Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
793
result(s) for
"Campbell, William C."
Sort by:
ACCEPTANCE OF THE EMINENT PARASITOLOGIST AWARD: CHEMOTHERAPY IN THE CONTEXT OF EMERGING PARASITIC DISEASES
It seems inevitable that chemotherapy will continue, at least in the near-term, to be a significant factor in the control of infectious diseases. The effectiveness of new drugs has invariably been reduced by the emergence of drug resistance. Efforts to thwart resistance should continue, but there are also other areas that might profitably be re-examined. They include (1) methods of new-drug discovery; (2) selection of parasite life-cycle targets; (3) epidemiological determinants of effectiveness in large-scale control programs; and (4) the economic, managerial, psychological, and political ramifications of drug discovery and drug utilization.
Journal Article
Acceptance of the 2016 Eminent Parasitologist Award: Chemotherapy in the Context of Emerging Parasitic Diseases
It seems inevitable that chemotherapy will continue, at least in the near-term, to be a significant factor in the control of infectious diseases. The effectiveness of new drugs has invariably been reduced by the emergence of drug resistance. Efforts to thwart resistance should continue, but there are also other areas that might profitably be re-examined. They include (1) methods of new-drug discovery; (2) selection of parasite life-cycle targets; (3) epidemiological determinants of effectiveness in large-scale control programs; and (4) the economic, managerial, psychological, and political ramifications of drug discovery and drug utilization.
Journal Article
History of the Discovery of Sulfaquinoxaline as a Coccidiostat
Sulfaquinoxaline played an important part in the demotion of roast chicken from vaunted Sunday-dinner status to an unrespected position on the everyday menu of the Western world. It had its origins in the chemical synthetic program that sprang from the introduction of sulfonamide drugs into human medicine in the 1930s. The program was sustained through the years of World War II despite declining clinical use of that chemical class. Several sulfa drugs were known to be active against the sporozoan parasite (Plasmodium spp.) that causes malaria, but were not satisfactory in clinical practice. A sulfonamide that had a long plasma half-life would ipso facto be considered promising as an antimalarial drug. Sulfaquinoxaline, synthesized during the war, was such a compound. It proved too toxic to be used in human malaria, but was found to be a superior agent against another sporozoan parasite, Eimeria spp., the causative agent of coccidiosis in domestic chickens. In 1948 sulfaquinoxaline was introduced commercially as a poultry coccidiostat. It was not the first sulfonamide found active against Eimeria spp. in poultry, but its practical success in disease control firmly established the routine incorporation of anticoccidial drugs in poultry feed. In this way, the drug exerted a major impact on the worldwide production of poultry meat. Although it has long been eclipsed by other drugs in poultry management, it continues to be used in other host species. This article describes the discovery of sulfaquinoxaline as a practical therapeutic agent, and examines the way in which the discovery arose from a partnership between industry and academia.
Journal Article
People, parasites, and plowshares
Dickson D. Despommier's vivid, visceral account of the biology, behavior, and history of parasites follows the interplay between these fascinating life forms and human society over thousands of years. Despommier focuses on long-term host-parasite associations, which have evolved to avoid or even subvert the human immune system. Some parasites do great damage to their hosts, while others have signed a kind of \"peace treaty\" in exchange for their long lives within them. Many parasites also practice clever survival strategies that medical scientists hope to mimic as they search for treatments for Crohn's disease, food allergies, type 1 diabetes, organ transplantation, and other medical challenges.
Despommier concentrates on particularly remarkable and often highly pathogenic organisms, describing their lifecycles and the mechanisms they use to avoid elimination. He details their attack and survival plans and the nature of the illnesses they cause in general terms, enabling readers of all backgrounds to steal a glimpse into the secret work of such effective invaders. He also points to the cultural contexts in which these parasites thrive and reviews the current treatments available to defeat them. Encouraging scientists to continue to study these organisms even if their threat is largely contained, Despommier shows how closer dissection of the substances parasites produce to alter our response to them could help unravel some of our most complex medical conundrums.
eBook
Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi
Ivermectin (IVM) is a broad-spectrum anthelmintic used in filariasis control programs. By binding to nematode glutamate-gated chloride channels (GluCls), IVM disrupts neurotransmission processes regulated by GluCl activity. IVM treatment of filarial infections is characterized by an initial dramatic drop in the levels of circulating microfilariae, followed by long-term suppression of their production, but the drug has little direct effect on microfilariae in culture at pharmacologically relevant concentrations. We localized Brugia malayi GluCl expression solely in a muscle structure that surrounds the microfilarial excretory-secretory (ES) vesicle, which suggests that protein release from the ES vesicle is regulated by GluCl activity. Consistent with this hypothesis, exposure to IVM in vitro decreased the amount of protein released from microfilariae. To better understand the scope of IVM effects on protein release by the parasite, three different expression patterns were identified from immunolocalization assays on a representative group of five microfilarial ES products. Patterns of expression suggest that the ES apparatus is the main source of regulated ES product release from microfilariae, as it is the only compartment that appears to be under neuromuscular control. Our results show that IVM treatment of microfilariae results in a marked reduction of protein release from the ES apparatus. Under in vivo conditions, the rapid microfilarial clearance induced by IVM treatment is proposed to result from suppression of the ability of the parasite to secrete proteins that enable evasion of the host immune system.
Journal Article
Applying Moral Development Literature And Ethical Theories To The Administration Of Taxes In Kosovo
The population of Kosovo had suffered years of abuse, ethnic cleansing, turmoil, human atrocities, and constant conflict - the results of which plunged Kosovo into costly war. Following the war Kosovo was placed under the protection of the United Nations in 1999. Kosovo received many years of support and developmental assistance from the international community and became a sovereign nation in February 2008. It was very important for Kosovo’s government to serve the needs of the people without continued oversight and intervention by the United Nations. Public institutions are vital to the success of the government. There is no institution more important to the successful development of a sovereign nation and their economy than the ethical administration of a tax authority. In the spring of 2008, after Kosovo’s declaration of independence, this study was initiated to determine the moral maturity of the members of the Tax Authority of Kosovo. This study provides a review of the current situation in Kosovo and discusses ethical considerations in tax administration. The paper further provides a comprehensive discussion of ethical concerns and discusses the importance of moral development in the tax administration of Kosovo. Recommendations for managers and future research are presented.
Journal Article
IN MEMORIAM: ASHTON C. CUCKLER
In the post-WW II era, after training at the Army Medical School in Washington D.C., he served in Italy as Laboratory Director for the Italian Medical Mission of the United Nations Relief and Rehabilitation Administration—an experience that probably influenced his decision to enter the pharmaceutical industry to work on the experimental chemotherapy of malaria. Because he was famously single-minded and fiscally strict in the pursuit of company objectives, it would surprise some to learn that Ash never raised the slightest objection when I devoted large chunks of time and resources to peripheral studies. (When I ordered a bottle of Irish Whisky through regular requisitioning channels, neither he nor anyone else batted an eye—all apparently having confidence that it was for scientific purposes.) He supported my spending time in the laboratory of Dr. (now Lord) Soulsby's laboratory in Cambridge, England, where immunology, not chemotherapy, was the focus of attention. Weight gain, feed efficiency, wool quality, disease prevention rather than cure—such things as these would henceforth be the measure of anthelmintic success.
Journal Article