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Background Palmoplantar hyperkeratosis is a cutaneous manifestation that had not been clearly associated with infection by the human T-cell lymphotropic virus, which is a retrovirus that in most cases does not develop clinical pathologies and its symptoms may be undetected. The skin is one of the most affected organs, however until now only seborrheic dermatitis, xerosis/ichthyosis and infective dermatitis associated with HTLV-1 have been described as cutaneous clinical manifestations of this disease. Case presentation We present the case of a 36-year-old male patient with serologically documented HTLV-1 infection, who presented symptoms of diarrhea, malabsorption due to Strongyloides stercoralis , and in whom a physical examination revealed an association with generalized xerosis and palmoplantar keratoderma confirmed by skin biopsy. Other infectious etiologies and malignancy were ruled out. This clinical manifestation was managed with dermal hydration, and skin care which improved the thickened skin and make it less noticeable. Conclusions According to our experience, this is the first reported case of palmoplantar keratoderma associated with a human lymphotropic virus infection. This is a skin manifestation that has not been confirmed in conjunction with HTLV-I before. This implies that palmoplantar keratoderma is a new clinical manifestation of this infection, that should be considered in the initial approach of patients in endemic areas with these dermatological characteristics.

Taenia solium is the most common parasitic infection of the central nervous system and it can cause parenchymal or extra-parenchymal lesions. Subarachnoid cysticercosis is a type of extra-parenchymal infection in which the prevalence is not known and racemose NC with cerebellar involvement has been rarely reported. The diagnosis is challenging because of its similarity to other infectious diseases or to subarachnoid involvement of systemic malignancies. Treatment usually requires cysticide drugs, however, there are no randomized studies concerning the anti-parasitic treatment in subarachnoid NC. We present a case of racemose NC in the cerebellar hemisphere to draw attention to this pathology, endemic in many parts of the world; and highlight all the current gaps in our understanding of this entity.Taenia solium is the most common parasitic infection of the central nervous system and it can cause parenchymal or extra-parenchymal lesions. Subarachnoid cysticercosis is a type of extra-parenchymal infection in which the prevalence is not known and racemose NC with cerebellar involvement has been rarely reported. The diagnosis is challenging because of its similarity to other infectious diseases or to subarachnoid involvement of systemic malignancies. Treatment usually requires cysticide drugs, however, there are no randomized studies concerning the anti-parasitic treatment in subarachnoid NC. We present a case of racemose NC in the cerebellar hemisphere to draw attention to this pathology, endemic in many parts of the world; and highlight all the current gaps in our understanding of this entity.

To estimate the gastroschisis seasonality and trend of prevalence in recent years, stratified by maternal age and geographical clusters of São Paulo state, a population–based study was designed. We used data from the Live Births Information System (SINASC) in São Paulo state, Brazil, from 2005 to 2016. Trends of prevalence were evaluated for the specific subgroups using the Prais–Winsten regression model, and the Durbin–Watson test was used, to estimate the regression coefficient, the annual percent change (APC), and 95% confidence interval (CI). We observed 1576 cases of gastroschisis among 7,317,657 live births (LB), a prevalence of 2.154 (95% CI: 2.047–2.260) per 10,000 LB which included, 50.6% males, 67.4% Caucasians, 53.4% preterm births, and 80.9% caesarean births. The prevalence of gastroschisis significantly increased by 2.6% (95% CI: 0.0–5.2) per year, and this trend was higher in mothers aged 30–34 years (APC: 10.2, 95% CI: 1.4–19.4) than in mothers of other age groups. Between 2011 and 2016, we identified the existence of seasonality based on the date of conception in the middle months of the year (p = 0.002). This is the first and largest population–based study summarizing current epidemiology and identifying trend of prevalence of gastroschisis in São Paulo state.

