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Stereotactic body radiation therapy in patients with spine metastases maximizes local tumor control and preserves neurologic function. A novel approach could be the use of stereotactic body radiation therapy with simultaneous integrated boost delivering modality. The aim of the present study is to report our experience in the treatment of spine metastases using a frameless radiosurgery system delivering stereotactic body radiation therapy–simultaneous integrated boost technique. The primary endpoints were the pain control and the time to local progression; the secondary ones were the overall survival and toxicity. A total of 20 patients with spine metastases and 22 metastatic sites were treated in our center with stereotactic body radiation therapy–simultaneous integrated boost between December 2007 and July 2018. Stereotactic body radiation therapy–simultaneous integrated boost treatments were delivered doses of 8 to 10 Gy in 1 fraction to isodose line of 50%. The median follow-up was 35 months (range: 12-110). The median time to local progression for all patients was not reached and the actuarial 1-, 2-, and 3-years local free progression rate was 86.36%. In 17 of 20 patients, a complete pain remission was observed and 3 of 20 patients had a partial pain remission (complete pain remission + partial pain remission: 100%). The median overall survival was 38 months (range 12-83). None of the patients experienced neither radiation adverse events (grade 1-4) nor reported pain flair reaction. None of the patients included in our series experienced vertebral compression fracture. Spine radiosurgery with stereotactic body radiation therapy–simultaneous integrated boost is safe. The use of this modality in spine metastases patients provides an excellent local control.

This research aims at pointing out those constrains and incentives conditioning family farm choices about investments, technical and managerial knowledge and expertness. The planned target has to be achieved through the attainment of three stages. Family farm involves a lot of people by different kind of employee relations, based mostly on a temporary work, that are often within the limits of the work rules. The organization solutions adopted by family farm produce several effects: among which investments and human capital allotment stand out. This research analyses family farm characteristics in a local rural system of the Calabria Region, as the result of the various European Community and domestic interventions and the specific physical, social and economic features in the considered territory; the attention is focused on the olive growing family farm. The survey is made through interviews carried out by qualified operators using questionnaires organized on different modules.

The new model of rural development, based on the recognition of the economic, social and environmental function of the European agriculture, mainly headed to make strategies of intervention concerning about, from one side, the competitive ability of the agricultural and agro-industrial enterprises, and, from the other, the increasing of the economic, human, environmental and historical-cultural resources. In such context the multi-functional role of agriculture becomes central and the agricultural operators have to adapt themselves to items (the territories, the rural societies, the consumers, etc.) and to different prescriptions related to demands linked up with the productivity and/or the territory (defence of the ground, of the landscape, of the cultural traditions, of the rural development, of the environment, of the quality). The present research documents the results of a territorial social-economic investigation, developed with the aim of examining the productive and environmental potentialities of the terraced winegrowing present in the territory of the \"Costa Viola\" in the province of Reggio Calabria (Calabria, Italy). The study starts from an analysis of the territory and individualizes a sample of wine-growing farms in order to examine, through specific social economic investigations (developed through a questionnaire), the actual conditions of the grape cultivated terraces, the status of the \"representative farmer\" of the vineyards and the achieved economic results. The collected data concerned some social characteristics (age, degree of education, availability and/or propensity to innovation, to introduce new technologies, etc.).