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Hope against hope : three schools, one city, and the struggle to educate America's children
\"Geraldlynn is a lively, astute 14-year-old. Her family, displaced by Hurricane Katrina, returns home to find a radically altered public education system. Geraldlynns parents hope their daughter's new school will prepare her college-but the teenager has ideals and ambitions of her own. Aidan is a fresh-faced Harvard grad drawn to New Orleans by the possibility of bringing change to a flood-ravaged city. He teaches at an ambitious charter school with a group of newcomers determined to show the world they can use science, data, and hard work to build a model school. Mary Laurie is a veteran educator who becomes principal of one of the first public high schools to reopen after Katrina. Laurie and her staff find they must fight each day not only to educate the city's teenagers, but to keep the Walker community safe and whole. In this powerful narrative non-fiction debut, the lives of these three characters provide readers with a vivid and sobering portrait of education in twenty-first-century America. Hope Against Hope works in the same tradition as Random Family and There Are No Children Here to capture the challenges of growing up and learning in a troubled world\"-- Provided by publisher.
Book
Trial Reporting in ClinicalTrials.gov — The Final Rule
The final rule for reporting clinical trial results has now been issued by the Department of Health and Human Services. It aims to increase accountability in the clinical research enterprise, making key information available to researchers, funders, and the public.
Title VIII of the Food and Drug Administration (FDA) Amendments Act of 2007 (FDAAA) expanded the legal mandate for sponsors and others responsible for certain clinical trials of FDA-regulated drug, biologic, and device products to register their studies and report summary results information to ClinicalTrials.gov,
1
which is managed by the National Library of Medicine at the National Institutes of Health (NIH). The statute expanded registration requirements and provided a legally defined timeline with specific requirements for the systematic reporting of summary trial results. Although statutory components took effect before 2010, the FDAAA directed the Department of Health and Human Services . . .
Journal Article
The Hutchinson dictionary of symbols in art
Practical key to the understanding and appreciation of Western painting and sculpture.
Book
Lost in the shadows: reflections on the dark side of co-production
This article is a response to Oliver et al.’s Commentary ‘The dark side of coproduction: do the costs outweigh the benefits for health research?’ recently published in
Health Research Policy and Systems
(2019, 17:33). The original commentary raises some important questions about how and when to co-produce health research, including highlighting various professional costs to those involved. However, we identify four related limitations in their inquiry, as follows: (1) the adoption of a problematically expansive definition of co-production that fails to acknowledge key features that distinguish co-production from broader collaboration; (2) a strong focus on technocratic rationales for co-producing research and a relative neglect of democratic rationales; (3) the transposition of legitimate concerns relating to collaboration between researchers and practitioners onto work with patients, service users and marginalised citizens; and (4) the presentation of bad
practice
as an inherent flaw, or indeed ‘dark side’, of co-production without attending to the corrupting influence of
contextual
factors within academic research that facilitate and even promote such malpractice. The Commentary’s limitations can be seen to reflect the contemporary use of the term ‘co-production’ more broadly. We describe this phenomenon as ‘cobiquity’ – an apparent appetite for participatory research practice and increased emphasis on partnership working, in combination with the related emergence of a plethora of ‘co’ words, promoting a conflation of meanings and practices from different collaborative traditions. This phenomenon commonly leads to a misappropriation of the term ‘co-production’. Our main motivation is to address this imprecision and the detrimental impact it has on efforts to enable co-production with marginalised and disadvantaged groups. We conclude that Oliver et al. stray too close to ‘the problem’ of ‘co-production’ seeing only the dark side rather than what is casting the shadows. We warn against such a restricted view and argue for greater scrutiny of the structural factors that largely explain academia’s failure to accommodate and promote the egalitarian and utilitarian potential of co-produced research.