Despite technological advancements in mining, Chile lacks comprehensive risk management models for tailings storage facilities (TSFs), which hinders the prevention and mitigation of structural and environmental risks. This study aims to develop an integrated risk management model for TSFs in Chile, combining geological and mining engineering with an updated regulatory framework to enhance safety and reduce environmental impacts. The research adopts a mixed-methods approach. Qualitatively, it draws on 10 semi-structured interviews with engineers, geologists, academics, and professionals from the Chilean mining industry, selected through purposive sampling, to explore how and why the current risk management model should be improved. Quantitatively, it analyzes data from 303 surveys assessing the existing regulatory framework, a proposed new regulatory decree for Chile, and key variables to be considered in TSF risk management. The results present a new model that integrates geochemical and geotechnical characterization, process variables, in situ sensors, remote sensing, and artificial intelligence to generate dynamic risk indicators and early warning systems throughout the life cycle of the facility, including closure and liability valuation. Its multiscale design, adaptable to seismic and hydrogeological conditions and suitable for small- and medium-scale mining, overcomes existing static and fragmented approaches, enabling more effective decision-making with a focus on environmental and community safety. The study concludes that the model provides a robust and coherent tool for TSF risk management by integrating technical expertise, the current regulatory framework, and the management of key variables that enhance the ability to anticipate and mitigate structural and environmental risks.

In this paper a piezoelectric micropump to be used in a drug delivery system is presented, for the specific application of providing synthetic lacrimal fluid to people suffering from dry eye disease. The proposed design focuses on portability, low voltage polarization, and achieving an average output flow rate of 1.10 μ l/min, which is the average flow rate for lacrimal fluid production in a healthy individual. The micropump was simulated using the finite element analysis software COMSOL Multiphysics ® . The maximum flow rate obtained by a single micropump device was 0.39 μ l/min operating at 20 V peak with a frequency of 1.1 kHz. Aiming to achieve the desired output flow rate, an array of three parallel micropumps was designed to increase the output flow rate; this array obtained a flow rate of 1.15 μ l/min without the need of raising the polarizing voltage and only increasing the device power consumption from 8.56 to 25.7 pWh.

Water scarcity poses a significant threat to kiwifruit production, especially in Mediterranean climates. This study investigated the impact of late-season regulated deficit irrigation (RDI) on water use efficiency and fruit quality of yellow-fleshed kiwifruit (Actinidia chinensis cv. Soreli) over two seasons in central Chile. Four irrigation treatments were applied during fruit ripening: full irrigation (Control), moderate deficits for three or five weeks (D50S and D50L), and complete irrigation suspension for three weeks (D100). While D100 had minimal impact on stomatal conductance, it significantly reduced stem and leaf water potentials, indicating severe water stress. D100 treatment also showed the highest intrinsic water use efficiency (via δ13C enrichment) and improved water productivity by up to 20%. Fruits from D100 and D50S had higher soluble solids (up to 2.0 °Brix) without compromising firmness or yield. Sensory evaluations indicated greater consumer acceptance in water-stressed treatments, especially D100, due to enhanced color and flavor. Principal component analysis confirmed that moderate-to-severe-water stress correlated with favorable sensory profiles. These findings suggest that short-term, late-season water deficits can enhance fruit quality and water use efficiency without reducing yield, offering a sustainable strategy for kiwifruit production under increasing water limitations.

The estimated prevalence of esophageal atresia (EA) is 1 in 2500-4500 live births (LBs). Researchers have already identified risk factors, but the mechanisms are still unknown. The aim of this study is to identify EA prevalence trends and its risk factors in the São Paulo State (SPS) population database. We conducted a population-based study using all EA cases identified by the Live Births Information System across 14 years (2005-2018) to estimate EA prevalence trends in recent years, stratified by maternal age and SPS geographical clusters. We calculated the prevalence trends, regression coefficient (β), annual percent change (APC), and 95% confidence interval (CI). We found 820 EA cases among 8,536,101 LBs with a prevalence of 1.0/10,000 LBs in SPS, Brazil. There was no significant difference in distribution by sex. Among all the cases, the majority (65%) were Caucasian; 51.8% were born at term; 43% had weight of ≥2500 g; 95.4% were singleton; and 73.4% of births were by cesarean section. From 2005 to 2018, there was an increasing trend of EA prevalence (APC=6.5%) with the highest APC of 12.2%. The highest EA prevalence rate (1.7/10,000 LB) was found in the group with maternal age of ≥35 years. No significant seasonal variation was found based on the conception month (p=0.061). EA had an increasing prevalence trend in SPS, Brazil, in recent years, with the highest prevalence rate in the group with maternal age of ≥35 years. No seasonality was observed. This population-based study is the first to summarize the current epidemiology of EA in SPS LB.

