Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
4,689
result(s) for
"Campbell, Paul"
Sort by:
Practical programming : an introduction to computer science using Python 3.6
Classroom-tested by tens of thousands of students, this new edition of the bestselling intro to programming book is for anyone who wants to understand computer science. Learn about design, algorithms, testing, and debugging. Discover the fundamentals of programming with Python, including the new features in Python 3.6. Learn about design, algorithms, testing, and debugging. Write programs to solve real-world problems, and come away with everything you need to produce quality code.
Book
Major Cellular and Physiological Impacts of Ocean Acidification on a Reef Building Coral
As atmospheric levels of CO2 increase, reef-building corals are under greater stress from both increased sea surface temperatures and declining sea water pH. To date, most studies have focused on either coral bleaching due to warming oceans or declining calcification due to decreasing oceanic carbonate ion concentrations. Here, through the use of physiology measurements and cDNA microarrays, we show that changes in pH and ocean chemistry consistent with two scenarios put forward by the Intergovernmental Panel on Climate Change (IPCC) drive major changes in gene expression, respiration, photosynthesis and symbiosis of the coral, Acropora millepora, before affects on biomineralisation are apparent at the phenotype level. Under high CO2 conditions corals at the phenotype level lost over half their Symbiodinium populations, and had a decrease in both photosynthesis and respiration. Changes in gene expression were consistent with metabolic suppression, an increase in oxidative stress, apoptosis and symbiont loss. Other expression patterns demonstrate upregulation of membrane transporters, as well as the regulation of genes involved in membrane cytoskeletal interactions and cytoskeletal remodeling. These widespread changes in gene expression emphasize the need to expand future studies of ocean acidification to include a wider spectrum of cellular processes, many of which may occur before impacts on calcification.
Journal Article
Morphogenesis in Trypanosoma cruzi epimastigotes proceeds via a highly asymmetric cell division
Trypanosoma cruzi is a protist parasite that is the causative agent of Chagas disease, a neglected tropical disease endemic to the Americas. T . cruzi cells are highly polarized and undergo morphological changes as they cycle within their insect and mammalian hosts. Work on related trypanosomatids has described cell division mechanisms in several life-cycle stages and identified a set of essential morphogenic proteins that serve as markers for key events during trypanosomatid division. Here, we use Cas9-based tagging of morphogenic genes, live-cell imaging, and expansion microscopy to study the cell division mechanism of the insect-resident epimastigote form of T . cruzi , which represents an understudied trypanosomatid morphotype. We find that T . cruzi epimastigote cell division is highly asymmetric, producing one daughter cell that is significantly smaller than the other. Daughter cell division rates differ by 4.9 h, which may be a consequence of this size disparity. Many of the morphogenic proteins identified in T . brucei have altered localization patterns in T . cruzi epimastigotes, which may reflect fundamental differences in the cell division mechanism of this life cycle stage, which widens and shortens the cell body to accommodate the duplicated organelles and cleavage furrow rather than elongating the cell body along the long axis of the cell, as is the case in life-cycle stages that have been studied in T . brucei . This work provides a foundation for further investigations of T . cruzi cell division and shows that subtle differences in trypanosomatid cell morphology can alter how these parasites divide.
Journal Article
A land transformed : the Arabian Peninsula, Saudi Arabia, and Saudi Aramco
Includes information on before the oil era, Architecture of ʼAsir and Tihamah, handicrafts, The Bedouin, Neolithic tools, who is an Arab, frankincense, the Tayma stone, The prayer rug, the five pillars of Islam, the Hijri calendar and the two festivals, how Islamic science reached Europe, Arabic numerals, Arabic language, Arabic literature, the development of Islamic law, tribal settlers and nomads, rood, dress, money, music, Saudi women today, climate, falconry, crude oil, gasoline, the search for oil and gas, geology of Arabia, environmental accountability, Saudi Arabia and world energy, Makkah (Mecca), etc.
