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Introduction: Mortality is affected by several factors, including the place of residence. Several studies have found a gap in mortality between urban and rural residents. This study aimed to describe adjusted mortality rates in urban and rural areas of Mexico. Methods: Adjusted mortality rate per 100 000 inhabitants was estimated in urban and rural areas of Mexico, were grouped by sex, age, and main cause of death. Trend analysis was performed with a logarithmic regression of adjusted rates. Results: Mortality was higher in urban (622.1/100 000 inhabitants) than rural (549.5/100 000 inhabitants) areas of Mexico. Males showed the highest mortality rate in both studied areas, urban and Rural and Remote Health www.rrh.org.au James Cook University ISSN 1445-6354 1 2 3 4 5 1, 2, 3, 4, 5 rural (737.8 and 634.4/100 000 inhabitants respectively). A significant annual decrease of 0.5% in mortality rates was observed in both areas. Conclusion: In Mexico, there is a gap in mortality rates based on individuals' place of residence. Those who live in urban areas present the highest mortality rates.

Poisoning remains a major worldwide public health problem. Mortality varies by country, region and ethnicity. The objective of this study is to analyze recent trends in poisoning mortality in the Mexican population. Data regarding mortality induced by poisoning was obtained from a publicly available national database maintained by the National Institute of Statistics and Geography. During the period from 2000 to 2012, average mortality rates for unintentional and self-poisoning were 1.09 and 0.41 per 100000 population, respectively. The highest mortality rate for unintentional poisoning was in older individuals of both genders while the highest mortality for self-poisoning was in older men and young women. Additional studies are needed in Mexico, especially those that analyze risk factors in older individuals and young women.

In today’s pharmaceutical landscape, there’s an urgent need to develop new drug delivery systems that are appealing and effective in ensuring therapeutic adherence, particularly among paediatric patients. The advent of 3D printing in medicine is revolutionizing this space by enabling the creation of precise, customizable, and visually appealing dosage forms. In this study, we produced 250 mg metformin paediatric gummies based on the semi-solid extrusion (SSE) 3D printing technique. A pharmaceutical ink containing metformin was successfully formulated with optimal flow properties suitable for room-temperature printing. Using a quality by design approach, 3D printing and casting methodologies were compared. The 3D-printed gummies exhibited better firmness and sustained release at earlier times to avoid metformin release in the oral cavity and ensure palatability. The texture and physical appearance match those of gummies commercially available. In conclusion, SSE allowed for the successful manufacture of 3D-printed sugar-free gummies for the treatment of diabetes mellitus for paediatric patients and is an easily translatable approach to clinical practice.

A long held view about the occupation of southern proto-Jê pit house villages of the southern Brazilian highlands is that these sites represent cycles of long-term abandonment and reoccupation. However, this assumption is based on an insufficient number of radiocarbon dates for individual pit houses. To address this problem, we conducted a programme of comprehensive AMS radiocarbon dating and Bayesian modelling at the deeply stratified oversized pit House 1, Baggio I site (Cal. A.D. 1395-1650), Campo Belo do Sul, Santa Catarina state, Brazil. The stratigraphy of House 1 revealed an unparalleled sequence of twelve well preserved floors evidencing a major change in occupation dynamics including five completely burnt collapsed roofs. The results of the radiocarbon dating allowed us to understand for the first time the occupation dynamics of an oversized pit house in the southern Brazilian highlands. The Bayesian model demonstrates that House 1 was occupied for over two centuries with no evidence of major periods of abandonment, calling into question previous models of long-term abandonment. In addition, the House 1 sequence allowed us to tie transformations in ceramic style and lithic technology to an absolute chronology. Finally, we can provide new evidence that the emergence of oversized domestic structures is a relatively recent phenomenon among the southern proto-Jê. As monumental pit houses start to be built, small pit houses continue to be inhabited, evidencing emerging disparities in domestic architecture after AD 1000. Our research shows the importance of programmes of intensive dating of individual structures to understand occupation dynamics and site permanence, and challenges long held assumptions that the southern Brazilian highlands were home to marginal cultures in the context of lowland South America.

Phytoremediation is based on the use of plants to decontaminate water and soil. In this work, the capacity of high Andean vegetation in the absorption and translocation of heavy metals was analyzed. Species were identified to analyze the presence of metals in roots, stems, and leaves by spectrometry. The translocation factor was determined and analyzed by means of pattern clusters. Based on the floristic inventory, the dominance of the Poaceae and Asteraceae families was determined, and 12 plant species with a high importance value were selected. According to the ICP-AES, mercury (951.07 mg/kg) was determined in the roots of Lachemilla orbiculata, and chromium (21.88 mg/kg) in Carex bonplandii. Arsenic (2.79 mg/kg) was detected as being significantly higher than the values recorded in lowland plants. Cadmium mobility was high in all species, reaching higher values in Baccharis salicifolia (86.28%) and Calamagrostis intermedia (37.16%). Rumex acetocella accumulated lead in leaves (9.27%), while Taraxacum officinale (1.20%) and Calamagrostis intermedia (1.20%) accumulated silicon. Stabilization of chromium, mercury, and sodium was determined in the roots without translocation to higher organs. Finally, cluster analysis showed physiological interactions between metals as a toxicity mitigation mechanism affecting mobility. These findings suggest that they are hyperaccumulator species.