Chile, the leading exporter of cherries (Prunus avium L.) in the southern hemisphere, faces sustained variations in precipitation patterns and high evaporative demand in its productive areas. The low availability of water during the period of highest environmental demand makes it essential to reduce or suspend irrigation applications. In this scenario, regulated deficit irrigation (RDI) after harvest is an efficient strategy for optimizing water use without compromising orchard yields. This study was conducted over three consecutive seasons in a traditional commercial orchard of ‘Santina’ cherry trees grafted onto Colt rootstock, evaluating the effect of two levels of RDI, moderate (MDI) and severe (SDI), on productive and ecophysiological parameters. Both treatments resulted in water savings of between 10% and 28%, without negatively affecting yield or fruit quality. The SDI treatment, despite reaching higher levels of cumulative water stress, improved intrinsic water use efficiency while maintaining stable photosynthetic efficiency. In addition, an increase in the abundance of fine roots and beneficial rhizosphere bacteria populations, such as Azospirillum and Bacillus, was observed, suggesting the activation of water resilience mechanisms mediated by plant–microbiota interaction, possibly associated with stress-induced ecological memory and microbial legacy effects. These results position after-harvest RDI as a sustainable tool for coping with climate variability and water scarcity in commercial cherry orchards.

The super high-density (SHD) production system has recently been introduced to the Chilean European plum (Prunus domestica L.) industry, but the potential of applying regulated deficit irrigation (RDI) in this system remains unexplored. As irrigation water availability in Chile has been strongly jeopardized by climate change, there is an urgent need to validate water-conserving practices in modern production systems. A field study was conducted in a commercial SHD European plum orchard (cv. French grafted on Rootpac-20 rootstock) for two consecutive seasons in Peralillo, O’Higgins Region, Chile. The objective of this study was to assess the impact of a late water deficit (LD) on water productivity, fruit quality, plant water relations, and soil microbiota. The results showed that implementing LD enhanced water productivity by 40% without compromising fresh and dry fruit quality. Moderate to severe water stress induced no changes in physiological parameters such as stomatal conductance and photochemical efficiency. Additionally, the LD treatment significantly reduced soil moisture but increased the abundance of certain groups of beneficial soil microbiota and fine roots. These results highlight the potential of LD as a viable water-conserving practice in modern SHD European plum orchards, particularly in regions facing water scarcity due to climate change.

Extreme environments, such as hypersaline habitats, hot springs, deep-sea hydrothermal vents, glaciers, and permafrost, provide diverse ecological niches for studying microbial evolution. However, knowledge of microbial communities in extreme environments at high southern latitudes remains limited, aside from Antarctica. Laguna Timone is a hypersaline crater lake located in a Pleistocene maar of the Pali Aike Volcanic Field, southern Patagonia; the lake was formed during basaltic eruptions in a periglacial setting. Here, we report the first integrative characterization of microbial communities from biofilms and microbial mats in this lake using high-throughput 16S rRNA and ITS gene sequencing, along with mineralogical and hydrochemical analyses of water, sediments, and carbonates. Bacterial communities were dominated by the genera Enterobacterales ASV1, Pseudomonas, Oscillatoria, Nodularia, and Belliella, with site-specific assemblages. Fungal communities included Laetinaevia, Ilyonectria, Thelebolus, Plectosphaerella, and Acrostalagmus, each showing distinct distribution patterns. These baseline data contribute to understanding microbial dynamics in hypersaline maar environments and support future investigations. This integrative approach highlights key microbe–mineral relationships and underscores the potential of Laguna Timone as a natural laboratory for exploring biosignature formation and microbial adaptation in chemically extreme environments, both on early Earth and potentially beyond.