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Single-crystal superconductors of the general formula (LRE)–Ba–Cu–O (light rare earth, LRE = Nd, Sm, Eu and Gd) have considerable potential for engineering applications because of their ability to trap magnetic fields significantly higher than those achievable with permanent magnets. But the lack of a process by which these materials can be fabricated reliably and economically in the form of large single grains has severely hindered their development. We report a practical processing method for the fabrication in air of single-crystal (RE)BCO. The technique is economical and offers considerable freedom in terms of the processing parameters and reproducibility in growth of oriented single grains. The process is based primarily on the development of a new type of generic seed crystal that can effectively promote the epitaxial nucleation of any (RE)BCO system, and secondly on suppressing the formation of RE–Ba solid solution in a controlled manner within large grains processed in air.

Rosacea is a chronic dermatological disorder with a variety of clinical manifestations localized largely to the central face. The unclear etiology of rosacea fosters therapeutic difficulty; however, subtle clinical improvement with pharmacologic treatments of various drug categories suggests a multifactorial etiology of the disease. Factors that may contribute to disease pathogenesis include immune abnormality, vascular abnormality, neurogenic dysregulation, presence of cutaneous microorganisms, UV damage, and skin barrier dysfunction. The role of ivermectin in the treatment of rosacea may be as an anti-inflammatory and anti-parasitic agent targeting Demodex mites. In comparing topical ivermectin and metronidazole, ivermectin was more effective; this treatment modality boasted more improved quality of life, reduced lesion counts, and more favorable participant and physician assessment of disease severity. Patients who received ivermectin 1% cream had an acceptable safety profile. Ivermectin is efficacious in decreasing inflammatory lesion counts and erythema.

Psoriasis has an enormous impact on patients’ lives and is frequently associated with depression. Depression in psoriasis may be attributed, at least in part, to elevated proinflammatory cytokines rather than the psychosocial impact of psoriasis itself. Biologics that target inflammatory cytokines treat the clinical manifestations of psoriasis, but may also play a role in reducing associated depression. Multiple biologics have decreased symptoms of depression during clinical trials in psoriasis; however, these studies used a variety of depression screening tools, which limits comparison. Furthermore, it is difficult to distinguish whether improved depression is the result of the direct anti-inflammatory effect of the biologic, or the indirect effect of improved psoriasis leading to better psychological status. Future studies evaluating depression in patients with psoriasis could benefit from a standardized depression screening tool to mitigate discrepancies and facilitate comparison across treatment types. Here, we highlight the inflammatory overlap between psoriasis and depression by examining the pathophysiology of depression, and reviewing psoriasis clinical studies that assessed depression as an outcome measure.

Transport measurements performed on a cross-sectional slice prepared from a bulk GdBa 2 Cu 3 O 7- x -Ag single-grain superconductor of 25 mm in diameter are described and the results presented. The sample, which was fabricated via the buffer-assisted top-seeded infiltration growth process, was capable of trapping a maximum magnetic field of ~ 1 T at 77 K. Transport measurements on superconducting, bulk single-grain RE-Ba-Cu-O [(RE)BCO] samples are generally very challenging due to their large critical current densities and poor mechanical properties. We present a straightforward and reliable approach to prepare reproducibly specimens from the parent single grain and results of transport property measurements on these samples in a commercial Physical Property Measurement System (PPMS). Critical current densities determined via magnetic and transport measurements are compared and discussed.

The grain boundaries in superconducting MgB 2 are known to form effective magnetic flux pinning sites and, consequently, bulk MgB 2 containing a fine-grain microstructure fabricated from nanoscale Mg and B precursor powders exhibits good magnetic field-trapping performance below 20 K. We report here that the trapped field of MgB 2 bulk superconductors fabricated by an infiltration and growth process to yield a dense, pore-free microstructure, can be enhanced significantly by carbon-doping, which increases intra-band scattering within the superconducting grains. A maximum trapped field of 4.15 T has been measured at 7.5 K at the centre of a five-sample stack of Mg(B 1− xi C xi ) 2 bulk superconductors processed by infiltration and growth, which not only represents a ~40% increase in trapped field observed compared to undoped bulk MgB 2 , but also is the highest trapped field reported to date in MgB 2 samples processed under ambient pressure. The trapped field is observed to decay at a rate of <2%/day at 10 K, which suggests that bulk MgB 2 superconductors fabricated using the infiltration and growth technique can be used potentially to generate stable, high magnetic fields for a variety of engineering applications.

