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Background Working memory (WM) training in aging promotes an individual’s more flexible use of their resources. Conversely, WM training neural correlates have been rarely examined. In this pilot study, we aimed to assess both behavioral and neural correlates of WM training of trained and untrained (transfer effects) tasks in the short and long term. Methods With a double-blind, repeated-measures experimental design, 30 community-dwelling older adults (aged from 64 to 75) were randomly assigned to a training group (TG) or an active control group. Results For the trained task, behavioral data indicated an improved WM performance, and electrophysiological data showed a lateralized event-related potential activation after training and 6 months later (follow-up) in the TG only. Clear transfer effects ( n -back task) maintained at the follow-up appeared only on the electrophysiological level. Conclusions These results suggest that WM training can represent a promising approach to sustain older adults’ cognitive functioning and to modulate cortical plasticity, inducing long-lasting left-lateralized activation.

This study examined age-related differences between young and older adults' emotion regulation, hope, and optimism 1 year after the COVID-19 outbreak. Whether personality explained such outcomes was also examined. A sample of 228 young adults and 161 older adults was interviewed in April-May 2021 to complete questionnaires assessing cognitive reappraisal (CR) and expressive suppression (ES) emotion regulation strategies use, optimism, hope (agency and pathways components), and personality traits. Older adults reported greater CR and ES use, optimism, and hope-agency levels than young adults, whereas no age differences emerged for hope-pathway scores. Personality traits (more consistently emotional stability) contributed to explaining CR and ES use, and greater hopeful and optimistic dispositions. These findings confirm older adults' advantage in facing the emotional and psychological fallout of the COVID-19 pandemic in its third wave. They also underscore the importance of considering personality to depict individual profiles prone to experiencing long-term negative emotional/psychological consequences of emergencies as COVID-19.

Personality traits are suggested to influence adults' cognitive performance, but little is known about their association with visuo-spatial competence, in terms of those visuo-spatial abilities and inclinations crucial to remaining autonomous, especially with aging. This study newly investigated whether, and to what extent, major traits and narrower facets of personality influence young and older adults' performance in the so-called objective visuo-spatial abilities (mental rotation and visuo-spatial working memory [VSWM]), and self-assessed visuo-spatial inclinations (pleasure and anxiety in exploring places). Seventy young adults (18-35 years old) and 70 older adults (65-75 years old) completed the Big-Five questionnaire, objective rotation and VSWM tasks, and spatial self-assessments on pleasure and anxiety in exploring places. Hierarchical regression models confirmed that age negatively predicted the variance in objective visuo-spatial tasks, but not in self-assessed visuo-spatial inclinations, while only the latter were slightly influenced by gender (in favor of men). Further, both objective visuo-spatial abilities (albeit modestly) and self-assessed visuo-spatial inclinations were predicted by higher Conscientiousness. The latter were also predicted by higher Emotional Stability. Finally, a better objective visuo-spatial performance was explained (again modestly) by lower Dynamism and Politeness, and higher Emotion Control, while higher Perseverance, Emotion Control and Cooperativeness explained a moderate part of the variance in the positive self-assessed visuo-spatial inclinations. Our findings indicate that, beyond age and gender, some personality traits and facets predict self-assessed visuo-spatial inclinations to a larger extent than objective visuo-spatial performance. These results are discussed within the spatial cognition and aging framework.

During their lifetime, 20% of US women experience depression. Studies have indicated that a high Dietary Inflammatory Index (DII) score is associated with high C-reactive protein (CRP) levels and depression. No previous study has compared the association of the DII with different measures of depression (e.g., somatic, cognitive) among pre- and post-menopausal women. We used data from 2512 pre-menopausal and 2392 post-menopausal women from the National Health and Nutrition Examination Survey (NHANES) 2005–2010 database. We ran linear and logistic regression models to compare the association of the DII with survey-measured depression among pre- and post-menopausal women. We further assessed the mediation effect of CRP on the association of the DII and depression, using structural equation modeling. The odds of experiencing depression among pre-menopausal women was higher for all DII quartiles compared to the reference group (i.e., DII Q1), with an odds ratio (OR) of 3.2, 5.0, and 6.3 for Q2, Q3, and Q4, respectively (p < 0.05). Among post-menopausal women, only Q4 had 110% higher odds of experiencing depression compared to Q1 (p = 0.027). No mediation effect of CRP was found between DII and any of our depression outcome measures. Our findings suggest that lifestyle habits, such as diet, may have a stronger influence on mental health among pre-menopausal women than post-menopausal women.