Book
Genomic diversity across the Rickettsia and ‘Candidatus Megaira’ genera and proposal of genus status for the Torix group
Members of the bacterial genus
Rickettsia
were originally identified as causative agents of vector-borne diseases in mammals. However, many
Rickettsia
species are arthropod symbionts and close relatives of ‘
Candidatus
Megaira’, which are symbiotic associates of microeukaryotes. Here, we clarify the evolutionary relationships between these organisms by assembling 26 genomes of
Rickettsia
species from understudied groups, including the Torix group, and two genomes of ‘
Ca
. Megaira’ from various insects and microeukaryotes. Our analyses of the new genomes, in comparison with previously described ones, indicate that the accessory genome diversity and broad host range of Torix
Rickettsia
are comparable to those of all other
Rickettsia
combined. Therefore, the Torix clade may play unrecognized roles in invertebrate biology and physiology. We argue this clade should be given its own genus status, for which we propose the name ‘
Candidatus
Tisiphia’.
The bacterial genus
Rickettsia
includes vector-borne pathogens and arthropod symbionts that are close relatives of symbionts of microeukaryotes classified under the genus ‘
Candidatus
Megaira’. Here, Davison et al. clarify the evolutionary relationships between these organisms by assembling 28 genomes of understudied species, and propose that a distinct clade known as Torix
Rickettsia
should be considered a separate genus.
Journal Article
Orion by Walt Simonson
\"Walt Simonson's stunning, unmistakable art and storytelling are on full display here in his groundbreaking work ORION. Expanding the beloved universe originally created by Jack Kirby, Simonson's sprawling storylines and dynamic artwork elevate his titular hero, as well as the rest of the Fourth World's indispensible characters, to incredible new heights. Collected here for the first time are all twenty-five issues of Walter Simonson's ORION, as well as never-before reprinted short stories, pinups and sketch material.\"-- Provided by publisher.
BOOK
Education, Retirement and Career Transitions for 'Black' Ex-Professional Footballers
Drawing on a combination of interviews and auto-ethnographic data, Education, Retirement and Career Transitions for 'Black' Ex-Professional Footballers provides a case-study of 16 'black' British male professional footballers' preparedness and experiences of retirement and transition from careers as professional athletes to mainstream work.
eBook
Dementia Care Research and Psychosocial Factors
Cognitive impairment affects 32% of adults over 65, impacting approximately 250 million people globally [1,2]. Cognitive rehabilitation is an effective intervention for dementia to preserve independence, delay institutional care and reduce caregiver burden [3]. However, access to rehabilitation is currently limited by a shortage of skilled providers, particularly in low resource and remote settings.
Moneta Health is addressing this unmet need by delivering cognitive rehabilitation using an automated therapy delivery system. Patients receive personalized and interactive cognitive activities through a voice agent over the telephone focused on stimulating areas of cognitive deficit and teaching compensatory strategies. Automated calls are processed using artificial intelligence and reviewed by a speech-language pathologist (SLP) who assigns therapy content, performs skilled analysis, assesses progress and provides weekly feedback to the patient by telephone.
In a cohort of 75 patients who completed Moneta's program (average age 73 ± 10, average MoCA score 20 ± 5), 59% had MCI and 33% had dementia. Patients completed 2.6 digital therapy calls (58 minutes) per week, and 2.3x more sessions overall than traditional outpatient therapy [4]. Patients' cognitive function significantly improved on average by 18% (p <0.001), compared to 13% for traditional outpatient therapy [4, 5]. Self reported quality of life also significantly improved on average by 11% (p <0.001) [6].
Access to practical and personalized support is a critical component to helping older adults with cognitive impairment to remain independent in daily life. Moneta's AI-powered program by telephone offers a scalable model for improving access to cognitive rehabilitation, with demonstrated real world outcomes. References [1] Manley et al., JAMA Neurology, 2022;79(12):1242-1249. [2] Leaving No One Behind In An Ageing World: World Social Report, United Nations, 2023. [3] Kudlicka et al., Cognitive rehabilitation for people with mild to moderate dementia, Cochrane Database of Systematic Reviews, 2023. [4] Compared to therapy outcomes data in the National Outcomes Measurement System of the American Speech-Language-Hearing Association for ages 50-89, cognitive communication disorder, outpatient setting, accessed January 17, 2025. [5] Functional communication measure (FCM) for cognitive function assessed by a SLP. [6] Quality of Life in Neurological Disorders.
Journal Article