Photos lead people to believe that both true and false events have happened to them, even when those photos provide no evidence that the events occurred. Research has shown that these nonprobative photos increase false beliefs when combined with misleading suggestions and repeated exposure to the photo or target event. We propose that photos exert similar effects without those factors, and test that proposition in five experiments. In Experiment 1 , people saw the names of several animals and pretended to give food to or take food from each. Then people saw the animal names again, half with a photo of the animal and half alone, and decided whether they had an experience with each. The photos led people to believe they had experiences with the animals. Moreover, Experiments 2 – 5 provided evidence that photos exerted these effects by making it easier to bring related thoughts and images to mind—a feeling that people mistook as evidence of genuine experience. In each experiment, photos led people to believe positive claims about the past (but not negative claims), consistent with evidence that feelings of ease selectively increase positive judgments. Experiment 4 also showed that photos (like other manipulations of ease) bias people’s judgments broadly, producing false beliefs about other people’s pasts. Finally, in Experiment 5 , photos exerted more powerful effects when they depicted unfamiliar animals, and thus could most help bring information to mind. These findings suggest that nonprobative photos can distort the past without other factors that encourage false beliefs, and that they operate by helping related thoughts and images come to mind.

The finite element method has been used extensively in recent years to solve various problems related to applied superconductivity and provides a useful tool for analysing and predicting experimental results. Based on a recently-developed modelling framework, implemented in the finite element software package COMSOL Multiphysics, investigations on the minimum ring reinforcement required to prevent mechanical failure in bulk high-temperature superconducting magnets have been carried out. Assuming homogeneous Jc(B,T) across the bulk sample irrespective of its dimensions, the maximum magnetic stresses experienced, and the minimum ring thickness required to prevent the hoop and radial stresses from exceeding the tensile strength of the bulk superconductor have been determined for varying values of the Young's modulus, radius, height and temperature of a representative single-grain Ag-containing Gd-Ba-Cu-O bulk sample. This comprehensive analysis details the influence each of these key parameters has on the magnetic stress and hence their impact on the necessary ring thickness to prevent mechanical failure in any given system, i.e., for any combination of material properties and sample dimensions.

Large, single-grain Y–Ba–Cu–O (YBCO) was fabricated via the infiltration of Ba–Cu–O liquid into a precursor body composed of solid, porous Y2BaCuO5 (Y-211) and observed to trap a magnetic field of 0.15 T at 77 K. In this process a NdBCO seed crystal was used to promote heterogeneous nucleation, which allows the fabrication of single-grain YBCO containing a uniform and very fine distribution of Y-211 inclusions in the YBa2Cu3O7−δ(Y-123) matrix without the addition of Pt. These superior microstructural features and significant field trapping ability compared with samples processed by conventional top-seeded melt growth suggest this technique could be a practical alternative for processing large, single-grain superconductors for engineering applications.

Y-Ba-Cu-O (YBCO) single grains have the potential to generate large trapped magnetic fields for a variety of engineering applications, and research on the processing and properties of this material has attracted world-wide interest. In particular, the introduction of flux pinning centres to the large grain microstructure to improve its current density, Jc, and hence trapped field, has been investigated extensively over the past decade. Y2Ba4CuMOx [Y-2411(M)], where M = Nb, Ta, Mo, W, Ru, Zr, Bi and Ag, has been reported to form particularly effective flux pinning centres in YBCO due primarily to its ability to exist as nano-size inclusions in the superconducting phase matrix. However, the addition of the Y-2411(M) phase to the precursor composition complicates the melt-processing of single grains. We report an investigation of the growth rate of single YBCO grains containing Y-2411(Bi) phase inclusions and Y2O3. The superconducting properties of these large single grains have been measured specifically to investigate the effect of Y2O3 on broadening the growth window of these materials.