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"Caputi, Ross"
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The sacking of Fallujah : a people's history
The Iraqi city of Fallujah has become an epicenter of geopolitical conflict, where foreign powers and non-state actors have repeatedly waged war in residential neighborhoods with staggering humanitarian consequences. The Sacking of Fallujah is the first comprehensive study of the three recent sieges of this city, including those by the United States in 2004 and the Iraqi-led operation to defeat ISIS in 2016. Unlike dominant military accounts that focus on American soldiers and U.S. leaders and perpetuate the myth that the United States \"liberated\" the city, this book argues that Fallujah was destroyed by coalition forces, leaving public health crises, political destabilization, and mass civilian casualties in their wake. This meticulously researched account cuts through the propaganda to uncover the lived experiences of Fallujans under siege and occupation, and contextualizes these events within a broader history of U.S. policy in the Middle East. Relying on testimony from Iraqi civilians, the work of independent journalists, and documentation from human rights organizations, Ross Caputi, Richard Hil, and Donna Mulhearn place the experiences of Fallujah's residents at the center of this city's recent history.
Book
Howard Zinn
There are some harmful actions that can't be blamed on a single individual. Some harms can only come about when many people contribute, even though each person's actual contribution may seem small and insignificant. Imagine a working mother who buys a daily coffee and throws her styrofoam cup away when she's finished, a college graduate who takes a job that makes money over a job that does good, and the many Americans (and citizens of the \"coalition of the willing\" nations) who watched their country wage an unjust war. When these individual actions and inactions are multiplied by a population, they can result in enormous amounts of harm. When my former military unit, 1st Battalion 8th Marines, laid siege to Fallujah, Iraq, in November 2004, we forced 200,000 civilians to flee their homes, we killed hundreds (possibly thousands) of civilians, and we destroyed large portions of the city.
1
There isn't one person from my unit whom I can point my finger at and say he alone is responsible for the atrocities that ensued; everyone played a role.
Book Chapter
Identification of an Epi-metabolic dependency on EHMT2/G9a in T-cell acute lymphoblastic leukemia
Genomic studies have identified recurrent somatic alterations in genes involved in DNA methylation and post-translational histone modifications in acute lymphoblastic leukemia (ALL), suggesting new opportunities for therapeutic interventions. In this study, we identified G9a/
EHMT2
as a potential target in T-ALL through the intersection of epigenome-centered shRNA and chemical screens. We subsequently validated G9a with low-throughput CRISPR-Cas9-based studies targeting the catalytic G9a SET-domain and the testing of G9a chemical inhibitors in vitro, 3D, and in vivo T-ALL models. Mechanistically we determined that G9a repression promotes lysosomal biogenesis and autophagic degradation associated with the suppression of sestrin2 (
SESN2)
and inhibition of glycogen synthase kinase-3 (GSK-3), suggesting that in T-ALL glycolytic dependent pathways are at least in part under epigenetic control. Thus, targeting G9a represents a strategy to exhaust the metabolic requirement of T-ALL cells.
Journal Article
The Nature of Extremely Red H-4.5>4 Galaxies revealed with SEDS and CANDELS
We have analysed a sample of 25 extremely red H-[4.5]>4 galaxies, selected using 4.5 micron data from the Spitzer SEDS survey and deep H-band data from the Hubble Space Telescope (HST) CANDELS survey, over ~180 square arcmin of the UKIDSS Ultra Deep Survey (UDS) field. Our aim is to investigate the nature of this rare population of mid-infrared (mid-IR) sources that display such extreme near-to-mid-IR colours. Using up to 17-band photometry (U through 8.0 microns), we have studied in detail their spectral energy distributions, including possible degeneracies in the photometric redshift/internal extinction (zphot-Av) plane. Our sample appears to include sources of very different nature. Between 45% and 75% of them are dust-obscured, massive galaxies at 3300 microJy, which at 35) sources at zphot<1. Finally, we analyse in detail two zphot~6 galaxy candidates, and discuss their plausibility and implications. Overall, our red galaxy sample contains the tip of the iceberg of a larger population of z>3 galaxies to be discovered with the future James Webb Space Telescope.
Paper