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نص جديد تلقي الرواية ضوءا على تفاصيل الحياة في الريف الصيني، التي تتشابه مع الحياة في الريف المصري، حتى لنشعر أنها تتحدث عنا بنفس القدر الذي تتحدث فيه عن الصين، وقد بنى الروائي الصيني عالما كاملا داخل قرية صغيرة، من خلال مترادفات يحكيه عن الفتاة الصغيرة عباد الشمس، التي تتسم بهدوئها ورقتها ونقائها، وعهد الأخوة الذي ربطها بالفتى برونز، ووصفاه بأنه لن يتغير لعشرة آلاف سنة ! من خلال أحداث الرواية سنعرف كيف ربطت الأقدار بين مصير هذه الفتاة من المدينة وهذا الفتى من الريف. فقد كان على والد عباد الشمس أن يغادر المدينة ويتوجه إلى قرية القمح للعمل هناك بمدرسة الكوادر بعد موت زوجته والدة عباد الشمس، ولهذا، كان يصطحب ابنته معه في كل مكان، إذ لم يكن لديهما أقرباء آخرون، لأن والديها أيضا كانا يتيمين !، ولذلك، بعد أن غرق أبوها تقاتل أسرة ريفية فقيرة من قرية القمح كي تتبناها، وهي أسرة الفتى برونز. في هذه الرواية سنرى مستقبل عباد الشمس، وكيف استطاعت التواصل الحميم مع سكان قرية القمح، حتى أحس كل فرد فيها بأنها ابنة له.

Icariin is a prenylated flavonol glycoside isolated from Epimedium herb, and has been shown to be its main bioactive component. Recently, the antidepressant-like mechanism of icariin has been increasingly evaluated and demonstrated. However, there are few studies that have focused on the involvement of the phosphatidylinositol 3-kinase (PI3K)/serine-threonine protein kinase (AKT) signaling in mediating the perimenopausal depression effects of icariin. Perimenopausal depression is a chronic recurrent disease that leads to an increased risk of suicide, and poses a significant risk to public health. The aim of the present study was to explore the effect of icariin on the expression of the PI3K–AKT pathway related to proteins in a rat model of perimenopausal depression. Eighty percent of the left ovary and the entire right ovary were removed from the model rats. A perimenopausal depression model was created through 18 days of chronic unpredictable stimulation, followed by the gavage administration of target drugs for 30 consecutive days. We found that icariin administered at various doses significantly improved the apparent symptoms in the model rats, increased the organ indices of the uterus, spleen, and thymus, and improved the pathological changes in the ovaries. Moreover, icariin administration elevated the serum levels of female hormone estradiol (E2), testosterone (T), and interleukin (IL)-2, decreased those of follicle stimulating hormone (FSH) and luteotropic hormone (LH), promoted the expression levels of estrogen receptor (ER) and ERα in the hypothalamus, and increased those of serotonin (5-HT), dopamine (DA), and noradrenaline (NA) in the brain homogenate. Furthermore, icariin elevated the expression levels of AKT, phosphorylation-akt (p-AKT), PI3K (110 kDa), PI3K (85 kDa), and B-cell lymphoma 2 (Bcl-2) in the ovaries, and inhibited those of Bax. These results show that icariin administration rebalanced the disordered sex hormones in perimenopausal depression rats, regulated the secretion of neurotransmitters in the brain, boosted immune function, and improved the perimenopausal syndrome. The mechanism of action may be related to the regulation of the expression of PI3K–AKT pathway-related proteins.

رواية \"أمطار شجرة العطر\" حاصلة على جائزة أندرسن العالمية، تضم خمس قصص شيقة تغوص في المشاعر الإنسانية، بين شيخ أنقذ صبيا وعاش معه في قارب وسط البحر ويعملان بالصيد، وعائلة غنية يتدهور حالها ويعاني أحد أبنائها من الوحدة إلى أن يحقق ذاته ويكسب ثقة الآخرين، وثلاثة أطفال يعشقون لعبة التزحلق، فتعيش معهم قصة مليئة بالمغامرة تتجلى فيها معاني الصداقة والتضحية، وبين شجرة يؤثر عطرها القلوب ويتجمع حولها الأطفال في مهرجان شجرة العطر من كل عام.

