilar materials.

The discovery of epidermal growth factor receptor (EGFR) somatic mutations and the availability of tyrosine kinase inhibitors (TKIs) as targeted therapies have altered the therapeutic prospects of advanced non-small-cell lung cancer (NSCLC). G719X and S768I are uncommon mutations, and they often exist as compound mutations. A few reports have described the efficacy of first- and second-generation EGFR-TKIs. However, the efficacy of osimertinib in patients with these uncommon compound mutations is unknown. In this study, we reported the postoperative outcome of a patient with NSCLC and uncommon compound EGFR G719X and S768I mutations. After postoperative recurrence, the patient was treated with osimertinib, and an excellent and long-lasting clinical response was achieved. The patient has taken osimertinib for 31.0 months and exhibited a partial response, and her follow-up is ongoing.

The outbreak of pneumonia caused by novel coronavirus (SARS-CoV-2) in Wuhan, China, at the end of 2019 quickly escalated into a global health emergency. Since its outbreak until the 29th of April 2020, the pandemic has affected more than 3 million of people and caused 207,973 deaths globally. SARS-CoV-2 belongs to the β-coronavirus genus of the Coronavirus family, and it shares the same subfamily with severe acute respiratory syndrome-associated coronavirus (SARS-CoV) and Middle East respiratory syndrome-associated coronavirus (MERS-CoV), all of which lead to severe pneumonia. For cancer patients, especially those with lung cancers, their immune systems are compromised due to the disease itself as well as the treatment for cancer. The weakened immunity of these patients puts them at a higher risk of not only developing diseases but severe diseases. In this study, through a literature review and data collection, we focus on the selection and consideration of antitumor treatment strategies for advanced lung cancer during the coronavirus disease 2019 (COVID-19) epidemic.

Background The incidence of ocular metastasis from lung cancer is reported to be 0.1–7%, with adenocarcinoma and small cell lung cancer accounting for the highest proportions of these cases. The majority of cases involves metastasis to more than one other distal organ in addition to the eye. Here, we report for the first time, a case of lung squamous cell carcinoma with solitary symptomatic ocular metastasis as the initial manifestation that was managed by a multidisciplinary treatment (MDT). Case presentation A woman presented at the ophthalmology department of hospital with a 1-week history of left eye pain and blurred vision. Systemic examination led to the diagnosis of central lung cancer in the right lower lobe with ocular metastasis. After consultations with an MDT, including specialists from the surgery, internal medicine, ophthalmology, radiotherapy and imaging departments, the patient underwent surgery and chemotherapy. Her eye symptoms disappeared, and the ocular lesion was well controlled without any specific ocular treatment. The patient demonstrated a prolonged progression-free survival. Conclusion This is the first report of a rare case with solitary ocular metastasis as the initial manifestation of lung squamous cell carcinoma. This rare patient was treated based on evidence-based medicine, indicating the importance of cooperation within an MDT. The successful treatment of this case was reported as a new therapeutic reference for clinicians who encounter similar cases in the future.

Identification of tumor neoantigens is indispensable for the development of cancer immunotherapies. However, we are still lacking knowledge about the potential neoantigens derived from sequences outside protein-coding regions. Here, we comprehensively characterized the immunopeptidome landscape by integrating multi-omics data in acute myeloid leukemia (AML). Both canonical and non-canonical MHC-associated peptides (MAPs) in AML were identified. We found that the quality and characteristics of ncMAPs are comparable or superior to cMAPs, suggesting ncMAPs are indispensable sources for tumor neoantigens. We further proposed a computational framework to prioritize the neoantigens by integrating additional transcriptome and immunopeptidome in normal tissues. Notably, 6 of prioritized 13 neoantigens were derived from ncMAPs. The expressions of corresponding source genes are highly related to infiltrations of immune cells. Finally, a risk model was developed, which exhibited good performance for clinical prognosis in AML. Our findings expand potential cancer immunotherapy targets and provide in-depth insights into AML treatment, laying a new foundation for precision therapies in AML.