Introduction: This study examined the role of individual characteristics in predicting short- and long-term benefits of the Italian version of Cognitive Stimulation Therapy (CST-IT), an evidence-based intervention for people with mild-to-moderate dementia. Materials and Methods: Data were drawn from a sample (N=123) of people with dementia (PwD) who took part in a multicenter controlled clinical trial of CST-IT. Assessments at pre-test, immediately after completing the treatment, and 3 months later investigated the following outcomes: general cognitive functioning and language, mood and behavior, everyday functioning, and quality of life. Age, education and baseline (pre-test) cognitive functioning, mood (depression) and behavioral and neuropsychiatric symptoms were considered as predictors of any short- and long-term benefits. Results: Linear mixed-effects models showed that different individual characteristics -particularly education and age- influenced the benefits of CST-IT, depending on the outcome measures considered. Higher education predicted larger gains in general cognitive functioning and, along with less severe depressive symptoms, in language (magnification effects). Older age was associated with positive changes in mood (compensation effects). Albeit very modestly, older age was also associated with larger gains in everyday functioning (compensation effects). Gains in quality of life were predicted by older age and lower education (compensation effects). Baseline cognitive functioning, mood and/or behavioral symptoms broadly influenced performance too, but their role again depended on the outcomes considered. Discussion: These findings underscore the importance of considering and further exploring how psychosocial interventions like CST are affected by individual characteristics in order to maximize their efficacy for PwD.

Background This systematic review is intended to identify, categorize, and evaluate instruments assessing generalized and personal views of aging (VoA) in older adults as well as how these instruments have addressed views of changes in cognition with aging. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed, and the review was preregistered in PROSPERO (CRD42023407986). Studies presenting VoA instruments, also including a specific focus on views of changes in cognition with aging, were identified using the Scopus, PsycINFO, and Web of Science databases. Based on the Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) guidelines, risk of bias and GRADE assessments were conducted for each instrument. Results Of the 3,578 records emerged, 77 studies assessing measurement properties of 26 VoA instruments in samples of older adults were included. These instruments reflected diverse generalized and personal VoA concepts; few ones assessed or included items depicting views of changes in cognition with aging, with memory being the most frequently addressed cognitive domain. Conclusions Notwithstanding psychometric and measurement issues, this review provides a comprehensive summary of existing instruments assessing subjective VoA, which have clinical and applied utility in promoting healthy aging, especially for older adults at risk of pathological aging. The development and validation of new VoA scales, particularly to assess views on age-related cognitive changes with aging, is warranted.

Cognitive Reserve (CR) is often assessed with surveys spanning demographic, lifestyle, and socio-behavioral variables. The role of both past and current life experiences on CR has, however, rarely been examined. We developed the Current and Retrospective Cognitive Reserve (2CR) survey to assess classical CR proxies (socio-economic status, engagement in leisure and social activities) and other dimensions of potential importance (family engagement, religious/spiritual activity) both currently (CRc; in later adulthood) and retrospectively (CRr; as recalled from younger adulthood). We administered the 2CR, measures of general cognitive functioning, working memory (WM), crystallized—vocabulary— and fluid—reasoning—intelligence, and depressive symptoms (DS) to 235 community-dwelling Italian adults (ages 55–90 years). We used exploratory and confirmatory factor analyses to examine the 2CR latent structure, and we estimated correlations of its dimensions with cognitive abilities and DS. Analyses confirmed a three-level factor structure with two global CR factors (CRc and CRr) at the top level, dimensional CR factors (socio-economic status, family engagement, leisure activity, social engagement, and religious/spiritual activity) at mid-level and observed items at the lowest level. Item-factor representations partially differed across CRc and CRr. Both CRc and CRr were positively correlated with measures of intelligence, WM and DS, but associations of measures of intelligence were stronger for CRr, whereas associations of WM and DS were slightly stronger for CRc. The 2CR can be considered a reliable survey for assessing CR proxies within a multidimensional, “life stage-dependent” framework insofar as CRc are CRr closely related but also differently associated with intelligence, WM, and DS.

