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The paper introduces the system design for wireless data acquisition and remote transmission scheme of micro-seismic signals. Zigbee wireless network communication technique is used for wireless data collection of seismic wave detection sensor, Meanwhile GPRS wireless packet switching technique is used to complete remote data transmission. The solution is the combination application of Zigbee and GPRS to analyze and monitor micro-seismic signal. The experiment of the system demonstrates that the solution is stable, reliable, efficient and practical when used in the micro-seismic signals remote transmission.

创新型企业在上市前很难从公开市场获得宝贵的资金支持，往往会通过股权融资来解决企业发展的资金问题。为了探究创新型企业上市前如何选择股权融资，本文从创新型企业股权融资的行为选择角度出发，通过构建实证模型分别探究创新型企业股权融资的股权分配和资金性质选择。本文通过实证研究发现：（1）上市前股权融资的股权份额越大，参与股权投资的机构数量越多，各家投资机构获取股权份额的离散度越大，该轮融资领投机构获得股权份额越小，这与委托-代理理论一致，与信息不对称理论不一致。（2）在上市前股权融资时，相比于国有成分比例较低的企业，国有成分比例较高的企业会选择更高比例的产业投资资金，这有力地支持了融资约束假说，与信息不对称矛盾。

Background::Antenatal corticosteroids (ACS) can significantly improve the outcomes of preterm infants. This study aimed to describe the ACS use rates among preterm infants admitted to Chinese neonatal intensive care units (NICU) and to explore perinatal factors associated with ACS use, using the largest contemporary cohort of very preterm infants in China.Methods::This cross-sectional study enrolled all infants born at 24 +0 to 31 +6 weeks and admitted to 57 NICUs of the Chinese Neonatal Network from January 1st, 2019 to December 30th, 2019. The ACS administration was defined as at least one dose of dexamethasone and betamethasone given before delivery. Multiple logistic regressions were applied to determine the association between perinatal factors and ACS usage. Results::A total of 7828 infants were enrolled, among which 6103 (78.0%) infants received ACS. ACS use rates increased with increasing gestational age (GA), from 177/259 (68.3%) at 24 to 25 weeks’ gestation to 3120/3960 (78.8%) at 30 to 31 weeks’ ge

Background::Significant brain volume deviation is an essential phenotype in children with neurodevelopmental delay (NDD), but its genetic basis has not been fully characterized. This study attempted to analyze the genetic factors associated with significant whole-brain deviation volume (WBDV).Methods::We established a reference curve based on 4222 subjects ranging in age from the first postnatal day to 18 years. We recruited only NDD patients without acquired etiologies or positive genetic results. Cranial magnetic resonance imaging (MRI) and clinical exome sequencing (2742 genes) data were acquired. A genetic burden test was performed, and the results were compared between patients with and without significant WBDV. Literature review analyses and BrainSpan analysis based on the human brain developmental transcriptome were performed to detect the potential role of genetic risk factors in human brain development.Results::We recruited a total of 253 NDD patients. Among them, 26 had significantly decreased WBDV

Biodiversity underpins the fundamental elements for human well-being including food security, human health and access to clean water. In 2010, the Aichi Targets were adopted by world leaders to address the crisis of biodiversity loss. Despite conservation efforts, none of the Aichi Targets have been fully met. However, comprehensive analysis of the reasons for failure in terms of implementation mechanisms is, to date, rare and limited in scope. Here, we demonstrate that most parties did not set effective national targets in accordance with the Aichi Targets, and investments, knowledge and accountability for biodiversity conservation have been inadequate to enable effective implementation. We recommend that the new global targets under the post-2020 Global Biodiversity Framework should be adopted by parties as the minimum national targets to achieve the 2050 Vision. We propose that financial resources for biodiversity conservation are substantially increased through a variety of sources, including the deployment of new economic instruments such as payments for ecosystem services. In addition, science–policy interfaces at all levels need to be strengthened to integrate scientific, Indigenous and local knowledge to support decision-making. We suggest that a compliance and accountability mechanism, based on monitoring systems, is created to provide transparent and credible review of parties’ implementation of the new global targets. Learning from the failure to meet the Aichi Biodiversity Targets, the authors recommend effective global and national targets and other measures to ensure the post-2020 targets are more successful.

