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El trasfondo histórico y filosófico de tu obra es en sí de antología. Pero tú das unos pasos más allá de los estudios de moda —en sí valiosos— que se van acumulando sobre la filosofía desarrollada y compartida por estos máximos pensadores españoles. Tú profundizas en el continuo Ortega-Marías de una manera original pretendiendo convertir la teoría de la realidad radical e histórica de la persona en un manual de comportamiento ético y una estrategia social renovadora a escala ilimitada. En otras palabras, más allá del plano teórico, viene a ser en tus manos una filosofía aplicable a los problemas humanos actuales, personales, interpersonales y globales. (…) Naturalmente, al adoptar tal postura uno —y tú antes que nadie— se convierte en el enemigo de todo tipo de mentira, engaño y desfalco espiritual. Pasa por tu libro un nervio cervantino, lo cual puede acarrear hostilidades, pero también el consuelo, según las palabras del inmortal caballero manchego, de que Yo sé quien soy. Dr. Harold Raley Catedrático Emérito El autor de la obra, Manuel Carmona, es profesor de la URJC. [Texto de la editorial]

Nutritional supplements are popular among athletes to improve performance and physical recovery. Protein supplements fulfill this function by improving performance and increasing muscle mass; however, their effect on other organs or systems is less well known. Diet alterations can induce gut microbiota imbalance, with beneficial or deleterious consequences for the host. To test this, we performed a randomized pilot study in cross-country runners whose diets were complemented with a protein supplement (whey isolate and beef hydrolysate) (n = 12) or maltodextrin (control) (n = 12) for 10 weeks. Microbiota, water content, pH, ammonia, and short-chain fatty acids (SCFAs) were analyzed in fecal samples, whereas malondialdehyde levels (oxidative stress marker) were determined in plasma and urine. Fecal pH, water content, ammonia, and SCFA concentrations did not change, indicating that protein supplementation did not increase the presence of these fermentation-derived metabolites. Similarly, it had no impact on plasma or urine malondialdehyde levels; however, it increased the abundance of the Bacteroidetes phylum and decreased the presence of health-related taxa including Roseburia, Blautia, and Bifidobacterium longum. Thus, long-term protein supplementation may have a negative impact on gut microbiota. Further research is needed to establish the impact of protein supplements on gut microbiota.

Prostate cancer (PCa) is one of the most common cancers in older men and is associated with high mortality. Despite advances in screening for early detection of PCa, a large proportion of patients continue to be diagnosed with metastatic disease, with ~20% of men showing a high tumor grade and stage. Medicinal plant extracts have a great potential to prevent/treat PCa, as well as to reduce its incidence/prevalence and improve survival rates. One of the most promising extracts is curcumin, which is a major, nontoxic, bioactive compound of Curcuma longa. Curcumin has strong antitumor activity in vitro. However, its potential beneficial in vivo affects are limited by its low intestinal absorption and rapid metabolism. In this study, curcumin was impregnated into a biodegradable poly(lactic-co-glycolic) acid (PLGA) support and characterized by FTIR and DSC, and its release by UV spectrophotometry. PLGA-curcumin was tested in different subcutaneous PCa xenograft models (PC3, 22rv1, and DU145 PCa cell-lines), and its effects evaluated by tumor progression an immuno-histochemical analysis (Trichromic, Ki67 and TUNEL stainings), were compared with those of a commercial curcumin preparation. Our results indicate that curcumin-impregnated PLGA is significantly more active (~2-fold increase) with respect to oral curcumin, which supports its use for subcutaneous administration.

Thermoregulating microcapsules (MC) with flame-retardant properties were used to produce polyurethane (PU) foams. Thermogravimetric analyses of the microcapsules performed under atmospheric air and nitrogen confirmed that the hexa(methacryloylethylenedioxy) cyclotriphosphazene (PNC-HEMA) monomer raised the amount of residue after exposure to high temperature, proving the formation of a thermally stable char layer. Additionally, the flame-retardant properties of the microcapsules were analyzed by micro-combustion calorimetry (MCC), and the PU foams were tested by both MCC and cone calorimetry. The total heat release and maximum heat release rate were lower for microcapsules containing the flame-retardant PNC-HEMA. The composition of the microcapsules has been proved by MCC and TGA, where the release of the encapsulated phase change material (PCM) occurred at the expected temperature. However, in PU foams, the release of PCM is shifted to higher temperatures. Accordingly, these materials can be considered as an important alternative to commonly used microcapsules containing phase PCMs, where a lower flammability is required for their future application.