In volcanic arcs, magma evolves from basaltic to intermediate and felsic composition, resulting in arc crust maturation. It remains unclear whether processes involving mush during magmatic flare‐ups would enhance this evolution. This study revealed a temporal‐compositional evolution of plutonic rocks from mafic (∼94 Ma) to intermediate (∼92–88 Ma) to felsic (∼88 Ma) during a magmatic flare‐up event in the Gangdese arc, Tibet, with increasing radiogenic Sr–Nd isotope enrichment. Apatites in mafic and felsic rocks have εNd(t) values similar to their hosts, while intermediate rocks show higher values. The elemental composition of apatites in mafic and intermediate rocks is similar but differs from those in felsic rocks. Textural and compositional features indicate varying degrees of influence of mafic rock compositions by accumulation. Triangular and linear covariation relationships between apatite‐compatible (e.g., La) and ‐incompatible (e.g., Rb) elements with SiO2, respectively, for all plutonic rocks as a whole, confirm the incorporation of apatite‐rich mushes into the mixing process. These findings suggest that mafic magma crystallized into apatite‐rich mush, which was later remobilized and mixed with felsic magma to form intermediate magma. Felsic rocks represent end‐member magmas resulting from crustal anatexis and/or mafic magma differentiation. Thus, the Gangdese arc's maturation during the magmatic flare‐up progressed sequentially through mafic magma crystallization and mush formation, mush remobilization and mixing with felsic magma, and the eventual accumulation and segregation of felsic magma. This sequence of events during flare‐ups illustrates a common crustal maturation process in volcanic arcs, as also seen in the Andean Cordillera. Plain Language Summary To understand how continental crust grows from magmatism at subduction zones, we need to know how depleted primitive mafic magmas transform into enriched evolved rocks. New ideas about mush‐dominant transcrustal magmatic systems and magmatic flare‐ups challenge previous views. While increased magma during flare‐ups likely forms and mobilizes mushes, promoting differentiation and mature arc crust, there's no solid proof. This study examines apatite and whole‐rock geochemistry for rocks from three plutons in the Gangdese arc, southern Tibet, and analyzes and compares geochemical data from the Gangdese arc and the Andean Cordillera. Our findings reveal a three‐step transition in plutonic rock composition, from mafic to intermediate and then to felsic, during a Cretaceous flare‐up in the Gangdese arc. This change matches gradual radiogenic isotope enrichment. Apatites in mafic and felsic rocks have similar εNd(t) values to their host rocks, but intermediate rocks show higher values. Element‐SiO2 covariant relationships confirm apatite‐rich mush incorporation into the magma mixing/mingling. This study provides strong evidence of continental arc maturation through mafic magma crystallization, mush formation and remobilization, mixing with felsic magmas, and felsic magma accumulation. Similar patterns recognized in the Andean Cordillera suggest this is common in continental volcanic arcs. Key Points During the Cretaceous magmatic flare‐up event in the Gangdese arc, a temporal compositional evolution of plutonic rocks is unveiled Ubiquitous apatite antecrysts confirms remobilization and mixing of apatite‐rich mush with magma in the formation of intermediate arc rocks Arc maturation would be enhanced by the involvement of mush in magmatic processes during magmatic flare‐up events

ينطلق هذا المجلد من العلاقة الهيكلية بين \"الفضاء\" و\"الثقافة\"، ويجمع بين مفهوم \"الفضاء\" في الجغرافيا ومفهوم \"السياق\" في الدراسات الثقافية وغيرهم من المفاهيم الأخرى، ويشرح نماذج ودلالات وأهداف مبادرة \"الحزام والطريق\" في سياق الحضارة الحديثة، ويصف صورة امتداد الحضارة على المحور التاريخي لـ \"الحزام والطريق\"، ويحلل الدلالة الثقافية في كل من اتجاه القيمة وبناء القوة الناعمة وإنشاء السياق الشرقي الخاصين بمبادرة \"الحزام والطريق\"، ويفسر علاقة الارتباط بين الثقافة الوطنية لـ \"الحزام والطريق\" والفضاء الوطني، ويكشف عن السرد عبر الفضاء للرموز الثقافية لـ \"الحزام والطريق\" ويوضح التعبير الرقمي والمرئي لواقع \"الحزام والطريق\"

Grafting of C7 from the nonparalyzed to the paralyzed side in patients with arm paralysis resulted in greater improvements in power, spasticity, and function at 12 months than rehabilitation therapy alone, and functional connection to the ipsilateral cerebral hemisphere developed.