The precise and large-scale identification of intact glycopeptides is a critical step in glycoproteomics. Owing to the complexity of glycosylation, the current overall throughput, data quality and accessibility of intact glycopeptide identification lack behind those in routine proteomic analyses. Here, we propose a workflow for the precise high-throughput identification of intact N-glycopeptides at the proteome scale using stepped-energy fragmentation and a dedicated search engine. pGlyco 2.0 conducts comprehensive quality control including false discovery rate evaluation at all three levels of matches to glycans, peptides and glycopeptides, improving the current level of accuracy of intact glycopeptide identification. The N-glycoproteome of samples metabolically labeled with 15 N/ 13 C were analyzed quantitatively and utilized to validate the glycopeptide identification, which could be used as a novel benchmark pipeline to compare different search engines. Finally, we report a large-scale glycoproteome dataset consisting of 10,009 distinct site-specific N-glycans on 1988 glycosylation sites from 955 glycoproteins in five mouse tissues. Protein glycosylation is a heterogeneous post-translational modification that generates greater proteomic diversity that is difficult to analyze. Here the authors describe pGlyco 2.0, a workflow for the precise one step identification of intact N-glycopeptides at the proteome scale.

The remarkable advances in next-generation sequencing technology have enabled the wide usage of sequencing as a clinical tool. To promote the advance of precision oncology for breast cancer in China, here we report a large-scale prospective clinical sequencing program using the Fudan-BC panel, and comprehensively analyze the clinical and genomic characteristics of Chinese breast cancer. The mutational landscape of 1,134 breast cancers reveals that the most significant differences between Chinese and Western patients occurred in the hormone receptor positive, human epidermal growth factor receptor 2 negative breast cancer subtype. Mutations in p53 and Hippo signaling pathways are more prevalent, and 2 mutually exclusive and 9 co-occurring patterns exist among 9 oncogenic pathways in our cohort. Further preclinical investigation partially suggests that NF2 loss-of-function mutations can be sensitive to a Hippo-targeted strategy. We establish a public database (Fudan Portal) and a precision medicine knowledge base for data exchange and interpretation. Collectively, our study presents a leading approach to Chinese precision oncology treatment and reveals potentially actionable mutations in breast cancer. Chinese breast cancer patients have not been well represented in clinical sequencing studies. Here the authors analyse the mutational landscape of 1,134 Chinese breast cancer patients, finding actionable targets and a higher prevalence of p53 and Hippo pathway mutations compared to Western cohorts.

[Objective]To reveal the chilling and heat requirements of main cultivars of Ping'ou hybrid hazelnuts.[Method]The hydroponic experiments were carried out with excised annual shoots of 16 main cultivars of Ping'ou hybrid hazelnuts( Corylus heterophylla x C. avellana) as materials and excised annual shoots of the wild hazelnut( C.heterophylla Fisch.) as the control. The chilling and heat requirements were estimated by the observation of the phenological phase of the catkins,female inflorescences and leaf buds. [Result]There were great differences in the chilling requirements and the heat requirements among different organs of Ping'ou hybrid hazelnuts. The chilling requirements ranged 336 1 176 h for catkins,504 1 344 h for female inflorescences and 672 1 512 h for leaf buds. The heat requirements ranged 687. 0 998. 5 GDH[degrees]C for catkins,998. 5 3 496. 1 GDH[degrees]C for female inflorescences and2 546. 5 4 180. 3 GDH[degrees]C for leaf buds. When the cultivars and organs reach the minimum chilling requirem

Grafting of C7 from the nonparalyzed to the paralyzed side in patients with arm paralysis resulted in greater improvements in power, spasticity, and function at 12 months than rehabilitation therapy alone, and functional connection to the ipsilateral cerebral hemisphere developed.