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result(s) for
"Campbell, Matthew (Matthew J. B.)"
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The Oxford handbook of W.B. Yeats
A Handbook devoted to the poet W.B. Yeats (1865-1939) that examines how his work as a poet, playwright, critic, and public figure in the late 19th through the mid-20th century continues to influence writing in English, Irish, and worldwide Anglophone literatures.
Book
Irish Poetry under the Union, 1801–1924
This book retells the story of Irish poetry written in English between the union of Britain and Ireland in 1801 and the early years of the Irish Free State. Through careful poetic and historical analysis, Matthew Campbell offers ways to read that poetry as ruptured, musical, translated and new. The book starts with the Romantic songs and parodies of nationalist and unionist writers - Moore, Mahony, Ferguson and Mangan - in times of defeat, resurgence and famine. It continues through a discussion of English Victorian poets such as Tennyson, Arnold and Hopkins, who wrote Irish poems as the British Empire unraveled. Campbell's treatment ends with Yeats, seeking a new poetry emerging from under union in times of violence and civil war. The book offers both a literary history of nineteenth-century Irish poetry and a way of reading it for scholars of Irish studies as well as Romantic and Victorian literature.
eBook
The Cambridge Companion to Contemporary Irish Poetry
In the last fifty years Irish poets have produced some of the most exciting poetry in contemporary literature, writing about love and sexuality, violence and history, country and city. This book, first published in 2003, provides an introduction to major figures such as Seamus Heaney, and also introduces the reader to significant precursors like Louis MacNeice or Patrick Kavanagh, and vital contemporaries and successors: among others, Thomas Kinsella, Nuala Ní Dhomhnaill and Paul Muldoon. Readers will find discussions of Irish poetry from the traditional to the modernist, written in Irish as well as English, from both North and South. This Companion provides cultural and historical background to contemporary Irish poetry in the contexts of modern Ireland but also in the broad currents of modern world literature. It includes a chronology and guide to further reading and will prove invaluable to students and teachers alike.
eBook
Rhythm and Will in Victorian Poetry
In Rhythm and Will in Victorian Poetry, first published in 1999, Matthew Campbell explores the work of four Victorian poets - Tennyson, Browning, Hopkins and Hardy - as they show a consistent and innovative concern with questions of human agency and will. The Victorians saw the virtues attendant upon a strong will as central to themselves and to their culture, and Victorian poetry strove to find an aesthetic form to represent this sense of the human will. Through close study of the metre, rhyme and rhythm of a wide range of poems - including monologue, lyric and elegy - Campbell reveals how closely technical questions of poetics are related, in the work of these poets, to issues of psychology, ethics and social change. He goes on to discuss more general questions of poetics, and the implications of the achievement of the Victorian poets in a wider context, from Milton through Romanticism and into contemporary critical debate.
eBook
Memory and Memorials, 1789-1914
Ranging historically from the French Revolution to the beginnings of Modernism, this book examines the significance of memory in an era of furious social change. Through an examination of literature, history and science the authors explore the theme of memory as a tool of social progression. This book offers a fresh theoretical understanding of the period and a wealth of empirical material of use to the historian, literature student or social psychologist.
eBook
Avelumab plus axitinib versus sunitinib in advanced renal cell carcinoma: biomarker analysis of the phase 3 JAVELIN Renal 101 trial
We report on molecular analyses of baseline tumor samples from the phase 3 JAVELIN Renal 101 trial (
n
= 886;
NCT02684006
), which demonstrated significantly prolonged progression-free survival (PFS) with first-line avelumab + axitinib versus sunitinib in advanced renal cell carcinoma (aRCC). We found that neither expression of the commonly assessed biomarker programmed cell death ligand 1 (PD-L1) nor tumor mutational burden differentiated PFS in either study arm. Similarly, the presence of FcɣR single nucleotide polymorphisms was unimpactful. We identified important biological features associated with differential PFS between the treatment arms, including new immunomodulatory and angiogenesis gene expression signatures (GESs), previously undescribed mutational profiles and their corresponding GESs, and several HLA types. These findings provide insight into the determinants of response to combined PD-1/PD-L1 and angiogenic pathway inhibition and may aid in the development of strategies for improved patient care in aRCC.
Biomarker analysis of the phase 3 JAVELIN Renal 101 trial uncovers molecular determinants of therapy-specific outcomes, which may inform personalized treatment strategies for patients with advanced renal cell carcinoma.
Journal Article
Ecology of inorganic sulfur auxiliary metabolism in widespread bacteriophages
Microbial sulfur metabolism contributes to biogeochemical cycling on global scales. Sulfur metabolizing microbes are infected by phages that can encode auxiliary metabolic genes (AMGs) to alter sulfur metabolism within host cells but remain poorly characterized. Here we identified 191 phages derived from twelve environments that encoded 227 AMGs for oxidation of sulfur and thiosulfate (
dsrA
,
dsrC/tusE
,
soxC
,
soxD
and
soxYZ
). Evidence for retention of AMGs during niche-differentiation of diverse phage populations provided evidence that auxiliary metabolism imparts measurable fitness benefits to phages with ramifications for ecosystem biogeochemistry. Gene abundance and expression profiles of AMGs suggested significant contributions by phages to sulfur and thiosulfate oxidation in freshwater lakes and oceans, and a sensitive response to changing sulfur concentrations in hydrothermal environments. Overall, our study provides fundamental insights on the distribution, diversity, and ecology of phage auxiliary metabolism associated with sulfur and reinforces the necessity of incorporating viral contributions into biogeochemical configurations.
Some bacteriophage encode auxiliary metabolic genes (AMGs) that impact host metabolism and biogeochemical cycling during infection. Here the authors identify hundreds of AMGs in environmental phage encoding sulfur oxidation genes and use their global distribution to infer phage-mediated biogeochemical impacts.
Journal Article
Natural optical activity as the origin of the large chiroptical properties in π-conjugated polymer thin films
Polymer thin films that emit and absorb circularly polarised light have been demonstrated with the promise of achieving important technological advances; from efficient, high-performance displays, to 3D imaging and all-organic spintronic devices. However, the origin of the large chiroptical effects in such films has, until now, remained elusive. We investigate the emergence of such phenomena in achiral polymers blended with a chiral small-molecule additive (1-aza[6]helicene) and intrinsically chiral-sidechain polymers using a combination of spectroscopic methods and structural probes. We show that – under conditions relevant for device fabrication – the large chiroptical effects are caused by magneto-electric coupling (natural optical activity), not structural chirality as previously assumed, and may occur because of local order in a cylinder blue phase-type organisation. This disruptive mechanistic insight into chiral polymer thin films will offer new approaches towards chiroptical materials development after almost three decades of research in this area.
Polymer thin films that emit and absorb circularly polarised light are promising in achieving important technological advances, but the origin of the large chiroptical effects in such films has remained elusive. Here the authors demonstrate that in non-aligned polymer thin films, large chiroptical effects are caused by magneto-electric coupling, not structural chirality as previously assumed.
Journal Article