Journal Article
Cryptocurrencies in public and private law
This book examines how cryptocurrencies based on blockchain technologies fit into existing general law categories of public and private law. The book takes the common law systems of the United Kingdom as the centre of its study but extends beyond the UK to show how cryptocurrencies would be accommodated in some Western European and East Asian legal systems outside the common law tradition.0By investigating traditional conceptions of money in public law and private law the work examines the difficulties of fitting cryptocurrencies within those approaches and models. Fundamental questions regarding issues of ownership, transfer, conflict of laws, and taxation are addressed with a view to equipping the reader with the tools to answer common transactional questions about cryptocurrencies. The international contributor team uses the common law systems of the United Kingdom as a basis for the analysis, but also looks comparatively to other systems across the wider common law and civil law world to provide detailed examination of the legal problems encountered.
Book
Resting‐State Functional Connectivity of Sensorimotor and Default Mode Networks and Lower Limb Performance in Chronic Stroke: A Cross‐Sectional Study
Introduction Stroke disrupts functional brain connectivity, yet how this relates to lower limb motor and sensory abilities is not well understood. Greater knowledge of movement‐related brain connectivity can aide in the development of better interventions for recovery after stroke. Our objective was to evaluate the relationship between lower limb performance and resting‐state functional connectivity (rsFC) of large‐scale brain networks for individuals with chronic motor deficits (> 6 months) after stroke. Methods Resting‐state functional magnetic resonance imaging and lower limb clinical measures were collected for 37 individuals. Regions of interest (ROI)‐to‐ROI connectivity analysis was conducted for cortical sensorimotor network (SMN) (cortical SMN), SMN with both cortical and subcortical ROIs (SMN), and default mode network (DMN). Relationship of ROI–ROI connectivity and clinical measures or lesion load was assessed using general linear models. Graph theory metrics (global efficiency, clustering coefficient, and betweenness centrality) were related to clinical measures using elastic nets analysis. Results Greater connectivity between several SMN and DMN ROI pairs was associated with better gait speed, Timed‐Up‐and‐Go score, and monofilament perception. The majority of ROI pairs showing statistically significant relationship with clinical measures were interhemispheric, non‐homologous, and cortical‐to‐subcortical. Elastic net analysis for graph theory metrics revealed complexity and multi‐directionality of the relationship of the individual ROIs to clinical outcomes and lesion load. There were unique sets of ROIs associated with each clinical measure for different graph metrics. Conclusions rsFC between specific ROIs within SMN and DMN are related to lower limb performance. Non‐homologous interhemispheric ROI‐to‐ROI connectivity was featured in the analysis. Graph theory analysis demonstrates the complex role that an individual ROI has in relation to sensorimotor function of lower extremity. Trial Registration Clinicialtrials.gov registration number NCT03666533 Resting‐state connectivity between specific regions of interest (ROI) within SMN and DMN is related to lower limb performance. Interhemispheric connectivity of non‐homologous ROIs was associated with better function. Graph theory analysis demonstrated the complex role that an individual ROI has in relation to sensorimotor function of lower extremity.
Journal Article
From the forest to the sea : Emily Carr in British Columbia
Published in conjunction with the exhibition at Dulwich Picture Gallery on November 1, 2014-March 8, 2015 and Art Gallery of Ontario on April 11-July 12, 2015.