Proficient crop production is needed to ensure the feeding of a growing global population. The association of bacteria with plants plays an important role in the health state of the plants contributing to the increase of agricultural production. Endophytic bacteria are ubiquitous in most plant species providing, in most cases, plant promotion properties. However, the knowledge on the genetic determinants involved in the colonization of plants by endophytic bacteria is still poorly understood. In this work we have used a genetic approach based on the construction of fliM, pilX and eps knockout mutants to show that the motility mediated by a functional flagellum and the pili type IV, and the adhesion modulated by exopolysaccarides are required for the efficient colonization of rice roots by the endophyte Azoarcus sp. CIB. Moreover, we have demonstrated that expression of an exogenous diguanylate cyclase or phophodiesterase, which causes either an increase or decrease of the intracellular levels of the second messenger cyclic di-GMP (c-di-GMP), respectively, leads to a reduction of the ability of Azoarcus sp. CIB to colonize rice plants. Here we present results demonstrating the unprecedented role of the universal second messenger cyclic-di-GMP in plant colonization by an endophytic bacterium, Azoarcus sp. CIB. These studies pave the way to further strategies to modulate the interaction of endophytes with their target plant hosts.

Environmental pollutants can generate stress in plants causing increased ethylene production that leads to the inhibition of plant growth. Ethylene production by the stressed plant may be lowered by Plant Growth-Promoting Bacteria (PGPB) that metabolizes the immediate precursor of ethylene 1-aminocyclopropane-1-carboxylate (ACC). Thus, engineering PGPB with ACC deaminase activity can be a promising alternative to mitigate the harmful effects of pollutants and thus enhance plant production. Here we show that the aromatics-degrading and metal-resistant Azoarcus sp. CIB behaves as a PGP-bacterium when colonizing rice as an endophyte, showing a 30% increment in plant weight compared to non-inoculated plants. The cloning and expression of an acdS gene led to a recombinant strain, Azoarcus sp. CIB (pSEVA237acdS), possessing significant ACC deaminase activity (6716 nmol mg−1 h−1), constituting the first PGPB of the Rhodocyclaceae family equipped with this PGP trait. The recombinant CIB strain acquired the ability to protect inoculated rice plants from the stress induced by cadmium (Cd) exposure and to increase the Cd concentration in rice seedlings. The observed decrease of the levels of reactive oxygen species levels in rice roots confirms such a protective effect. The broad-host-range pSEVA237acdS plasmid paves the way to engineer PGPB with ACC deaminase activity to improve the growth of plants that might face stress conditions.

Renewable resources are playing a key role on the synthesis of biodegradable polyols. Moreover, the incorporation of covalently linked additives is increasing in importance in the polyurethane (PU) market. In this work, previously epoxidized grape seed oil and methyl oleate were transformed into phosphorylated biopolyols through an acid-catalyzed ring-opening hydrolysis in the presence of H 3 PO 4 . The formation of phosphate polyesters was confirmed by FT-IR and 31 P-NMR. However, the synthesis of a high-quality PU rigid foam was not possible using exclusively these polyols attending to their low hydroxyl value. In that way, different rigid PU foams were prepared from the phosphorylated biopolyols and the commercial polyol Alcupol R4520. It was observed that phosphorylated biopolyols can be incorporated up to a 57 wt.% in the PU synthesis without significant structural changes with respect to the commercial foam. Finally, thermogravimetric and EDAX analyses revealed an improvement of thermal stability by the formation of a protective phosphorocarbonaceous char layer.

Chia oil production and consumption have increased in recent years, producing a large number of by-products that had low utility or economic value for the industry. In this study, a biodegradable film was successfully prepared from mucilage extracted from defatted chia flour. The physical-chemical, optical, water vapor permeability (WVP), and mechanical properties of films made with two different types of chia matrixes (defatted flour and whole seeds) were determined. In general, defatted chia flour films exhibited a slightly reddish and yellowish color but still transparent in appearance, were good visible light barriers, and had better mechanical properties than films made with whole seeds. They also have greater WVP values than synthetic films such as low-density polyethylene. The results of the present study demonstrated that defatted chia flour can be used in producing edible films with improved quality characteristics.

El trasfondo histórico y filosófico de tu obra es en sí de antología. Pero tú das unos pasos más allá de los estudios de moda en sí valiosos que se van acumulando sobre la filosofía desarrollada y compartida por estos máximos pensadores españoles. Tú profundizas en el continuo Ortega-Marías de una manera original pretendiendo convertir la teoría de la realidad radical e histórica de la persona en un manual de comportamiento ético y una estrategia social renovadora a escala ilimitada. En otras palabras, más allá del plano teórico, viene a ser en tus manos una filosofía aplicable a los problemas humanos actuales, personales, interpersonales y globales. Naturalmente, al adoptar tal postura uno y tú antes que nadie se convierte en el enemigo de todo tipo de mentira, engaño y desfalco espiritual. Pasa por tu libro un nervio cervantino, lo cual puede acarrear hostilidades, pero también el consuelo, según las palabras del inmortal caballero manchego, de que “Yo sé quien soy\". Dr. Harold Raley Catedrático Emérito El autor de la obra, Manuel Carmona, es profesor de la URJC.