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Dyslipidemia is a common alteration in lipid metabolism that is a main cardiovascular risk factor. There are multiple causes of dyslipidemia and environmental and genetic factors are involved. We analyze the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and its association with serum lipids in young individuals of northeast Mexico. A total of 139 voluntary participants were separated into two groups based on body mass index were evaluated. Lipid profile and genotype were determined in both groups. No statistically significant difference was found in either group and among genotypes. Its is concluded that the TT genotype of the MTHFR gene polymorphism is not associated with dyslipidemia in young individuals.

Introduction: Mortality is affected by several factors, including the place of residence. Several studies have found a gap in mortality between urban and rural residents. This study aimed to describe adjusted mortality rates in urban and rural areas of Mexico. Methods: Adjusted mortality rate per 100 000 inhabitants was estimated in urban and rural areas of Mexico, were grouped by sex, age, and main cause of death. Trend analysis was performed with a logarithmic regression of adjusted rates. Results: Mortality was higher in urban (622.1/100 000 inhabitants) than rural (549.5/100 000 inhabitants) areas of Mexico. Males showed the highest mortality rate in both studied areas, urban and Rural and Remote Health www.rrh.org.au James Cook University ISSN 1445-6354 1 2 3 4 5 1, 2, 3, 4, 5 rural (737.8 and 634.4/100 000 inhabitants respectively). A significant annual decrease of 0.5% in mortality rates was observed in both areas. Conclusion: In Mexico, there is a gap in mortality rates based on individuals' place of residence. Those who live in urban areas present the highest mortality rates.

Background Unsafe storage of unused medications at home leads to an increased risk of toxicity, accidental childhood poisoning or risk for suicide, whereas an improper disposal of unwanted/expired medications from household raises concern about environmental pollution. Objective The aim of the study was to characterize expired medications collected according to the types of therapeutic groups, pharmaceutical dosage forms, expiration dates and were prescribed or over the counter drugs, and whether they came from Mexican health system or purchased by patients themselves. Setting The study was conducted in the metropolitan area of Monterrey during a 12-month period from March 2012 to February 2013. Method Unused/expired drugs were collected according to the collection and disposal of expired medication program instituted by the Department of Health of the State of Nuevo León. Pharmacists and students from The Autonomous University of Nuevo León recorded types of therapeutic groups, total of medicines in each group, among other classification criteria. Main outcome measure The proportion of every collected therapeutic group, type of dosage forms, and expiration date. Results The amount of medications classified was 22,140 items corresponding to a 30 % of the total collected medications in that period of time; most of them belonged to the non-steroidal anti-inflammatory drugs (16.11 %). According to the pharmaceutical dosage forms, results showed that a high percentage were solid dosage forms (73.39 %), of the total unused/expired medications, most of them were prescription drugs (91 %) which were purchased at private pharmacies. Expiration date of medications ranges from 1995 to 2016, being 2011 the outstanding year (36.66 %). Conclusion Addressing the aspect of unused drug disposition constitutes a challenge for Mexican government, due to health implications related to inadequate disposition. No matter how efficient the programs of collection and disposal of expired drugs are, none of them can collect all unused or expired drugs, that is the reason why the best approach might be to prevent this need.

Poisoning remains a major worldwide public health problem. Mortality varies by country, region and ethnicity. The objective of this study is to analyze recent trends in poisoning mortality in the Mexican population. Data regarding mortality induced by poisoning was obtained from a publicly available national database maintained by the National Institute of Statistics and Geography. During the period from 2000 to 2012, average mortality rates for unintentional and self-poisoning were 1.09 and 0.41 per 100000 population, respectively. The highest mortality rate for unintentional poisoning was in older individuals of both genders while the highest mortality for self-poisoning was in older men and young women. Additional studies are needed in Mexico, especially those that analyze risk factors in older individuals and young women.

La subutilización e inadecuada disposición de medicamentos caducos representa un importante problema. El objetivo de este estudio fue describir el patrón y la cantidad de medicamentos cardiovasculares no utilizados en el área Metropolitana de Monterrey, en el estado de Nuevo León, México. A través de varias vías de difusión, se invitó a los habitantes a depositar los medicamentos que no utilizan en diversos centros de acopio distribuidos en el área metropolitana, el período de acopio fue de 12 meses. Los medicamentos individuales fueron identificados, contabilizados y clasificados de acuerdo con el sistema Anatómica, Terapéutica y Química (ATC, por sus siglas en inglés). La diferencia entre los fármacos agrupados se probó con ANOVA o Chi cuadrado según corresponda. El costo de cada medicamento identificado se obtuvo a través de la consulta de precio en al menos tres farmacias. Durante el tiempo de estudio se recolectaron un total de 207963 unidades, de las cuales los hipolipemiantes fueron los más abundantes, el costo estimado de todos los medicamentos cardiovasculares fue de 0,03 USD por habitante. Los resultados muestran que una gran cantidad de medicamentos cardiovasculares se desperdician y esto representa un costo importante.

Dyslipidemia is a common alteration in lipid metabolism that is a main cardiovascular risk factor. There are multiple causes of dyslipidemia and environmental and genetic factors are involved. We analyze the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and its association with serum lipids in young individuals of northeast Mexico. A total of 139 voluntary participants were separated into two groups based on body mass index were evaluated. Lipid profile and genotype were determined in both groups. No statistically significant difference was found in either group and among genotypes. Its is concluded that the TT genotype of the MTHFR gene polymorphism is not associated with dyslipidemia in young individuals.