Book
Transcriptomic Changes in Response to Form of Selenium on the Interferon-Tau Signaling Mechanism in the Caruncular Tissue of Beef Heifers at Maternal Recognition of Pregnancy
We have reported that selenium (Se) provided to grazing beef cattle in an inorganic (ISe) form versus a 1:1 mixture (MIX) of inorganic and organic (OSe) forms affects cholesterol biosynthesis in the corpus luteum (CL), the abundance of interferon tau (IFNτ) and progesterone (P4)-induced mRNAs in the caruncular (CAR) tissue of the endometrium, and conceptus length at maternal recognition of pregnancy (MRP). In this study, beef heifers were supplemented with a vitamin–mineral mix containing 35 ppm Se as ISe or MIX to achieve a Se-adequate status. Inseminated heifers were killed at MRP (d 17, n = 6 per treatment) for tissue collection. In CAR samples from MIX versus ISe heifers, qPCR revealed that mRNA encoding the thyroid regulating DIO2 and DIO3 was decreased (p < 0.05) and a complete transcriptomic analysis revealed effects on the interferon JAK-STAT1/2 pathway, including decreased expression of mRNAs encoding the classical interferon stimulated genes IFIT1, IFIT2, IFIT3, IRF1, IRF9, ISG15, OAS2, and RSAD2 (p < 0.05). Treatment also affected the abundance of mRNAs contributing to the immunotolerant environment (p < 0.05). In combination, these findings suggest more advanced preparation of the CAR and developing conceptus for implantation and to evade immune rejection by the maternal system in MIX- vs. ISe-treated heifers.
Journal Article
Lifelong learning in the workplace: the knowledge management role of corporate universities in China
In the current era of constant change, both employees and enterprises face the daunting challenge of lifelong learning. To address enterprises’ dissatisfaction with the knowledge provided by traditional universities, a growing number of corporate universities are being established, representing a crucial strategic pathway for enterprises. This study thus adopts the coding methodology of grounded theory to analyze the internal mechanism of a sample of seven corporate universities in China enabling organizations’ lifelong learning. Adopting the knowledge-based view (KBV), this study also identifies how corporate universities empower organizations, establishing a path model whose paths include “generating strategic knowledge”, “sharing business knowledge”, “optimizing governance knowledge” and “transforming cultural knowledge”. Accordingly, this study establishes a theoretical path model and explores how to empower organizations’ lifelong learning in the context of China. Moreover, our qualitative conclusions not only enrich the literature on corporate universities and their complex functions concerning lifelong learning and knowledge management but also have important implications for managers in enterprises and corporate universities.
Journal Article
Early Stopping in Experimentation With Real-Time Functional Magnetic Resonance Imaging Using a Modified Sequential Probability Ratio Test
Introduction: Functional magnetic resonance imaging (fMRI) often involves long scanning durations to ensure the associated brain activity can be detected. However, excessive experimentation can lead to many undesirable effects, such as from learning and/or fatigue effects, discomfort for the subject, excessive motion artifacts and loss of sustained attention on task. Overly long experimentation can thus have a detrimental effect on signal quality and accurate voxel activation detection. Here, we propose dynamic experimentation with real-time fMRI using a novel statistically driven approach that invokes early stopping when sufficient statistical evidence for assessing the task-related activation is observed. Methods: Voxel-level sequential probability ratio test (SPRT) statistics based on general linear models (GLMs) were implemented on fMRI scans of a mathematical 1-back task from 12 healthy teenage subjects and 11 teenage subjects born extremely preterm (EPT). This approach is based on likelihood ratios and allows for systematic early stopping based on target statistical error thresholds. We adopt a two-stage estimation approach that allows for accurate estimates of GLM parameters before stopping is considered. Early stopping performance is reported for different first stage lengths, and activation results are compared with full durations. Finally, group comparisons are conducted with both early stopped and full duration scan data. Numerical parallelization was employed to facilitate completion of computations involving a new scan within every repetition time (TR). Results: Use of SPRT demonstrates the feasibility and efficiency gains of automated early stopping, with comparable activation detection as with full protocols. Dynamic stopping of stimulus administration was achieved in around half of subjects, with typical time savings of up to 33% (4 min on a 12 min scan). A group analysis produced similar patterns of activity for control subjects between early stopping and full duration scans. The EPT group, individually, demonstrated more variability in location and extent of the activations compared to the normal term control group. This was apparent in the EPT group results, reflected by fewer and smaller clusters. Conclusion: A systematic statistical approach for early stopping with real-time fMRI experimentation has been implemented. This dynamic approach has promise for reducing subject burden and fatigue effects.
Journal Article