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"Caplan, Arthur L"
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Should scientists be allowed to bring distant human ancestors back to life?
Recent efforts by a private company to modify modern species with ancient DNA in the name of ‘de-extinction’ are both scientifically and morally suspect. A bright line requiring more than press releases as well as independent ethical oversight must be drawn before they are extended to distant human and hominid ancestors.
Journal Article
Are We What We Eat? The Moral Imperative of the Medical Profession to Promote Plant-Based Nutrition
The typical Western diet, high in processed and animal-based foods, is nutritionally and ethically problematic. Beyond the well-documented cruelty to animals that characterizes the practices of the factory-farming industry, current patterns of meat consumption contribute to medical and moral harm in humans on both an individual level and a public health scale. We aim to deconstruct, by highlighting their fallacies, the common positive and normative arguments that are used to defend current nutritional patterns. Animal-based foods promote the mechanisms that underlie chronic cardiometabolic disease, whereas whole-food plant-based nutrition can reverse them. Factory farming of animals also contributes to climate change, antibiotic resistance, and the spread of infectious diseases. Finally, the current allocation of nutritional resources in the United States is unjust. A societal shift toward more whole-food plant-based patterns of eating stands to provide significant health benefits and ethical advantages, and the medical profession has a duty to advocate accordingly. Although it remains important for individuals to make better food choices to promote their own health, personal responsibility is predicated on sound advice and on resource equity, including the availability of healthy options. Nutrition equity is a moral imperative and should be a top priority in the promotion of public health.
Journal Article
Combined Analysis of Asthma Safety Trials of Long-Acting β2-Agonists
In four clinical trials, the use of a long-acting β
2
-agonist plus an inhaled glucocorticoid did not result in a higher frequency of serious asthma events than the use of an inhaled glucocorticoid alone but was associated with a lower frequency of exacerbations.
Journal Article
Chloe’s Law: A Powerful Legislative Movement Challenging a Core Ethical Norm of Genetic Testing
Since the early 1970s, the ethical norm governing counselors involved in testing and screening for genetic conditions related to reproduction has been strict neutrality. Counseling about reproductive genetics was to be patient centered but nondirective. Many advocates for people with Down syndrome believe that high abortion rates following a diagnosis of this condition show an unfounded bias against those with Down syndrome. These advocates have succeeded in enacting federal and state legislation that requires women who receive a prenatal diagnosis of Down syndrome to receive positive information about the condition, thereby ending the nominal goal of value-neutral counseling and setting the stage for further normative shifts in clinical reproductive genetics as counseling expands because of cell-free testing.
Journal Article
Editors’ and authors’ individual conflicts of interest disclosure and journal transparency. A cross-sectional study of high-impact medical specialty journals
ObjectiveTo assess the fulfilment of authors’ and editors’ individual disclosure of potential conflicts of interest in a group of highly influential medicine journals across a variety of specialties.DesignCross-sectional analysis.Setting and participantsTop-ranked five journals as per 2017 Journal Citation Report impact factor of 26 medical, surgery and imaging specialties.InterventionsObservational analysis.Primary and secondary outcome measuresPercentage of journals requiring disclosure of authors’ and editors’ individual potential conflicts of interest (CoI). Journals that were listed as followers of the International Committee of Medical Journal Editors (ICMJE) Recommendations, members of the Committee on Publication Ethics (COPE) and linked to a third party (ie, college, professional association/society, public institution).ResultsAlthough 99% (129/130) of journals required author’s CoI disclosure, only 12% (16/130) reported individual editors’ potential CoIs. Forty−five per cent (58/130) of journals were followers of the ICMJE Recommendations, and 73% (95/130) were COPE members. Most (69%; 90/130) were linked to a college, professional society/association or public institution. Only one journal did not have policies on individual authors’ and editors’ CoI disclosure.ConclusionVery few high-impact medical journals disclosed their editorial teams’ individual potential CoIs—conversely, almost all required disclosure of authors’ individual CoIs. Journal followers of the ICMJE Recommendations should regularly disclose the editors’ individual CoIs, as this is the only legitimate way to ask the same transparency of authors.
Journal Article
Science in the fight to uphold the rights of children
The United States is the only major nation to not yet have ratified the United Nations Convention on the Rights of the Child (UNCRC). Recently, there has been an erosion of the rights of children across America, Europe, and elsewhere, but through science, we may have an opportunity to counter some of this alarming trend. In the area of vaccines, the scientific community can raise its voice on the dangers that nonmedical exemptions and delays pose to children at risk for measles, influenza, and other childhood illnesses. Poverty places infants and children at high risk for illness and homelessness. Gun violence and gun-related accidents are killing on average four American children daily, and climate change is promoting global pediatric malnutrition. Increasing international, federal, and state support to seek innovative solutions to these and related issues is a moral imperative.
Journal Article