Background Unsafe storage of unused medications at home leads to an increased risk of toxicity, accidental childhood poisoning or risk for suicide, whereas an improper disposal of unwanted/expired medications from household raises concern about environmental pollution. Objective The aim of the study was to characterize expired medications collected according to the types of therapeutic groups, pharmaceutical dosage forms, expiration dates and were prescribed or over the counter drugs, and whether they came from Mexican health system or purchased by patients themselves. Setting The study was conducted in the metropolitan area of Monterrey during a 12-month period from March 2012 to February 2013. Method Unused/expired drugs were collected according to the collection and disposal of expired medication program instituted by the Department of Health of the State of Nuevo León. Pharmacists and students from The Autonomous University of Nuevo León recorded types of therapeutic groups, total of medicines in each group, among other classification criteria. Main outcome measure The proportion of every collected therapeutic group, type of dosage forms, and expiration date. Results The amount of medications classified was 22,140 items corresponding to a 30 % of the total collected medications in that period of time; most of them belonged to the non-steroidal anti-inflammatory drugs (16.11 %). According to the pharmaceutical dosage forms, results showed that a high percentage were solid dosage forms (73.39 %), of the total unused/expired medications, most of them were prescription drugs (91 %) which were purchased at private pharmacies. Expiration date of medications ranges from 1995 to 2016, being 2011 the outstanding year (36.66 %). Conclusion Addressing the aspect of unused drug disposition constitutes a challenge for Mexican government, due to health implications related to inadequate disposition. No matter how efficient the programs of collection and disposal of expired drugs are, none of them can collect all unused or expired drugs, that is the reason why the best approach might be to prevent this need.

Research has shown the benefits of peer interaction to scaffold learning of disciplinary literacies. We extend knowledge in this area to examine peer interaction and the affordances it creates when emergent bilinguals engage with multimodal texts in disciplines to make meaning. Using discourse analysis of the interactions of a small group of third graders carrying out a project in science class, we explored how four emergent bilinguals collaborated to design, produce, and distribute traditional and alternative texts. We found that translanguaging and transmodal collaborative structures support learning processes and comprehension to make sense of and contextualize disciplinary knowledge. A dynamic and recursive translanguaging pattern emerges in which the introduction and contextualization of knowledge happens in Spanish, the interaction occurs mainly in English, and the creation is in both English and Spanish. We discuss the affordances of these collaborative structures for supporting students in science and promoting Spanish and student bilingualism.

La subutilización e inadecuada disposición de medicamentos caducos representa un importante problema. El objetivo de este estudio fue describir el patrón y la cantidad de medicamentos cardiovasculares no utilizados en el área Metropolitana de Monterrey, en el estado de Nuevo León, México. A través de varias vías de difusión, se invitó a los habitantes a depositar los medicamentos que no utilizan en diversos centros de acopio distribuidos en el área metropolitana, el período de acopio fue de 12 meses. Los medicamentos individuales fueron identificados, contabilizados y clasificados de acuerdo con el sistema Anatómica, Terapéutica y Química (ATC, por sus siglas en inglés). La diferencia entre los fármacos agrupados se probó con ANOVA o Chi cuadrado según corresponda. El costo de cada medicamento identificado se obtuvo a través de la consulta de precio en al menos tres farmacias. Durante el tiempo de estudio se recolectaron un total de 207963 unidades, de las cuales los hipolipemiantes fueron los más abundantes, el costo estimado de todos los medicamentos cardiovasculares fue de 0,03 USD por habitante. Los resultados muestran que una gran cantidad de medicamentos cardiovasculares se desperdician y esto representa un costo importante.

The Andean paramos are unique and biodiverse environments. Located between the upper limit of forest and perpetual snow, they provide ecosystem services, especially freshwater supply; however, anthropogenic activities and climate change have altered their distribution and composition. This paper analyses the influence of altitude and climatic factors on the floristic composition of the páramos. A quasi-experimental study was used in three altitudinal gradients, collecting geolocalised data on species and bioclimatic variables. Principal component analysis, using the HJ-Biplot visualisation technique and k-means clustering algorithms, was applied to explore the relationships between factors. It was determined that the lower zone is nuanced by the presence of Solanaceae, which are important for human food. In the middle zone, there is a high diversity, with the Ericaceae and Caprifoliaceae families standing out, while in the upper zone, the Ericaceae and Gentianaceae families are accentuated. The PCA reveals that strata 2 and 3 share family taxa, while stratum 1 shows differences. Altitude and precipitation directly influence the distribution of species in each stratum; the Asteraceae family is dominant in the canton for its contribution to the principal components.

Climate change has accelerated the retreat of Andean glaciers, with significant recent losses in the tropical Andes. This study evaluates the extinction of the Carihuairazo volcano glacier (Ecuador), quantifying its area from 1312.5 m2 in September 2023 to 101.2 m2 in January 2024, its thickness (from 2.5 m to 0.71 m), and its volume (from 2638.85 m3 to 457.18 m3), before its complete deglaciation in February 2024; this rapid melting and its small size classify it as a glacierette. Multivariate analyses (PCA and biclustering) were performed to correlate climatic variables (temperature, solar radiation, precipitation, relative humidity, vapor pressure, and wind) with glacier surface and thickness. The PCA explained 70.26% of the total variance, with Axis 1 (28.01%) associated with extreme thermal conditions (temperatures up to 8.18 °C and radiation up to 16.14 kJ m−2 day−1), which probably drove its disappearance. Likewise, Axis 2 (21.56%) was related to favorable hydric conditions (precipitation between 39 and 94 mm) during the initial phase of glacier monitoring. Biclustering identified three groups of variables: Group 1 (temperature, solar radiation, and vapor pressure) contributed most to deglaciation; Group 2 (precipitation, humidity) apparently benefited initial stability; and Group 3 (wind) played a secondary role. These results, validated through in situ measurements, provide scientific evidence of the disappearance of the Carihuairazo volcano glacier by February 2024. They also corroborate earlier projections that anticipated its extinction by the middle of this decade. The early disappearance of this glacier highlights the vulnerability of small tropical Andean glaciers and underscores the urgent need for water security strategies focused on management, adaptation, and resilience.