Perennial ryegrass ( Lolium perenne ) is a widely cultivated forage and turf grass species. Salt stress can severely damage the growth of grass plants. The genome-wide molecular mechanisms of salt tolerance have not been well understood in perennial grass species. In this study, the salt sensitive genotype P1 (PI265351, Chile) and the salt tolerant genotype P2 (PI368892, Algeria) of perennial ryegrass were subjected to 200 mM NaCl, and transcriptomics and metabolomics analyses were performed. A total of 5,728 differentially expressed genes (DEGs) were identified through pairwise comparisons. Antioxidant enzyme encoding genes ( LpSOD1 , LpCAT1 ), ion channel gene LpCaC1 and transcription factors ( LpERFs , LpHSF1 and LpMYB1 ) were significantly upregulated in P2, suggesting their involvement in regulating expression of salt-responsive genes for salt tolerance. Functional analysis of DEGs revealed that biosynthesis of secondary metabolites, carbohydrate metabolism and signal transduction were the main pathways in response to salt stress. Weighted gene co-expression network analysis (WGCNA) based on RNA-Seq data showed that membrane transport and ABC transporters were significantly correlated with salt tolerance-related traits. The combined transcriptomics and metabolomics analysis demonstrated that the phenylpropanoid biosynthesis pathway was a major secondary metabolic pathway in the salt response of perennial ryegrass. Especially, the tolerant genotype P2 had greater amounts of upregulated phenylpropanoids, flavonoids and anthocyanins and higher expressions of relevant genes in the pathway than the sensitive genotype P1, indicating a role of phenylpropanoid biosynthesis for perennial ryegrass to adapt to salt stress. The results provided insights into the molecular mechanisms of perennial ryegrass adaptation to salinity and laid a base for genetic improvement of salt tolerance in perennial grass species.

To develop novel anti-inflammatory agents, a series of 5-alkyl-4-oxo-4,5-dihydro-[1, 2, 4]triazolo[4,3-a]quinoxaline-1-carboxamide derivatives were designed, synthesised, and evaluated for anti-inflammatory effects using RAW264.7 cells. Structures of the synthesised compounds were determined using 1 H NMR, 13  C NMR, and HRMS. All the compounds were screened for anti-inflammatory activity based on their inhibitory effects against LPS-induced NO release. Among them, 5-(3,4,5-trimethoxybenzyl)-4-oxo-4,5-dihydro-[1, 2, 4]triazolo[4,3-a]quinoxaline-1-carboxamide (6p) showed the highest anti-inflammatory activity and inhibited NO release more potently than the lead compound D1. Further studies revealed that compound 6p reduced the levels of NO, TNF-α, and IL-6, and that its anti-inflammatory activity involves the inhibition of COX-2 and iNOS and downregulation of the mitogen-activated protein kinases (MAPK) signal pathway. Notably, compound 6p displayed more prominent anti-inflammatory activity than D1 and the positive control ibuprofen in the in vivo acute inflammatory model. Overall, these findings indicate that compound 6p is a therapeutic candidate for the treatment of inflammation.

The present study was envisaged to investigate the chemical constituents and the intervention effects of Portulaca oleracea extract (POE) on acute alcoholic liver injury of rats. The chemical composition of POE was detected by high performance liquid chromatography (HPLC). Sixty male Wistar rats were divided into 6 groups: Normal control (NC) group, acute alcoholic liver injury model group (ALI), low, medium and high dose of POE (25, 50, 100 mg/kg) groups and bifendate (BF, 3.75 mg/kg) group. Each group was given by intragastrical administration for 7 days. Alcoholic liver injury was induced in the experimental model by administering 50% ethanol at 8 mL/kg and repeated administration after 6 h, for a period of 7 days. The results showed that pretreatment with POE significantly reduced the ethanol-elevated serum level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and triglyceride (TG). The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) in liver were enhanced followed by administration of POE, while the content of nitric oxide (NO) and malondialdehyde (MDA) was found to decrease. Hepatic content of tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) was also reduced by POE treatment. These results indicated that POE could increase the antioxidant capacity and relieve the inflammatory injury of the liver cells induced by ethanol. Meanwhile, in our study, POE reduced the expression of miR-122, acetyl coenzyme A carboxylase (ACC) 1 mRNA and protein and increased the expression of lipoprotein lipase (LPL) mRNA and protein in liver, which indicated that POE could improve the lipid metabolism disorder induced by ethanol. Our findings suggested that POE had protective effects on acute alcoholic liver injury of rats.

This study aims to investigate the colonization and diversity of endophytic fungi in Amomum villosum roots across different planting locations and at various growth ages, and to analyze the fungal composition. In this study, we performed Illumina-based ITS sequencing to investigate the effects of growth ages and sample plots on the rhizosphere fungi of A. villosum . Colonization analysis revealed widespread colonization by arbuscular mycorrhizal fungi (AMF) and dark septate endophytes (DSEs), but colonization rates did not increase significantly with plant age. Glomus was the dominant AMF genus, while Exophiala , Cladosporium and Cladophialophora dominated the DSE community. Beneficial fungi included Phoma , Acremonium , Myrothecium and Trichoderma . Alpha and beta diversity analyses indicated that fungal diversity, abundance, and community composition were significantly influenced by planting location but not by plant age. Collectively, planting location drives divergent root fungal communities in A. villosum , while plant age selectively affects specific taxa. AMF and DSEs were considered to be dominant beneficial microorganisms and were largely responsible for the growth and development of A. villosum . This study provides valuable insights for identifying beneficial endophytic fungi in A. villosum and optimizes the application of AMF and DSE agents in its ecological cultivation.