Background Loneliness is a major health issue among older adults. The aim of this study was to assess the relationship between loneliness, in its social and emotional facets, and the cognitive (language), and behavioral/psychological functioning as well as quality of life (QoL) in people with mild and moderate dementia, i.e., considering dementia severity as an individual characteristic. Methods This cross-sectional study involved 58 people with mild dementia and 55 people with moderate dementia. Participants completed the Social and Emotional Loneliness scale, along with measures assessing their language skills, the frequency and severity of their behavioral and psychological symptoms, and their QoL. Results Socio-demographic characteristics and depression, but not loneliness or its social and emotional facets, contributed to explain participants’ behavioral and psychological symptoms, regardless of dementia severity. Loneliness explained, though to a small extent (8% of variance), language skills in people with moderate dementia, with social loneliness only accounting for language skills (18% of variance) in this group. Loneliness also modestly accounted for dysphoria symptoms in both the mildly and moderately impaired (6% and 5% of variance, respectively) individuals with social loneliness predicting dysphoric mood in the former group only (7% of variance). Loneliness also explained, to a larger extent, QoL in both the mildly impaired and moderately impaired individuals (27% and 20% of variance, respectively), its social facet predicting QoL in the mildly impaired (30% of variance), and its emotional facet in the moderately impaired (21% of variance) group. Conclusion These findings suggest that loneliness and its facets have a clear impact on perceived QoL, and influence the language skills and dysphoria symptoms of people with dementia, to a degree that depends on dementia severity. The assessment of loneliness and its facets in people with dementia considering dementia severity, and the promotion of social inclusion to reduce it should be considered by professionals.

The Dietary Inflammatory Index (DII) is designed to assess the inflammatory potential of the diet. While previous research has utilized DII among college-aged women, no study to date has validated it in this population. We conducted a construct validation of DII among 393 healthy women aged 18–31 years against a robust panel of 14 inflammatory biomarkers, including CRP, IL-1β, IL-4, IL-6, IL-10, and TNF-α, which were used in the development of DII. Three linear regression models were constructed: (1) an age-adjusted model, (2) the most parsimonious model based on likelihood ratio tests, and (3) a fully adjusted model for age, race, body mass index, waist circumference, physical activity, smoking status, and nonsteroidal anti-inflammatory drug use. DII was derived from the Harvard food frequency questionnaire and categorized into quartiles. Consistent with our hypothesis, DII was negatively and significantly associated with back-transformed IL-10 levels, confirming that a more pro-inflammatory diet was associated with lower levels of an anti-inflammatory cytokine (Model 3: Q4 vs. Q1 β = 0.62; 95% CI: 0.42, 0.93; p-trend = 0.04). While validated in other populations, DII may not be a suitable tool for assessing the inflammatory potential of the diet among college-aged women.

The increasing ownership of mobile phones and advances in hardware and software position these devices as cost-effective personalized tools for health promotion and management among women with gestational diabetes mellitus (GDM). Numerous mobile phone apps are available online; however, to our knowledge, no review has documented how these apps are developed and evaluated in relation to GDM. The objective of our review was to answer the following 2 research questions: (1) What is known from the existing literature about the availability, functionality, and effectiveness of mobile phone apps on GDM prevention and management? (2) What is the role of health literacy in these apps? We searched 7 relevant electronic databases for original research documents using terms related to mobile phone apps, GDM, and health literacy. We thematically categorized selected articles using a framework adapted from Arksey and O'Malley. We included 12 articles related to 7 apps or systems in the final analysis. We classified articles around 2 themes: (1) description of the development, feasibility, or usability of the apps or systems, and (2) trial protocols. The degree of personalization varied among the apps for GDM, and decision support systems can be used to generate time-efficient personalized feedback for both patients and health care providers. Health literacy was considered during the development or measured as an outcome by some apps. There is a limited body of research on mobile phone apps in relation to GDM prevention and management. Mobile phone apps can provide time- and cost-efficient personalized interventions for GDM. Several randomized controlled trials have been launched recently to evaluate the effectiveness of the apps. Consideration of health literacy should be improved when developing features of the apps.