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"Carter, John"
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Warriors on horseback : the inside story of the professional jockey
A remarkable and riveting insight into the lives of jockeys. Jockeys who earn a living race riding on racehorses are a remarkable group. They are fiercely competitive on the racecourse but enjoy a tribal kinship in the weighing room. The minimum requirements for long-term success are courage, skill, athleticism and an intuitive understanding of how to \"get a tune\" out of a horse. This book celebrates these warriors on horseback, both the old and the new, highlighting the headline performers for jump racing and flat racing in the last five centuries--male and female and from around the globe--as well as taking the reader on a behind-the-scenes look at the lifestyle of professional jockeys in the 21st century. The book takes a tour of Aintree's weighing room, tracks a day in the life of a Derby-winning jockey and investigates the twin challenges faced by jockeys: inevitable injuries and 24/7 weight management. The book also looks back at historical events where jockeys have made the headlines, including the scandal of jockey Sam Chifney, Lord Bunbury and the Prince of Wales; Captain Becher and his attempt to negotiate Aintree's formidable fences during the Grand National's inaugural running; Fred Archer, who committed suicide in the mists of mental and physical misery; Red Pollard's partnership with the great American horse, Seabiscuit; Bob Champion, who recovered from cancer to win the Grand National, and Frankie Dettori's magnificent seven wins in one day at Ascot. Dettori is just one of the more recent jockeys featured; others include Lester Piggott, Bill Shoemaker, Scobie Breasley, Julie Krone, John Francome and Tony McCoy. The book features quotes and insights from eminent jockeys and racing insiders, people who know the profession and the sport; and is illustrated with captivating images from the world of horseracing. Includes foreword by Bob Champion MBE, former jump jockey and Grand National winner.
Book
Epidemiological and clinical characteristics of symptomatic hereditary transthyretin amyloid polyneuropathy: a global case series
We describe 542 cases of symptomatic hereditary transthyretin amyloid polyneuropathy (ATTR-PN) identified through a review of the literature published between 2005 and 2016. Approximately 18% of the cases were from countries where ATTR-PN is traditionally considered to be endemic (i.e., Portugal, Japan, and Sweden). East Asia (Japan, China, Taiwan, and South Korea) contributed a sizeable combined proportion (37.0%,
n
= 200) with Japan (
n
= 92) and China (
n
= 71) being the primary contributors. The most common genotypes among the 65 genotypes represented in the sample were Val30Met (47.6%), Ser77Tyr (10%), Ala97Ser (6.5%), and Phe64Leu (4.4%). Cases with genotypes other than the aforementioned four had the lowest ages at onset (mean 49.2 [standard deviation {SD} 21.0; inter-quartile range {IQR}14.7]) and diagnosis (mean 53.4 [SD 21.0; IQR 14.7]). Conversely, Phe64Leu mean age of onset was 67.5 (SD 8.8; IQR 5.2) and mean age of diagnosis was 71.3 (SD 8.8; IQR 5.4). The prevalence of upper and lower limb involvement at the time of diagnosis (67 and 41%) observed across all cases is consistent with the typical presentation of ATTR-PN. Other notable findings at the time of diagnosis included a high rate of impotence among the Ala97Ser cases versus all others (67% vs. 21%) and a high rate of non-motor visual symptoms (i.e., visual opacities and glaucoma) in the Ser77Tyr cases versus all others (93% vs. 16%). Though comparisons were made descriptively and were hindered by inconsistency of reporting across the cases, these findings support the notion that ATTR-PN is a more phenotypically and geographically variable disease than is typically considered.
Journal Article
How to train a train
Loco for locomotives? Get your ticket ready--here's everything you need to know about finding, keeping, and training your very own pet train.
Book
Violence and crime in nineteenth-century England
This book illuminates the origins and development of violence as a social issue by examining a critical period in the evolution of attitudes towards violence. It explores the meaning of violence through an accessible mixture of detailed empirical research and a broad survey of cutting-edge historical theory.
The author discusses topics such as street fighting, policing, sports, community discipline and domestic violence and shows how the nineteenth century established enduring patterns in views of violence.
Violence and Crime in Nineteenth-Century England will be essential reading for advanced students and researchers of modern British history, social and cultural history and criminology.
eBook
How to track a truck
\"A whimsical guide to training a \"pet truck\" instructs young enthusiasts on how to identify the most compatible truck for one's personality and how to use orange cone lures to secure a loyal vehicle.\"-- Provided by publisher.
Book
Inactivation of DAP12 in PMN Inhibits TREM1-Mediated Activation in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is an autoimmune disease characterized by dysregulated and chronic systemic inflammatory responses that affect the synovium, bone, and cartilage causing damage to extra-articular tissue. Innate immunity is the first line of defense against invading pathogens and assists in the initiation of adaptive immune responses. Polymorphonuclear cells (PMNs), which include neutrophils, are the largest population of white blood cells in peripheral blood and functionally produce their inflammatory effect through phagocytosis, cytokine production and natural killer-like cytotoxic activity. TREM1 (triggering receptor expressed by myeloid cells) is an inflammatory receptor in PMNs that signals through the use of the intracellular activating adaptor DAP12 to induce downstream signaling. After TREM crosslinking, DAP12's tyrosines in its ITAM motif get phosphorylated inducing the recruitment of Syk tyrosine kinases and eventual activation of PI3 kinases and ERK signaling pathways. While both TREM1 and DAP12 have been shown to be important activators of RA pathogenesis, their activity in PMNs or the importance of DAP12 as a possible therapeutic target have not been shown. Here we corroborate, using primary RA specimens, that isolated PMNs have an increased proportion of both TREM1 and DAP12 compared to normal healthy control isolated PMNs both at the protein and gene expression levels. This increased expression is highly functional with increased activation of ERK and MAPKs, secretion of IL-8 and RANTES and cytotoxicity of target cells. Importantly, based on our hypothesis of an imbalance of activating and inhibitory signaling in the pathogenesis of RA we demonstrate that inhibition of the DAP12 signaling pathway inactivates these important inflammatory cells.
Journal Article
