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Purpose To assess the safety of reimplantation of cryopreserved ovarian tissue from advanced-stage breast cancer patients. Methods Cryopreserved ovarian cortical fragments were obtained from 13 advanced-stage breast cancer patients aged 17–35 years. After thawing, part of the ovarian cortical tissue was grafted to severe combined immunodeficient mice for 6 months. The presence of malignant mammary cells in ovarian tissue was evaluated after thawing as well as after grafting by 1) histology and immunohistochemistry (epithelial membrane antigen, Her2/neu and gross cystic disease fluid protein 15 identification), and 2) detection of the MGB2 gene by qPCR. Results No malignant cells were evidenced by histology and immunohistochemistry. None of the mice died during the 6-month grafting period, nor developed macroscopically visible masses. MGB2 gene expression was detected by qPCR and confirmed by sequencing in frozen-thawed ovarian tissue in 4 cases and in grafts in 1 case. Conclusions This pilot study is the first to evaluate the risk of contamination of cryopreserved ovarian tissue from advanced-stage breast cancer patients by xenotransplantation for 6 months to immunodeficient mice, associated with more conventional screening methods. Our xenografting results are reassuring, but caution needs to be exercised, as MGB2 gene expression was detected in some cases. Larger numbers of ovarian tissue samples from patients with advanced-stage breast cancer are required to confirm our findings before ovarian tissue transplantation can be contemplated in these patients.

Although post-transplant lymphoproliferative disorder is a classical complication encountered after kidney transplantation, its diagnosis can still be challenging and its outcome life-threatening. Most cases are related to Epstein-Barr virus (EBV) infection and occur mainly in the first year post-transplant, favoured by the seronegative EBV status of the recipient transplanted with a kidney from a seropositive donor, and strong immunosuppression. We report the case of a young kidney-pancreas transplant recipient who developed post-transplant lymphoproliferative disorder (PTLD) early after transplantation, with a rapid fatal issue. We review the pathogenesis, clinical presentation, and management of PTLD with a focus on prevention.

Background: Solitary extramedullary plasmacytoma (SEP) is a rare malignant neoplasm arising from plasma cells. SEP mostly occurs in the upper respiratory tract. Thyroid gland is rarely affected (<78 cases). Methods/results: We describe the case of a 78-year-old woman presenting a rapidly enlarging palpable thyroid mass. Neck computed tomography scan showed enlargement of both thyroid lobes. Laboratory tests were normal, including serum protein level with no monoclonal gamma globulin peak. Cytology was suspicious for lymphoma. Biopsy showed an infiltrating neoplasm composed of atypical tumor cells with abundant cytoplasm and eccentric nuclei. These revealed diffuse immunoreactivity for CD138 and predominant staining for immunoglobulin kappa light chains. Clinical workup for multiple myeloma was negative. Conclusions: SEP should be considered in the differential diagnosis of a rapidly enlarging thyroid nodule and be distinguished from involvement of thyroid in multiple myeloma, mucosa-associated lymphoid tissue lymphoma, plasma cell granuloma and medullary carcinoma. Clinical correlation and immunohistochemistry are crucial in avoiding pitfalls.

Measurements ofb -hadron lifetimes are reported usingppcollision data, corresponding to an integrated luminosity of 1.0fb ⁻¹ , collected by the LHCb detector at a centre-of-mass energy of7 Tev. Using the exclusive decaysB⁺→ J/ψ K⁺ ,B⁰→ J/ψ K^(*)(892)⁰ ,B⁰→ J/ψ K⁰_(\\rm S) ,Λ_(b)⁰→ J/ψ ΛandB⁰_(s)→ J/ψ φthe average decay times in these modes are measured to beτ_(B⁺→ J/ψ K⁺)=1.637 ±0.004±0.003 ps,τ_(B⁰→ J/ψ K^(*)(892)⁰)=1.524 ±0.006±0.004 ps,τ_(B⁰→ J/ψ K⁰_(\\rm S))=1.499 ±0.013±0.005 ps,τ_(Λ_(b)⁰→ J/ψ Λ)=1.415 ±0.027±0.006 ps andτ_(B⁰_(s)→ J/ψ φ)=1.480 ±0.011±0.005 ps, where the first uncertainty is statistical and the second is systematic. These represent the most precise lifetime measurements in these decay modes. In addition, ratios of these lifetimes, and the ratio of the decay-width difference,ΔΓ_(d) , to the average width,Γ_(d) , in theB⁰system,Δ Γ_(d)/Γ_(d) = -0.044 ± 0.025 ± 0.011 , are reported. All quantities are found to be consistent with Standard Model expectations.

A search for associated production of aZboson with an open charm meson is presented using a data sample, corresponding to an integrated luminosity of1.0 \\mathrm{fb}{^(-')}{}of proton–proton collisions at a centre-of-mass energy of 7 TeV, collected by the LHCb experiment. %% Seven candidate events for associated production of aZboson with aD⁰meson and four candidate events for aZboson with aD⁺meson are observed with a combined significance of 5.1standard deviations. The production cross-sections in the forward region are measured to beσ_(Z→μ⁺μ⁻\\!{,}{D}{⁰}) = 2.50±1.12±0.22pbσ_(Z→μ⁺μ⁻\\!{,}{D}{⁺}) = 0.44±0.23±0.03pb,where the first uncertainty is statistical and the second systematic.

The production ofJ/ψmesons with rapidity 1.5

A search for previously unobserved decays of beauty baryons to the final states$K^0_{\\rm\\scriptscriptstyle S} p \\pi^{-}$and$K^0_{\\rm\\scriptscriptstyle S}p K^{-}$is reported. The analysis is based on a data sample corresponding to an integrated luminosity of$1.0\\,$ fb $^{-1}$of$pp$collisions. The$\\Lambda^0_{b} \\rightarrow \\overline{\\kern -0.2em K}^0_{\\rm\\scriptscriptstyle S}p \\pi^{-}$decay is observed with a significance of$8.6\\,\\sigma$ , with branching fraction eqnarray* B(^0_b -0.2em K^0 p ^-) & = & ( 1.26 0.19 0.09 0.34 0.05 ) 10^-5 \\,, eqnarray* where the uncertainties are statistical, systematic, from the ratio of fragmentation fractions$f_{\\Lambda}/f_{d}$ , and from the branching fraction of the$B^0 \\rightarrow K^0_{\\rm\\scriptscriptstyle S}\\pi^{+}\\pi^{-}$normalisation channel, respectively. A first measurement is made of the$CP$asymmetry, giving eqnarray* A_C\\!P (^0_b -0.2em K^0 p ^-) & = & 0.22 0.13\\,(stat) 0.03\\,(syst) \\, . eqnarray* No significant signals are seen for$\\Lambda^0_{b} \\rightarrow K^0_{\\rm\\scriptscriptstyle S}p K^{-}$decays,$\\Xi^{0}_{b}$decays to both the$K^0_{\\rm\\scriptscriptstyle S}p \\pi^{-}$and$K^0_{\\rm\\scriptscriptstyle S}p K^{-}$final states, and the$\\Lambda^0_{b} \\rightarrow D^{-}_{s} (\\rightarrow K^0_{\\rm\\scriptscriptstyle S} K^{-}) p$decay, and upper limits on their branching fractions are reported.